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The map label for this gene is hemH [H]

Identifier: 209550880

GI number: 209550880

Start: 3393232

End: 3394266

Strand: Direct

Name: hemH [H]

Synonym: Rleg2_3304

Alternate gene names: 209550880

Gene position: 3393232-3394266 (Clockwise)

Preceding gene: 209550879

Following gene: 209550881

Centisome position: 74.77

GC content: 59.81

Gene sequence:

>1035_bases
ATGACAGCAGATACTTCACTCCGCCCGGCAGACCATCCGGCCGTCAAGTCAGGCAAGGTCGGTGTCCTGCTGGTCAATCT
CGGCACGCCCGATGGCACCGATTACACGTCGATGCGCCGCTATCTCCGGGAGTTCTTGACCGATCGCCGCGTCATCGAAT
GGTCGCCGTGGAAGTGGTATCCGATCCTGTTCGGTGTCGTGCTCAACACCCGCCCGCGGAAAGTCGGCAAGGCCTATGAG
CTGATCTGGAACAAGGAGAAGAACGAAAGTTATCTCCGCACTTATACGCGCAACCAGTCCGAGCTGATGGCCGAGCACCT
GAAGGATCTGGCGACGGTCAAAGTGGATTGGGCGATGCGCTACGGCACGCCGTCGATCGCCTCGCGCATCGAGGCGTTGA
AGCAAGAGGGCTGCGACCGTATCGTGCTCTTCCCGCTTTATCCGCAATATGCGGCGGCAACGACCGCCACCGTCAACGAC
AAGGCGTTCCAGAAGCTGCTTTCAATGCGCTGGCAGCCGGCATTACGCACCGTGCCCGACTATCACGACGACGAGACCTA
TATCGAAGCGCTCGCAACGTCCGTCGAAAAGCATCTTGCGACGCTCGACTGGAAGCCGGAGATGCTGCTCGCCTCCTTCC
ACGGCATTCCGATGTCCTATTTCAAGCAGGGCGATCCCTATTACTGTCAATGCCAGAAGACCGGCCGGCTGCTGCGCGAG
CGGCTGGGGCTGACCAAGGAAAACTTCATGGTCACTTTCCAGTCCCGCTTCGGGCCGGAGGAATGGCTGCAGCCCTATAC
CGACAAGACGGTGGAGAAGCTCGCCCAAGACGGCGTCAAGCGCATCGCCGTCATCAATCCCGGCTTCGTTTCCGACTGTC
TGGAAACGCTTGAGGAGATCGCCGAACAGGCCGCCCATTCATTCCACGAGAATGGCGGCGAGAAGTTCGCGCATATTCCC
TGCCTCAACGACGGCGAGGACGGCATGACGGTGCTGGAAAAGGTCGTCCGCCGCGAATTGCAGGGCTGGATCTAA

Upstream 100 bases:

>100_bases
CCGGCCCGGGCTTTCCCGGGCCGGCTTTTCTTTCTATAGGGTGAACCACGATCTCGGGGCTGCGTATGAGCCGACGAGAC
AAAAGAGCATTGGGACCAGA

Downstream 100 bases:

>100_bases
GAGATTCCACGCTGAAAAATCTGCCCTGACTCATCCTTCCTTTCCTAGGAGGTGGGGCATCCGTGGGTCATTTCTTCCTC
GCAAAGAACATGCTACCTCA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTADTSLRPADHPAVKSGKVGVLLVNLGTPDGTDYTSMRRYLREFLTDRRVIEWSPWKWYPILFGVVLNTRPRKVGKAYE
LIWNKEKNESYLRTYTRNQSELMAEHLKDLATVKVDWAMRYGTPSIASRIEALKQEGCDRIVLFPLYPQYAAATTATVND
KAFQKLLSMRWQPALRTVPDYHDDETYIEALATSVEKHLATLDWKPEMLLASFHGIPMSYFKQGDPYYCQCQKTGRLLRE
RLGLTKENFMVTFQSRFGPEEWLQPYTDKTVEKLAQDGVKRIAVINPGFVSDCLETLEEIAEQAAHSFHENGGEKFAHIP
CLNDGEDGMTVLEKVVRRELQGWI

Sequences:

>Translated_344_residues
MTADTSLRPADHPAVKSGKVGVLLVNLGTPDGTDYTSMRRYLREFLTDRRVIEWSPWKWYPILFGVVLNTRPRKVGKAYE
LIWNKEKNESYLRTYTRNQSELMAEHLKDLATVKVDWAMRYGTPSIASRIEALKQEGCDRIVLFPLYPQYAAATTATVND
KAFQKLLSMRWQPALRTVPDYHDDETYIEALATSVEKHLATLDWKPEMLLASFHGIPMSYFKQGDPYYCQCQKTGRLLRE
RLGLTKENFMVTFQSRFGPEEWLQPYTDKTVEKLAQDGVKRIAVINPGFVSDCLETLEEIAEQAAHSFHENGGEKFAHIP
CLNDGEDGMTVLEKVVRRELQGWI
>Mature_343_residues
TADTSLRPADHPAVKSGKVGVLLVNLGTPDGTDYTSMRRYLREFLTDRRVIEWSPWKWYPILFGVVLNTRPRKVGKAYEL
IWNKEKNESYLRTYTRNQSELMAEHLKDLATVKVDWAMRYGTPSIASRIEALKQEGCDRIVLFPLYPQYAAATTATVNDK
AFQKLLSMRWQPALRTVPDYHDDETYIEALATSVEKHLATLDWKPEMLLASFHGIPMSYFKQGDPYYCQCQKTGRLLRER
LGLTKENFMVTFQSRFGPEEWLQPYTDKTVEKLAQDGVKRIAVINPGFVSDCLETLEEIAEQAAHSFHENGGEKFAHIPC
LNDGEDGMTVLEKVVRRELQGWI

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=347, Percent_Identity=25.6484149855908, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI60499025, Length=340, Percent_Identity=25.5882352941176, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=42.2360248447205, Blast_Score=248, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6324750, Length=343, Percent_Identity=23.9067055393586, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17864156, Length=340, Percent_Identity=24.7058823529412, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=24.5353159851301, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39550; Mature: 39418

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADTSLRPADHPAVKSGKVGVLLVNLGTPDGTDYTSMRRYLREFLTDRRVIEWSPWKWY
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCHH
PILFGVVLNTRPRKVGKAYELIWNKEKNESYLRTYTRNQSELMAEHLKDLATVKVDWAMR
HHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHEEEEHHHC
YGTPSIASRIEALKQEGCDRIVLFPLYPQYAAATTATVNDKAFQKLLSMRWQPALRTVPD
CCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCC
YHDDETYIEALATSVEKHLATLDWKPEMLLASFHGIPMSYFKQGDPYYCQCQKTGRLLRE
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHCCCCCEEEEHHHHHHHHH
RLGLTKENFMVTFQSRFGPEEWLQPYTDKTVEKLAQDGVKRIAVINPGFVSDCLETLEEI
HHCCCHHHEEEEEHHHCCCHHHHCCCCHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHH
AEQAAHSFHENGGEKFAHIPCLNDGEDGMTVLEKVVRRELQGWI
HHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TADTSLRPADHPAVKSGKVGVLLVNLGTPDGTDYTSMRRYLREFLTDRRVIEWSPWKWY
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCHH
PILFGVVLNTRPRKVGKAYELIWNKEKNESYLRTYTRNQSELMAEHLKDLATVKVDWAMR
HHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHEEEEHHHC
YGTPSIASRIEALKQEGCDRIVLFPLYPQYAAATTATVNDKAFQKLLSMRWQPALRTVPD
CCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCC
YHDDETYIEALATSVEKHLATLDWKPEMLLASFHGIPMSYFKQGDPYYCQCQKTGRLLRE
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHCCCCCEEEEHHHHHHHHH
RLGLTKENFMVTFQSRFGPEEWLQPYTDKTVEKLAQDGVKRIAVINPGFVSDCLETLEEI
HHCCCHHHEEEEEHHHCCCHHHHCCCCHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHH
AEQAAHSFHENGGEKFAHIPCLNDGEDGMTVLEKVVRRELQGWI
HHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA