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The map label for this gene is hutH [H]

Identifier: 209551932

GI number: 209551932

Start: 4531334

End: 4532920

Strand: Reverse

Name: hutH [H]

Synonym: Rleg2_4365

Alternate gene names: 209551932

Gene position: 4532920-4531334 (Counterclockwise)

Preceding gene: 209551933

Following gene: 209551931

Centisome position: 99.89

GC content: 66.1

Gene sequence:

>1587_bases
ATGCAGCACGAACGCCCTGGCATCGAACTTTCCGGACGGCCGCTCGGTTTTGCCGAGATGGTGGCGATCGGTGCGGGCAA
GGCGACGATTTCGGCTTCGGCCACCGGCATGGCCCGCATCGCCATTGCCCGCGAGATCGTCGAGGATGCGATCGCCTCCG
GCATGCCCGTCTACGGTTCGACGACCGGCGTCGGCGCCATGAAGGATGTGGAATGGTCGGCCGACGAACTCGACACTTTC
AATCTCGGCCTGGTGCGCGCCCATCATTTCGGCACCGGCACGCCGTTTTCCTGCAATGTCGTACGCAATGCCATGGCGAT
CCGCGTCAATACGGCTCTGACCGGCCAGGTCGGCTGCACGCCGGAGCTGATCGAGGCCTATATCACCATGCTGAAAGCCG
ATCTCATCCCGGTCGTGCGCCGCACCGGCTCGATCGGCTGCGCCGATATCGGCCTGATGGGGCAGATCGGCGCGGTGCTG
ACCGGGGTCGGCGAAGCGATCTACCGCGGCAACCGCATGCAGGCGGCTGAGGCTTTCCGGGCGGCCGGACTGCAGCCGGT
GCGGATGGCGCCGCGCGACAGCCTCGCCTCGCTCAGCATCAATGCGGTGAGTTTTGCCGCGGCGGCGGAAACGACGCGCA
ATGCGGCTGCCTCGATCCGCATCCTGCTGGCGACGGCGATGATGGCGGCCGGCGCGCTCGGCGCATCGCGTGATCCGTGG
AAGGCGGTCCGCCATGTCGGCACGGCGCGCGAAGCACTGATCGGCGCCTGGCTCTGCAATGCCTCCGACGATTGGAACTG
GCCGGTCGCAACCCATGTGCAGGATCCGCTCAGCCTGCGCATGATCGCCCAGGTGTTCGGCGCGGTCATCGAAAACCTGC
TGTCGACCGGCCATAAAATCCTTGCCGCCACCGGGCGCTCGGACGACAACCCGGTCGTGGTCGAAGGCCGGGTGATGACC
TCCGGCGGTTCGCTTCCACTCGACGTGACGATCCTGCTCGAATCGGCGGCCCTCTGCATGGCGCATGCGGCGCGCAACGC
CTTCAACCGCTGCGTCATTCTCGGCAACGGCCAGCGGCGCGACCTGCCGGTCAACCTGGTGCCGCCGGGACGGATCGCCA
CCGGATTCGGGCCGATCATCAAACTTGCCGGCGAGATTTTTTCGCGTGTGCTGTCGATGTCCAATCCCGTGTCGGCGCAG
TCGCTGGTGGTGGCGGCGGGGCTGGAGGACGAGGCGGCCTTCCTGCCGCTGGTCATCGAGCGCTTCGAGCGGCAGATGCA
GGCGTTGAAGCGCCTGGCAGCACTGGAGGCGCTGCTCTCCGCCCAGGCGATCGACATCCTCGGCGATGAACCGAAGGGCG
TCGCCGCCATGCTCTACGAGGTCGTGCGCAAACATGCGGATTTCTATATCGTGGACAGGCCGCTTTCGGCTGAGGTGGAG
GCAATCGAGGAGGAGCTCGGCTCAGACGACTTCCTGTCGAGACTGACCGCACAGGTTCCGATCGCCTCCTTCGACGATTT
CTTTGCGCTCGGATCACTGGAGCATATCGAGGAGCGGCTGGCCCGCCACGAGGCGCAGGCCATCTGA

Upstream 100 bases:

>100_bases
GTGAGTTGATCCGCCTGTCAAAAACATGCTGTGTTCGGCATTTAGGATATCCCATGTGACGGAGGGGCCGCTTAATCTCA
TAATCTAGGAGATATGGCAC

Downstream 100 bases:

>100_bases
ACTCGGCTTTTTGGAGGAGGCGTCATGGACTTCGATCTCGTTCTGCAGGGCACGGTGGTGCTGCCGGACCGTATTCTCGA
AGAAGGCTATGTTGCCGCCC

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MQHERPGIELSGRPLGFAEMVAIGAGKATISASATGMARIAIAREIVEDAIASGMPVYGSTTGVGAMKDVEWSADELDTF
NLGLVRAHHFGTGTPFSCNVVRNAMAIRVNTALTGQVGCTPELIEAYITMLKADLIPVVRRTGSIGCADIGLMGQIGAVL
TGVGEAIYRGNRMQAAEAFRAAGLQPVRMAPRDSLASLSINAVSFAAAAETTRNAAASIRILLATAMMAAGALGASRDPW
KAVRHVGTAREALIGAWLCNASDDWNWPVATHVQDPLSLRMIAQVFGAVIENLLSTGHKILAATGRSDDNPVVVEGRVMT
SGGSLPLDVTILLESAALCMAHAARNAFNRCVILGNGQRRDLPVNLVPPGRIATGFGPIIKLAGEIFSRVLSMSNPVSAQ
SLVVAAGLEDEAAFLPLVIERFERQMQALKRLAALEALLSAQAIDILGDEPKGVAAMLYEVVRKHADFYIVDRPLSAEVE
AIEEELGSDDFLSRLTAQVPIASFDDFFALGSLEHIEERLARHEAQAI

Sequences:

>Translated_528_residues
MQHERPGIELSGRPLGFAEMVAIGAGKATISASATGMARIAIAREIVEDAIASGMPVYGSTTGVGAMKDVEWSADELDTF
NLGLVRAHHFGTGTPFSCNVVRNAMAIRVNTALTGQVGCTPELIEAYITMLKADLIPVVRRTGSIGCADIGLMGQIGAVL
TGVGEAIYRGNRMQAAEAFRAAGLQPVRMAPRDSLASLSINAVSFAAAAETTRNAAASIRILLATAMMAAGALGASRDPW
KAVRHVGTAREALIGAWLCNASDDWNWPVATHVQDPLSLRMIAQVFGAVIENLLSTGHKILAATGRSDDNPVVVEGRVMT
SGGSLPLDVTILLESAALCMAHAARNAFNRCVILGNGQRRDLPVNLVPPGRIATGFGPIIKLAGEIFSRVLSMSNPVSAQ
SLVVAAGLEDEAAFLPLVIERFERQMQALKRLAALEALLSAQAIDILGDEPKGVAAMLYEVVRKHADFYIVDRPLSAEVE
AIEEELGSDDFLSRLTAQVPIASFDDFFALGSLEHIEERLARHEAQAI
>Mature_528_residues
MQHERPGIELSGRPLGFAEMVAIGAGKATISASATGMARIAIAREIVEDAIASGMPVYGSTTGVGAMKDVEWSADELDTF
NLGLVRAHHFGTGTPFSCNVVRNAMAIRVNTALTGQVGCTPELIEAYITMLKADLIPVVRRTGSIGCADIGLMGQIGAVL
TGVGEAIYRGNRMQAAEAFRAAGLQPVRMAPRDSLASLSINAVSFAAAAETTRNAAASIRILLATAMMAAGALGASRDPW
KAVRHVGTAREALIGAWLCNASDDWNWPVATHVQDPLSLRMIAQVFGAVIENLLSTGHKILAATGRSDDNPVVVEGRVMT
SGGSLPLDVTILLESAALCMAHAARNAFNRCVILGNGQRRDLPVNLVPPGRIATGFGPIIKLAGEIFSRVLSMSNPVSAQ
SLVVAAGLEDEAAFLPLVIERFERQMQALKRLAALEALLSAQAIDILGDEPKGVAAMLYEVVRKHADFYIVDRPLSAEVE
AIEEELGSDDFLSRLTAQVPIASFDDFFALGSLEHIEERLARHEAQAI

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=491, Percent_Identity=26.2729124236253, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17567831, Length=492, Percent_Identity=25.4065040650407, Blast_Score=111, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 55877; Mature: 55877

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHERPGIELSGRPLGFAEMVAIGAGKATISASATGMARIAIAREIVEDAIASGMPVYGS
CCCCCCCCEECCCCCCHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
TTGVGAMKDVEWSADELDTFNLGLVRAHHFGTGTPFSCNVVRNAMAIRVNTALTGQVGCT
CCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEHHHHHCEEEEEEEEEEECCCCCC
PELIEAYITMLKADLIPVVRRTGSIGCADIGLMGQIGAVLTGVGEAIYRGNRMQAAEAFR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AAGLQPVRMAPRDSLASLSINAVSFAAAAETTRNAAASIRILLATAMMAAGALGASRDPW
HCCCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KAVRHVGTAREALIGAWLCNASDDWNWPVATHVQDPLSLRMIAQVFGAVIENLLSTGHKI
HHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
LAATGRSDDNPVVVEGRVMTSGGSLPLDVTILLESAALCMAHAARNAFNRCVILGNGQRR
EEECCCCCCCCEEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
DLPVNLVPPGRIATGFGPIIKLAGEIFSRVLSMSNPVSAQSLVVAAGLEDEAAFLPLVIE
CCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCHHHHHHHHH
RFERQMQALKRLAALEALLSAQAIDILGDEPKGVAAMLYEVVRKHADFYIVDRPLSAEVE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHH
AIEEELGSDDFLSRLTAQVPIASFDDFFALGSLEHIEERLARHEAQAI
HHHHHCCCHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQHERPGIELSGRPLGFAEMVAIGAGKATISASATGMARIAIAREIVEDAIASGMPVYGS
CCCCCCCCEECCCCCCHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
TTGVGAMKDVEWSADELDTFNLGLVRAHHFGTGTPFSCNVVRNAMAIRVNTALTGQVGCT
CCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEHHHHHCEEEEEEEEEEECCCCCC
PELIEAYITMLKADLIPVVRRTGSIGCADIGLMGQIGAVLTGVGEAIYRGNRMQAAEAFR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AAGLQPVRMAPRDSLASLSINAVSFAAAAETTRNAAASIRILLATAMMAAGALGASRDPW
HCCCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KAVRHVGTAREALIGAWLCNASDDWNWPVATHVQDPLSLRMIAQVFGAVIENLLSTGHKI
HHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
LAATGRSDDNPVVVEGRVMTSGGSLPLDVTILLESAALCMAHAARNAFNRCVILGNGQRR
EEECCCCCCCCEEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
DLPVNLVPPGRIATGFGPIIKLAGEIFSRVLSMSNPVSAQSLVVAAGLEDEAAFLPLVIE
CCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCHHHHHHHHH
RFERQMQALKRLAALEALLSAQAIDILGDEPKGVAAMLYEVVRKHADFYIVDRPLSAEVE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHH
AIEEELGSDDFLSRLTAQVPIASFDDFFALGSLEHIEERLARHEAQAI
HHHHHCCCHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA