Click here to switch to the map view.

The map label for this gene is pepB [H]

Identifier: 209695214

GI number: 209695214

Start: 1840008

End: 1841789

Strand: Reverse

Name: pepB [H]

Synonym: VSAL_I1729

Alternate gene names: 209695214

Gene position: 1841789-1840008 (Counterclockwise)

Preceding gene: 209695215

Following gene: 209695211

Centisome position: 55.39

GC content: 39.0

Gene sequence:

>1782_bases
ATGACAGCTCCTAGCTGGGATCTTTCCGTTGCTTTTGAATCATTAAATGATCCAAAATTAGATGCGACAATCATTACTAT
TGAACAAAAAATAAAGACGCTTTTCAGTTCGACTGCTGAATTACATGCTAGTGCATTACAACAAGCGATTTTAGACAGAG
AATCCATTTCAGTGTTACTTGCAACAGTGGCGAGTTATGGTAATTGTATTGCTTCTGTTGATGCGTCTGATAACCAAGCA
AAAGCGCTTGTGAATAAGATGAATAAATTGTCATCCGAATTATCACAAGCTTTTAGCCCTTATCTTGATGCGATAGTGAA
TTCACCAACCGCTTTATTTGAAGAGGTTCTATCATACAGTGAAGAATTAGAAGCCCAACGTTTCTTATTAGAAGAAGAAA
GGAAGCTTATTGCGACACGTTTGAGTGTTAAAGAAGAGCAGCTTCTCTCTGCTATGAGTGTTGATGGTAAAAATGCATGG
GGCCGTTTATACGATAATATTACCGGTTCTATGACCGTGACGTTAGCGCTGTCTAATGGAGAGCAAGAAACCATTGGTTT
ATCGCAAGCTGCAAGTATTTTATACGGAAGTGATGAAAACCGTAGAGAACCAGCATGGCGAGCAATTCAATTAGCAATGA
AACAAAATCAAGAGAGTTTGTCTGCCATTTTAAATGCGTTATCGGGGTGGCGGTTAGCTGAATATGAAAAACGAAGCGCA
ACAGCGTCAGTACATTTTTTGGAGTCAAGTTTACATGGTAGCCGTATAGAACAAGCAACATTAGATAGCATGATGTCAGT
AGCAAAGAAAAATCGTGCTGTAGGACAAAAAGCGGCACGTTTAATGGCTAAAATGTTTGGTACTGAGAAGCTAACACCTT
GGGATCAACTTGCTTCAATGCCTCCATTGAGTGGAAGTGCTTCTACTTATTCTTTTGATGAAGCGATAGATATCATTAAA
GAGGCATTTGGCAGCGTATCTCAAGAAATGGCCGATTTTGTGGCTCTGATGGTAACTAATGGTTGGATCGATGCAGCACC
GCAATCGACTAAACGTCTTAGTGCGTATTGTACTAAGTTTGCAGATTCGCGCACACCTCTAGTCTTTATGACGTGGGGTG
ACAGTATGTCGGATGTATTAACGCTTGCTCATGAATTAGGTCATGCATTCCATAATTGGGTAATGCGAGACATGCCTTTA
TGTAAAACAAAGTACCCAATGACATTAGCGGAAACCGCCTCTATTTTTGCAGAAAATGCAGTTCGTGATGCGTTATTGGC
AAAGGCGAAAACAAAAGAAGATAAAATAGAAATGTTATGGGAGGAGTTATCTTCCGCTTTAGCATTAACGATAAATATTC
CAGTACGTTATGAATTTGAAAAATCATTTTATGAACAACGCTCAACTCAGGAGTTAGGGCCAGAGCAACTGTCAGAGTTA
ATGAGTAAAACGTGGAATGATTGGTATGGTGATTCAATGTCAGAACCTGATTCATTATTCTGGGCAAGTAAATTACATTT
CAGCATTCCTGAGGTGAGTTTTTATAATTACCCGTATTTATTTGGTTATCTATTTAGCATCGGTGTATACGCACAACGAG
AAGCAAAAGGGGATAGCTTTTATCGTGATTATGTTAATTTATTGCGTGATACTGGCTCAATGCGTGCAGAAGACGTCGTG
AATAAGCATTTGCAAATGGATTTAACGAAAGAGTTTTTTTGGCAGCAGAGTTTGGATAGGGTAAGTAAACAAATTGATGA
ATTTGAGCGATTGATTGGATAG

Upstream 100 bases:

>100_bases
AATAATGCAGTAAATAACGAAAAAAAGAGAGCTGAAGATATTGAGTACTTAATGGGTACTATTGGCTTTATATAATAAAA
CGCGAATAAAGGACCGTATT

Downstream 100 bases:

>100_bases
TAGAAAATAATAAAGCGTCTACATGTAGACGCTTTATTTTTATTAAATCAAAATGGTGTTGATTTAATATTAGTCACGAA
AGTTAGTGAATTGGAATGGT

Product: oligopeptidase F

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MTAPSWDLSVAFESLNDPKLDATIITIEQKIKTLFSSTAELHASALQQAILDRESISVLLATVASYGNCIASVDASDNQA
KALVNKMNKLSSELSQAFSPYLDAIVNSPTALFEEVLSYSEELEAQRFLLEEERKLIATRLSVKEEQLLSAMSVDGKNAW
GRLYDNITGSMTVTLALSNGEQETIGLSQAASILYGSDENRREPAWRAIQLAMKQNQESLSAILNALSGWRLAEYEKRSA
TASVHFLESSLHGSRIEQATLDSMMSVAKKNRAVGQKAARLMAKMFGTEKLTPWDQLASMPPLSGSASTYSFDEAIDIIK
EAFGSVSQEMADFVALMVTNGWIDAAPQSTKRLSAYCTKFADSRTPLVFMTWGDSMSDVLTLAHELGHAFHNWVMRDMPL
CKTKYPMTLAETASIFAENAVRDALLAKAKTKEDKIEMLWEELSSALALTINIPVRYEFEKSFYEQRSTQELGPEQLSEL
MSKTWNDWYGDSMSEPDSLFWASKLHFSIPEVSFYNYPYLFGYLFSIGVYAQREAKGDSFYRDYVNLLRDTGSMRAEDVV
NKHLQMDLTKEFFWQQSLDRVSKQIDEFERLIG

Sequences:

>Translated_593_residues
MTAPSWDLSVAFESLNDPKLDATIITIEQKIKTLFSSTAELHASALQQAILDRESISVLLATVASYGNCIASVDASDNQA
KALVNKMNKLSSELSQAFSPYLDAIVNSPTALFEEVLSYSEELEAQRFLLEEERKLIATRLSVKEEQLLSAMSVDGKNAW
GRLYDNITGSMTVTLALSNGEQETIGLSQAASILYGSDENRREPAWRAIQLAMKQNQESLSAILNALSGWRLAEYEKRSA
TASVHFLESSLHGSRIEQATLDSMMSVAKKNRAVGQKAARLMAKMFGTEKLTPWDQLASMPPLSGSASTYSFDEAIDIIK
EAFGSVSQEMADFVALMVTNGWIDAAPQSTKRLSAYCTKFADSRTPLVFMTWGDSMSDVLTLAHELGHAFHNWVMRDMPL
CKTKYPMTLAETASIFAENAVRDALLAKAKTKEDKIEMLWEELSSALALTINIPVRYEFEKSFYEQRSTQELGPEQLSEL
MSKTWNDWYGDSMSEPDSLFWASKLHFSIPEVSFYNYPYLFGYLFSIGVYAQREAKGDSFYRDYVNLLRDTGSMRAEDVV
NKHLQMDLTKEFFWQQSLDRVSKQIDEFERLIG
>Mature_592_residues
TAPSWDLSVAFESLNDPKLDATIITIEQKIKTLFSSTAELHASALQQAILDRESISVLLATVASYGNCIASVDASDNQAK
ALVNKMNKLSSELSQAFSPYLDAIVNSPTALFEEVLSYSEELEAQRFLLEEERKLIATRLSVKEEQLLSAMSVDGKNAWG
RLYDNITGSMTVTLALSNGEQETIGLSQAASILYGSDENRREPAWRAIQLAMKQNQESLSAILNALSGWRLAEYEKRSAT
ASVHFLESSLHGSRIEQATLDSMMSVAKKNRAVGQKAARLMAKMFGTEKLTPWDQLASMPPLSGSASTYSFDEAIDIIKE
AFGSVSQEMADFVALMVTNGWIDAAPQSTKRLSAYCTKFADSRTPLVFMTWGDSMSDVLTLAHELGHAFHNWVMRDMPLC
KTKYPMTLAETASIFAENAVRDALLAKAKTKEDKIEMLWEELSSALALTINIPVRYEFEKSFYEQRSTQELGPEQLSELM
SKTWNDWYGDSMSEPDSLFWASKLHFSIPEVSFYNYPYLFGYLFSIGVYAQREAKGDSFYRDYVNLLRDTGSMRAEDVVN
KHLQMDLTKEFFWQQSLDRVSKQIDEFERLIG

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 66551; Mature: 66420

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPSWDLSVAFESLNDPKLDATIITIEQKIKTLFSSTAELHASALQQAILDRESISVLL
CCCCCCCHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATVASYGNCIASVDASDNQAKALVNKMNKLSSELSQAFSPYLDAIVNSPTALFEEVLSYS
HHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EELEAQRFLLEEERKLIATRLSVKEEQLLSAMSVDGKNAWGRLYDNITGSMTVTLALSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEEECCC
EQETIGLSQAASILYGSDENRREPAWRAIQLAMKQNQESLSAILNALSGWRLAEYEKRSA
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHH
TASVHFLESSLHGSRIEQATLDSMMSVAKKNRAVGQKAARLMAKMFGTEKLTPWDQLASM
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
PPLSGSASTYSFDEAIDIIKEAFGSVSQEMADFVALMVTNGWIDAAPQSTKRLSAYCTKF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ADSRTPLVFMTWGDSMSDVLTLAHELGHAFHNWVMRDMPLCKTKYPMTLAETASIFAENA
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
VRDALLAKAKTKEDKIEMLWEELSSALALTINIPVRYEFEKSFYEQRSTQELGPEQLSEL
HHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCEEEHHHHHHHHHHHHHHCCHHHHHHH
MSKTWNDWYGDSMSEPDSLFWASKLHFSIPEVSFYNYPYLFGYLFSIGVYAQREAKGDSF
HHHHCCHHCCCCCCCCCHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
YRDYVNLLRDTGSMRAEDVVNKHLQMDLTKEFFWQQSLDRVSKQIDEFERLIG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TAPSWDLSVAFESLNDPKLDATIITIEQKIKTLFSSTAELHASALQQAILDRESISVLL
CCCCCCHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATVASYGNCIASVDASDNQAKALVNKMNKLSSELSQAFSPYLDAIVNSPTALFEEVLSYS
HHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EELEAQRFLLEEERKLIATRLSVKEEQLLSAMSVDGKNAWGRLYDNITGSMTVTLALSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEEECCC
EQETIGLSQAASILYGSDENRREPAWRAIQLAMKQNQESLSAILNALSGWRLAEYEKRSA
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHH
TASVHFLESSLHGSRIEQATLDSMMSVAKKNRAVGQKAARLMAKMFGTEKLTPWDQLASM
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
PPLSGSASTYSFDEAIDIIKEAFGSVSQEMADFVALMVTNGWIDAAPQSTKRLSAYCTKF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ADSRTPLVFMTWGDSMSDVLTLAHELGHAFHNWVMRDMPLCKTKYPMTLAETASIFAENA
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
VRDALLAKAKTKEDKIEMLWEELSSALALTINIPVRYEFEKSFYEQRSTQELGPEQLSEL
HHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCEEEHHHHHHHHHHHHHHCCHHHHHHH
MSKTWNDWYGDSMSEPDSLFWASKLHFSIPEVSFYNYPYLFGYLFSIGVYAQREAKGDSF
HHHHCCHHCCCCCCCCCHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
YRDYVNLLRDTGSMRAEDVVNKHLQMDLTKEFFWQQSLDRVSKQIDEFERLIG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]