Click here to switch to the map view.

The map label for this gene is cynR [H]

Identifier: 209694742

GI number: 209694742

Start: 1303596

End: 1304492

Strand: Direct

Name: cynR [H]

Synonym: VSAL_I1196

Alternate gene names: 209694742

Gene position: 1303596-1304492 (Clockwise)

Preceding gene: 209694740

Following gene: 209694743

Centisome position: 39.2

GC content: 39.69

Gene sequence:

>897_bases
ATGGGCATGCTTGATCTACATTGGCTTAAAACATTTGTAACGTTAGCCGAATTAAAACACTTTGGTAAAACAGCCACGGC
TCTACACATGACGCAACCTAACGTTAGTTTACATATCAAACAGTTAGAAAGAACAACTCGAGTGAAGTTGATTGAAAGAA
ACCCATTTCATTTAACGGAAGCAGGCGTTCGATTATTAGAAACCAGTCAAAATACATTAATGGAGTTGCAAGTGTGCCAA
GCGGATCTCAACGCCATTAATGATTTAAGTCGTGGAACGTTGACGATTGCGGCAAGCGATATTATTTCGCGCTTATTATT
GATTGGGCCATTCCAATTATTTAAGCAAGAGTTCCCCGGAATAGATTTTTCTCTGCTTAATACCACCTCTTCACAGGCGT
CTGAATTAGTGAAAAGTGCCGAAGCTGATCTTGGATTTGTTATCGCACAAAAAGAGAGTCAACCGCTTCATTTTACTGAA
CTTCAGCAAATAAAGTGGTGCGCATTGGGGAACCATCTTGAAAAGTGGCAACAAGCGAATTTTGATCCTACTATTGTTTT
AGACAGTGAACCTACGCTCATATTATTAGGTCATGATACACGAACACGAGATTTACTTGATTTGGCGTTGCCATCTTTGA
ATTTGCTTAAGTACCGGATCATGGAGGTGGGCAGTGTTGATGCTCAGATTGATTGGGCTGAGGCAGGGTTTGGTGTTGCC
ATCGTTCCTGAATTCTCTATTCACCCAAAGCGAAACCTTAAAACGACAGTAACGCTATTACCGAAATTCCCAACAACCAG
TTTAGGTTACATTGTTAGACAGAATCAGATTTTATCTAAAGCAATTAAACAGTTACTTAAATGGGTGGATGAAGAAATTA
TTCGCTCTCAAAAATAG

Upstream 100 bases:

>100_bases
ATGTTAATCCTAATAAATCAATATGAGAAATTAATTATAATTATCGACTTGATAAGAAATCCATATATCATATTGAGTGA
AATGCATTCAAAAAAAGAGT

Downstream 100 bases:

>100_bases
ACATTTTTTACTCTCCAGTTTATGTAGCAGGTGTCTTGTTTTTAGGGGGCTGACGTAATGTTCGTGCTACTGAAAATTGA
TTTTAAAAGCACCTATGTTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGMLDLHWLKTFVTLAELKHFGKTATALHMTQPNVSLHIKQLERTTRVKLIERNPFHLTEAGVRLLETSQNTLMELQVCQ
ADLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPGIDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTE
LQQIKWCALGNHLEKWQQANFDPTIVLDSEPTLILLGHDTRTRDLLDLALPSLNLLKYRIMEVGSVDAQIDWAEAGFGVA
IVPEFSIHPKRNLKTTVTLLPKFPTTSLGYIVRQNQILSKAIKQLLKWVDEEIIRSQK

Sequences:

>Translated_298_residues
MGMLDLHWLKTFVTLAELKHFGKTATALHMTQPNVSLHIKQLERTTRVKLIERNPFHLTEAGVRLLETSQNTLMELQVCQ
ADLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPGIDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTE
LQQIKWCALGNHLEKWQQANFDPTIVLDSEPTLILLGHDTRTRDLLDLALPSLNLLKYRIMEVGSVDAQIDWAEAGFGVA
IVPEFSIHPKRNLKTTVTLLPKFPTTSLGYIVRQNQILSKAIKQLLKWVDEEIIRSQK
>Mature_297_residues
GMLDLHWLKTFVTLAELKHFGKTATALHMTQPNVSLHIKQLERTTRVKLIERNPFHLTEAGVRLLETSQNTLMELQVCQA
DLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPGIDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTEL
QQIKWCALGNHLEKWQQANFDPTIVLDSEPTLILLGHDTRTRDLLDLALPSLNLLKYRIMEVGSVDAQIDWAEAGFGVAI
VPEFSIHPKRNLKTTVTLLPKFPTTSLGYIVRQNQILSKAIKQLLKWVDEEIIRSQK

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=165, Percent_Identity=30.9090909090909, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693105, Length=299, Percent_Identity=23.7458193979933, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788748, Length=294, Percent_Identity=24.8299319727891, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33596; Mature: 33465

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMLDLHWLKTFVTLAELKHFGKTATALHMTQPNVSLHIKQLERTTRVKLIERNPFHLTE
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHEEEEECCCCEEHH
AGVRLLETSQNTLMELQVCQADLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHHHHHCCC
IDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTELQQIKWCALGNHLEKWQQAN
CCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
FDPTIVLDSEPTLILLGHDTRTRDLLDLALPSLNLLKYRIMEVGSVDAQIDWAEAGFGVA
CCCEEEECCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEHHCCCCCEE
IVPEFSIHPKRNLKTTVTLLPKFPTTSLGYIVRQNQILSKAIKQLLKWVDEEIIRSQK
EECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GMLDLHWLKTFVTLAELKHFGKTATALHMTQPNVSLHIKQLERTTRVKLIERNPFHLTE
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHEEEEECCCCEEHH
AGVRLLETSQNTLMELQVCQADLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHHHHHCCC
IDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTELQQIKWCALGNHLEKWQQAN
CCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
FDPTIVLDSEPTLILLGHDTRTRDLLDLALPSLNLLKYRIMEVGSVDAQIDWAEAGFGVA
CCCEEEECCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEHHCCCCCEE
IVPEFSIHPKRNLKTTVTLLPKFPTTSLGYIVRQNQILSKAIKQLLKWVDEEIIRSQK
EECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]