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The map label for this gene is ddc [H]

Identifier: 209695482

GI number: 209695482

Start: 2178698

End: 2180341

Strand: Reverse

Name: ddc [H]

Synonym: VSAL_I2032

Alternate gene names: 209695482

Gene position: 2180341-2178698 (Counterclockwise)

Preceding gene: 209695483

Following gene: 209695481

Centisome position: 65.57

GC content: 39.23

Gene sequence:

>1644_bases
ATGGTAACAGACAACAAAACGGCAGATGCCAACCTAGAAAGTATGCTGCGAATTTTTACTGTTCCGGAAGCGCCCGATTC
GACACTTGGTAAAATAGAACAAGAACTCTCTCAAAATCTAAATCAGTTTTTAAGAGAGCATATTGTTGCCGAAGAAAAGC
CATTAACGGAAATTGAAAAAGACTTTACTGACTCGTCAATGCCAGAATATCCAACCTATGTTTCTGAGCATACCGAGCAT
TTATTAGAGACCGTTGTTTCACAGTCCGTTCATACTTCAGCGCCAAGCTTCATTGGTCACATGACATCCGCATTGCCTTA
TTTCTTAATGCCACTGTCAAAGATCATGATTGCGTTAAACCAAAACTTGGTGAAAATTGAAACCTCTAAAGCCTTCACTC
CATTAGAGCGCCAAGTTTTAGGTATGTTACATCGATTGATCTACGGTCAAGAAAGCGCATTTTATGAACGTTGGATGCAC
AGTGCTGACCACTCATTAGGCGCTTTTTGTTCTGGCGGGACAATTGCAAACATTACGGCGTTATGGGTAGCACGAAATCG
CTTATTACAACCAGAAGGCAATTTTAAAGGAATTGCTCAAGAAGGGTTATTTGCGGCTTTAACGCATTACAAATACAGTG
GTTTAGCTATTTTTGTTTCAGAACGTGGTCATTACTCTGTAAAAAAAGCCGCTGATGTACTTGGTATCGGTCAGGATAGC
GTTATTCCAGTCAAGACTGATAACAATAATCGCATTTGTCTGCATGATCTTAAGCTAAAGATGGCTCAAGCCAAAGAGAA
AAACATTAAGCCATTAGCTATCATCGGCGTTGCAGGTACAACAGAAACTGGCACTATCGATCCATTACGAGCTTTAGCTG
AAGTAGCAAAACAAGTAAATTGCCATTTCCACGTTGATGCCGCTTGGGGCGGAGCGACCTTAATGTCGAACCAATACCGT
TATTTACTTGATGGCATCGATTTAGCGGATTCAGTCACCATTGATGCACATAAGCAACTTTATGTTCCTATGGGTGCAGG
CATGGTCATATTTAAAGACCCAGAATTGATGTCTTCTATTCAACATCATGCCGAGTATATTTTACGAAAAGGTTCAAAAG
ATTTAGGCAGACACACATTAGAAGGCTCTCGAAGTGGTATGGCAATGCTGCTTTATTCTTGTTTTAATGTAATCAGTCGA
CCTGGCTATGAATTATTGATCAATCAAAGCATTGAGAAAGCAAAATATTTTGCTGAGATTATTGATCAACAAGACGATTT
TGAAGTTATTACTCAGCCTGAGCTTTGTTTATTAACCTATCGATATATTCCAAAGAATGTAACGTTAGCACTTACAAAAG
CAAATCCTGAGCAAACCATTGAGATTTATGACCACCTAGATGAACTGACTAAGTTTATTCAAAAAACTCAACGAGAAACC
GGGAAATCATTTGTATCTCGAACTCGACTAACACCTGAAGCGTATCAAAATATGCCGACCATCGTATTTCGAGTCGTTTT
AGCCAATCCGTTAACCACCAAAGAGATCCTTCACTCTGTATTAATTGAGCAGAGAGAAATCGCACAAAAAAGCGAAATAT
CACTCCCACAATTGACGAAATTGGCTGATTCTATTTTAAAATAA

Upstream 100 bases:

>100_bases
AAGACATTTTTGTCATTTTGTTCTAAATTGTGCCTTTTAGTCTCCAGCAAAGAGTGTATTTTCTTTGCCTTTCAATCACC
AACAGAATAGAACAGATACC

Downstream 100 bases:

>100_bases
AGACATTATTGGGTTATATAAGTTGTTTTAATTTTGTAAAACAACTTATGTAACCTGTAATTCATTTCCTTAAACTCTGA
AAATAAACCACATAATCAAA

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MVTDNKTADANLESMLRIFTVPEAPDSTLGKIEQELSQNLNQFLREHIVAEEKPLTEIEKDFTDSSMPEYPTYVSEHTEH
LLETVVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIYGQESAFYERWMH
SADHSLGAFCSGGTIANITALWVARNRLLQPEGNFKGIAQEGLFAALTHYKYSGLAIFVSERGHYSVKKAADVLGIGQDS
VIPVKTDNNNRICLHDLKLKMAQAKEKNIKPLAIIGVAGTTETGTIDPLRALAEVAKQVNCHFHVDAAWGGATLMSNQYR
YLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSIQHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISR
PGYELLINQSIEKAKYFAEIIDQQDDFEVITQPELCLLTYRYIPKNVTLALTKANPEQTIEIYDHLDELTKFIQKTQRET
GKSFVSRTRLTPEAYQNMPTIVFRVVLANPLTTKEILHSVLIEQREIAQKSEISLPQLTKLADSILK

Sequences:

>Translated_547_residues
MVTDNKTADANLESMLRIFTVPEAPDSTLGKIEQELSQNLNQFLREHIVAEEKPLTEIEKDFTDSSMPEYPTYVSEHTEH
LLETVVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIYGQESAFYERWMH
SADHSLGAFCSGGTIANITALWVARNRLLQPEGNFKGIAQEGLFAALTHYKYSGLAIFVSERGHYSVKKAADVLGIGQDS
VIPVKTDNNNRICLHDLKLKMAQAKEKNIKPLAIIGVAGTTETGTIDPLRALAEVAKQVNCHFHVDAAWGGATLMSNQYR
YLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSIQHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISR
PGYELLINQSIEKAKYFAEIIDQQDDFEVITQPELCLLTYRYIPKNVTLALTKANPEQTIEIYDHLDELTKFIQKTQRET
GKSFVSRTRLTPEAYQNMPTIVFRVVLANPLTTKEILHSVLIEQREIAQKSEISLPQLTKLADSILK
>Mature_547_residues
MVTDNKTADANLESMLRIFTVPEAPDSTLGKIEQELSQNLNQFLREHIVAEEKPLTEIEKDFTDSSMPEYPTYVSEHTEH
LLETVVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIYGQESAFYERWMH
SADHSLGAFCSGGTIANITALWVARNRLLQPEGNFKGIAQEGLFAALTHYKYSGLAIFVSERGHYSVKKAADVLGIGQDS
VIPVKTDNNNRICLHDLKLKMAQAKEKNIKPLAIIGVAGTTETGTIDPLRALAEVAKQVNCHFHVDAAWGGATLMSNQYR
YLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSIQHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISR
PGYELLINQSIEKAKYFAEIIDQQDDFEVITQPELCLLTYRYIPKNVTLALTKANPEQTIEIYDHLDELTKFIQKTQRET
GKSFVSRTRLTPEAYQNMPTIVFRVVLANPLTTKEILHSVLIEQREIAQKSEISLPQLTKLADSILK

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=510, Percent_Identity=27.6470588235294, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4503875, Length=510, Percent_Identity=27.6470588235294, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI58331246, Length=478, Percent_Identity=26.5690376569038, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI194294551, Length=467, Percent_Identity=27.1948608137045, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI197383062, Length=452, Percent_Identity=26.7699115044248, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI4503281, Length=384, Percent_Identity=20.8333333333333, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI132814448, Length=384, Percent_Identity=20.8333333333333, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI92110055, Length=355, Percent_Identity=23.0985915492958, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555682, Length=476, Percent_Identity=26.890756302521, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71993062, Length=457, Percent_Identity=26.9146608315098, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71993058, Length=392, Percent_Identity=28.0612244897959, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI17136594, Length=456, Percent_Identity=28.7280701754386, Blast_Score=175, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24657193, Length=372, Percent_Identity=28.2258064516129, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24657185, Length=372, Percent_Identity=28.2258064516129, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24657188, Length=372, Percent_Identity=28.2258064516129, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI21356415, Length=463, Percent_Identity=24.622030237581, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI221476190, Length=231, Percent_Identity=24.6753246753247, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585143, Length=231, Percent_Identity=24.6753246753247, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585139, Length=231, Percent_Identity=24.6753246753247, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 61326; Mature: 61326

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTDNKTADANLESMLRIFTVPEAPDSTLGKIEQELSQNLNQFLREHIVAEEKPLTEIEK
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DFTDSSMPEYPTYVSEHTEHLLETVVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALN
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
QNLVKIETSKAFTPLERQVLGMLHRLIYGQESAFYERWMHSADHSLGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHH
LWVARNRLLQPEGNFKGIAQEGLFAALTHYKYSGLAIFVSERGHYSVKKAADVLGIGQDS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
VIPVKTDNNNRICLHDLKLKMAQAKEKNIKPLAIIGVAGTTETGTIDPLRALAEVAKQVN
EEEEEECCCCEEEEEHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCC
CHFHVDAAWGGATLMSNQYRYLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSI
CEEEEECCCCCHHHHCCCCHHHHCCCCCCCCEEEECCCEEEEECCCCEEEEECHHHHHHH
QHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISRPGYELLINQSIEKAKYFAEI
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHH
IDQQDDFEVITQPELCLLTYRYIPKNVTLALTKANPEQTIEIYDHLDELTKFIQKTQRET
HCCCCCCEEECCCCCEEEEHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
GKSFVSRTRLTPEAYQNMPTIVFRVVLANPLTTKEILHSVLIEQREIAQKSEISLPQLTK
HHHHHHHHCCCHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LADSILK
HHHHHCC
>Mature Secondary Structure
MVTDNKTADANLESMLRIFTVPEAPDSTLGKIEQELSQNLNQFLREHIVAEEKPLTEIEK
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DFTDSSMPEYPTYVSEHTEHLLETVVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALN
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
QNLVKIETSKAFTPLERQVLGMLHRLIYGQESAFYERWMHSADHSLGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHH
LWVARNRLLQPEGNFKGIAQEGLFAALTHYKYSGLAIFVSERGHYSVKKAADVLGIGQDS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
VIPVKTDNNNRICLHDLKLKMAQAKEKNIKPLAIIGVAGTTETGTIDPLRALAEVAKQVN
EEEEEECCCCEEEEEHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCC
CHFHVDAAWGGATLMSNQYRYLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSI
CEEEEECCCCCHHHHCCCCHHHHCCCCCCCCEEEECCCEEEEECCCCEEEEECHHHHHHH
QHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISRPGYELLINQSIEKAKYFAEI
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHH
IDQQDDFEVITQPELCLLTYRYIPKNVTLALTKANPEQTIEIYDHLDELTKFIQKTQRET
HCCCCCCEEECCCCCEEEEHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
GKSFVSRTRLTPEAYQNMPTIVFRVVLANPLTTKEILHSVLIEQREIAQKSEISLPQLTK
HHHHHHHHCCCHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LADSILK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]