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The map label for this gene is ggt [H]

Identifier: 209550857

GI number: 209550857

Start: 3369399

End: 3371135

Strand: Direct

Name: ggt [H]

Synonym: Rleg2_3281

Alternate gene names: 209550857

Gene position: 3369399-3371135 (Clockwise)

Preceding gene: 209550856

Following gene: 209550858

Centisome position: 74.25

GC content: 62.41

Gene sequence:

>1737_bases
ATGGGCCGCCTGCATATCGGGACGATCTCGGTCATATCGGCACTGTCGCTGAGCCTGACCTCTGTTTTCGCCGCCTCGCC
CGCGCCTGTCGAGGCCGAGCACGGCATGGTCGTCACCGCCCAGCATCTGGCGACCGATGTCGGCGTCGAGGTGCTGAAGG
GCGGCGGCAATGCCGTCGATGCAGCCGTTGCCGTTGGTTATGCGCTGGCGGTCGTCTATCCCTCGGCCGGTAATCTCGGC
GGTGGCGGCTTCATGACCATTCGCCTGAAGGACGGCACCAAGACCTTCCTCGATTTCCGCGAACGCGCGCCCCTTGCCGC
CACGAAGACAATGTATCTCGATGCCAAGGGCGATATCGTGCCGCGCGCCAGCCTCGACGGCTATCTTGCCGTCGGCGTTC
CCGGCTCCGTGATGGGCTTCGAAACCGCACGCGAGAAATACGGCACAAAGCCGCGCCAGGATCTGATCGCACCGGCACTT
CGCTTCGCCAGGGAAGGCTACACGCTGGAACAGGGCGATGCCGCAAGTTTCGCCGGCAGCGCCAAGCGCCTCGCCAAGGA
CGAGGCGGCGGCGAAGATTTTCCTGAAACCCGATGGCAAAGCCTATGCATTGGGCGAAAAGCTCCAGCAGCCCGACCTTG
CCGCGGTCCTGGCGGCCATATCGGAAAAAGGTCCTGACGCCTTCTACAAGGCCGCGCCCGCCGAAGCGATCGTCAAGGCA
AGCCAGGCTAAGGGCGGCATCCTCGCCAGGCAAGATTTCGAGCAATATGCCGTGCGCGAGTTGAAGCCGGTCGAATGCAA
TTATCGCGGTTACGACATCATCTCCTCGCCGCCGCCTTCCTCCGGCGGCGTCATCATCTGCGAGATCCTCAACGTTCTCG
AAGGTTATCCGATTTCTTACCTGGGCTACGGCTCGGCCGAAACCGTGCATGTGATGGTCGAGGCTATGCGTTATGCCTAT
GTCGACCGCAACGCTGCGCTCGGCGATCCCGATTTCGTCGAGAACCCGGTCGCAAAACTCATCGACAAGACCTATGCCAA
GGAGATCGCCGCCAAGATCGATCCCTACAAGGCCGGCACGTCGGCCAACCTTAAACCGCTCGGCGGCAAGGAAAGCACCG
AGACGACGCATTATTCGATCATCGACGACGAGGGCAATGCGGTCGCCGTCACCTATACGCTGAACGGCTCCTTCGGCGCT
GCCGTCGTAGCGCCCGGCACCGGCGTCCTGCTCAACAACGAGATGGACGATTTCACCTCCAAGCCCGGCGTGCCGAACCT
TTATGGCCTCGTCCAGGGCGAGGCGAACGCCATCGCACCGAAGAAGACACCGCTCTCCTCGATGAGCCCGACGATCGTCA
CCAAGGACGGCAAGCCTTTCATGGTGATCGGCAGCCCCGGCGGCTCGCGCATCATCACCATCACGCTGGAGGCGATCCTC
AACGTGGTCGATTTCGGCATGGATATCAGCCAGGCGGTGAATGCGCCGCGTATCCACCATCAATGGCAGCCCGATAAGGT
CTATCTCGAACCTTATGCAATTTCGCCCGATACGGAAAAGACCCTCGCCGCCATGGGCTACAGCTTCGATGGCGGCAATG
ACGCGCCGCTCTGGGGCCAGGCCGCCGGCATCCTCGTCGGCGGCAAAAGCCTCGCCGCCATCGAAAAGGGCGGCGGTGCG
CGCTATAACGGCGCCATGGACAGCCGCGCGACTGAAGGTTCGGCAAACGGCTACTGA

Upstream 100 bases:

>100_bases
GGAAACTCGCCGAGCTTCTTGCCTAAAGCCAAACCCTTGCATTGCCTCGGGCCGTCGCGGCCCCATATGTTTTCCATCAT
TGTCCATAGGAGGGGAAATC

Downstream 100 bases:

>100_bases
CGATCGCCAGCGGCAGGCGACAAACGCGACGAGCCATTCATGTCACGGTGACAAAGTCGCCGTTCACAAACGGCTGGCCG
CGCCCTAAGCATGAGCGAAC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MGRLHIGTISVISALSLSLTSVFAASPAPVEAEHGMVVTAQHLATDVGVEVLKGGGNAVDAAVAVGYALAVVYPSAGNLG
GGGFMTIRLKDGTKTFLDFRERAPLAATKTMYLDAKGDIVPRASLDGYLAVGVPGSVMGFETAREKYGTKPRQDLIAPAL
RFAREGYTLEQGDAASFAGSAKRLAKDEAAAKIFLKPDGKAYALGEKLQQPDLAAVLAAISEKGPDAFYKAAPAEAIVKA
SQAKGGILARQDFEQYAVRELKPVECNYRGYDIISSPPPSSGGVIICEILNVLEGYPISYLGYGSAETVHVMVEAMRYAY
VDRNAALGDPDFVENPVAKLIDKTYAKEIAAKIDPYKAGTSANLKPLGGKESTETTHYSIIDDEGNAVAVTYTLNGSFGA
AVVAPGTGVLLNNEMDDFTSKPGVPNLYGLVQGEANAIAPKKTPLSSMSPTIVTKDGKPFMVIGSPGGSRIITITLEAIL
NVVDFGMDISQAVNAPRIHHQWQPDKVYLEPYAISPDTEKTLAAMGYSFDGGNDAPLWGQAAGILVGGKSLAAIEKGGGA
RYNGAMDSRATEGSANGY

Sequences:

>Translated_578_residues
MGRLHIGTISVISALSLSLTSVFAASPAPVEAEHGMVVTAQHLATDVGVEVLKGGGNAVDAAVAVGYALAVVYPSAGNLG
GGGFMTIRLKDGTKTFLDFRERAPLAATKTMYLDAKGDIVPRASLDGYLAVGVPGSVMGFETAREKYGTKPRQDLIAPAL
RFAREGYTLEQGDAASFAGSAKRLAKDEAAAKIFLKPDGKAYALGEKLQQPDLAAVLAAISEKGPDAFYKAAPAEAIVKA
SQAKGGILARQDFEQYAVRELKPVECNYRGYDIISSPPPSSGGVIICEILNVLEGYPISYLGYGSAETVHVMVEAMRYAY
VDRNAALGDPDFVENPVAKLIDKTYAKEIAAKIDPYKAGTSANLKPLGGKESTETTHYSIIDDEGNAVAVTYTLNGSFGA
AVVAPGTGVLLNNEMDDFTSKPGVPNLYGLVQGEANAIAPKKTPLSSMSPTIVTKDGKPFMVIGSPGGSRIITITLEAIL
NVVDFGMDISQAVNAPRIHHQWQPDKVYLEPYAISPDTEKTLAAMGYSFDGGNDAPLWGQAAGILVGGKSLAAIEKGGGA
RYNGAMDSRATEGSANGY
>Mature_577_residues
GRLHIGTISVISALSLSLTSVFAASPAPVEAEHGMVVTAQHLATDVGVEVLKGGGNAVDAAVAVGYALAVVYPSAGNLGG
GGFMTIRLKDGTKTFLDFRERAPLAATKTMYLDAKGDIVPRASLDGYLAVGVPGSVMGFETAREKYGTKPRQDLIAPALR
FAREGYTLEQGDAASFAGSAKRLAKDEAAAKIFLKPDGKAYALGEKLQQPDLAAVLAAISEKGPDAFYKAAPAEAIVKAS
QAKGGILARQDFEQYAVRELKPVECNYRGYDIISSPPPSSGGVIICEILNVLEGYPISYLGYGSAETVHVMVEAMRYAYV
DRNAALGDPDFVENPVAKLIDKTYAKEIAAKIDPYKAGTSANLKPLGGKESTETTHYSIIDDEGNAVAVTYTLNGSFGAA
VVAPGTGVLLNNEMDDFTSKPGVPNLYGLVQGEANAIAPKKTPLSSMSPTIVTKDGKPFMVIGSPGGSRIITITLEAILN
VVDFGMDISQAVNAPRIHHQWQPDKVYLEPYAISPDTEKTLAAMGYSFDGGNDAPLWGQAAGILVGGKSLAAIEKGGGAR
YNGAMDSRATEGSANGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=478, Percent_Identity=35.3556485355649, Blast_Score=248, Evalue=2e-65,
Organism=Homo sapiens, GI73915090, Length=478, Percent_Identity=35.3556485355649, Blast_Score=248, Evalue=2e-65,
Organism=Homo sapiens, GI73915096, Length=478, Percent_Identity=35.3556485355649, Blast_Score=248, Evalue=2e-65,
Organism=Homo sapiens, GI73915094, Length=478, Percent_Identity=35.3556485355649, Blast_Score=248, Evalue=2e-65,
Organism=Homo sapiens, GI113429324, Length=475, Percent_Identity=32, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI113429326, Length=481, Percent_Identity=32.016632016632, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI153266885, Length=479, Percent_Identity=28.1837160751566, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI109148539, Length=498, Percent_Identity=29.9196787148594, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI153266901, Length=480, Percent_Identity=28.3333333333333, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI153266907, Length=478, Percent_Identity=26.7782426778243, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI30581157, Length=137, Percent_Identity=45.2554744525547, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI30581155, Length=137, Percent_Identity=45.2554744525547, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI218505805, Length=137, Percent_Identity=40.8759124087591, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310124095, Length=137, Percent_Identity=35.7664233576642, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1789856, Length=500, Percent_Identity=51, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17506189, Length=501, Percent_Identity=35.9281437125749, Blast_Score=242, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI212646519, Length=488, Percent_Identity=34.0163934426229, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI72000294, Length=488, Percent_Identity=34.0163934426229, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17542894, Length=552, Percent_Identity=30.9782608695652, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI193208245, Length=498, Percent_Identity=31.1244979919679, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193208247, Length=498, Percent_Identity=31.1244979919679, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17564448, Length=434, Percent_Identity=25.8064516129032, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI72001497, Length=226, Percent_Identity=25.6637168141593, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=226, Percent_Identity=25.6637168141593, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=532, Percent_Identity=29.5112781954887, Blast_Score=173, Evalue=7e-44,
Organism=Drosophila melanogaster, GI161077880, Length=512, Percent_Identity=30.6640625, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI45551474, Length=512, Percent_Identity=30.6640625, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI161077878, Length=512, Percent_Identity=30.6640625, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642670, Length=512, Percent_Identity=30.6640625, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642666, Length=512, Percent_Identity=30.6640625, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI161077496, Length=531, Percent_Identity=32.015065913371, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI18859893, Length=527, Percent_Identity=32.258064516129, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI18859741, Length=508, Percent_Identity=27.5590551181102, Blast_Score=177, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 60471; Mature: 60340

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLHIGTISVISALSLSLTSVFAASPAPVEAEHGMVVTAQHLATDVGVEVLKGGGNAVD
CCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHCHHEECCCCCHHH
AAVAVGYALAVVYPSAGNLGGGGFMTIRLKDGTKTFLDFRERAPLAATKTMYLDAKGDIV
HHHHHHEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEEEEECCCCEE
PRASLDGYLAVGVPGSVMGFETAREKYGTKPRQDLIAPALRFAREGYTLEQGDAASFAGS
ECCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AKRLAKDEAAAKIFLKPDGKAYALGEKLQQPDLAAVLAAISEKGPDAFYKAAPAEAIVKA
HHHHHHCCCCEEEEECCCCCEEECHHHCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHH
SQAKGGILARQDFEQYAVRELKPVECNYRGYDIISSPPPSSGGVIICEILNVLEGYPISY
HCCCCCEEEHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCEEHHHHHHHHCCCCEEE
LGYGSAETVHVMVEAMRYAYVDRNAALGDPDFVENPVAKLIDKTYAKEIAAKIDPYKAGT
EECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SANLKPLGGKESTETTHYSIIDDEGNAVAVTYTLNGSFGAAVVAPGTGVLLNNEMDDFTS
CCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEECCCCCEEECCCCHHHCC
KPGVPNLYGLVQGEANAIAPKKTPLSSMSPTIVTKDGKPFMVIGSPGGSRIITITLEAIL
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHHH
NVVDFGMDISQAVNAPRIHHQWQPDKVYLEPYAISPDTEKTLAAMGYSFDGGNDAPLWGQ
HHHHCCCCHHHHCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCC
AAGILVGGKSLAAIEKGGGARYNGAMDSRATEGSANGY
CCEEEECCCEEEEEECCCCCEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GRLHIGTISVISALSLSLTSVFAASPAPVEAEHGMVVTAQHLATDVGVEVLKGGGNAVD
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHCHHEECCCCCHHH
AAVAVGYALAVVYPSAGNLGGGGFMTIRLKDGTKTFLDFRERAPLAATKTMYLDAKGDIV
HHHHHHEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEEEEECCCCEE
PRASLDGYLAVGVPGSVMGFETAREKYGTKPRQDLIAPALRFAREGYTLEQGDAASFAGS
ECCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AKRLAKDEAAAKIFLKPDGKAYALGEKLQQPDLAAVLAAISEKGPDAFYKAAPAEAIVKA
HHHHHHCCCCEEEEECCCCCEEECHHHCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHH
SQAKGGILARQDFEQYAVRELKPVECNYRGYDIISSPPPSSGGVIICEILNVLEGYPISY
HCCCCCEEEHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCEEHHHHHHHHCCCCEEE
LGYGSAETVHVMVEAMRYAYVDRNAALGDPDFVENPVAKLIDKTYAKEIAAKIDPYKAGT
EECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SANLKPLGGKESTETTHYSIIDDEGNAVAVTYTLNGSFGAAVVAPGTGVLLNNEMDDFTS
CCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEECCCCCEEECCCCHHHCC
KPGVPNLYGLVQGEANAIAPKKTPLSSMSPTIVTKDGKPFMVIGSPGGSRIITITLEAIL
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHHH
NVVDFGMDISQAVNAPRIHHQWQPDKVYLEPYAISPDTEKTLAAMGYSFDGGNDAPLWGQ
HHHHCCCCHHHHCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCC
AAGILVGGKSLAAIEKGGGARYNGAMDSRATEGSANGY
CCEEEECCCEEEEEECCCCCEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]