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The map label for this gene is tyrS [H]

Identifier: 209554094

GI number: 209554094

Start: 156662

End: 157909

Strand: Reverse

Name: tyrS [H]

Synonym: UUR10_0132

Alternate gene names: 209554094

Gene position: 157909-156662 (Counterclockwise)

Preceding gene: 209554521

Following gene: 209554315

Centisome position: 18.06

GC content: 25.48

Gene sequence:

>1248_bases
ATGCATAATTTAATTAAGGATTTAAAAGCGCGAAATTTAATTAACAATATAACTAATGAAGAGAAATTAAAAAAAGCCTT
AGCAGAAAACAAGGGGATTTATGTTGGCTTTGATCCCTCAGCTGATAGTTTACACTTAGGAAACTACATTATGATTATGT
TGTTAAAACGTTTTCGTTTACATAACATTAAAACATTCGCACTAGTTGGTGGTGCTACAGGGATGATTGGTGATCCAAGT
GGCAAATCAGCCGAACGTAACTTATTAGATAAAACAATTTTAGAACACAATATTACAAAAATAAAATATCAACTTGAAAA
ATTTACTAATTCTCAAGTTATTAATAATTATGACTTTTATAAAAACATGACTTTCTTAGATTTCTTACGTGATGTAGGTA
AACTAATTAATATTAATTATTTACTAGAAAAAGAAATTATTAGCTCACGTTTAGATGTAGGTATTTCATATACAGAATTT
AGTTATAACTTGCTACAAGGTTATGATTTTTTACAATTATATAAAAATGATAATATTGCCATTCAAGCTGGTGGTAGTGA
TCAATGAGGTAATATTACAACTGGAATCGAAATAATTCGTAAAAGTTTAGGTGATGATAATATTGCTTGTGGTTTAACAA
TTAATCTATTAACAAATTCTGAAGGTAAAAAATTTGGTAAAAGCGAAAAAGGTGCTATTTATTTAGATGAAAATAAATCA
AGTGTTTATGAAATGTACCAATTCTTAATTAATCAAACAGATGCTGATGTAGAAAAATTATTAAATTTCTTAACATTAAT
TGATGTTGATGAAATAAATAAAATAATGCAAGCACATAAAGAAAATCCAGCTTTAAGAATCGCTCAAAAAGCATTAGCTC
AAGCGGTTGTAGTTGATGTACATGGACAACAAAAATATGAACAAGCATTACATATTAGTCAAGTATTGTTTAATGGAAAT
ATTAATGAATTAAATCAAGAAGAATTTAATATTGCCATTAAAAGTTTACCAACAACAAAATTAGATAAAGATGAAATTAA
AATAATTGATTTATTAAATTTAGCTAATATTTCATCAAGTAATCGTGTTGCACGTGATTTTTTAAGTACAGGGTCAATTT
TAGTTAATGATATTAAAGTAAATGATGAAAACTTTTTAGTTAAAAAACAAGATGCTATTAATCAGGAATTTAGTATTATT
AAAAAAGGTAAGCGAAATTATTTCTTAATTGTATGAAACAAAGATTAA

Upstream 100 bases:

>100_bases
AACATTTAATTATAAGGCAAATCAATAACTTAATTTAAAGATATTAGTATTAAAATATATATTATAGATTAAGTAATTAT
TAAGGATAATAAATAAATTT

Downstream 100 bases:

>100_bases
AACTAAGTCATTTTTGTTTATAATATATATGTCATTACAATATTAAGTGGCGAACCTTGTCAGGCCAGAGATGGAGCAGC
AATAGCATAATCTTTTTATG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MHNLIKDLKARNLINNITNEEKLKKALAENKGIYVGFDPSADSLHLGNYIMIMLLKRFRLHNIKTFALVGGATGMIGDPS
GKSAERNLLDKTILEHNITKIKYQLEKFTNSQVINNYDFYKNMTFLDFLRDVGKLININYLLEKEIISSRLDVGISYTEF
SYNLLQGYDFLQLYKNDNIAIQAGGSDQWGNITTGIEIIRKSLGDDNIACGLTINLLTNSEGKKFGKSEKGAIYLDENKS
SVYEMYQFLINQTDADVEKLLNFLTLIDVDEINKIMQAHKENPALRIAQKALAQAVVVDVHGQQKYEQALHISQVLFNGN
INELNQEEFNIAIKSLPTTKLDKDEIKIIDLLNLANISSSNRVARDFLSTGSILVNDIKVNDENFLVKKQDAINQEFSII
KKGKRNYFLIVWNKD

Sequences:

>Translated_415_residues
MHNLIKDLKARNLINNITNEEKLKKALAENKGIYVGFDPSADSLHLGNYIMIMLLKRFRLHNIKTFALVGGATGMIGDPS
GKSAERNLLDKTILEHNITKIKYQLEKFTNSQVINNYDFYKNMTFLDFLRDVGKLININYLLEKEIISSRLDVGISYTEF
SYNLLQGYDFLQLYKNDNIAIQAGGSDQ*GNITTGIEIIRKSLGDDNIACGLTINLLTNSEGKKFGKSEKGAIYLDENKS
SVYEMYQFLINQTDADVEKLLNFLTLIDVDEINKIMQAHKENPALRIAQKALAQAVVVDVHGQQKYEQALHISQVLFNGN
INELNQEEFNIAIKSLPTTKLDKDEIKIIDLLNLANISSSNRVARDFLSTGSILVNDIKVNDENFLVKKQDAINQEFSII
KKGKRNYFLIV*NKD
>Mature_415_residues
MHNLIKDLKARNLINNITNEEKLKKALAENKGIYVGFDPSADSLHLGNYIMIMLLKRFRLHNIKTFALVGGATGMIGDPS
GKSAERNLLDKTILEHNITKIKYQLEKFTNSQVINNYDFYKNMTFLDFLRDVGKLININYLLEKEIISSRLDVGISYTEF
SYNLLQGYDFLQLYKNDNIAIQAGGSDQ*GNITTGIEIIRKSLGDDNIACGLTINLLTNSEGKKFGKSEKGAIYLDENKS
SVYEMYQFLINQTDADVEKLLNFLTLIDVDEINKIMQAHKENPALRIAQKALAQAVVVDVHGQQKYEQALHISQVLFNGN
INELNQEEFNIAIKSLPTTKLDKDEIKIIDLLNLANISSSNRVARDFLSTGSILVNDIKVNDENFLVKKQDAINQEFSII
KKGKRNYFLIV*NKD

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=439, Percent_Identity=33.2574031890661, Blast_Score=225, Evalue=5e-59,
Organism=Escherichia coli, GI1787925, Length=423, Percent_Identity=41.371158392435, Blast_Score=326, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI25145802, Length=426, Percent_Identity=31.924882629108, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI25145805, Length=331, Percent_Identity=30.2114803625378, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6325160, Length=437, Percent_Identity=34.0961098398169, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI20130383, Length=433, Percent_Identity=34.1801385681293, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46733; Mature: 46733

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNLIKDLKARNLINNITNEEKLKKALAENKGIYVGFDPSADSLHLGNYIMIMLLKRFRL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCEECCHHHHHHHHHHHHH
HNIKTFALVGGATGMIGDPSGKSAERNLLDKTILEHNITKIKYQLEKFTNSQVINNYDFY
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
KNMTFLDFLRDVGKLININYLLEKEIISSRLDVGISYTEFSYNLLQGYDFLQLYKNDNIA
HCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCEEEEEECCCEE
IQAGGSDQGNITTGIEIIRKSLGDDNIACGLTINLLTNSEGKKFGKSEKGAIYLDENKSS
EEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEEECCCHH
VYEMYQFLINQTDADVEKLLNFLTLIDVDEINKIMQAHKENPALRIAQKALAQAVVVDVH
HHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECC
GQQKYEQALHISQVLFNGNINELNQEEFNIAIKSLPTTKLDKDEIKIIDLLNLANISSSN
CHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCCCCCCEEEEEEHHHCCCCCCC
RVARDFLSTGSILVNDIKVNDENFLVKKQDAINQEFSIIKKGKRNYFLIVNKD
HHHHHHHCCCCEEEEEEEECCCCEEEECHHHCCHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MHNLIKDLKARNLINNITNEEKLKKALAENKGIYVGFDPSADSLHLGNYIMIMLLKRFRL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCEECCHHHHHHHHHHHHH
HNIKTFALVGGATGMIGDPSGKSAERNLLDKTILEHNITKIKYQLEKFTNSQVINNYDFY
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
KNMTFLDFLRDVGKLININYLLEKEIISSRLDVGISYTEFSYNLLQGYDFLQLYKNDNIA
HCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCEEEEEECCCEE
IQAGGSDQGNITTGIEIIRKSLGDDNIACGLTINLLTNSEGKKFGKSEKGAIYLDENKSS
EEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEEECCCHH
VYEMYQFLINQTDADVEKLLNFLTLIDVDEINKIMQAHKENPALRIAQKALAQAVVVDVH
HHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECC
GQQKYEQALHISQVLFNGNINELNQEEFNIAIKSLPTTKLDKDEIKIIDLLNLANISSSN
CHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCCCCCCEEEEEEHHHCCCCCCC
RVARDFLSTGSILVNDIKVNDENFLVKKQDAINQEFSIIKKGKRNYFLIVNKD
HHHHHHHCCCCEEEEEEEECCCCEEEECHHHCCHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA