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The map label for this gene is fabB [H]

Identifier: 209694630

GI number: 209694630

Start: 1163084

End: 1164295

Strand: Direct

Name: fabB [H]

Synonym: VSAL_I1071

Alternate gene names: 209694630

Gene position: 1163084-1164295 (Clockwise)

Preceding gene: 209694628

Following gene: 209694631

Centisome position: 34.98

GC content: 44.47

Gene sequence:

>1212_bases
ATGAAAAGAGCCGTAATTACAGGCATGGGCATTGTTTCAAGTATCGGTAACAATGTTGAAGAAGTATTAGAATCTCTGAA
AGCGGGTAAATCAGGCATTAACTTCTCTGAGCAGTTCGCCGAAAAAGGCCTGCGCAGTAATGTTTGGGGCAATTTGAAAA
TGAACCCAGCGGATCACATTGATCGCAAAAAAATGCGTTTTATGGGTGATGCGGCTGCATTTGCTTACATTTCAATGGAG
CAAGCAGTAGCGGATTCTGGCTTAACTGAAGATCAAGTTTCAAATGATCGTACCGGTATTGTTGCAGGTTCTGGTGGTGC
ATCATCACTAAACCAAGTGAATGCAGTGGATATCTTGCGTGAAAAAGGCGTTAAGCGTGTTGGACCATATATGGTTCCTC
GTACAATGGCTTCTACAGTATCGGCGTGTCTTGCAACTCCGTTTAAAATTCGCGGTGTTAACTACTCAATGAGTTCTGCA
TGTGCAACGTCTGCGCACTGTATTGGTCACGCGGTAGAGCTTATTCAATTAGGCAAACAAGACGTAATGTTTGCTGGTGG
TGGTGAAGAGCTAGATTGGTCTTTAACGATGATGTTTGATGCGATGGGCGCACTATCATCGAAATACAATGACACACCAG
ATAAAGCATCTCGTACGTACGATACAGACCGTGATGGTTTTGTTATCTCTGGCGGCGGCGGCATGGTTGTTATTGAAGAA
CTTGAACACGCATTAGCTCGTGGCGCAAAAATCTACGGTGAAGTCGTTGGTTACGGTGCAACATCAGACGGCTACGACAT
GGTAGCTCCGTCAGGTGAAGGCGCAGTTCGTTGTATGAAAATGGCGATGCAAAATGTAGACAGTGTTGATTACGTGAATA
CTCACGGTACATCAACGCCTGTTGGTGACGCGAAAGAGCTAGGCGCTATCCAAGAAGTCTTTGGTACCAATAGCCCAGCA
ATTTCTGCAACTAAAGCAATGACTGGTCACGCACTAGGTGCGGCGGGTGTTCATGAAGCTATTTATTCAACATTAATGTT
AGAGCACGGTTTTATCGCGCCAAGCATCAATATTGAAACCTTAGATCCTGCTGCTGAAGGCCTTGATATCGTGACTGAAA
AACGTGATCAAGAACTAACAACGGTAATGTCTAACAGCTTTGGCTTTGGTGGCACAAACGCAACGTTAGTAATTAAGAAA
TTCGAAGCATAA

Upstream 100 bases:

>100_bases
AATCTACGTCGGATTTTAACGACTTATAGGAAAGCTGACCACTTTGTTGTGCTATCTTCGCTATTATCTACCAAGATTTA
TGACTTATTAGGAAAGAATC

Downstream 100 bases:

>100_bases
TATTGCGCAGTGACTAACGTTTAAAATAATGAAAACCCAGCCAATTGGTTGGGTTTTTTTATGACTGTTTTTTATTGCTA
GGATTAATACTTAGGTAGAT

Product: 3-ketoacyl-ACP synthase FabB

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKRAVITGMGIVSSIGNNVEEVLESLKAGKSGINFSEQFAEKGLRSNVWGNLKMNPADHIDRKKMRFMGDAAAFAYISME
QAVADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDILREKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSA
CATSAHCIGHAVELIQLGKQDVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPDKASRTYDTDRDGFVISGGGGMVVIEE
LEHALARGAKIYGEVVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTPVGDAKELGAIQEVFGTNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINIETLDPAAEGLDIVTEKRDQELTTVMSNSFGFGGTNATLVIKK
FEA

Sequences:

>Translated_403_residues
MKRAVITGMGIVSSIGNNVEEVLESLKAGKSGINFSEQFAEKGLRSNVWGNLKMNPADHIDRKKMRFMGDAAAFAYISME
QAVADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDILREKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSA
CATSAHCIGHAVELIQLGKQDVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPDKASRTYDTDRDGFVISGGGGMVVIEE
LEHALARGAKIYGEVVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTPVGDAKELGAIQEVFGTNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINIETLDPAAEGLDIVTEKRDQELTTVMSNSFGFGGTNATLVIKK
FEA
>Mature_403_residues
MKRAVITGMGIVSSIGNNVEEVLESLKAGKSGINFSEQFAEKGLRSNVWGNLKMNPADHIDRKKMRFMGDAAAFAYISME
QAVADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDILREKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSA
CATSAHCIGHAVELIQLGKQDVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPDKASRTYDTDRDGFVISGGGGMVVIEE
LEHALARGAKIYGEVVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTPVGDAKELGAIQEVFGTNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINIETLDPAAEGLDIVTEKRDQELTTVMSNSFGFGGTNATLVIKK
FEA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=427, Percent_Identity=35.3629976580796, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI223972627, Length=170, Percent_Identity=40, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=24.6478873239437, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=72.3456790123457, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=39.8058252427184, Blast_Score=260, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=35.3919239904988, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=40.8239700374532, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI212642053, Length=353, Percent_Identity=26.3456090651558, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=411, Percent_Identity=25.3041362530414, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=30.8724832214765, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=38.3886255924171, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI221330659, Length=420, Percent_Identity=24.5238095238095, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19920632, Length=420, Percent_Identity=24.5238095238095, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24581345, Length=362, Percent_Identity=22.9281767955801, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42478; Mature: 42478

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGMGIVSSIGNNVEEVLESLKAGKSGINFSEQFAEKGLRSNVWGNLKMNPADHI
CCCEEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCHHCCCCCCEECCCHHHH
DRKKMRFMGDAAAFAYISMEQAVADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDILR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
EKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSACATSAHCIGHAVELIQLGKQ
HCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPDKASRTYDTDRDGFVISGGGGMVVIEE
CEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYGEVVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTP
HHHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCCC
VGDAKELGAIQEVFGTNSPAISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINIET
CCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEE
LDPAAEGLDIVTEKRDQELTTVMSNSFGFGGTNATLVIKKFEA
CCCHHCCCHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKRAVITGMGIVSSIGNNVEEVLESLKAGKSGINFSEQFAEKGLRSNVWGNLKMNPADHI
CCCEEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCHHCCCCCCEECCCHHHH
DRKKMRFMGDAAAFAYISMEQAVADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDILR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
EKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSACATSAHCIGHAVELIQLGKQ
HCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPDKASRTYDTDRDGFVISGGGGMVVIEE
CEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYGEVVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTP
HHHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCCC
VGDAKELGAIQEVFGTNSPAISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINIET
CCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEE
LDPAAEGLDIVTEKRDQELTTVMSNSFGFGGTNATLVIKKFEA
CCCHHCCCHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]