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The map label for this gene is dgoD [H]

Identifier: 209551055

GI number: 209551055

Start: 3594742

End: 3595890

Strand: Direct

Name: dgoD [H]

Synonym: Rleg2_3479

Alternate gene names: 209551055

Gene position: 3594742-3595890 (Clockwise)

Preceding gene: 209551054

Following gene: 209551056

Centisome position: 79.22

GC content: 61.62

Gene sequence:

>1149_bases
ATGAAGATCACCAAACTCACCACCTATATCGTTCCGCCGCGCTGGCTGTTTTTGAAGATCGAGACCGACGAGGGCATCAT
CGGCTGGGGCGAACCGGTCGTCGAAGGCCGCGCGCTGACCGTCCAAGCCGCCGTCCACGAACTGGAAGACTATCTGATCG
GCAAGGATCCCTTCCTGATCGAGGACCACTGGACGGTCATGTATCGCGGCGGCTTCTATCGCGGCGGCGCTGTACACATG
AGCGCCATCTCCGGCATCGACCAGGCGCTGTGGGACATCAAGGGCAAGGCCCTCGGCCAGCCGATCCATTCCCTGCTGGG
CGGCCAGCTGCGCGACCGCATCAAGGTCTATTCCTGGATCGGCGGCGATCGTCCGGCGGATGTCGCCAACAATGCCAGAG
AGGTGGTCGCCCGCGGCTTCAAGGCGATCAAGCTCAACGGCTGCGAGGAAATGCAGATCGTCGACACCAACGAGAAGGTG
GAAAAGGCGGTCGAAACCATCGCCGTCATCCGCGAGGCGATCGGCCCGCATATCGGCATCGGCGTCGATTTCCACGGCCG
CGTGCACAAGCCGATGGCCAAGGTTCTCGCCAAAGAACTCGAACCCTACAAGCTGATGTTCATCGAGGAGCCGGTTCTTT
CGGAAAACAAGGAGGCGCTGCGCGACATCGTCAACCATACCTCGACGCCGATCGCGCTTGGCGAACGGCTCTTTTCGCGC
TGGGACTTCAAGCAGGTCCTGTCGGACGGTTATGTCGACATCATCCAGCCGGATCTGTCGCATGCCGGCGGCATCACCGA
GTGCCGCAAGATCGCGGCGATGGCCGAAGCCTATGATGTGGCGCTGGCGCCGCATTGCCCGCTAGGCCCGATCGCACTCG
CCGCCTGCCTGCAGGTCGATGCCGTCAGCTATAATGCCTTCATCCAGGAACAGAGCCTCGGCATCCATTACAACAAGGGC
AACGACATCCTCGACTACATCTCCAACAAGGAGGTGTTCCAATATGCCGATGGTTTCGTCTCGATCCCCCAGGGGCCCGG
TCTCGGCATCGAAGTCGACGAGGCCTATGTCATCGAGCGCGCGAGGGAAGGCCACCGCTGGCGCAACCCGATCTGGCGCC
ACGCCGACGGCAGTTTCGCCGAATGGTAA

Upstream 100 bases:

>100_bases
CGCGACCTTGCCGCCGCCGAAAAGGCGATCGGCAGAACGAAATAAGCAATCCGTGGCTGGGCCGCCGGTCAAAAATCTGA
AGAGAGACTGAAGAGCAGCG

Downstream 100 bases:

>100_bases
GAAGAAAGGGTCGCGCAAGCGGCCCTTTTTTCATTCGCCGTGTAGCAAATCGGTCATCTCGTCCGTCATGGTGGAAACGC
AAACAGGAGATCTTACGATG

Product: galactonate dehydratase

Products: NA

Alternate protein names: GalD [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKITKLTTYIVPPRWLFLKIETDEGIIGWGEPVVEGRALTVQAAVHELEDYLIGKDPFLIEDHWTVMYRGGFYRGGAVHM
SAISGIDQALWDIKGKALGQPIHSLLGGQLRDRIKVYSWIGGDRPADVANNAREVVARGFKAIKLNGCEEMQIVDTNEKV
EKAVETIAVIREAIGPHIGIGVDFHGRVHKPMAKVLAKELEPYKLMFIEEPVLSENKEALRDIVNHTSTPIALGERLFSR
WDFKQVLSDGYVDIIQPDLSHAGGITECRKIAAMAEAYDVALAPHCPLGPIALAACLQVDAVSYNAFIQEQSLGIHYNKG
NDILDYISNKEVFQYADGFVSIPQGPGLGIEVDEAYVIERAREGHRWRNPIWRHADGSFAEW

Sequences:

>Translated_382_residues
MKITKLTTYIVPPRWLFLKIETDEGIIGWGEPVVEGRALTVQAAVHELEDYLIGKDPFLIEDHWTVMYRGGFYRGGAVHM
SAISGIDQALWDIKGKALGQPIHSLLGGQLRDRIKVYSWIGGDRPADVANNAREVVARGFKAIKLNGCEEMQIVDTNEKV
EKAVETIAVIREAIGPHIGIGVDFHGRVHKPMAKVLAKELEPYKLMFIEEPVLSENKEALRDIVNHTSTPIALGERLFSR
WDFKQVLSDGYVDIIQPDLSHAGGITECRKIAAMAEAYDVALAPHCPLGPIALAACLQVDAVSYNAFIQEQSLGIHYNKG
NDILDYISNKEVFQYADGFVSIPQGPGLGIEVDEAYVIERAREGHRWRNPIWRHADGSFAEW
>Mature_382_residues
MKITKLTTYIVPPRWLFLKIETDEGIIGWGEPVVEGRALTVQAAVHELEDYLIGKDPFLIEDHWTVMYRGGFYRGGAVHM
SAISGIDQALWDIKGKALGQPIHSLLGGQLRDRIKVYSWIGGDRPADVANNAREVVARGFKAIKLNGCEEMQIVDTNEKV
EKAVETIAVIREAIGPHIGIGVDFHGRVHKPMAKVLAKELEPYKLMFIEEPVLSENKEALRDIVNHTSTPIALGERLFSR
WDFKQVLSDGYVDIIQPDLSHAGGITECRKIAAMAEAYDVALAPHCPLGPIALAACLQVDAVSYNAFIQEQSLGIHYNKG
NDILDYISNKEVFQYADGFVSIPQGPGLGIEVDEAYVIERAREGHRWRNPIWRHADGSFAEW

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994953, Length=382, Percent_Identity=64.6596858638743, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1787864, Length=414, Percent_Identity=32.6086956521739, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI226510960, Length=278, Percent_Identity=28.7769784172662, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 42561; Mature: 42561

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00908 MR_MLE_1 ; PS00909 MR_MLE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITKLTTYIVPPRWLFLKIETDEGIIGWGEPVVEGRALTVQAAVHELEDYLIGKDPFLI
CCEEEEEEEEECCEEEEEEEECCCCEEECCCCHHCCCEEEHHHHHHHHHHHHCCCCCEEE
EDHWTVMYRGGFYRGGAVHMSAISGIDQALWDIKGKALGQPIHSLLGGQLRDRIKVYSWI
ECCEEEEECCCEECCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHCC
GGDRPADVANNAREVVARGFKAIKLNGCEEMQIVDTNEKVEKAVETIAVIREAIGPHIGI
CCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
GVDFHGRVHKPMAKVLAKELEPYKLMFIEEPVLSENKEALRDIVNHTSTPIALGERLFSR
EECCCCCHHHHHHHHHHHHCCCEEEEEEECCHHCCCHHHHHHHHHCCCCCHHHHHHHHHH
WDFKQVLSDGYVDIIQPDLSHAGGITECRKIAAMAEAYDVALAPHCPLGPIALAACLQVD
CCHHHHHCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHH
AVSYNAFIQEQSLGIHYNKGNDILDYISNKEVFQYADGFVSIPQGPGLGIEVDEAYVIER
HHHHHHEEEECCCCEEECCCCHHHHHHCCCHHHHHCCCEEECCCCCCCCEEECHHHHHHH
AREGHRWRNPIWRHADGSFAEW
HHCCCHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKITKLTTYIVPPRWLFLKIETDEGIIGWGEPVVEGRALTVQAAVHELEDYLIGKDPFLI
CCEEEEEEEEECCEEEEEEEECCCCEEECCCCHHCCCEEEHHHHHHHHHHHHCCCCCEEE
EDHWTVMYRGGFYRGGAVHMSAISGIDQALWDIKGKALGQPIHSLLGGQLRDRIKVYSWI
ECCEEEEECCCEECCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHCC
GGDRPADVANNAREVVARGFKAIKLNGCEEMQIVDTNEKVEKAVETIAVIREAIGPHIGI
CCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
GVDFHGRVHKPMAKVLAKELEPYKLMFIEEPVLSENKEALRDIVNHTSTPIALGERLFSR
EECCCCCHHHHHHHHHHHHCCCEEEEEEECCHHCCCHHHHHHHHHCCCCCHHHHHHHHHH
WDFKQVLSDGYVDIIQPDLSHAGGITECRKIAAMAEAYDVALAPHCPLGPIALAACLQVD
CCHHHHHCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHH
AVSYNAFIQEQSLGIHYNKGNDILDYISNKEVFQYADGFVSIPQGPGLGIEVDEAYVIER
HHHHHHEEEECCCCEEECCCCHHHHHHCCCHHHHHCCCEEECCCCCCCCEEECHHHHHHH
AREGHRWRNPIWRHADGSFAEW
HHCCCHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA