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The map label for this gene is tesB [H]

Identifier: 209551342

GI number: 209551342

Start: 3895205

End: 3896089

Strand: Reverse

Name: tesB [H]

Synonym: Rleg2_3771

Alternate gene names: 209551342

Gene position: 3896089-3895205 (Counterclockwise)

Preceding gene: 209551344

Following gene: 209551341

Centisome position: 85.86

GC content: 62.49

Gene sequence:

>885_bases
ATGACGCGCGAGACATCAGGGCCTTCGGCGATGGAGACGCTGCTTTCGACGCTCGACCTGGAGCCGATCGAAGTCGATAT
CTTCCGCGGGCGCAGCCCGCAGGCCGGCTGGCAGCGGGTCTTCGGCGGCCAGGTGATCGGCCAGGCGCTGATGGCGGCGC
AGCGCACCATCGAGGGCGAGCGTTTCGTCCATTCGCTGCATGCTTATTTCATGCGTCCGGGCGATCCCTCGGTGCCGATC
ATCTATCAGGCGGAGCGGATCCGCGACGGATCGAGCTTCAATACCCGGCGCGTCGTCGCCATCCAGCACGGCAAGGCGAT
CTTCACGCTGTCGGCTTCCTTCCAGGTGGAGGAGCCGGGCTTCGACCACCAGATCGCCATGCCCGAGGTCGAAATGCCGG
AAGCGCTGCTCGGCGAACAGCAGATCAAGGATCAGTATCTGACGCATGCGCCGGAGGCGATCCGAAAATACTGGCAGCGC
GAGCGGCCGATCGAAATCCGTCCCGTCTCGCTGACGCATTATTTTTCCGACAAGAAGCTCGACCCCAAACAGGATGTCTG
GGTGCGCGCCACTGGCCCGGTTCCCGATGATCGGCTCTATCAGGCGGCGGTTCTTGCCTATCTCTCGGACATGACCCTGC
TCGATACCTCGCTCTATGCACACGGCACCTCCATCTTCGACCAGAGTCTGCAGGTGGCGAGCCTCGATCATTCCATGTGG
TTCCACAGACCCTGCAAGCTCGACGACTGGCTGCTCTATACGCAGGACAGCCCCTCGGCTTCGGGCGCTAGAGGGCTGAC
CCGGGGCAGCCTCTTTGCCCGATCGGGTGCGCTGATCGCCTCCGTCGCGCAGGAAGGTCTGATTCGGAAAAAGGCAAATG
AATAA

Upstream 100 bases:

>100_bases
CCAGCATATCCAGCATCGCGCCGCTCCCTTACCTTGTGCCTCAGATGTGACCTATATAGATCATCGCAACTTCACTTCCT
ACCGCCGGGAGGCATGCAAA

Downstream 100 bases:

>100_bases
ATAATAGGCATCTTTGAAAATTTGCGCATTATTTGTGCGCTTATTGGCCAATCATTTGCCTGTTTATTGGCTCTCCATAT
TATAATTGTTATTTTTCAAT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTRETSGPSAMETLLSTLDLEPIEVDIFRGRSPQAGWQRVFGGQVIGQALMAAQRTIEGERFVHSLHAYFMRPGDPSVPI
IYQAERIRDGSSFNTRRVVAIQHGKAIFTLSASFQVEEPGFDHQIAMPEVEMPEALLGEQQIKDQYLTHAPEAIRKYWQR
ERPIEIRPVSLTHYFSDKKLDPKQDVWVRATGPVPDDRLYQAAVLAYLSDMTLLDTSLYAHGTSIFDQSLQVASLDHSMW
FHRPCKLDDWLLYTQDSPSASGARGLTRGSLFARSGALIASVAQEGLIRKKANE

Sequences:

>Translated_294_residues
MTRETSGPSAMETLLSTLDLEPIEVDIFRGRSPQAGWQRVFGGQVIGQALMAAQRTIEGERFVHSLHAYFMRPGDPSVPI
IYQAERIRDGSSFNTRRVVAIQHGKAIFTLSASFQVEEPGFDHQIAMPEVEMPEALLGEQQIKDQYLTHAPEAIRKYWQR
ERPIEIRPVSLTHYFSDKKLDPKQDVWVRATGPVPDDRLYQAAVLAYLSDMTLLDTSLYAHGTSIFDQSLQVASLDHSMW
FHRPCKLDDWLLYTQDSPSASGARGLTRGSLFARSGALIASVAQEGLIRKKANE
>Mature_293_residues
TRETSGPSAMETLLSTLDLEPIEVDIFRGRSPQAGWQRVFGGQVIGQALMAAQRTIEGERFVHSLHAYFMRPGDPSVPII
YQAERIRDGSSFNTRRVVAIQHGKAIFTLSASFQVEEPGFDHQIAMPEVEMPEALLGEQQIKDQYLTHAPEAIRKYWQRE
RPIEIRPVSLTHYFSDKKLDPKQDVWVRATGPVPDDRLYQAAVLAYLSDMTLLDTSLYAHGTSIFDQSLQVASLDHSMWF
HRPCKLDDWLLYTQDSPSASGARGLTRGSLFARSGALIASVAQEGLIRKKANE

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=294, Percent_Identity=44.2176870748299, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI1786657, Length=270, Percent_Identity=47.037037037037, Blast_Score=271, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI71988741, Length=294, Percent_Identity=36.734693877551, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17558508, Length=303, Percent_Identity=37.953795379538, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI115532456, Length=282, Percent_Identity=37.2340425531915, Blast_Score=166, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17531889, Length=282, Percent_Identity=37.2340425531915, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17531885, Length=282, Percent_Identity=37.2340425531915, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI212645202, Length=263, Percent_Identity=36.5019011406844, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71982224, Length=290, Percent_Identity=33.1034482758621, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322480, Length=336, Percent_Identity=26.7857142857143, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33045; Mature: 32914

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRETSGPSAMETLLSTLDLEPIEVDIFRGRSPQAGWQRVFGGQVIGQALMAAQRTIEGE
CCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
RFVHSLHAYFMRPGDPSVPIIYQAERIRDGSSFNTRRVVAIQHGKAIFTLSASFQVEEPG
HHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCCCCEEEEEEECCCEEEEEEEEEEECCCC
FDHQIAMPEVEMPEALLGEQQIKDQYLTHAPEAIRKYWQRERPIEIRPVSLTHYFSDKKL
CCCEEECCCCCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCC
DPKQDVWVRATGPVPDDRLYQAAVLAYLSDMTLLDTSLYAHGTSIFDQSLQVASLDHSMW
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHEEECCHHHH
FHRPCKLDDWLLYTQDSPSASGARGLTRGSLFARSGALIASVAQEGLIRKKANE
CCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRETSGPSAMETLLSTLDLEPIEVDIFRGRSPQAGWQRVFGGQVIGQALMAAQRTIEGE
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
RFVHSLHAYFMRPGDPSVPIIYQAERIRDGSSFNTRRVVAIQHGKAIFTLSASFQVEEPG
HHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCCCCEEEEEEECCCEEEEEEEEEEECCCC
FDHQIAMPEVEMPEALLGEQQIKDQYLTHAPEAIRKYWQRERPIEIRPVSLTHYFSDKKL
CCCEEECCCCCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCC
DPKQDVWVRATGPVPDDRLYQAAVLAYLSDMTLLDTSLYAHGTSIFDQSLQVASLDHSMW
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHEEECCHHHH
FHRPCKLDDWLLYTQDSPSASGARGLTRGSLFARSGALIASVAQEGLIRKKANE
CCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]