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The map label for this gene is hexR [H]

Identifier: 209695481

GI number: 209695481

Start: 2177492

End: 2178346

Strand: Reverse

Name: hexR [H]

Synonym: VSAL_I2031

Alternate gene names: 209695481

Gene position: 2178346-2177492 (Counterclockwise)

Preceding gene: 209695482

Following gene: 209695480

Centisome position: 65.51

GC content: 38.83

Gene sequence:

>855_bases
ATGAATACCATTGAAAAAATACAAAATAATCTAGATAACTTTAGTAAATCAGAACGTAAAGTTGCTGAAGTTATAATGGC
ATCACCACAAACTGCAATTCATTCAAGTATCGCAACCTTAGCTAAAATGGCCGATGTTAGTGAGCCTACGGTTAACCGTT
TTTGTCGCCGTCTTGATACTAAAGGGTTTCCTGATTTTAAACTTCACCTTGCTCAAAGTCTGGCAAACGGCACACCTTAT
GTAAATCGCAATGTTGAAGAACATGATGGACCAGATGCGTATACTCATAAGATTTTTGAATCGACAATGGCATGCCTTGA
TGTTGCTAAAAACAGTCTTGATCCAATGCAAATTAACCGTGCTGTAGATTTGTTAACTCAAGCAAAGAAAATTTCATTCT
TTGGCTTAGGCGCTTCAGCATCCGTTGCTCATGATGCCATGAATAAATTCTTCCGTTTTAACATTCCAATCACTTGCTTT
GATGACATTGTAATGCAACGCATGAGCTGTATTAATAGTACAGAAAATGATGTCGTTGTTCTTATTTCTCATACTGGTCG
TACAAAGAGCTTGGTAGAAATCGCAGAGCTGGCAAGATCAAATGGTGCAACCGTTATCGCCATTACTGCGAAAGAATCGC
CATTAGAAAAAATGTCTTCTCTAGCGATTTGTTTAGACGTTCCTGAAGACACTGACGTTTATATGCCAATGGCCAGCCGT
GTAGTGCAAATGACGGTCATTGATGTTCTAGCTACTGGCTTTACACTCCGCCGCGGTGCAGGATTTAGAGATAATTTAAA
ACGCGTTAAAGAAGCACTTAAAGACTCACGCTTTGAAAAAGAAAACCACTATTAA

Upstream 100 bases:

>100_bases
AAATAATACTTATATTTTATAATCTTAACCAGAGCATATCGCTTGAGTCTATTCTTGTTAAGGTTATACCCTATTACGCA
CTGAACGTAGAAGAATACAT

Downstream 100 bases:

>100_bases
GTCTTTTTGAATTTACTTCATCTCAATAAAACAAAGCTAATGTAATGATACATTGGCTTTATTATTTCTATAAAATCAAT
ATCCTACTACTTCCCCCCTG

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNTIEKIQNNLDNFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEHDGPDAYTHKIFESTMACLDVAKNSLDPMQINRAVDLLTQAKKISFFGLGASASVAHDAMNKFFRFNIPITCF
DDIVMQRMSCINSTENDVVVLISHTGRTKSLVEIAELARSNGATVIAITAKESPLEKMSSLAICLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGAGFRDNLKRVKEALKDSRFEKENHY

Sequences:

>Translated_284_residues
MNTIEKIQNNLDNFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEHDGPDAYTHKIFESTMACLDVAKNSLDPMQINRAVDLLTQAKKISFFGLGASASVAHDAMNKFFRFNIPITCF
DDIVMQRMSCINSTENDVVVLISHTGRTKSLVEIAELARSNGATVIAITAKESPLEKMSSLAICLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGAGFRDNLKRVKEALKDSRFEKENHY
>Mature_284_residues
MNTIEKIQNNLDNFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEHDGPDAYTHKIFESTMACLDVAKNSLDPMQINRAVDLLTQAKKISFFGLGASASVAHDAMNKFFRFNIPITCF
DDIVMQRMSCINSTENDVVVLISHTGRTKSLVEIAELARSNGATVIAITAKESPLEKMSSLAICLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGAGFRDNLKRVKEALKDSRFEKENHY

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=281, Percent_Identity=73.6654804270463, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI87082369, Length=238, Percent_Identity=24.3697478991597, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=25.9541984732824, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082130, Length=214, Percent_Identity=27.5700934579439, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31569; Mature: 31569

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIEKIQNNLDNFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVNRNVEEHDGPDAYTHKIFESTMACLDVAKNSLDPMQINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AVDLLTQAKKISFFGLGASASVAHDAMNKFFRFNIPITCFDDIVMQRMSCINSTENDVVV
HHHHHHHHHHHHEEECCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCEEE
LISHTGRTKSLVEIAELARSNGATVIAITAKESPLEKMSSLAICLDVPEDTDVYMPMASR
EEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCEEEEEECCCCCCEEHHHHHH
VVQMTVIDVLATGFTLRRGAGFRDNLKRVKEALKDSRFEKENHY
HHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure
MNTIEKIQNNLDNFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVNRNVEEHDGPDAYTHKIFESTMACLDVAKNSLDPMQINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AVDLLTQAKKISFFGLGASASVAHDAMNKFFRFNIPITCFDDIVMQRMSCINSTENDVVV
HHHHHHHHHHHHEEECCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCEEE
LISHTGRTKSLVEIAELARSNGATVIAITAKESPLEKMSSLAICLDVPEDTDVYMPMASR
EEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCEEEEEECCCCCCEEHHHHHH
VVQMTVIDVLATGFTLRRGAGFRDNLKRVKEALKDSRFEKENHY
HHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]