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The map label for this gene is hemC [H]

Identifier: 209551271

GI number: 209551271

Start: 3826937

End: 3827866

Strand: Direct

Name: hemC [H]

Synonym: Rleg2_3699

Alternate gene names: 209551271

Gene position: 3826937-3827866 (Clockwise)

Preceding gene: 209551265

Following gene: 209551272

Centisome position: 84.33

GC content: 67.53

Gene sequence:

>930_bases
ATGCAAACAAAACCTTTCCGGATCGGCACGCGGGGCAGCCCGCTGGCGCTTGCCCAGGCGCATGAGGCCCGCGACAGGCT
GATGGCGGCGCATCATCTGCCCGAAGAGATGTTCGAGATCGTCGTGCTGTCGACCAAGGGCGATCGCATCACCGACCGGT
CGCTGGCTGAGATCGGCGGCAAGGGCCTCTTCACCGAGGAGCTCGAACAGCAGCTTACCACAGGCGAGCTGGATTTCGCC
GTGCACTCCGCCAAGGACATGCCGACGAAGCTGCCCGACGGCCTCCATCTCTCCGCCTATCTGCCGCGCGAGGATATCCG
CGACGCCGTCATCGGCCGCACCGCGCCCAAACTGATCGACCTGCCGCATGGCGCCACCGTCGGCTCCTCGTCGCTGCGCC
GCCAGGCACTGATCCGCCGCATGCGGCCCGATATCAATGTCGTGACCTTCCGCGGCCTGGTGGAAACGCGCCTGCGCAAG
CTCGAAGAAGGCCAGGTCGACGCCACCTTGCTGGCCCTTGCCGGCCTGAAACGGCTGGGCAAGGTCGAGGTTCTCACAGA
TATTCTCGACCCCGACACCTTCCCGCCGGCGCCGGCGCAGGGGGCGATCTGCCTCGAAAGCCGCATCGGCGATACTCAGA
TCGACGATCTGCTGGCGCCGGTCAACGATGCCGCGACCTTCGACACCGTCTCCTGCGAACGCGCCTTCCTCGCCGCGCTC
GACGGCTCCTGCCGCACACCGATCGGCGGTTATGCCGTCTGCGAAGGCGATCTGATCCGCTTCTCCGGCCTCATCATCAC
CCCCGACGGCCGCAGCCAGCATGCGGTGACGACCGACGGCCACCGCCGCGATGCGGCCGCACTCGGCACCCGCGCCGGCC
AGGACGTGCGCGCAAGGGCCGGCAGCGCCTTTTTCGACGACTGGCACTGA

Upstream 100 bases:

>100_bases
TGCCAAGGATACGCAGAAAGGGAACCATGAGGCCTGTTCGTTGATTGCGATGGGATGGAAACCCGTTTACGAGAACTCCG
GTAACAACGGAACTGAGCGG

Downstream 100 bases:

>100_bases
CGCAGCCATGCGCGTGCTCGTCACCCGCCCCGCGCATTCGGCTGAAAAAACCGCACAACGTCTGCGTGACATGGGCCACG
AGCCGCTGCTGCTGCCGCTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MQTKPFRIGTRGSPLALAQAHEARDRLMAAHHLPEEMFEIVVLSTKGDRITDRSLAEIGGKGLFTEELEQQLTTGELDFA
VHSAKDMPTKLPDGLHLSAYLPREDIRDAVIGRTAPKLIDLPHGATVGSSSLRRQALIRRMRPDINVVTFRGLVETRLRK
LEEGQVDATLLALAGLKRLGKVEVLTDILDPDTFPPAPAQGAICLESRIGDTQIDDLLAPVNDAATFDTVSCERAFLAAL
DGSCRTPIGGYAVCEGDLIRFSGLIITPDGRSQHAVTTDGHRRDAAALGTRAGQDVRARAGSAFFDDWH

Sequences:

>Translated_309_residues
MQTKPFRIGTRGSPLALAQAHEARDRLMAAHHLPEEMFEIVVLSTKGDRITDRSLAEIGGKGLFTEELEQQLTTGELDFA
VHSAKDMPTKLPDGLHLSAYLPREDIRDAVIGRTAPKLIDLPHGATVGSSSLRRQALIRRMRPDINVVTFRGLVETRLRK
LEEGQVDATLLALAGLKRLGKVEVLTDILDPDTFPPAPAQGAICLESRIGDTQIDDLLAPVNDAATFDTVSCERAFLAAL
DGSCRTPIGGYAVCEGDLIRFSGLIITPDGRSQHAVTTDGHRRDAAALGTRAGQDVRARAGSAFFDDWH
>Mature_309_residues
MQTKPFRIGTRGSPLALAQAHEARDRLMAAHHLPEEMFEIVVLSTKGDRITDRSLAEIGGKGLFTEELEQQLTTGELDFA
VHSAKDMPTKLPDGLHLSAYLPREDIRDAVIGRTAPKLIDLPHGATVGSSSLRRQALIRRMRPDINVVTFRGLVETRLRK
LEEGQVDATLLALAGLKRLGKVEVLTDILDPDTFPPAPAQGAICLESRIGDTQIDDLLAPVNDAATFDTVSCERAFLAAL
DGSCRTPIGGYAVCEGDLIRFSGLIITPDGRSQHAVTTDGHRRDAAALGTRAGQDVRARAGSAFFDDWH

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=275, Percent_Identity=39.2727272727273, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI66933009, Length=271, Percent_Identity=39.8523985239852, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI48994974, Length=296, Percent_Identity=42.9054054054054, Blast_Score=213, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319996, Length=260, Percent_Identity=36.1538461538462, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI20130425, Length=261, Percent_Identity=40.6130268199234, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33502; Mature: 33502

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKPFRIGTRGSPLALAQAHEARDRLMAAHHLPEEMFEIVVLSTKGDRITDRSLAEIGG
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCCCCCCHHHHHHHCC
KGLFTEELEQQLTTGELDFAVHSAKDMPTKLPDGLHLSAYLPREDIRDAVIGRTAPKLID
CCCCHHHHHHHHCCCCHHHEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCEEE
LPHGATVGSSSLRRQALIRRMRPDINVVTFRGLVETRLRKLEEGQVDATLLALAGLKRLG
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
KVEVLTDILDPDTFPPAPAQGAICLESRIGDTQIDDLLAPVNDAATFDTVSCERAFLAAL
HHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DGSCRTPIGGYAVCEGDLIRFSGLIITPDGRSQHAVTTDGHRRDAAALGTRAGQDVRARA
CCCCCCCCCCEEEECCCEEEEECEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHC
GSAFFDDWH
CCCCCCCCC
>Mature Secondary Structure
MQTKPFRIGTRGSPLALAQAHEARDRLMAAHHLPEEMFEIVVLSTKGDRITDRSLAEIGG
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCCCCCCHHHHHHHCC
KGLFTEELEQQLTTGELDFAVHSAKDMPTKLPDGLHLSAYLPREDIRDAVIGRTAPKLID
CCCCHHHHHHHHCCCCHHHEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCEEE
LPHGATVGSSSLRRQALIRRMRPDINVVTFRGLVETRLRKLEEGQVDATLLALAGLKRLG
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
KVEVLTDILDPDTFPPAPAQGAICLESRIGDTQIDDLLAPVNDAATFDTVSCERAFLAAL
HHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DGSCRTPIGGYAVCEGDLIRFSGLIITPDGRSQHAVTTDGHRRDAAALGTRAGQDVRARA
CCCCCCCCCCEEEECCCEEEEECEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHC
GSAFFDDWH
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]