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The map label for this gene is coaBC [H]

Identifier: 209551922

GI number: 209551922

Start: 4520476

End: 4521687

Strand: Reverse

Name: coaBC [H]

Synonym: Rleg2_4355

Alternate gene names: 209551922

Gene position: 4521687-4520476 (Counterclockwise)

Preceding gene: 209551923

Following gene: 209551920

Centisome position: 99.64

GC content: 66.83

Gene sequence:

>1212_bases
ATGGCTCTCAGCGGCAAACGCATCCTCCTCATCATCTCCGGCGGCATCGCCGCCTATAAGAGCCTGGATCTGATCCGCCG
GCTGCGCGAGCGCGGCGCCAGCGTGCGCCCGGTGATGACCAAAGGCGCCCAGGAATTCGTCACGCCGCTGGCCGTCGGCG
CGCTGGCGGCTGACCATGTTTTCCTCGATCTGTTTTCGCGTGAGGACGAGCAGGATGTCGGCCATATCAGGCTGGCGCGC
GACTGCGACCTCGTGCTGATCGCCCCGGCGACCGCCGACCTGATGGCGAAGATGGCAAACGGACTGGCCGACGATCTCGC
CTCGACCGTGCTTTTGGCGACGGAGAGGCCGGTGCTGGCCGCACCGGCGATGAACCCCAGCATGTGGGCGCATCCGGCGA
CGCGGCGCAATGCGGCGCTGCTCAGGGCAGACGGCATCCGCTTCGTCGGGCCGATGGCCGGCGAGATGGCCGAAAGCCGC
GAGGCCGGGCTCGGCCGGATGGCGGAGCCGCTGGAGATCGTTGCGGCCGCCGAAACCATGCTCGACGACGGGGAAAAACC
GCTGAAAGGCCGCAAGGCGATCGTCACCTCAGGCCCGACGCATGAGCCGATCGATCCGGTGCGTTATATCGCCAACCGCT
CCTCCGGCCGGCAGGGCCATGCGATCGCCGCCGCCCTTGCCAAACTGGGCGCCGAAGTGACGCTGGTCTCGGGGCCGGTG
ACCATCGCCGATCCTGTCGGCGTCAACACCGTGCATGTCGAGCGGGCGGAGGAAATGCGCGACGCCGTGCTGGCGGCACT
GCCGGCCGATATCGCCGTCATGGTCGCGGCGGTGGCGGACTGGCGGGTGGCCTCGGCCGCCGACCAGAAGCTGAAGAAAC
ATCCCGGCGAATCCATTCCGACGCTGGCGCTGACCGAGAACCCCGACATCCTCAAGACTCTGGGACATCATACGATGCGG
CCGAAGCTGGTGATCGGCTTTGCCGCCGAGACGCAGGACGTGGAAAGCAATGCCAAGGCGAAACTCGAGCGCAAGGGCGC
CGATATAATCGTCGCCAATGACGTCTCGCCTGCCACCGGCATCATGGGCGGCGGCCGCAACAGCGTCAAACTCATTCGCC
GTGACGGCGTCGAGCAATGGCCGGATCTCGCCAAGGAAGAGGTTGCCGAAAGGCTGGCGGCGCTGATCGCGGCGCGCTTT
ATGCAGGAATAG

Upstream 100 bases:

>100_bases
CCAGACCAGGCGGGGCGAGCGCATGTCGCCGGCGCGATTGCATGTTCTTCACCAAAGGCTTAGGGTCGGGGCCGGTCAAT
AAGGCGACGGGAAGAAAGCC

Downstream 100 bases:

>100_bases
CCACCCGCTGCGGCTTGGCGGCGCCCCGCTTTTCCGGCCGGAAACCGACGACCTCAACGCCATCCTTGCCGACGGTGACG
GCGCTGCCATCGGGAATTTC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MALSGKRILLIISGGIAAYKSLDLIRRLRERGASVRPVMTKGAQEFVTPLAVGALAADHVFLDLFSREDEQDVGHIRLAR
DCDLVLIAPATADLMAKMANGLADDLASTVLLATERPVLAAPAMNPSMWAHPATRRNAALLRADGIRFVGPMAGEMAESR
EAGLGRMAEPLEIVAAAETMLDDGEKPLKGRKAIVTSGPTHEPIDPVRYIANRSSGRQGHAIAAALAKLGAEVTLVSGPV
TIADPVGVNTVHVERAEEMRDAVLAALPADIAVMVAAVADWRVASAADQKLKKHPGESIPTLALTENPDILKTLGHHTMR
PKLVIGFAAETQDVESNAKAKLERKGADIIVANDVSPATGIMGGGRNSVKLIRRDGVEQWPDLAKEEVAERLAALIAARF
MQE

Sequences:

>Translated_403_residues
MALSGKRILLIISGGIAAYKSLDLIRRLRERGASVRPVMTKGAQEFVTPLAVGALAADHVFLDLFSREDEQDVGHIRLAR
DCDLVLIAPATADLMAKMANGLADDLASTVLLATERPVLAAPAMNPSMWAHPATRRNAALLRADGIRFVGPMAGEMAESR
EAGLGRMAEPLEIVAAAETMLDDGEKPLKGRKAIVTSGPTHEPIDPVRYIANRSSGRQGHAIAAALAKLGAEVTLVSGPV
TIADPVGVNTVHVERAEEMRDAVLAALPADIAVMVAAVADWRVASAADQKLKKHPGESIPTLALTENPDILKTLGHHTMR
PKLVIGFAAETQDVESNAKAKLERKGADIIVANDVSPATGIMGGGRNSVKLIRRDGVEQWPDLAKEEVAERLAALIAARF
MQE
>Mature_402_residues
ALSGKRILLIISGGIAAYKSLDLIRRLRERGASVRPVMTKGAQEFVTPLAVGALAADHVFLDLFSREDEQDVGHIRLARD
CDLVLIAPATADLMAKMANGLADDLASTVLLATERPVLAAPAMNPSMWAHPATRRNAALLRADGIRFVGPMAGEMAESRE
AGLGRMAEPLEIVAAAETMLDDGEKPLKGRKAIVTSGPTHEPIDPVRYIANRSSGRQGHAIAAALAKLGAEVTLVSGPVT
IADPVGVNTVHVERAEEMRDAVLAALPADIAVMVAAVADWRVASAADQKLKKHPGESIPTLALTENPDILKTLGHHTMRP
KLVIGFAAETQDVESNAKAKLERKGADIIVANDVSPATGIMGGGRNSVKLIRRDGVEQWPDLAKEEVAERLAALIAARFM
QE

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=186, Percent_Identity=32.7956989247312, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87082301, Length=403, Percent_Identity=44.4168734491315, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17560194, Length=193, Percent_Identity=33.160621761658, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24657262, Length=181, Percent_Identity=30.3867403314917, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42768; Mature: 42637

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSGKRILLIISGGIAAYKSLDLIRRLRERGASVRPVMTKGAQEFVTPLAVGALAADHV
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
FLDLFSREDEQDVGHIRLARDCDLVLIAPATADLMAKMANGLADDLASTVLLATERPVLA
HHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEE
APAMNPSMWAHPATRRNAALLRADGIRFVGPMAGEMAESREAGLGRMAEPLEIVAAAETM
CCCCCCCCCCCCCCCCCCEEEEECCCEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LDDGEKPLKGRKAIVTSGPTHEPIDPVRYIANRSSGRQGHAIAAALAKLGAEVTLVSGPV
HCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCE
TIADPVGVNTVHVERAEEMRDAVLAALPADIAVMVAAVADWRVASAADQKLKKHPGESIP
EEECCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TLALTENPDILKTLGHHTMRPKLVIGFAAETQDVESNAKAKLERKGADIIVANDVSPATG
EEEECCCCHHHHHHCCCCCCCEEEEEECCCCCCHHCHHHHHHHHCCCCEEEECCCCCCCC
IMGGGRNSVKLIRRDGVEQWPDLAKEEVAERLAALIAARFMQE
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALSGKRILLIISGGIAAYKSLDLIRRLRERGASVRPVMTKGAQEFVTPLAVGALAADHV
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
FLDLFSREDEQDVGHIRLARDCDLVLIAPATADLMAKMANGLADDLASTVLLATERPVLA
HHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEE
APAMNPSMWAHPATRRNAALLRADGIRFVGPMAGEMAESREAGLGRMAEPLEIVAAAETM
CCCCCCCCCCCCCCCCCCEEEEECCCEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LDDGEKPLKGRKAIVTSGPTHEPIDPVRYIANRSSGRQGHAIAAALAKLGAEVTLVSGPV
HCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCE
TIADPVGVNTVHVERAEEMRDAVLAALPADIAVMVAAVADWRVASAADQKLKKHPGESIP
EEECCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TLALTENPDILKTLGHHTMRPKLVIGFAAETQDVESNAKAKLERKGADIIVANDVSPATG
EEEECCCCHHHHHHCCCCCCCEEEEEECCCCCCHHCHHHHHHHHCCCCEEEECCCCCCCC
IMGGGRNSVKLIRRDGVEQWPDLAKEEVAERLAALIAARFMQE
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA