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The map label for this gene is dapA

Identifier: 209695804

GI number: 209695804

Start: 2549488

End: 2550369

Strand: Reverse

Name: dapA

Synonym: VSAL_I2379

Alternate gene names: 209695804

Gene position: 2550369-2549488 (Counterclockwise)

Preceding gene: 209695807

Following gene: 209695803

Centisome position: 76.7

GC content: 40.7

Gene sequence:

>882_bases
ATGTTCTCAGGTAGCATTGTCGCCTTAGTGACACCATTGGACACCGATGGTGAAGTTGATTACACAAGTTTAAAAAATCT
CGTTGATTATCATATTAATGCAGGTACAGATGGCATTGTTGCTGTTGGCACTACTGGTGAGTCAGCGACATTAAGTGTAG
AAGAACATGTCAAGTTAGTGATGAAAACGCTTGAGTTTTCTGATGGCAGAATTCCTGTTATTGCCGGTACTGGCGCAAAC
GCGACTCATGAAGCGGTAACGTTCAGTAAATTATTTCGAGATTCAGGTGTTGCTGGCTGTTTAAGCGTAACGCCTTATTA
TAATAAGCCAACACAAGAAGGTTTATTCTTACATTATAAAGCGATTTCTGAATCCACGGATGTACCTCAAATCCTTTACA
ATGTTCCGGGTCGCACGGCCGTAGATTTATTGCCAGAAACGGTAGCTCGTTTAGCTGAATTTGATAATATTGTCGCTTTA
AAAGATGCGACAGCAGAATTAGACCGAATTGCAATTACGCGTGAACTTTGTGGTGATAAATTTATCCAACTAAGTGGTGA
TGACGCAACGGCACTTGAATTTGTTAAAATGGGCGGTCATGGTGTTATTTCTGTAACGGCAAACGTAGCAGCAAAAGACA
TGGCAACCATGTTTGCATTAGCGGCTCAAGGTAAGTTTGAAGAAGCGGAAATTATTAATCAACGCTTAATGCCATTACAT
CAGGATTTGTTTGTTGAAGCGAATCCAATGCCTGTTAAATGGGCCACTCATCGTTTAGGGATGATTACTCACCCTGATAT
TCGTTTACCACTAACAGAATTAAGTCATTCAGCACAACCAGTTGTTGAACAAGCATTAATTCGTGCTGGTGTGTTGAAGT
AG

Upstream 100 bases:

>100_bases
GTGATTGTATGATGAACAAGGGCGATAACGCTTTGCCATCATATTAATGAATAACTCAATTTGTTCGCCATTCTCAGGCT
GATTAAAAAGGGAGAAGGAT

Downstream 100 bases:

>100_bases
TAGGATAAAAAATGAAAGTGAACACTCGCTTTGTTGTTGGATCATTGATGGTTGCTATGTTAGCGGCTTGTTCAAGCAGT
CCAACTGAGCGTCGCCAAGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MFSGSIVALVTPLDTDGEVDYTSLKNLVDYHINAGTDGIVAVGTTGESATLSVEEHVKLVMKTLEFSDGRIPVIAGTGAN
ATHEAVTFSKLFRDSGVAGCLSVTPYYNKPTQEGLFLHYKAISESTDVPQILYNVPGRTAVDLLPETVARLAEFDNIVAL
KDATAELDRIAITRELCGDKFIQLSGDDATALEFVKMGGHGVISVTANVAAKDMATMFALAAQGKFEEAEIINQRLMPLH
QDLFVEANPMPVKWATHRLGMITHPDIRLPLTELSHSAQPVVEQALIRAGVLK

Sequences:

>Translated_293_residues
MFSGSIVALVTPLDTDGEVDYTSLKNLVDYHINAGTDGIVAVGTTGESATLSVEEHVKLVMKTLEFSDGRIPVIAGTGAN
ATHEAVTFSKLFRDSGVAGCLSVTPYYNKPTQEGLFLHYKAISESTDVPQILYNVPGRTAVDLLPETVARLAEFDNIVAL
KDATAELDRIAITRELCGDKFIQLSGDDATALEFVKMGGHGVISVTANVAAKDMATMFALAAQGKFEEAEIINQRLMPLH
QDLFVEANPMPVKWATHRLGMITHPDIRLPLTELSHSAQPVVEQALIRAGVLK
>Mature_293_residues
MFSGSIVALVTPLDTDGEVDYTSLKNLVDYHINAGTDGIVAVGTTGESATLSVEEHVKLVMKTLEFSDGRIPVIAGTGAN
ATHEAVTFSKLFRDSGVAGCLSVTPYYNKPTQEGLFLHYKAISESTDVPQILYNVPGRTAVDLLPETVARLAEFDNIVAL
KDATAELDRIAITRELCGDKFIQLSGDDATALEFVKMGGHGVISVTANVAAKDMATMFALAAQGKFEEAEIINQRLMPLH
QDLFVEANPMPVKWATHRLGMITHPDIRLPLTELSHSAQPVVEQALIRAGVLK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=281, Percent_Identity=25.9786476868327, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=61.6438356164384, Blast_Score=386, Evalue=1e-109,
Organism=Escherichia coli, GI87082415, Length=297, Percent_Identity=29.96632996633, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=29.3877551020408, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789620, Length=293, Percent_Identity=25.5972696245734, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_ALISL (B6EJT2)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263734.1
- ProteinModelPortal:   B6EJT2
- GeneID:   6987727
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2379
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31560; Mature: 31560

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSGSIVALVTPLDTDGEVDYTSLKNLVDYHINAGTDGIVAVGTTGESATLSVEEHVKLV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHEEECCCCCCEEEEECCCCCEEEEHHHHHHHH
MKTLEFSDGRIPVIAGTGANATHEAVTFSKLFRDSGVAGCLSVTPYYNKPTQEGLFLHYK
HHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEE
AISESTDVPQILYNVPGRTAVDLLPETVARLAEFDNIVALKDATAELDRIAITRELCGDK
ECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCCE
FIQLSGDDATALEFVKMGGHGVISVTANVAAKDMATMFALAAQGKFEEAEIINQRLMPLH
EEEECCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
QDLFVEANPMPVKWATHRLGMITHPDIRLPLTELSHSAQPVVEQALIRAGVLK
HHHEEECCCCCEEEHHHHCCCEECCCCCCCHHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MFSGSIVALVTPLDTDGEVDYTSLKNLVDYHINAGTDGIVAVGTTGESATLSVEEHVKLV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHEEECCCCCCEEEEECCCCCEEEEHHHHHHHH
MKTLEFSDGRIPVIAGTGANATHEAVTFSKLFRDSGVAGCLSVTPYYNKPTQEGLFLHYK
HHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEE
AISESTDVPQILYNVPGRTAVDLLPETVARLAEFDNIVALKDATAELDRIAITRELCGDK
ECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCCE
FIQLSGDDATALEFVKMGGHGVISVTANVAAKDMATMFALAAQGKFEEAEIINQRLMPLH
EEEECCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
QDLFVEANPMPVKWATHRLGMITHPDIRLPLTELSHSAQPVVEQALIRAGVLK
HHHEEECCCCCEEEHHHHCCCEECCCCCCCHHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA