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The map label for this gene is purK [H]

Identifier: 209550851

GI number: 209550851

Start: 3364348

End: 3365424

Strand: Direct

Name: purK [H]

Synonym: Rleg2_3275

Alternate gene names: 209550851

Gene position: 3364348-3365424 (Clockwise)

Preceding gene: 209550850

Following gene: 209550852

Centisome position: 74.14

GC content: 64.81

Gene sequence:

>1077_bases
ATGACGGCAAGAACGATCGGTATCATCGGCGGCGGCCAGCTCGGCCGCATGCTGGCCATTGCCGCTGCCAGGCTGAATTT
TCGCACGGTCATTCTCGAGCCGCAGGCCGACTGCCCGGCCGCCCAGCTCGCCAACCGGCAGATCACCGCCGCCTATGACG
ATCCGGCGGCCCTGGCCGAACTCGCCGATGTCTGCGATGTCGTCACTTACGAATTCGAGAACGTGCCCGTCTCAGCCGCC
GAGGCGCTTTCGGCAAGCATTCCCGTCTATCCGCCGCCGAAGGCGCTGGAGGCCGCCCAGGACCGCCTGGTCGAAAAGCG
CTTCCTGAATGATTGCGGCATATCAACCGCCCGCTTCCATGCGATCGACAGCCAGGCCGATCTTGAGGCGGCACTCCGGG
ATTTCGGCGGCCAGGGCGTGCTGAAGACGCGCCGTCTCGGTTATGACGGCAAGGGCCAGAGGGTTTTCCGTTCAGCCGCC
GACAGCGCTGATGGCGCCTATGCCGCGCTCGGCGCCGTGCCGCTGATCCTCGAAAGTTTCGTCGCCTTCGAACGCGAGGT
CTCGATCATCGCCGCCCGCGCCACGGACGGCACGGTCGTCTGCTTCGATCCCGCCGAGAATGTCCATCGCAACGGCATCC
TTCACACCTCAACGGTTCCGGCGGCGATCTCGCCGGCGACGGCGGACGCCGCGCGCCGATCGGCCGAAAAGATCCTTGCA
GCATTGAACTATGTCGGCGTCATCGGCATCGAATTCTTCGTGCTTGCCGATGGCGGCCTGATTGCCAACGAGATGGCGCC
GCGTGTCCACAATTCCGGCCACTGGACGGAGGCCGCCTGCGTCGTCAGCCAGTTCGAGCAGCATATCCGCGCCGTCACAG
GCCTGCCGATCGGCAATGCCGAGCGGCATTCCGACTGCGTCATGCAGAACCTGATCGGCGACGATATCCTGGCCGTTCCC
GACTGGCTGCAACGCCCCGATACCCTGGTTCATCTCTACGGCAAGACGGAATGGCGTCCCGGCCGCAAGATGGGCCATGT
CACCACCTTGACGCCGAAATCGCCGGTTTTGGCCTGA

Upstream 100 bases:

>100_bases
CCGCCGTGCTTGCCCTTTCCGACGAAGAAGTCGCCGACCGGCTCGACGAGTGGCGCGAGCGCCAGAGTGCTGCCGTCGCC
GAATACCCGATGGACGACCT

Downstream 100 bases:

>100_bases
GAAAACACAGCTTCGCCTTGGGAAAAACACCGTCATGCGGTTGACACGGAAAAGGTGACGGGGTATCTGCTCCCCCACCT
AAACAGCGCGCCCGATGGCG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTARTIGIIGGGQLGRMLAIAAARLNFRTVILEPQADCPAAQLANRQITAAYDDPAALAELADVCDVVTYEFENVPVSAA
EALSASIPVYPPPKALEAAQDRLVEKRFLNDCGISTARFHAIDSQADLEAALRDFGGQGVLKTRRLGYDGKGQRVFRSAA
DSADGAYAALGAVPLILESFVAFEREVSIIAARATDGTVVCFDPAENVHRNGILHTSTVPAAISPATADAARRSAEKILA
ALNYVGVIGIEFFVLADGGLIANEMAPRVHNSGHWTEAACVVSQFEQHIRAVTGLPIGNAERHSDCVMQNLIGDDILAVP
DWLQRPDTLVHLYGKTEWRPGRKMGHVTTLTPKSPVLA

Sequences:

>Translated_358_residues
MTARTIGIIGGGQLGRMLAIAAARLNFRTVILEPQADCPAAQLANRQITAAYDDPAALAELADVCDVVTYEFENVPVSAA
EALSASIPVYPPPKALEAAQDRLVEKRFLNDCGISTARFHAIDSQADLEAALRDFGGQGVLKTRRLGYDGKGQRVFRSAA
DSADGAYAALGAVPLILESFVAFEREVSIIAARATDGTVVCFDPAENVHRNGILHTSTVPAAISPATADAARRSAEKILA
ALNYVGVIGIEFFVLADGGLIANEMAPRVHNSGHWTEAACVVSQFEQHIRAVTGLPIGNAERHSDCVMQNLIGDDILAVP
DWLQRPDTLVHLYGKTEWRPGRKMGHVTTLTPKSPVLA
>Mature_357_residues
TARTIGIIGGGQLGRMLAIAAARLNFRTVILEPQADCPAAQLANRQITAAYDDPAALAELADVCDVVTYEFENVPVSAAE
ALSASIPVYPPPKALEAAQDRLVEKRFLNDCGISTARFHAIDSQADLEAALRDFGGQGVLKTRRLGYDGKGQRVFRSAAD
SADGAYAALGAVPLILESFVAFEREVSIIAARATDGTVVCFDPAENVHRNGILHTSTVPAAISPATADAARRSAEKILAA
LNYVGVIGIEFFVLADGGLIANEMAPRVHNSGHWTEAACVVSQFEQHIRAVTGLPIGNAERHSDCVMQNLIGDDILAVPD
WLQRPDTLVHLYGKTEWRPGRKMGHVTTLTPKSPVLA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=345, Percent_Identity=34.4927536231884, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1788155, Length=359, Percent_Identity=27.2980501392758, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324702, Length=368, Percent_Identity=34.7826086956522, Blast_Score=224, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 38170; Mature: 38039

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARTIGIIGGGQLGRMLAIAAARLNFRTVILEPQADCPAAQLANRQITAAYDDPAALAE
CCCEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCEEEEECCCHHHHHH
LADVCDVVTYEFENVPVSAAEALSASIPVYPPPKALEAAQDRLVEKRFLNDCGISTARFH
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEE
AIDSQADLEAALRDFGGQGVLKTRRLGYDGKGQRVFRSAADSADGAYAALGAVPLILESF
ECCCHHHHHHHHHHCCCCCCEEHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VAFEREVSIIAARATDGTVVCFDPAENVHRNGILHTSTVPAAISPATADAARRSAEKILA
HHHHHCEEEEEEECCCCEEEEECCHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHH
ALNYVGVIGIEFFVLADGGLIANEMAPRVHNSGHWTEAACVVSQFEQHIRAVTGLPIGNA
HHHHHHHEEEEEEEEECCCEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
ERHSDCVMQNLIGDDILAVPDWLQRPDTLVHLYGKTEWRPGRKMGHVTTLTPKSPVLA
CHHHHHHHHHHCCCCCEECCHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
TARTIGIIGGGQLGRMLAIAAARLNFRTVILEPQADCPAAQLANRQITAAYDDPAALAE
CCEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCEEEEECCCHHHHHH
LADVCDVVTYEFENVPVSAAEALSASIPVYPPPKALEAAQDRLVEKRFLNDCGISTARFH
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEE
AIDSQADLEAALRDFGGQGVLKTRRLGYDGKGQRVFRSAADSADGAYAALGAVPLILESF
ECCCHHHHHHHHHHCCCCCCEEHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VAFEREVSIIAARATDGTVVCFDPAENVHRNGILHTSTVPAAISPATADAARRSAEKILA
HHHHHCEEEEEEECCCCEEEEECCHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHH
ALNYVGVIGIEFFVLADGGLIANEMAPRVHNSGHWTEAACVVSQFEQHIRAVTGLPIGNA
HHHHHHHEEEEEEEEECCCEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
ERHSDCVMQNLIGDDILAVPDWLQRPDTLVHLYGKTEWRPGRKMGHVTTLTPKSPVLA
CHHHHHHHHHHCCCCCEECCHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]