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The map label for this gene is nadC [H]

Identifier: 209696037

GI number: 209696037

Start: 2843902

End: 2844801

Strand: Direct

Name: nadC [H]

Synonym: VSAL_I2628

Alternate gene names: 209696037

Gene position: 2843902-2844801 (Clockwise)

Preceding gene: 209696031

Following gene: 209696038

Centisome position: 85.53

GC content: 43.11

Gene sequence:

>900_bases
ATGGACCTCAGCATGATTAAAACCCACGACAGCGACTCTCGTCTTGAATATTTAAAACAGCAACTTCCTGCTGAAATTAC
TCGCGCCGTTGCCGATACACTTCGTGAAGATCTAGGAGGAACACTTGATGTTTCTGCTGATATCACAGCAAGTTTAATCT
CAGAAGACAGTCAATCTGTTGCGACGATTATTACCCGAGAACACGGTGTATTTTGTGGAAAAATGTGGGCCGAAGAAGTA
TTTAAACAATTAGGCGGGACCGTTACGATTGAATGGCACGTAGAAGATGGCGACAAAGTAAAACCAAACCAAACACTTTG
TACATTAAGCGGCCCTTCACGCGCCCTACTAACGGGTGAGCGTAATGCGATGAACTTTATTCAAACGTTGTCTGGTTGTT
CGACTATTACCGCAACCTATGCTGAAAAAATCGCACACACAAAATGCCGCTTACTTGATACGCGTAAAACCATCCCAGGG
TTACGCAGTGCATTAAAATACGCCGTCGCGTGTGGCGGTGGTTATAATCATCGTATCGGTGTGTTTGATGCTTATCTAAT
TAAAGAAAACCACATCATTGCATGTGGTGGCATTGAAAAGGCCATTTCAACGGCAAAAGAATTGAATCCGGGCAAGCCTG
TAGAAGTCGAAACAGAAAGTTTAGAAGAGTTGCAACAAGCCATTGATGCAGGGGCTGATATTATTATGCTCGATAATTTC
ACCACAGACATGATGCGTGAAGCCGTTAAACTAAACGCAGGTCGTGCTGCATTAGAAAATTCAGGTAATGTCACTTTAGA
TACCATCGCGGAATACGCAGAAACAGGGGTCAATTATATCTCTGTGGGCGCCTTAACTAAGCACCTTACTGCAATGGATT
TATCCATGCGTTTTAAATAA

Upstream 100 bases:

>100_bases
TCTATTCCTACATAAATTGAAGTAACTTTAGGTATCTTATGATGAAATTCTGCTCTAGCGCGAGTATTATTGTGTGAATC
AACTTATTTCAAATAATTCA

Downstream 100 bases:

>100_bases
ATTAATCTCACCTTGTTTTATAAAAGAGCCAGCCTTAATGGTTGGCTCTTTTTGTTTAAACTGAACATAAAAATCATCTA
CTTTCTTTGATGAACACCAC

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MDLSMIKTHDSDSRLEYLKQQLPAEITRAVADTLREDLGGTLDVSADITASLISEDSQSVATIITREHGVFCGKMWAEEV
FKQLGGTVTIEWHVEDGDKVKPNQTLCTLSGPSRALLTGERNAMNFIQTLSGCSTITATYAEKIAHTKCRLLDTRKTIPG
LRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
TTDMMREAVKLNAGRAALENSGNVTLDTIAEYAETGVNYISVGALTKHLTAMDLSMRFK

Sequences:

>Translated_299_residues
MDLSMIKTHDSDSRLEYLKQQLPAEITRAVADTLREDLGGTLDVSADITASLISEDSQSVATIITREHGVFCGKMWAEEV
FKQLGGTVTIEWHVEDGDKVKPNQTLCTLSGPSRALLTGERNAMNFIQTLSGCSTITATYAEKIAHTKCRLLDTRKTIPG
LRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
TTDMMREAVKLNAGRAALENSGNVTLDTIAEYAETGVNYISVGALTKHLTAMDLSMRFK
>Mature_299_residues
MDLSMIKTHDSDSRLEYLKQQLPAEITRAVADTLREDLGGTLDVSADITASLISEDSQSVATIITREHGVFCGKMWAEEV
FKQLGGTVTIEWHVEDGDKVKPNQTLCTLSGPSRALLTGERNAMNFIQTLSGCSTITATYAEKIAHTKCRLLDTRKTIPG
LRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
TTDMMREAVKLNAGRAALENSGNVTLDTIAEYAETGVNYISVGALTKHLTAMDLSMRFK

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=293, Percent_Identity=33.1058020477816, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1786299, Length=294, Percent_Identity=61.5646258503401, Blast_Score=348, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6321162, Length=285, Percent_Identity=30.5263157894737, Blast_Score=123, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32489; Mature: 32489

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSMIKTHDSDSRLEYLKQQLPAEITRAVADTLREDLGGTLDVSADITASLISEDSQSV
CCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHCCCCHHH
ATIITREHGVFCGKMWAEEVFKQLGGTVTIEWHVEDGDKVKPNQTLCTLSGPSRALLTGE
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEEEECCCCCEEEECC
RNAMNFIQTLSGCSTITATYAEKIAHTKCRLLDTRKTIPGLRSALKYAVACGGGYNHRIG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEE
VFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
HEEEEEEECCCEEEECCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEECCC
TTDMMREAVKLNAGRAALENSGNVTLDTIAEYAETGVNYISVGALTKHLTAMDLSMRFK
CHHHHHHHHHHCCCHHHHCCCCCEEHHHHHHHHHCCCCEEEHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MDLSMIKTHDSDSRLEYLKQQLPAEITRAVADTLREDLGGTLDVSADITASLISEDSQSV
CCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHCCCCHHH
ATIITREHGVFCGKMWAEEVFKQLGGTVTIEWHVEDGDKVKPNQTLCTLSGPSRALLTGE
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEEEECCCCCEEEECC
RNAMNFIQTLSGCSTITATYAEKIAHTKCRLLDTRKTIPGLRSALKYAVACGGGYNHRIG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEE
VFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
HEEEEEEECCCEEEECCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEECCC
TTDMMREAVKLNAGRAALENSGNVTLDTIAEYAETGVNYISVGALTKHLTAMDLSMRFK
CHHHHHHHHHHCCCHHHHCCCCCEEHHHHHHHHHCCCCEEEHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]