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The map label for this gene is dut [H]

Identifier: 209551913

GI number: 209551913

Start: 4511108

End: 4511578

Strand: Reverse

Name: dut [H]

Synonym: Rleg2_4346

Alternate gene names: 209551913

Gene position: 4511578-4511108 (Counterclockwise)

Preceding gene: 209551915

Following gene: 209551912

Centisome position: 99.42

GC content: 67.09

Gene sequence:

>471_bases
ATGACCATTCATCATGATCTGAGACCGACGCTGAACCTCATCCGCCTGGCCAATGGCGAAGGCCTCGACCTGCCCGCCTA
TGAAAGCAAGGGGGCGGCCGGCATGGACCTGCGCGCCGCCGTCGACGAGGCCGCACCGCTGACGCTTCAGCCCGGCAAAC
GGGCGCTGGTGCCGACCGGCTTCATCTTCGAAATCCCCGAAGGTTTCGAAGGCCAGGTGCGGCCGCGCTCCGGCCTCGCC
TTCAAACACGGCATCACCTGCCTGAATTCGCCCGGCACCGTCGACAGCGACTATCGCGGCGAGGTGAAGGTGCTGCTCGC
CAACCTCGGCGACGAAGCCTTCACCGTCGAGCGCGGTATGCGCATCGCCCAGATGGTGATCGCGCCGGTGACGCAGATGC
GGGTGGCCGAAAGTGCCGCCGCAAGCGAGACGACACGCGGCGCCGGTGGCTTCGGCTCCACCGGCGTGTGA

Upstream 100 bases:

>100_bases
TTTCGGCCATACTATGAATCCTGTGGAATTGCCGCGTATCTAGCGATTAAAGCCCGGCATTGCAATTGACCTCGGCGTTC
GCTGCGCAAAGTAATGGGCC

Downstream 100 bases:

>100_bases
TGACAAAGCGCCCCGACAGCGCGGGCCTCTTCTTCCGGCAGGATTATTTCGGCGACCCGGCCGGCTGGGCGGCCTTGGTG
CGCCTGCTCCAGGATATTTT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MTIHHDLRPTLNLIRLANGEGLDLPAYESKGAAGMDLRAAVDEAAPLTLQPGKRALVPTGFIFEIPEGFEGQVRPRSGLA
FKHGITCLNSPGTVDSDYRGEVKVLLANLGDEAFTVERGMRIAQMVIAPVTQMRVAESAAASETTRGAGGFGSTGV

Sequences:

>Translated_156_residues
MTIHHDLRPTLNLIRLANGEGLDLPAYESKGAAGMDLRAAVDEAAPLTLQPGKRALVPTGFIFEIPEGFEGQVRPRSGLA
FKHGITCLNSPGTVDSDYRGEVKVLLANLGDEAFTVERGMRIAQMVIAPVTQMRVAESAAASETTRGAGGFGSTGV
>Mature_155_residues
TIHHDLRPTLNLIRLANGEGLDLPAYESKGAAGMDLRAAVDEAAPLTLQPGKRALVPTGFIFEIPEGFEGQVRPRSGLAF
KHGITCLNSPGTVDSDYRGEVKVLLANLGDEAFTVERGMRIAQMVIAPVTQMRVAESAAASETTRGAGGFGSTGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=145, Percent_Identity=42.7586206896552, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI4503423, Length=145, Percent_Identity=42.7586206896552, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI70906441, Length=145, Percent_Identity=42.7586206896552, Blast_Score=97, Evalue=7e-21,
Organism=Escherichia coli, GI1790071, Length=138, Percent_Identity=42.0289855072464, Blast_Score=108, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988561, Length=153, Percent_Identity=43.7908496732026, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319729, Length=135, Percent_Identity=41.4814814814815, Blast_Score=89, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24583610, Length=132, Percent_Identity=41.6666666666667, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19921126, Length=132, Percent_Identity=41.6666666666667, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16434; Mature: 16303

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIHHDLRPTLNLIRLANGEGLDLPAYESKGAAGMDLRAAVDEAAPLTLQPGKRALVPTG
CCCCCCCCHHEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEECCCCCEECCCC
FIFEIPEGFEGQVRPRSGLAFKHGITCLNSPGTVDSDYRGEVKVLLANLGDEAFTVERGM
EEEECCCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCCEEEEEECCCCCEEEHHHHH
RIAQMVIAPVTQMRVAESAAASETTRGAGGFGSTGV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TIHHDLRPTLNLIRLANGEGLDLPAYESKGAAGMDLRAAVDEAAPLTLQPGKRALVPTG
CCCCCCCHHEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEECCCCCEECCCC
FIFEIPEGFEGQVRPRSGLAFKHGITCLNSPGTVDSDYRGEVKVLLANLGDEAFTVERGM
EEEECCCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCCEEEEEECCCCCEEEHHHHH
RIAQMVIAPVTQMRVAESAAASETTRGAGGFGSTGV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA