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The map label for this gene is menB [H]

Identifier: 209694659

GI number: 209694659

Start: 1197861

End: 1198727

Strand: Direct

Name: menB [H]

Synonym: VSAL_I1101

Alternate gene names: 209694659

Gene position: 1197861-1198727 (Clockwise)

Preceding gene: 209694658

Following gene: 209694660

Centisome position: 36.02

GC content: 44.64

Gene sequence:

>867_bases
ATGGCAAGAACTGTTGGCATTTCAGAAGAAGAACTTTACCCTCCAGTAAATTGGACAGATTGCACTGCGCAATATGAAGA
CATTCAATATCATAAATCTGCAGATGGCATTGCAAAAATTACGATTGCACGTCCGCAAGTACGTAACGCATTCCGTCCTG
GTACGGTTAAAGAGATGATGGATGCGCTAGCAGATGCTCGTTATGACGAGAAAGTTGGCGTTATTGTTCTAACGGGGTTA
GGCGAAGAGGCTTTCTGTTCTGGTGGTGATCAGAAGATCCGTGGCGATTACGGTGGTTACCGTGATGACAGCGGCACACA
CCACTTAAATGTATTGGATTTCCAACGTCAAATTCGTACGTGTCCAAAACCAGTGATTGCTGCGGTTGCAGGCTACGCTG
TTGGTGGTGGTCATGTACTTCATATGATGTGTGATTTAACTATCGCAGCAGAGAACGCTCAATTTGGTCAAACAGGTCCT
AAAGTCGGTTCTTTTGATGGCGGTTGGGGTGCATCTTACATGGCTCGTATCGTAGGCCAGAAAAAAGCTCGGGAGATTTG
GTTCTTATGTCGTTTCTATGATGCTCAAGAAGCACTAGACATGGGTTTAGTAAACACCGTCGTCCCTGTTGCTGATTTAG
AGAAAGAAACGGTTCGCTGGTGTCGTGAGACGCTACAACATAGTCCAATGGCATTACGTTGTCTAAAAGCAGCATTAAAT
GCAGATTGTGATGGTCAAGCCGGTCTTCAAGAACTTGCTGGTAATGCAACAATGATGTTCTACATGACTGAAGAAGGTCA
AGAAGGTCGTAACGCATTTAATGAAAAACGCCGCCCTGATTTCGATAAATTCCCTCGTAATCCATAA

Upstream 100 bases:

>100_bases
TATCAAATCATTGCTCAGGCTGGTCATAACGCTCATGTGGAACAGCCCGAACGCTTTACACATGTACTTAATACATTCTT
ACAACAATGGACATAACCCC

Downstream 100 bases:

>100_bases
GCGACACTATCACTTATTTTGATAAGTTTGAGAGGCTCTCTGGAGTCTCTTTTTTCTTTTTATTGGTTGGAGTAACAAAT
GAAAACAGCCAAGATATATC

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MARTVGISEEELYPPVNWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGTVKEMMDALADARYDEKVGVIVLTGL
GEEAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQFGQTGP
KVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCLKAALN
ADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP

Sequences:

>Translated_288_residues
MARTVGISEEELYPPVNWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGTVKEMMDALADARYDEKVGVIVLTGL
GEEAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQFGQTGP
KVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCLKAALN
ADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
>Mature_287_residues
ARTVGISEEELYPPVNWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGTVKEMMDALADARYDEKVGVIVLTGLG
EEAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQFGQTGPK
VGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCLKAALNA
DCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=280, Percent_Identity=33.9285714285714, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=32.8063241106719, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4502327, Length=253, Percent_Identity=30.0395256916996, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=30.622009569378, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=30.622009569378, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=30.622009569378, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI25453481, Length=251, Percent_Identity=25.4980079681275, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI51538573, Length=251, Percent_Identity=25.4980079681275, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4757966, Length=251, Percent_Identity=25.4980079681275, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI51538581, Length=251, Percent_Identity=25.4980079681275, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4757968, Length=251, Percent_Identity=25.8964143426295, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI49355787, Length=251, Percent_Identity=25.8964143426295, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI68989263, Length=214, Percent_Identity=28.9719626168224, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI70995211, Length=238, Percent_Identity=28.1512605042017, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=280, Percent_Identity=84.6428571428571, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=32.6530612244898, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082183, Length=237, Percent_Identity=29.957805907173, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI221142681, Length=257, Percent_Identity=29.5719844357977, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=28.515625, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=33.7349397590361, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25145438, Length=252, Percent_Identity=34.5238095238095, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=207, Percent_Identity=30.4347826086957, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=28.0952380952381, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=223, Percent_Identity=27.8026905829596, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=29.5566502463054, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=197, Percent_Identity=25.8883248730964, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI20129971, Length=268, Percent_Identity=34.7014925373134, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24653477, Length=268, Percent_Identity=34.7014925373134, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=30.5882352941176, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357171, Length=180, Percent_Identity=32.7777777777778, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24654903, Length=190, Percent_Identity=30.5263157894737, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650670, Length=257, Percent_Identity=28.0155642023346, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31856; Mature: 31725

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00018 EF_HAND_1 ; PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTVGISEEELYPPVNWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGTVKEMM
CCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECHHHHHCCCCCHHHHHH
DALADARYDEKVGVIVLTGLGEEAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRT
HHHHCCCCCCCCCEEEEECCCCHHHHCCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHH
CPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGASYMARIVGQ
CCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
KKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCLKAALN
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHC
ADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
CCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHCCCCCC
>Mature Secondary Structure 
ARTVGISEEELYPPVNWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGTVKEMM
CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECHHHHHCCCCCHHHHHH
DALADARYDEKVGVIVLTGLGEEAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRT
HHHHCCCCCCCCCEEEEECCCCHHHHCCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHH
CPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGASYMARIVGQ
CCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
KKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCLKAALN
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHC
ADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
CCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]