Click here to switch to the map view.

The map label for this gene is upp

Identifier: 209695814

GI number: 209695814

Start: 2558416

End: 2559042

Strand: Reverse

Name: upp

Synonym: VSAL_I2389

Alternate gene names: 209695814

Gene position: 2559042-2558416 (Counterclockwise)

Preceding gene: 209695817

Following gene: 209695812

Centisome position: 76.96

GC content: 40.67

Gene sequence:

>627_bases
ATGAAAGTTGTTGAAGTAAAACATCCGCTAATAAAACATAAAATTGGTTTAATGCGCGAAGGCGATATCAGCACTAAGCG
TTTTCGTGAATTAGCAACTGAAGTAGGTAGCTTACTTACTTATGAAGCAACATCAGACTTTGAGACAGAAAAAGTAACTA
TCAATGGCTGGAACGGCCCTGTTGAAGTTGACCAAATTAAAGGTAAAAAAGTAACGGTAGTGCCAATCTTACGTGCAGGT
CTTGGCATGATGGATGGCGTTCTTGAGCACATCCCAAGTGCGCGTATCAGTGTTGTTGGTATTTACCGTGACGAAGAAAC
GTTAGAGCCTGTACCTTACTTTAACAAGTTAGCGTCTAACATCGATGAGCGTATTGCTTTAGTTGTTGATCCAATGCTAG
CGACTGGCGGTTCTATGATCGCAACGCTTGATCTTTTAAAAGAGAAAGGCTGTAAGAACTTTAAAATTCTTGTTCTTGTT
GCTGCTCCTGAAGGCATTGCTGCATTAGAAAAAGCGCATCCAGATGTTGAGCTTTATACTGCGGCTATCGATGAGAAGTT
GAATGATAAAGGTTACATCATTCCAGGTCTTGGTGATGCTGGTGATAAGATCTTCGGTACTAAGTAA

Upstream 100 bases:

>100_bases
TATTTGAGAATGACGGCATAAATTATTTTAATGTGTAGTCATTTTTTATATGAAAAGTATGTATAATTGAAAGGTTTGAT
TAATGTATCTGGAGTCAGAA

Downstream 100 bases:

>100_bases
TCGGCACCATTAAGTAATTATATGTACTGGATGCTTTAAGCATTAAAAAAGGATTGATGGGTAACCATCAATCCTTTTTA
TTTACCCTAGACCTAGACCT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKVVEVKHPLIKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETEKVTINGWNGPVEVDQIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEKGCKNFKILVLV
AAPEGIAALEKAHPDVELYTAAIDEKLNDKGYIIPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKVVEVKHPLIKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETEKVTINGWNGPVEVDQIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEKGCKNFKILVLV
AAPEGIAALEKAHPDVELYTAAIDEKLNDKGYIIPGLGDAGDKIFGTK
>Mature_208_residues
MKVVEVKHPLIKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETEKVTINGWNGPVEVDQIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEKGCKNFKILVLV
AAPEGIAALEKAHPDVELYTAAIDEKLNDKGYIIPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=27.2277227722772, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=27.2277227722772, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=85.0961538461538, Blast_Score=372, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.8756218905473, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.8756218905473, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=41.304347826087, Blast_Score=104, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_ALISL (B6EJU2)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263744.1
- GeneID:   6989055
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2389
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22669; Mature: 22669

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVEVKHPLIKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETEKVTINGWNGP
CCEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCCC
VEVDQIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFNKLASN
EEEEECCCCEEEEEHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHC
IDERIALVVDPMLATGGSMIATLDLLKEKGCKNFKILVLVAAPEGIAALEKAHPDVELYT
HHHHEEEEECHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCCEEEH
AAIDEKLNDKGYIIPGLGDAGDKIFGTK
HHHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKVVEVKHPLIKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETEKVTINGWNGP
CCEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCCC
VEVDQIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFNKLASN
EEEEECCCCEEEEEHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHC
IDERIALVVDPMLATGGSMIATLDLLKEKGCKNFKILVLVAAPEGIAALEKAHPDVELYT
HHHHEEEEECHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCCEEEH
AAIDEKLNDKGYIIPGLGDAGDKIFGTK
HHHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA