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The map label for this gene is gyrB [H]

Identifier: 209551517

GI number: 209551517

Start: 4094099

End: 4096534

Strand: Direct

Name: gyrB [H]

Synonym: Rleg2_3946

Alternate gene names: 209551517

Gene position: 4094099-4096534 (Clockwise)

Preceding gene: 209551516

Following gene: 209551520

Centisome position: 90.22

GC content: 61.08

Gene sequence:

>2436_bases
ATGAGCGATACATCCGCGACGGAAAACGGCGTAAGCACCGAATATGGCGCAGATTCCATCAAGGTTCTGAAGGGCCTTGA
TGCCGTGCGCAAGCGTCCCGGCATGTATATCGGCGATACCGACGATGGCTCCGGCCTTCATCACATGGTCTATGAAGTCG
TCGACAACGCGATAGACGAAGCGCTTGCCGGCCATGCCGACATCGTCACCGTCACGCTCAATCCGGATGGCTCGGTGACC
GTCACCGACAACGGCCGCGGCATCCCGACGGACATTCATACCGGGGAAGGTGTATCGGCGGCCGAAGTCATCATGACGCA
GCTGCATGCCGGCGGCAAGTTCGACCAGAATTCCTACAAGGTCTCCGGCGGTCTGCACGGCGTCGGCGTCTCCGTCGTCA
ACGCATTGTCTGTCTGGCTGAAACTGAAGATCCGCCGCCAGGGCAAGATCCATGAGATGAGCTTCACCCATGGCGTGGCC
GATGCGCCGCTCAAGGTCACCGGCGAAGCGCCCAATGAGACCGGCACGGAAGTGAGCTTCATGCCGAGCACCGACACTTT
CACCATGACGGAGTTCGACTACGGCACGCTCGAGCACCGCCTGCGCGAACTTGCCTTCCTGAACTCGGGCGTGCGCATCC
TGCTGACCGACAAGCGCCATTCCGATATCAAGCAGGAAGAGCTGCGTTATGACGGCGGCCTCGAGGCTTTCGTCGCTTAT
CTCGACCGCGCCAAGAAGTCACTCGTCGACAAGCCGGTCGCCATCCGCGGCGAAAAGGACGGCATCACCGTCGAAGTCGC
GATGTGGTGGAACGACAGCTATCACGAGAACGTGCTCTGCTTCACCAACAACATCCCGCAGCGCGACGGCGGCACGCATA
TGGCCGGTTTCCGCGCGGCATTGACACGCCAGGTGGTATCCTACGCCGACAGTTCCGGCATCACCAAAAGAGAAAAGGTG
ACGCTGCAGGGCGAGGATTGCCGCGAAGGCCTGACGGCGGTGCTCTCGGTCAAGGTGCCCGATCCGAAATTCTCCTCGCA
GACCAAGGATAAACTCGTTTCTTCGGAAGTCCGTCCGGTTGTCGAAAGTCTCGTCAACGAGGCGCTGAATACCTGGTTCG
AAGAACATCCGAGCGAAGCCAAGATTCTGGTCGGCAAGGTCGTCGAGGCAGCGGCGGCGCGTGAAGCGGCCCGCAAAGCC
CGCGAATTGACCCGCCGGAAGGGCGCACTCGATATCGCCTCGCTGCCCGGCAAACTCGCCGACTGCTCAGAACGTGATCC
GACAAAATCCGAAGTCTTCCTCGTCGAGGGCGATTCCGCCGGCGGCTCGGCCAAGCAGGGCCGCTCGCGAGAAAACCAGG
CGATCCTGCCGTTGCGCGGCAAGATCCTCAATGTCGAGCGTGCCCGTTTCGATAAGATGCTGTCGAGCCAGGAAATCGGC
ACGCTGATCACCGCACTCGGCACCGGCATCGGCAAGGACGAGTTCAACGTCGAAAAGCTGCGTTATCACAAAATCATCAT
CATGACGGATGCCGATGTCGACGGCGCCCATATCCGCACCTTGCTGCTGACCTTTTTCTTCCGCCAGATGCCGGAACTGA
TCGAGCGCGGCCATCTCTATATCGCCCAGCCGCCACTCTATAAGGTCTCGCGCGGCAAGTCGGTGCAGTATCTGAAGGAC
GAAAAGGCGCTCGAGGAATACCTCATCAGCCAGGGCCTGGAAGATGCGGCGCTGAAGCTCGGCAGCGGCGAAGTCCGCAC
CGGCCAGGATCTGCGTGAGGTTATCCTCGATGCGTTGCGCATGCGCGCTTTGCTCGACAATCTCCATTCGCGTTACAATC
GTGCGGCCATCGAACAGGCGGCGATCGCCGGCGCTCTCAATGCCGAACGCGTCAGCGACCGGGCAAGAGCCCAGGCATTG
ACGAGCGAGGTAGCAAGCCGCCTCGACATCATCGCCGAGGAAACCGAACGTGGCTGGCAGGGCGATCTGACCAGCGATGG
CGGTCTGCGTCTCGAACGCATGGTCCGCGGCGTCAAGGAAATCGTCGTGCTCGACATGGCGCTGATCGGCTCCTCGGATG
CTCGGCATATCGACCAGCTGACGTCACGGCTCAAGGAAATCTATCAGACGCCGCCGTCGCTGCATCGCCGCGAAGGCGAC
CTCGAGATTTCGGGCCCGCGCGCCTTGCTCGATGCAATCTTCGCGACCGGCCGCAAGGGCCTGACGATGCAGCGCTATAA
GGGTCTTGGCGAGATGAATGCCGAGCAGCTCTGGGAAACCACGCTCGATCCGAACGTCCGTTCGCTGCTGCAGGTCAAGG
TCCCCGACGCCACCGATGCCGACGGTCTCTTCGCCCGGTTGATGGGTGACGAAGTCGAACCGCGGCGCGAATTTATCCAG
GACAACGCGCTGAGCGTCGCAAACCTCGATATCTGA

Upstream 100 bases:

>100_bases
TTGGGAAGTGTGTCCAAAAAACCTATATACGAGAGTGAAGAAAGCCGGTGATTCGCAAGGCGCGCCGCAGCTTTACGACA
ACAGGGAAAATCTCGACAGA

Downstream 100 bases:

>100_bases
TTGTTATTTTTACAAGCAAAAGCCCCGCTGTCCCCAGACGGCGGGGCTTTTGCTTGTGTCGGGCGCTTAATCCGCGACGA
AACGGCCGTTGAACGCCACC

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 811; Mature: 810

Protein sequence:

>811_residues
MSDTSATENGVSTEYGADSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDEALAGHADIVTVTLNPDGSVT
VTDNGRGIPTDIHTGEGVSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSVWLKLKIRRQGKIHEMSFTHGVA
DAPLKVTGEAPNETGTEVSFMPSTDTFTMTEFDYGTLEHRLRELAFLNSGVRILLTDKRHSDIKQEELRYDGGLEAFVAY
LDRAKKSLVDKPVAIRGEKDGITVEVAMWWNDSYHENVLCFTNNIPQRDGGTHMAGFRAALTRQVVSYADSSGITKREKV
TLQGEDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPVVESLVNEALNTWFEEHPSEAKILVGKVVEAAAAREAARKA
RELTRRKGALDIASLPGKLADCSERDPTKSEVFLVEGDSAGGSAKQGRSRENQAILPLRGKILNVERARFDKMLSSQEIG
TLITALGTGIGKDEFNVEKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGHLYIAQPPLYKVSRGKSVQYLKD
EKALEEYLISQGLEDAALKLGSGEVRTGQDLREVILDALRMRALLDNLHSRYNRAAIEQAAIAGALNAERVSDRARAQAL
TSEVASRLDIIAEETERGWQGDLTSDGGLRLERMVRGVKEIVVLDMALIGSSDARHIDQLTSRLKEIYQTPPSLHRREGD
LEISGPRALLDAIFATGRKGLTMQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVPDATDADGLFARLMGDEVEPRREFIQ
DNALSVANLDI

Sequences:

>Translated_811_residues
MSDTSATENGVSTEYGADSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDEALAGHADIVTVTLNPDGSVT
VTDNGRGIPTDIHTGEGVSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSVWLKLKIRRQGKIHEMSFTHGVA
DAPLKVTGEAPNETGTEVSFMPSTDTFTMTEFDYGTLEHRLRELAFLNSGVRILLTDKRHSDIKQEELRYDGGLEAFVAY
LDRAKKSLVDKPVAIRGEKDGITVEVAMWWNDSYHENVLCFTNNIPQRDGGTHMAGFRAALTRQVVSYADSSGITKREKV
TLQGEDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPVVESLVNEALNTWFEEHPSEAKILVGKVVEAAAAREAARKA
RELTRRKGALDIASLPGKLADCSERDPTKSEVFLVEGDSAGGSAKQGRSRENQAILPLRGKILNVERARFDKMLSSQEIG
TLITALGTGIGKDEFNVEKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGHLYIAQPPLYKVSRGKSVQYLKD
EKALEEYLISQGLEDAALKLGSGEVRTGQDLREVILDALRMRALLDNLHSRYNRAAIEQAAIAGALNAERVSDRARAQAL
TSEVASRLDIIAEETERGWQGDLTSDGGLRLERMVRGVKEIVVLDMALIGSSDARHIDQLTSRLKEIYQTPPSLHRREGD
LEISGPRALLDAIFATGRKGLTMQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVPDATDADGLFARLMGDEVEPRREFIQ
DNALSVANLDI
>Mature_810_residues
SDTSATENGVSTEYGADSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDEALAGHADIVTVTLNPDGSVTV
TDNGRGIPTDIHTGEGVSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSVWLKLKIRRQGKIHEMSFTHGVAD
APLKVTGEAPNETGTEVSFMPSTDTFTMTEFDYGTLEHRLRELAFLNSGVRILLTDKRHSDIKQEELRYDGGLEAFVAYL
DRAKKSLVDKPVAIRGEKDGITVEVAMWWNDSYHENVLCFTNNIPQRDGGTHMAGFRAALTRQVVSYADSSGITKREKVT
LQGEDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPVVESLVNEALNTWFEEHPSEAKILVGKVVEAAAAREAARKAR
ELTRRKGALDIASLPGKLADCSERDPTKSEVFLVEGDSAGGSAKQGRSRENQAILPLRGKILNVERARFDKMLSSQEIGT
LITALGTGIGKDEFNVEKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGHLYIAQPPLYKVSRGKSVQYLKDE
KALEEYLISQGLEDAALKLGSGEVRTGQDLREVILDALRMRALLDNLHSRYNRAAIEQAAIAGALNAERVSDRARAQALT
SEVASRLDIIAEETERGWQGDLTSDGGLRLERMVRGVKEIVVLDMALIGSSDARHIDQLTSRLKEIYQTPPSLHRREGDL
EISGPRALLDAIFATGRKGLTMQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVPDATDADGLFARLMGDEVEPRREFIQD
NALSVANLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=639, Percent_Identity=25.0391236306729, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI19913406, Length=635, Percent_Identity=23.7795275590551, Blast_Score=139, Evalue=8e-33,
Organism=Escherichia coli, GI48994957, Length=810, Percent_Identity=58.641975308642, Blast_Score=901, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=593, Percent_Identity=40.4721753794266, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535065, Length=615, Percent_Identity=24.2276422764228, Blast_Score=139, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI212645845, Length=522, Percent_Identity=23.7547892720307, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI212645657, Length=222, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=596, Percent_Identity=26.1744966442953, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI17136538, Length=530, Percent_Identity=25.0943396226415, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89080; Mature: 88949

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTSATENGVSTEYGADSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHH
ALAGHADIVTVTLNPDGSVTVTDNGRGIPTDIHTGEGVSAAEVIMTQLHAGGKFDQNSYK
HHCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
VSGGLHGVGVSVVNALSVWLKLKIRRQGKIHEMSFTHGVADAPLKVTGEAPNETGTEVSF
ECCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEHHHCCCCCCCEEEECCCCCCCCCEEEE
MPSTDTFTMTEFDYGTLEHRLRELAFLNSGVRILLTDKRHSDIKQEELRYDGGLEAFVAY
ECCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCHHHHHHH
LDRAKKSLVDKPVAIRGEKDGITVEVAMWWNDSYHENVLCFTNNIPQRDGGTHMAGFRAA
HHHHHHHHHCCCCEEECCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHH
LTRQVVSYADSSGITKREKVTLQGEDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPV
HHHHHHHHHCCCCCCCCCEEEECCHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
VESLVNEALNTWFEEHPSEAKILVGKVVEAAAAREAARKARELTRRKGALDIASLPGKLA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCC
DCSERDPTKSEVFLVEGDSAGGSAKQGRSRENQAILPLRGKILNVERARFDKMLSSQEIG
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHH
TLITALGTGIGKDEFNVEKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGHLY
HHHHHHHCCCCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
IAQPPLYKVSRGKSVQYLKDEKALEEYLISQGLEDAALKLGSGEVRTGQDLREVILDALR
EECCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
MRALLDNLHSRYNRAAIEQAAIAGALNAERVSDRARAQALTSEVASRLDIIAEETERGWQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDLTSDGGLRLERMVRGVKEIVVLDMALIGSSDARHIDQLTSRLKEIYQTPPSLHRREGD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCC
LEISGPRALLDAIFATGRKGLTMQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVPDATDA
EEECCHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCHHHHEEEECCCCCCH
DGLFARLMGDEVEPRREFIQDNALSVANLDI
HHHHHHHHCCCCCHHHHHHHCCCCCEEECCC
>Mature Secondary Structure 
SDTSATENGVSTEYGADSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHH
ALAGHADIVTVTLNPDGSVTVTDNGRGIPTDIHTGEGVSAAEVIMTQLHAGGKFDQNSYK
HHCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
VSGGLHGVGVSVVNALSVWLKLKIRRQGKIHEMSFTHGVADAPLKVTGEAPNETGTEVSF
ECCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEHHHCCCCCCCEEEECCCCCCCCCEEEE
MPSTDTFTMTEFDYGTLEHRLRELAFLNSGVRILLTDKRHSDIKQEELRYDGGLEAFVAY
ECCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCHHHHHHH
LDRAKKSLVDKPVAIRGEKDGITVEVAMWWNDSYHENVLCFTNNIPQRDGGTHMAGFRAA
HHHHHHHHHCCCCEEECCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHH
LTRQVVSYADSSGITKREKVTLQGEDCREGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPV
HHHHHHHHHCCCCCCCCCEEEECCHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
VESLVNEALNTWFEEHPSEAKILVGKVVEAAAAREAARKARELTRRKGALDIASLPGKLA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCC
DCSERDPTKSEVFLVEGDSAGGSAKQGRSRENQAILPLRGKILNVERARFDKMLSSQEIG
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHH
TLITALGTGIGKDEFNVEKLRYHKIIIMTDADVDGAHIRTLLLTFFFRQMPELIERGHLY
HHHHHHHCCCCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
IAQPPLYKVSRGKSVQYLKDEKALEEYLISQGLEDAALKLGSGEVRTGQDLREVILDALR
EECCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
MRALLDNLHSRYNRAAIEQAAIAGALNAERVSDRARAQALTSEVASRLDIIAEETERGWQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDLTSDGGLRLERMVRGVKEIVVLDMALIGSSDARHIDQLTSRLKEIYQTPPSLHRREGD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCC
LEISGPRALLDAIFATGRKGLTMQRYKGLGEMNAEQLWETTLDPNVRSLLQVKVPDATDA
EEECCHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCHHHHEEEECCCCCCH
DGLFARLMGDEVEPRREFIQDNALSVANLDI
HHHHHHHHCCCCCHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226640 [H]