Click here to switch to the map view.

The map label for this gene is lpxC

Identifier: 209696047

GI number: 209696047

Start: 2855249

End: 2856166

Strand: Reverse

Name: lpxC

Synonym: VSAL_I2639

Alternate gene names: 209696047

Gene position: 2856166-2855249 (Counterclockwise)

Preceding gene: 209696048

Following gene: 209696045

Centisome position: 85.9

GC content: 40.85

Gene sequence:

>918_bases
ATGATCAGACAACGTACACTGAAAAGTATAGTGCAAATGACAGGGGTGGGTTTACACTCAGGCCGTAAAGTCACGCTTAC
TCTTCGTCCTGCAGCGGCAAATACAGGTGTAATTTATCGTCGTACAGACCTTAATCCACCGGTTGATTTCCCTGCGGATC
CAGAGTCAGTTCGCGATACTATGCTATGCACAGCGTTAGTTAATGATGATGGCGTACGAATCTCAACGGTTGAACACTTA
AACGCTGCATTAGCGGGCGTTGGTATTGATAACGTAGTTATCGAAGTCGATGCTCCTGAAATTCCAATTATGGATGGCAG
TGCGAGTCCTTTTGTTTATCTTTTACAATCTGCGGGTATTGAAGAACTTAATACAGCGAAGAAATTCATTCGTATTAAGA
AACCTGTTCGCATTGAAGATGGTGATAAGTGGGCTGAAATTCGTCCTTATAACGGTTTCCGCTTAGATTTCACAATTGAC
TTCAATCACCCTGCGATTGAATCTGATGACCAAAAATTAGTGTTTGAATTTTCAAGCCAATCGTTTATTAAAGATATTTC
ACGTGCCCGTACTTTTGGGTTCATGCGTGATATCGAGTACTTACAATCACAAAACCTATGTTTAGGCGGCAGTTTTGATT
GTGCTATTGTACTAGATGATTACCGTATTCTTAATGAAGACGGGTTACGTTTTGAAAATGAATTTGTAACACATAAAGTA
CTAGATGCTGTTGGCGACCTTTATATGTGTGGTCATAGTATTCTTGGTGAGTTAAGTGCTTATAAATCAGGTCATGCACT
AAATAATCAGTTGCTCCGTGCCGTTCTTGCTGATCAAGAAGCATGGGAGTGGACAACCATTGAAGATGAAAAAGACTCTC
CAGTTGCGTTTATGCAACCGGGAATGGTTCTTGCGTAA

Upstream 100 bases:

>100_bases
CATCAAAACGATTTGGTTTTATTAGAAGACTTATGCTAAAATTCCAAACCAGTTCATTGAATTGGTTTGGATTCAAGTAT
ATTTAAGTTGGGATGAGCAT

Downstream 100 bases:

>100_bases
ACTATCATCGAAATAAAAAAGCCAAGCATTGCTTGGCTTTTTTTATGTCTGAAGAATAAAGCTTATTTTTTATTTGCCAA
GGCAGCTAGGCTCTCTAAGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDTMLCTALVNDDGVRISTVEHL
NAALAGVGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGIEELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTID
FNHPAIESDDQKLVFEFSSQSFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFENEFVTHKV
LDAVGDLYMCGHSILGELSAYKSGHALNNQLLRAVLADQEAWEWTTIEDEKDSPVAFMQPGMVLA

Sequences:

>Translated_305_residues
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDTMLCTALVNDDGVRISTVEHL
NAALAGVGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGIEELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTID
FNHPAIESDDQKLVFEFSSQSFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFENEFVTHKV
LDAVGDLYMCGHSILGELSAYKSGHALNNQLLRAVLADQEAWEWTTIEDEKDSPVAFMQPGMVLA
>Mature_305_residues
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDTMLCTALVNDDGVRISTVEHL
NAALAGVGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGIEELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTID
FNHPAIESDDQKLVFEFSSQSFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFENEFVTHKV
LDAVGDLYMCGHSILGELSAYKSGHALNNQLLRAVLADQEAWEWTTIEDEKDSPVAFMQPGMVLA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=76.7213114754098, Blast_Score=507, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_ALISL (B6ELH0)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263977.1
- GeneID:   6987857
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2639
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.- [C]

Molecular weight: Translated: 34016; Mature: 34016

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDT
CCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
MLCTALVNDDGVRISTVEHLNAALAGVGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGI
EEEEEEECCCCEEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCHHHEEHHCCH
EELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTIDFNHPAIESDDQKLVFEFSSQ
HHHHHHHHHHHHCCCEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEEEEEECCH
SFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFENEFVTHKV
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECEEEECCCCCEECHHHHHHHH
LDAVGDLYMCGHSILGELSAYKSGHALNNQLLRAVLADQEAWEWTTIEDEKDSPVAFMQP
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEECC
GMVLA
CEECC
>Mature Secondary Structure
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDT
CCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
MLCTALVNDDGVRISTVEHLNAALAGVGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGI
EEEEEEECCCCEEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCHHHEEHHCCH
EELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTIDFNHPAIESDDQKLVFEFSSQ
HHHHHHHHHHHHCCCEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEEEEEECCH
SFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFENEFVTHKV
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECEEEECCCCCEECHHHHHHHH
LDAVGDLYMCGHSILGELSAYKSGHALNNQLLRAVLADQEAWEWTTIEDEKDSPVAFMQP
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEECC
GMVLA
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA