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The map label for this gene is fba [H]

Identifier: 209554395

GI number: 209554395

Start: 866909

End: 867778

Strand: Reverse

Name: fba [H]

Synonym: UUR10_0701

Alternate gene names: 209554395

Gene position: 867778-866909 (Counterclockwise)

Preceding gene: 209554409

Following gene: 209554109

Centisome position: 99.23

GC content: 29.2

Gene sequence:

>870_bases
ATGTTTTCATTAGTTAACGCAAAAAAAATGGTTCAAAACGCCTATAAAAATCATTATGCAATTGCTGCGATTAACATTAA
TAATTTAGAATGAATTAAAGCAGCACTATTAGCAGCACAAGAGACAAACTCACCCCTTTTATTAGCAACATCAGAAGGCG
CTGTAAAGTACATGGGTGGTTATGATAATTGTTATGCAATGGTAGTTAATTTAATGAAACAAATGAATATTAAAACTCCT
GTTTGTTTACATTTAGATCATGGTACATATGAAGGATGTATAAAAGCTATAGACGCTGGTTATTCATCAATTATGTATGA
TGGATCAAAAATTTCTATTCAAGAAAATATTGAAAACACAAAAAAACTTTTAGCAATTGCAAAATCAAAAAACGTTTCAG
TAGAAGTTGAAGTTGGTTCAATTGGTGGAACAGAAGATGGCATTACTTCAGAGGGCGAATTAGCTAATGTTAATGATTGC
TATCAAATGTGCTTACTAGATATAGATATGTTAGCGTGTGGTATTGGTAATATTCATGGTTTATATCCTGAAAATTGAAA
AGGTTTAAATTTTGATTTATTAAAAGAAATTAATATAAAAGTTAATAAACCCATCGTTTTACATGGCGGTTCTGGAATTA
GTGAAGAACAAATTCTAAAAGCAATTAGTTTAGGTGTGGCAAAAATTAATATTAATACTGAATGCCAAATTGCGTTTTCA
AATGCATTACAAGATCATCTAATAAAAGCTGGGGATTTAGTAGCAGCAAAACAATATGATCCACGAAAAGTTTTAGCTTA
TGGTGTTGATGCAATTAAAAACACAATTATTGAAAAATTCACTAAGTTTAATAGTTTAAATAAAGCATAA

Upstream 100 bases:

>100_bases
TTGTAGGCTATGACGATGAAGAGGAAGAATTCAAAACTAATAGCACTTCTGATAAAGATGAAATCGAAGATGAAGAGGAA
TTAGAAGAGGAAGAATAAAA

Downstream 100 bases:

>100_bases
ATGAAGGAGAAATAAAATGGCATTATCAGCAGGTATTGTTGGTTTACCAAATGTTGGCAAATCCACATTATTTAATACAA
TTACAAATTCAAAAGTAGAA

Product: fructose-1,6-bisphosphate aldolase, class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MFSLVNAKKMVQNAYKNHYAIAAININNLEWIKAALLAAQETNSPLLLATSEGAVKYMGGYDNCYAMVVNLMKQMNIKTP
VCLHLDHGTYEGCIKAIDAGYSSIMYDGSKISIQENIENTKKLLAIAKSKNVSVEVEVGSIGGTEDGITSEGELANVNDC
YQMCLLDIDMLACGIGNIHGLYPENWKGLNFDLLKEINIKVNKPIVLHGGSGISEEQILKAISLGVAKININTECQIAFS
NALQDHLIKAGDLVAAKQYDPRKVLAYGVDAIKNTIIEKFTKFNSLNKA

Sequences:

>Translated_289_residues
MFSLVNAKKMVQNAYKNHYAIAAININNLE*IKAALLAAQETNSPLLLATSEGAVKYMGGYDNCYAMVVNLMKQMNIKTP
VCLHLDHGTYEGCIKAIDAGYSSIMYDGSKISIQENIENTKKLLAIAKSKNVSVEVEVGSIGGTEDGITSEGELANVNDC
YQMCLLDIDMLACGIGNIHGLYPEN*KGLNFDLLKEINIKVNKPIVLHGGSGISEEQILKAISLGVAKININTECQIAFS
NALQDHLIKAGDLVAAKQYDPRKVLAYGVDAIKNTIIEKFTKFNSLNKA
>Mature_289_residues
MFSLVNAKKMVQNAYKNHYAIAAININNLE*IKAALLAAQETNSPLLLATSEGAVKYMGGYDNCYAMVVNLMKQMNIKTP
VCLHLDHGTYEGCIKAIDAGYSSIMYDGSKISIQENIENTKKLLAIAKSKNVSVEVEVGSIGGTEDGITSEGELANVNDC
YQMCLLDIDMLACGIGNIHGLYPEN*KGLNFDLLKEINIKVNKPIVLHGGSGISEEQILKAISLGVAKININTECQIAFS
NALQDHLIKAGDLVAAKQYDPRKVLAYGVDAIKNTIIEKFTKFNSLNKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=290, Percent_Identity=34.4827586206897, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI87082041, Length=277, Percent_Identity=33.2129963898917, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788072, Length=296, Percent_Identity=33.1081081081081, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1789293, Length=346, Percent_Identity=27.4566473988439, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322790, Length=339, Percent_Identity=27.1386430678466, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31085; Mature: 31085

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSLVNAKKMVQNAYKNHYAIAAININNLEIKAALLAAQETNSPLLLATSEGAVKYMGGY
CCCCHHHHHHHHHHHHCCEEEEEEEECCEEEEEEEEEECCCCCCEEEEECCCCEEECCCC
DNCYAMVVNLMKQMNIKTPVCLHLDHGTYEGCIKAIDAGYSSIMYDGSKISIQENIENTK
HHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCHHEEECCCEEEEHHHHHHHH
KLLAIAKSKNVSVEVEVGSIGGTEDGITSEGELANVNDCYQMCLLDIDMLACGIGNIHGL
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
YPENKGLNFDLLKEINIKVNKPIVLHGGSGISEEQILKAISLGVAKININTECQIAFSNA
CCCCCCCCCEEEEECCEEECCCEEEECCCCCCHHHHHHHHHCCEEEEECCCEEEEEEHHH
LQDHLIKAGDLVAAKQYDPRKVLAYGVDAIKNTIIEKFTKFNSLNKA
HHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSLVNAKKMVQNAYKNHYAIAAININNLEIKAALLAAQETNSPLLLATSEGAVKYMGGY
CCCCHHHHHHHHHHHHCCEEEEEEEECCEEEEEEEEEECCCCCCEEEEECCCCEEECCCC
DNCYAMVVNLMKQMNIKTPVCLHLDHGTYEGCIKAIDAGYSSIMYDGSKISIQENIENTK
HHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCHHEEECCCEEEEHHHHHHHH
KLLAIAKSKNVSVEVEVGSIGGTEDGITSEGELANVNDCYQMCLLDIDMLACGIGNIHGL
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
YPENKGLNFDLLKEINIKVNKPIVLHGGSGISEEQILKAISLGVAKININTECQIAFSNA
CCCCCCCCCEEEEECCEEECCCEEEECCCCCCHHHHHHHHHCCEEEEECCCEEEEEEHHH
LQDHLIKAGDLVAAKQYDPRKVLAYGVDAIKNTIIEKFTKFNSLNKA
HHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]