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The map label for this gene is trpF [H]

Identifier: 209551524

GI number: 209551524

Start: 4101605

End: 4102273

Strand: Direct

Name: trpF [H]

Synonym: Rleg2_3953

Alternate gene names: 209551524

Gene position: 4101605-4102273 (Clockwise)

Preceding gene: 209551523

Following gene: 209551525

Centisome position: 90.38

GC content: 58.59

Gene sequence:

>669_bases
ATGAAACCCGATATCAAGATCTGTGGCTTGAAGACGCCAGAAGCGATCGATCGTGCGCTGGAACGCGGCGCGACCCATAT
CGGTTTTATCTTCTTCGAAAAGAGCCCTCGTTACATCGAGCCGGACCTGGCGGGTAAACTGGCCGAACCCGCGCGTGGCA
AGGCGAAGATCGTCGCCGTCGTCGTCGATCCCAGCAACGACGAGCTTGATGAGATCGTCTCGCTGTTGAAGCCGGATATT
CTGCAGCTGCACGGCAATGAGAGCCCCGAACATGTGCTGACGATCAAGGCGCTCTATGGCCTGCCGGTCATGAAAGTCTT
TTCCGTGCGCACGGCCGACGATCTGAAGCGCGTCGAGGCCTATATCGGCATCGCCGATCGGTTCCTGTTCGACGCGAAAG
CGCCGAAGGGTTCGGAACTGCCCGGCGGCAACGGCATTTCCTTCGATTGGAGCCTTTTGAGCTGGCTCGACGGCAGCATC
GACTACATGCTCTCAGGCGGGCTGAACAAGGACAATGTCGCGGATGCGCTTGTGAAGACCAAGGCACGTGGTATCGACGT
CTCCTCGGGCGTCGAGACTGCGCCTGGCGTGAAGAGCGTCGCAATGATCGATGAATTTTTCGATGCGGTCGAAGAGGCGG
ATGCGCCTGTCATGGCCTCAGGGAGTTGA

Upstream 100 bases:

>100_bases
GCTGCACGCCATTGATTTCGACTGATCGACGTTGGCGCTAAATGCAGCCTAGCACGCAAATTGGCTCGACTCTTGCTGCA
TTTCGTGTCACTTCGCTGCC

Downstream 100 bases:

>100_bases
GAGTGAACGAAACGCCTAAACCGAATTCCTTCCGTTCCGGGCCTGATGAAGACGGCCGCTTCGGCATCTATGGCGGTCGT
TTCGTTGCCGAAACGTTGAT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKPDIKICGLKTPEAIDRALERGATHIGFIFFEKSPRYIEPDLAGKLAEPARGKAKIVAVVVDPSNDELDEIVSLLKPDI
LQLHGNESPEHVLTIKALYGLPVMKVFSVRTADDLKRVEAYIGIADRFLFDAKAPKGSELPGGNGISFDWSLLSWLDGSI
DYMLSGGLNKDNVADALVKTKARGIDVSSGVETAPGVKSVAMIDEFFDAVEEADAPVMASGS

Sequences:

>Translated_222_residues
MKPDIKICGLKTPEAIDRALERGATHIGFIFFEKSPRYIEPDLAGKLAEPARGKAKIVAVVVDPSNDELDEIVSLLKPDI
LQLHGNESPEHVLTIKALYGLPVMKVFSVRTADDLKRVEAYIGIADRFLFDAKAPKGSELPGGNGISFDWSLLSWLDGSI
DYMLSGGLNKDNVADALVKTKARGIDVSSGVETAPGVKSVAMIDEFFDAVEEADAPVMASGS
>Mature_222_residues
MKPDIKICGLKTPEAIDRALERGATHIGFIFFEKSPRYIEPDLAGKLAEPARGKAKIVAVVVDPSNDELDEIVSLLKPDI
LQLHGNESPEHVLTIKALYGLPVMKVFSVRTADDLKRVEAYIGIADRFLFDAKAPKGSELPGGNGISFDWSLLSWLDGSI
DYMLSGGLNKDNVADALVKTKARGIDVSSGVETAPGVKSVAMIDEFFDAVEEADAPVMASGS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=214, Percent_Identity=28.5046728971963, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320210, Length=217, Percent_Identity=33.6405529953917, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 23857; Mature: 23857

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDIKICGLKTPEAIDRALERGATHIGFIFFEKSPRYIEPDLAGKLAEPARGKAKIVAV
CCCCCEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCEECCHHHCCCCCCCCCCEEEEEE
VVDPSNDELDEIVSLLKPDILQLHGNESPEHVLTIKALYGLPVMKVFSVRTADDLKRVEA
EECCCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEHHHHCCHHHHHHHCCCHHHHHHHHH
YIGIADRFLFDAKAPKGSELPGGNGISFDWSLLSWLDGSIDYMLSGGLNKDNVADALVKT
HHHHHHHHHEECCCCCCCCCCCCCCCEEHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
KARGIDVSSGVETAPGVKSVAMIDEFFDAVEEADAPVMASGS
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MKPDIKICGLKTPEAIDRALERGATHIGFIFFEKSPRYIEPDLAGKLAEPARGKAKIVAV
CCCCCEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCEECCHHHCCCCCCCCCCEEEEEE
VVDPSNDELDEIVSLLKPDILQLHGNESPEHVLTIKALYGLPVMKVFSVRTADDLKRVEA
EECCCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEHHHHCCHHHHHHHCCCHHHHHHHHH
YIGIADRFLFDAKAPKGSELPGGNGISFDWSLLSWLDGSIDYMLSGGLNKDNVADALVKT
HHHHHHHHHEECCCCCCCCCCCCCCCEEHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
KARGIDVSSGVETAPGVKSVAMIDEFFDAVEEADAPVMASGS
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA