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The map label for this gene is upp [H]

Identifier: 209554315

GI number: 209554315

Start: 155792

End: 156415

Strand: Reverse

Name: upp [H]

Synonym: UUR10_0130

Alternate gene names: 209554315

Gene position: 156415-155792 (Counterclockwise)

Preceding gene: 209554094

Following gene: 209553994

Centisome position: 17.89

GC content: 30.45

Gene sequence:

>624_bases
ATGCACAAAATTATTAATCATCCATTAATTAAAGATAAGTTGACGCGTATGCGAAAAGTTTCAACAGTTTCTACTGTTTT
CCGTACAAATTTAGAAGAGCTAACGCAATTAATGGTTTACGAAGCAACAAAGGATTTAGAATTAAACGAAATTGAGATTG
AAACACCTGTTGTTAAAAATGCAAAAGGTTATAAATTAAAAAATAAAATTTGTTTAATCCCTATTTTAAGAGCTGGTATT
GGAATGGTTGATGGTGTTAAAAGTTTAATCCCAACAGCAACAATTGGTCATATTGGTTTATATCGTAATGAAGAAACACT
AAAACCAGTAGAATATTTTAAAAAATTCCCTAAAAACATTTCAGAATCAGATGTTATTATCTTAGATCCAATGTTAGCAA
CAGGAGGGAGTGTTGTTGAAGCTGTTAATATTATTAAAAAATACAACCCTAAATCCATTAAATTTGTGTGCATTGTTGCA
GCTCCAGAAGGGCTTGAATATGTTCAAAAAATTCATCCAGATGTTGATGTATATATCGCAGCATTAGATGATAAACTAAA
TGAAAATGGTTATATCACTCCTGGTTTAGGTGATGCAGGAGATCGAATCTTTGGTACTAAATAA

Upstream 100 bases:

>100_bases
TTTTTCATTTTATTAAGTTATTTATAATAATAAAATTTATAATTAAGAACGAGTATTAAAAACTATATATACAAGTTAAG
TGATTTAAGGAGTTATAAAT

Downstream 100 bases:

>100_bases
TTTATTATAATATAATAAAGAAAAAAGCAATCCATAATTGGATTGCTTTTTATTTAATAAATGGAGCAGATGACGAGAAT
CGAACTCGCGTCTCGACCTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKNAKGYKLKNKICLIPILRAGI
GMVDGVKSLIPTATIGHIGLYRNEETLKPVEYFKKFPKNISESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVA
APEGLEYVQKIHPDVDVYIAALDDKLNENGYITPGLGDAGDRIFGTK

Sequences:

>Translated_207_residues
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKNAKGYKLKNKICLIPILRAGI
GMVDGVKSLIPTATIGHIGLYRNEETLKPVEYFKKFPKNISESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVA
APEGLEYVQKIHPDVDVYIAALDDKLNENGYITPGLGDAGDRIFGTK
>Mature_207_residues
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKNAKGYKLKNKICLIPILRAGI
GMVDGVKSLIPTATIGHIGLYRNEETLKPVEYFKKFPKNISESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVA
APEGLEYVQKIHPDVDVYIAALDDKLNENGYITPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=203, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI57863312, Length=203, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=51.207729468599, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17539892, Length=195, Percent_Identity=27.1794871794872, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17539894, Length=195, Percent_Identity=27.1794871794872, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=36.4583333333333, Blast_Score=124, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28573516, Length=210, Percent_Identity=29.0476190476191, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573514, Length=210, Percent_Identity=29.0476190476191, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573512, Length=210, Percent_Identity=29.0476190476191, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550449, Length=210, Percent_Identity=29.0476190476191, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358379, Length=151, Percent_Identity=25.8278145695364, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23051; Mature: 23051

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
AKGYKLKNKICLIPILRAGIGMVDGVKSLIPTATIGHIGLYRNEETLKPVEYFKKFPKNI
CCCCEECCCEEEEEHHHHCCCHHHHHHHHCCCCHHCCEEEECCCCCCCHHHHHHHHCCCC
SESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVAAPEGLEYVQKIHPDVDVYIA
CCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCEEEEE
ALDDKLNENGYITPGLGDAGDRIFGTK
EECCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
AKGYKLKNKICLIPILRAGIGMVDGVKSLIPTATIGHIGLYRNEETLKPVEYFKKFPKNI
CCCCEECCCEEEEEHHHHCCCHHHHHHHHCCCCHHCCEEEECCCCCCCHHHHHHHHCCCC
SESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVAAPEGLEYVQKIHPDVDVYIA
CCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCEEEEE
ALDDKLNENGYITPGLGDAGDRIFGTK
EECCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA