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The map label for this gene is moeZ [H]

Identifier: 209551662

GI number: 209551662

Start: 4264906

End: 4265730

Strand: Reverse

Name: moeZ [H]

Synonym: Rleg2_4091

Alternate gene names: 209551662

Gene position: 4265730-4264906 (Counterclockwise)

Preceding gene: 209551663

Following gene: 209551661

Centisome position: 94.0

GC content: 65.21

Gene sequence:

>825_bases
ATGACGGAGGCGACTTTTCCCGGTATCGAGCGCCATGATAAGATCGGCGCCATGGAACCGCTCAGCCCCGACGAAATCGC
CCGTTATCACCGTCACATCCTGCTCCCCGAAATCGGCGGCGCGGGTCAGCAAAAGTTGAAAGCCGCCCGTGTGCTGGTGA
TCGGCGCAGGCGGCCTCGGTGCGCCGGTGCTGCAATATCTGGCCGCAGCCGGGATTGGCACGCTCGGTATCGTCGACGAC
GACCGGGTGTCGCTGTCGAACCTGCAGCGCCAGGTGATCCATGATTCCGGCACGATCGGCGAATTGAAGACGGAAAGTGC
CGCCTTCGCCATCGCCAGGCTCAATCCGCATGTCCGGCTGATCCGCTTCGAGGAACGCTTTTCCGCCGAGACCGCCCGCC
GGCAGCTCTCCGGCTTCGATCTGCTGATCGACGGCTCCGACAATTTCGACACGCGTTATGCCGCCGCCGATGCGGCTGAG
GAAGCCCGCCTTCCGCTTGTCAGCGGCGCCGTCGGGCGCTTCGACGGTTCGCTGACAGTTCTCAAACCCTATGAGAGCGC
CGAGGACGGGACGCCCAACCCCCGATATCGAGATCTCTTTCCGGAAGCGCCGCCGGCGGGGCTCATTCCCGCCTGCGCCG
AGGCCGGGGTCATCGGCGCGCTCACCGGCGTAATCGGCACGATGATGGCGATGGAGGCGATCAAGCTCGTCACCGGCACC
GGAGAGCCGCTGGTCGGACGGCTGCTGCTCTATGACGCGCTCTCGGCCCGGTTCGACACGGTCCGCTACAGAAGACGCCG
GGCAACACAAAGACAGGCCGGATGA

Upstream 100 bases:

>100_bases
TGGGCGGCCAGGCCTTCATGACCGGAACCGATCGCGCCATGTTTTCGGCGTTGGGCGACAGGGCGCAAGTCTTCACGGTG
GCCGACGGAAAGATATTCGA

Downstream 100 bases:

>100_bases
CGATTTTTCCTCTTGATCATAATTTCACACGCTGGGACGAGTTGCTCGCACTGATCCTCACCGCCTTTGCTTCGATGAAC
GGCAGGATCGATCCGCCATC

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MTEATFPGIERHDKIGAMEPLSPDEIARYHRHILLPEIGGAGQQKLKAARVLVIGAGGLGAPVLQYLAAAGIGTLGIVDD
DRVSLSNLQRQVIHDSGTIGELKTESAAFAIARLNPHVRLIRFEERFSAETARRQLSGFDLLIDGSDNFDTRYAAADAAE
EARLPLVSGAVGRFDGSLTVLKPYESAEDGTPNPRYRDLFPEAPPAGLIPACAEAGVIGALTGVIGTMMAMEAIKLVTGT
GEPLVGRLLLYDALSARFDTVRYRRRRATQRQAG

Sequences:

>Translated_274_residues
MTEATFPGIERHDKIGAMEPLSPDEIARYHRHILLPEIGGAGQQKLKAARVLVIGAGGLGAPVLQYLAAAGIGTLGIVDD
DRVSLSNLQRQVIHDSGTIGELKTESAAFAIARLNPHVRLIRFEERFSAETARRQLSGFDLLIDGSDNFDTRYAAADAAE
EARLPLVSGAVGRFDGSLTVLKPYESAEDGTPNPRYRDLFPEAPPAGLIPACAEAGVIGALTGVIGTMMAMEAIKLVTGT
GEPLVGRLLLYDALSARFDTVRYRRRRATQRQAG
>Mature_273_residues
TEATFPGIERHDKIGAMEPLSPDEIARYHRHILLPEIGGAGQQKLKAARVLVIGAGGLGAPVLQYLAAAGIGTLGIVDDD
RVSLSNLQRQVIHDSGTIGELKTESAAFAIARLNPHVRLIRFEERFSAETARRQLSGFDLLIDGSDNFDTRYAAADAAEE
ARLPLVSGAVGRFDGSLTVLKPYESAEDGTPNPRYRDLFPEAPPAGLIPACAEAGVIGALTGVIGTMMAMEAIKLVTGTG
EPLVGRLLLYDALSARFDTVRYRRRRATQRQAG

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=255, Percent_Identity=43.921568627451, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI23510338, Length=185, Percent_Identity=29.1891891891892, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI23510340, Length=185, Percent_Identity=29.1891891891892, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787048, Length=250, Percent_Identity=40.4, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87082356, Length=243, Percent_Identity=38.6831275720165, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789177, Length=135, Percent_Identity=28.8888888888889, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17540406, Length=246, Percent_Identity=38.2113821138211, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI193203301, Length=144, Percent_Identity=25.6944444444444, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=257, Percent_Identity=40.8560311284047, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320598, Length=166, Percent_Identity=27.1084337349398, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325438, Length=158, Percent_Identity=30.379746835443, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24582879, Length=261, Percent_Identity=43.2950191570881, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI28573937, Length=195, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24660640, Length=141, Percent_Identity=28.3687943262411, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129973, Length=188, Percent_Identity=31.3829787234043, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 29359; Mature: 29228

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEATFPGIERHDKIGAMEPLSPDEIARYHRHILLPEIGGAGQQKLKAARVLVIGAGGLG
CCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHEECCCCCCCCHHHHHEEEEEEEECCCCC
APVLQYLAAAGIGTLGIVDDDRVSLSNLQRQVIHDSGTIGELKTESAAFAIARLNPHVRL
HHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHEEEEECCCCEEE
IRFEERFSAETARRQLSGFDLLIDGSDNFDTRYAAADAAEEARLPLVSGAVGRFDGSLTV
EEEHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHCCHHHHCCCHHHCCHHHCCCCEEE
LKPYESAEDGTPNPRYRDLFPEAPPAGLIPACAEAGVIGALTGVIGTMMAMEAIKLVTGT
ECCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GEPLVGRLLLYDALSARFDTVRYRRRRATQRQAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEATFPGIERHDKIGAMEPLSPDEIARYHRHILLPEIGGAGQQKLKAARVLVIGAGGLG
CCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHEECCCCCCCCHHHHHEEEEEEEECCCCC
APVLQYLAAAGIGTLGIVDDDRVSLSNLQRQVIHDSGTIGELKTESAAFAIARLNPHVRL
HHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHEEEEECCCCEEE
IRFEERFSAETARRQLSGFDLLIDGSDNFDTRYAAADAAEEARLPLVSGAVGRFDGSLTV
EEEHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHCCHHHHCCCHHHCCHHHCCCCEEE
LKPYESAEDGTPNPRYRDLFPEAPPAGLIPACAEAGVIGALTGVIGTMMAMEAIKLVTGT
ECCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GEPLVGRLLLYDALSARFDTVRYRRRRATQRQAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]