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The map label for this gene is gyrA [H]

Identifier: 209695246

GI number: 209695246

Start: 1879456

End: 1882113

Strand: Reverse

Name: gyrA [H]

Synonym: VSAL_I1767

Alternate gene names: 209695246

Gene position: 1882113-1879456 (Counterclockwise)

Preceding gene: 209695251

Following gene: 209695244

Centisome position: 56.6

GC content: 41.99

Gene sequence:

>2658_bases
TTGAGGGATATTGGCTCTATGAGCGATCTTGCTAAAGGGATCACGCCCGTAAATATTGAAGATGAGCTTCGAGGTTCATA
CCTAGACTATGCGATGTCAGTAATCGTTGGTCGTGCTCTTCCAGATGTGCGTGATGGTCTAAAACCTGTACACCGCCGTG
TTTTATTCGCGATGGATGTATTAGGTAATGATTGGAATAAACCATATAAAAAATCTGCCCGTGTCGTCGGCGACGTAATT
GGTAAGTATCACCCACATGGTGATAGTGCTGTATACGACACGATAGTACGTATGGCGCAGCCGTTCTCACTACGCTATAT
GCTTGTTGATGGCCAAGGTAACTTTGGTTCTATCGATGGTGACTCTGCTGCGGCAATGCGTTATACCGAAGTTCGTATGT
CGAAAATTGCCCACGAATTGTTGGCCGATTTAGACAAAGAAACCGTCGATTACGTTCCTAACTATGATGGTACAGAACAG
ATCCCTGCGGTATTACCTACTCGTGTACCTAACTTATTAGTTAATGGTTCATCAGGTATCGCAGTTGGTATGGCAACTAA
TATACCTCCTCATAACTTAACTGAAGTGGTTAATGGTTGTTTAGCATTCATCGAGAATGAAGATATTACTATCGATGAGC
TAATAAACTACATTCCAGGTCCTGACTTTCCGACAGCTGCATTAATCAGTGGTCGTAAAGGCATCGTTGATGCATATAAA
ACAGGCCGCGGTAAAGTTTACATGCGTTCTAAAGCAAATATCGAAGCGGACAAAAATGGTAAAGAAACCATTATTGTTAC
TGAGATCCCTTATCAAGTTAACAAAGCACGTGTGATCGAAAAGATCGCTGAGCTTGTTAAAGATAAGAAAGTCGAAGGTA
TTTCAGCACTGCGTGACGAATCTGATAAAGATGGTATGCGTATTGTTATCGAATGTAAGCGTGATGCAGTGGGTGAGGTG
GTTCTTAATAACTTATTCTCATTAACTCAGCTTCAAACTACATTCGGCGTAAACATGGTGGCACTTGATAATGGCCAACC
AAAACTGTTCAACTTAAAAGAAATGTTGAAGTGTTTTGTTGATCACCGTCGTGAAGTGGTAACTCGCCGTACAATTTTTG
AATTACGCAAAGCGCGTGATCGTGCTCATATCCTTGAAGGTTTGGCGCTGGCATTAGCAAACATTGATGAGATCATTGAT
CTAATCAAAAATGCGCCATCACCAGCAGAAGCAAAGCAAGGCCTAGTCGCTCGCGGTTGGGATCTTGGTAATGTTGCCGA
CATGCTAGAGCGTGCTGGTACAGATGCTGCTCGTCCTGATTGGTTAGAGCCAGAGTTTGGTATTCGTGAAGGTCAATACT
TCTTAACGGAACAACAAGCTCAAGCAATTCTAGAATTACGTCTACACCGTTTAACTGGTTTAGAACATGAAAAAATTCTA
GATGAATACAAAGCACTATTAGATGAAATCGCAGAGCTAATGCATATCCTTGCAAGCACTGAACGTCTAATGGAAATCAT
TCGTGATGAATTAATTACGGTTCGTGATACTTATGGTGATGAGCGTCGCACTGAAATTGGTGCTGCTATTCACGATATCG
ATATAGAAGACTTAATCACACAAGAAGATGTTGTAGTAACACTTTCTCGTGAAGGTTATGTTAAGTACCAAATTCTAGGT
GATTACGAAGCGCAACGTCGTGGTGGTAAAGGTAAGAGTGCAACTAAGATGAAGGACACCGATTATATCGAGCGTCTACT
TGTTGCTAACACTCATGATAATATCCTTTGCTTCTCTACACGTGGTAAAGCATACAGCTTGAAAGTATTCCAACTTCCTC
AAGCAAGCCGCACCGCTCGTGGTAAGCCTATCGTGAACATTCTTCCTCTAGAAGAAGGTGAGCGTATTACAGCGATTCTA
CCAGTATCTGAATATTCTGAAGATAAGTTCATCTTCATGGCAACAGGTGATGGTACGGTTAAGAAAACATCTTTAGATCA
ATTTGCTAAAGTTCGTGCAAACGGCTTAATTGCAGTTAATCTACGTGAAGATGATTCATTAATCGGCGTCGATATTACGA
CGGGTTCAAATGAAATCATGCTGTTCTCTAAAGCCGGTAAAGTCGTTCGTTTCAGCGAAGAACATGTTCGTGGAATGGGC
CGTACTGCTTCAGGTGTTCGTGGTATGAAACTGACTGGTGAAGATCAGGTTGTTTCATTGATTGTTCCTTCTAATGAAGG
TGACATTCTAACGGTGACAGAAAATGGGTACGGTAAACGTACTAAAATTTCTGAATACCCTACGAAGAGCCGTGCAACAC
AAGGTGTTGTTTCTATCAAGGTTTCAGATCGTAACGGCAGTGTTGTCGGTGCAGTTCAAGCTGAAGATGGTGATGAGTTC
ATGATGATCACGGATGCAGGTACGTTAGTTCGTACACGCGTATCGGAAGTAAGCCAAGTGGGTCGTAATACCCAAGGTGT
TACACTGATCCGTACTGCTGAAGATGAAAATGTAGTTGGTTTACAACGCATTGATGAACCAGAAGAGCTTGAAATTCTTG
AAGGTGATGTAGTAGAAGGTGAAGAAGAGGCGACAGTAATTACTGAAGCAACTGAAACTCCTGACGCTGAATCAGATGAA
GATACGACAGAAGAATAA

Upstream 100 bases:

>100_bases
GCTATATTTTGCAATCTTGCACGTTTATCAGTATCAATTACTTTATCTTTATAGTGGATCTAATTGATAAAGTAATTGAT
ATTGATACGACAGAACTAAT

Downstream 100 bases:

>100_bases
TTTTTCTTAACGTATTAAAAAGCCCGCTTATTTTTAAGCGGGCTTTTTTGTCTCTGTAATTTGACAAATTTGAAGTAGTT
TTAGCAAATATCAAATTTAC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 885; Mature: 885

Protein sequence:

>885_residues
MRDIGSMSDLAKGITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDVLGNDWNKPYKKSARVVGDVI
GKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQ
IPAVLPTRVPNLLVNGSSGIAVGMATNIPPHNLTEVVNGCLAFIENEDITIDELINYIPGPDFPTAALISGRKGIVDAYK
TGRGKVYMRSKANIEADKNGKETIIVTEIPYQVNKARVIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEV
VLNNLFSLTQLQTTFGVNMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELRKARDRAHILEGLALALANIDEIID
LIKNAPSPAEAKQGLVARGWDLGNVADMLERAGTDAARPDWLEPEFGIREGQYFLTEQQAQAILELRLHRLTGLEHEKIL
DEYKALLDEIAELMHILASTERLMEIIRDELITVRDTYGDERRTEIGAAIHDIDIEDLITQEDVVVTLSREGYVKYQILG
DYEAQRRGGKGKSATKMKDTDYIERLLVANTHDNILCFSTRGKAYSLKVFQLPQASRTARGKPIVNILPLEEGERITAIL
PVSEYSEDKFIFMATGDGTVKKTSLDQFAKVRANGLIAVNLREDDSLIGVDITTGSNEIMLFSKAGKVVRFSEEHVRGMG
RTASGVRGMKLTGEDQVVSLIVPSNEGDILTVTENGYGKRTKISEYPTKSRATQGVVSIKVSDRNGSVVGAVQAEDGDEF
MMITDAGTLVRTRVSEVSQVGRNTQGVTLIRTAEDENVVGLQRIDEPEELEILEGDVVEGEEEATVITEATETPDAESDE
DTTEE

Sequences:

>Translated_885_residues
MRDIGSMSDLAKGITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDVLGNDWNKPYKKSARVVGDVI
GKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQ
IPAVLPTRVPNLLVNGSSGIAVGMATNIPPHNLTEVVNGCLAFIENEDITIDELINYIPGPDFPTAALISGRKGIVDAYK
TGRGKVYMRSKANIEADKNGKETIIVTEIPYQVNKARVIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEV
VLNNLFSLTQLQTTFGVNMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELRKARDRAHILEGLALALANIDEIID
LIKNAPSPAEAKQGLVARGWDLGNVADMLERAGTDAARPDWLEPEFGIREGQYFLTEQQAQAILELRLHRLTGLEHEKIL
DEYKALLDEIAELMHILASTERLMEIIRDELITVRDTYGDERRTEIGAAIHDIDIEDLITQEDVVVTLSREGYVKYQILG
DYEAQRRGGKGKSATKMKDTDYIERLLVANTHDNILCFSTRGKAYSLKVFQLPQASRTARGKPIVNILPLEEGERITAIL
PVSEYSEDKFIFMATGDGTVKKTSLDQFAKVRANGLIAVNLREDDSLIGVDITTGSNEIMLFSKAGKVVRFSEEHVRGMG
RTASGVRGMKLTGEDQVVSLIVPSNEGDILTVTENGYGKRTKISEYPTKSRATQGVVSIKVSDRNGSVVGAVQAEDGDEF
MMITDAGTLVRTRVSEVSQVGRNTQGVTLIRTAEDENVVGLQRIDEPEELEILEGDVVEGEEEATVITEATETPDAESDE
DTTEE
>Mature_885_residues
MRDIGSMSDLAKGITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDVLGNDWNKPYKKSARVVGDVI
GKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQ
IPAVLPTRVPNLLVNGSSGIAVGMATNIPPHNLTEVVNGCLAFIENEDITIDELINYIPGPDFPTAALISGRKGIVDAYK
TGRGKVYMRSKANIEADKNGKETIIVTEIPYQVNKARVIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEV
VLNNLFSLTQLQTTFGVNMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELRKARDRAHILEGLALALANIDEIID
LIKNAPSPAEAKQGLVARGWDLGNVADMLERAGTDAARPDWLEPEFGIREGQYFLTEQQAQAILELRLHRLTGLEHEKIL
DEYKALLDEIAELMHILASTERLMEIIRDELITVRDTYGDERRTEIGAAIHDIDIEDLITQEDVVVTLSREGYVKYQILG
DYEAQRRGGKGKSATKMKDTDYIERLLVANTHDNILCFSTRGKAYSLKVFQLPQASRTARGKPIVNILPLEEGERITAIL
PVSEYSEDKFIFMATGDGTVKKTSLDQFAKVRANGLIAVNLREDDSLIGVDITTGSNEIMLFSKAGKVVRFSEEHVRGMG
RTASGVRGMKLTGEDQVVSLIVPSNEGDILTVTENGYGKRTKISEYPTKSRATQGVVSIKVSDRNGSVVGAVQAEDGDEF
MMITDAGTLVRTRVSEVSQVGRNTQGVTLIRTAEDENVVGLQRIDEPEELEILEGDVVEGEEEATVITEATETPDAESDE
DTTEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=347, Percent_Identity=28.2420749279539, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI19913406, Length=411, Percent_Identity=26.2773722627737, Blast_Score=81, Evalue=6e-15,
Organism=Escherichia coli, GI1788562, Length=875, Percent_Identity=73.8285714285714, Blast_Score=1341, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=714, Percent_Identity=37.2549019607843, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI212645845, Length=374, Percent_Identity=25.668449197861, Blast_Score=80, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=286, Percent_Identity=27.972027972028, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=282, Percent_Identity=28.0141843971631, Blast_Score=76, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=24.4956772334294, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=351, Percent_Identity=27.3504273504274, Blast_Score=79, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 97863; Mature: 97863

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDIGSMSDLAKGITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDV
CCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCC
DSAAAMRYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTRVPNLLVNGSSGI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHCCCCCCCEEEECCCCE
AVGMATNIPPHNLTEVVNGCLAFIENEDITIDELINYIPGPDFPTAALISGRKGIVDAYK
EEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHCCCCCCHHHHH
TGRGKVYMRSKANIEADKNGKETIIVTEIPYQVNKARVIEKIAELVKDKKVEGISALRDE
CCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCC
SDKDGMRIVIECKRDAVGEVVLNNLFSLTQLQTTFGVNMVALDNGQPKLFNLKEMLKCFV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCEECHHHHHHHHH
DHRREVVTRRTIFELRKARDRAHILEGLALALANIDEIIDLIKNAPSPAEAKQGLVARGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEECCC
DLGNVADMLERAGTDAARPDWLEPEFGIREGQYFLTEQQAQAILELRLHRLTGLEHEKIL
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHH
DEYKALLDEIAELMHILASTERLMEIIRDELITVRDTYGDERRTEIGAAIHDIDIEDLIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCHHHHCC
QEDVVVTLSREGYVKYQILGDYEAQRRGGKGKSATKMKDTDYIERLLVANTHDNILCFST
CCCEEEEEECCCEEEEEEECCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEC
RGKAYSLKVFQLPQASRTARGKPIVNILPLEEGERITAILPVSEYSEDKFIFMATGDGTV
CCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCE
KKTSLDQFAKVRANGLIAVNLREDDSLIGVDITTGSNEIMLFSKAGKVVRFSEEHVRGMG
EECCHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEECHHHHHCCC
RTASGVRGMKLTGEDQVVSLIVPSNEGDILTVTENGYGKRTKISEYPTKSRATQGVVSIK
CCCCCCCCEEECCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCEEEEE
VSDRNGSVVGAVQAEDGDEFMMITDAGTLVRTRVSEVSQVGRNTQGVTLIRTAEDENVVG
EECCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
LQRIDEPEELEILEGDVVEGEEEATVITEATETPDAESDEDTTEE
HHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDIGSMSDLAKGITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDV
CCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCC
DSAAAMRYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTRVPNLLVNGSSGI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHCCCCCCCEEEECCCCE
AVGMATNIPPHNLTEVVNGCLAFIENEDITIDELINYIPGPDFPTAALISGRKGIVDAYK
EEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHCCCCCCHHHHH
TGRGKVYMRSKANIEADKNGKETIIVTEIPYQVNKARVIEKIAELVKDKKVEGISALRDE
CCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCC
SDKDGMRIVIECKRDAVGEVVLNNLFSLTQLQTTFGVNMVALDNGQPKLFNLKEMLKCFV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCEECHHHHHHHHH
DHRREVVTRRTIFELRKARDRAHILEGLALALANIDEIIDLIKNAPSPAEAKQGLVARGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEECCC
DLGNVADMLERAGTDAARPDWLEPEFGIREGQYFLTEQQAQAILELRLHRLTGLEHEKIL
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHH
DEYKALLDEIAELMHILASTERLMEIIRDELITVRDTYGDERRTEIGAAIHDIDIEDLIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCHHHHCC
QEDVVVTLSREGYVKYQILGDYEAQRRGGKGKSATKMKDTDYIERLLVANTHDNILCFST
CCCEEEEEECCCEEEEEEECCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEC
RGKAYSLKVFQLPQASRTARGKPIVNILPLEEGERITAILPVSEYSEDKFIFMATGDGTV
CCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCE
KKTSLDQFAKVRANGLIAVNLREDDSLIGVDITTGSNEIMLFSKAGKVVRFSEEHVRGMG
EECCHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEECHHHHHCCC
RTASGVRGMKLTGEDQVVSLIVPSNEGDILTVTENGYGKRTKISEYPTKSRATQGVVSIK
CCCCCCCCEEECCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCEEEEE
VSDRNGSVVGAVQAEDGDEFMMITDAGTLVRTRVSEVSQVGRNTQGVTLIRTAEDENVVG
EECCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
LQRIDEPEELEILEGDVVEGEEEATVITEATETPDAESDEDTTEE
HHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]