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The map label for this gene is cbf2 [H]

Identifier: 209551115

GI number: 209551115

Start: 3666272

End: 3667153

Strand: Reverse

Name: cbf2 [H]

Synonym: Rleg2_3539

Alternate gene names: 209551115

Gene position: 3667153-3666272 (Counterclockwise)

Preceding gene: 209551119

Following gene: 209551114

Centisome position: 80.81

GC content: 60.2

Gene sequence:

>882_bases
ATGTTGAGCACCAACAAACTTGCCGTTCTGGCGTTCGCAACTTTTGTTGCGCTCCAGGCCCCGGCCTACGCCGATGACGC
GGTCATCGCCAAGGTCGGCAATCTGGAGATTCACCAGTCGGAACTCGACCTTGCCGTCGCCAATCTCGACCCGCAGCTGG
CACAGCTGCCCGACGACCAGAAGAAGGTCGCAGCCCTTTCCGCCGCCATCGACGTGAAGCTGCTCGCCGCCGACGCTGCG
GCCGAGAAGCTCGATCAGACCGACGAATTCAAGAAGCGCATGCAGTATCTCACCGACCGCGAGCTGCACAACGCCTACTT
CAAGAAGCATGTCGTCGACATCGTGACGCCCGAAGAAGTCAAGGCCCGCTACGACAAGGAAGTCGCCGCCCTGCCGAAGC
AGGAGGAAGTCCACGCCCGTCATATCCTCGTCAAGACCGAGGATGAAGCCAAGGACATCATCAAGCAGCTCGATGCCGGC
AAGGATTTCGCCGAACTCGCCAAGGAAAAGTCCACCGATCCGAACAAGTCGGAAGGCGGCGACCTCGGCTATTTCTCGCG
CGGCCGCATGGTCAAGGAATTCGAGGACGCAGCCTTCGCGCTTGAAAAGGGCACCTATTCCAAGACGCCTGTTAAAACCG
ATTTCGGCTATCATGTCATCAAGGTCGAGGATAAGCGCGACGCCCCGCCGCCGCCCTTCGAGCAGGTGCAGGACCAGGTT
CGTCAGCTCGTCATGCGCGACAAGTATCTTGAGCTTCTGAACAAGGCGAAGGCCTCGGCCAAGATCGAAATCAGCGACGA
GACGCTGCGCAAGGGTTACGACCAGGCCAACAAGCAGCCGGAGCCGGGCAGTGAGCCCGTCGCACCGGCGCCGAAGCAGT
AA

Upstream 100 bases:

>100_bases
GATTTGGCGGATACAGAAAGGCCACAATCCGGTGTTGATGGCTATTTTGGGCCGATTCAGGCGATGCTGAAACCGGCGAT
GTAACTGTGAAGGGTATTTC

Downstream 100 bases:

>100_bases
TAGTCGCATCAGGGCCCGGTTTTTCCGGGCCCTTTACTGCATAATTCCTTAAATCGGAATCGATTTAAGGGCAAAATTAT
GCAGCAATTTTAAAGTGTTA

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: Major antigen peb4A [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLSTNKLAVLAFATFVALQAPAYADDAVIAKVGNLEIHQSELDLAVANLDPQLAQLPDDQKKVAALSAAIDVKLLAADAA
AEKLDQTDEFKKRMQYLTDRELHNAYFKKHVVDIVTPEEVKARYDKEVAALPKQEEVHARHILVKTEDEAKDIIKQLDAG
KDFAELAKEKSTDPNKSEGGDLGYFSRGRMVKEFEDAAFALEKGTYSKTPVKTDFGYHVIKVEDKRDAPPPPFEQVQDQV
RQLVMRDKYLELLNKAKASAKIEISDETLRKGYDQANKQPEPGSEPVAPAPKQ

Sequences:

>Translated_293_residues
MLSTNKLAVLAFATFVALQAPAYADDAVIAKVGNLEIHQSELDLAVANLDPQLAQLPDDQKKVAALSAAIDVKLLAADAA
AEKLDQTDEFKKRMQYLTDRELHNAYFKKHVVDIVTPEEVKARYDKEVAALPKQEEVHARHILVKTEDEAKDIIKQLDAG
KDFAELAKEKSTDPNKSEGGDLGYFSRGRMVKEFEDAAFALEKGTYSKTPVKTDFGYHVIKVEDKRDAPPPPFEQVQDQV
RQLVMRDKYLELLNKAKASAKIEISDETLRKGYDQANKQPEPGSEPVAPAPKQ
>Mature_293_residues
MLSTNKLAVLAFATFVALQAPAYADDAVIAKVGNLEIHQSELDLAVANLDPQLAQLPDDQKKVAALSAAIDVKLLAADAA
AEKLDQTDEFKKRMQYLTDRELHNAYFKKHVVDIVTPEEVKARYDKEVAALPKQEEVHARHILVKTEDEAKDIIKQLDAG
KDFAELAKEKSTDPNKSEGGDLGYFSRGRMVKEFEDAAFALEKGTYSKTPVKTDFGYHVIKVEDKRDAPPPPFEQVQDQV
RQLVMRDKYLELLNKAKASAKIEISDETLRKGYDQANKQPEPGSEPVAPAPKQ

Specific function: Ppiases Accelerate The Folding Of Proteins. It Prefers Amino Acid Residues With Hydrophobic Side Chains Like Leucine And Phenylalanine In The P1 Position Of The Peptides Substrates. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=95, Percent_Identity=41.0526315789474, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1790211, Length=84, Percent_Identity=45.2380952380952, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786645, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786238, Length=144, Percent_Identity=36.1111111111111, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17537235, Length=95, Percent_Identity=48.4210526315789, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356303, Length=95, Percent_Identity=44.2105263157895, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 32600; Mature: 32600

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSTNKLAVLAFATFVALQAPAYADDAVIAKVGNLEIHQSELDLAVANLDPQLAQLPDDQ
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHEECCCCEEEHHHHCEEEECCCHHHHHCCCHH
KKVAALSAAIDVKLLAADAAAEKLDQTDEFKKRMQYLTDRELHNAYFKKHVVDIVTPEEV
HHHHHHHHHHHHHEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KARYDKEVAALPKQEEVHARHILVKTEDEAKDIIKQLDAGKDFAELAKEKSTDPNKSEGG
HHHHHHHHHHCCCHHHHHHHEEEEECCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCC
DLGYFSRGRMVKEFEDAAFALEKGTYSKTPVKTDFGYHVIKVEDKRDAPPPPFEQVQDQV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
RQLVMRDKYLELLNKAKASAKIEISDETLRKGYDQANKQPEPGSEPVAPAPKQ
HHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLSTNKLAVLAFATFVALQAPAYADDAVIAKVGNLEIHQSELDLAVANLDPQLAQLPDDQ
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHEECCCCEEEHHHHCEEEECCCHHHHHCCCHH
KKVAALSAAIDVKLLAADAAAEKLDQTDEFKKRMQYLTDRELHNAYFKKHVVDIVTPEEV
HHHHHHHHHHHHHEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KARYDKEVAALPKQEEVHARHILVKTEDEAKDIIKQLDAGKDFAELAKEKSTDPNKSEGG
HHHHHHHHHHCCCHHHHHHHEEEEECCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCC
DLGYFSRGRMVKEFEDAAFALEKGTYSKTPVKTDFGYHVIKVEDKRDAPPPPFEQVQDQV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
RQLVMRDKYLELLNKAKASAKIEISDETLRKGYDQANKQPEPGSEPVAPAPKQ
HHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]