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The map label for this gene is purE [H]

Identifier: 209550850

GI number: 209550850

Start: 3363854

End: 3364351

Strand: Direct

Name: purE [H]

Synonym: Rleg2_3274

Alternate gene names: 209550850

Gene position: 3363854-3364351 (Clockwise)

Preceding gene: 209550849

Following gene: 209550851

Centisome position: 74.13

GC content: 65.86

Gene sequence:

>498_bases
ATGATGACAGACCGACCGTCCGTCGCCATCATCATGGGCAGCCAGTCCGACTGGGAGACCATGAAGAACGCCGCCGACAC
GCTGGAGGCGCTGGAAATCGCTTATGATGCGCGCATCATTTCGGCGCACCGCACACCCGACCGGCTGGTCAATTTTGCCA
AGGGTGCACGGGCCGAGGGCTTCAAGGTCATCATCGCCGGCGCCGGCGGCGCCGCCCACCTGCCTGGAATGGCCGCATCG
ATGACGCCGCTGCCGGTTTTCGGCGTGCCGGTCCAGTCCAAAACCATGTCCGGCCAGGACAGCCTTCTTTCCATCGTGCA
GATGCCAGCCGGCATTCCTGTCGGCACGCTCGCCATCGGCAAGGCCGGCGCGGTCAACGCCGCCCTTCTCGCCGCCGCCG
TGCTTGCCCTTTCCGACGAAGAAGTCGCCGACCGGCTCGACGAGTGGCGCGAGCGCCAGAGTGCTGCCGTCGCCGAATAC
CCGATGGACGACCTATGA

Upstream 100 bases:

>100_bases
CCAGCGCATGAAGAAGAAGAAGCTCGTCATCAAGGACAGGCTTTCGAAGCTGGAAGATCAGATCATCCCTGACATCATCG
CCTGAGGGGGATAGCGACAA

Downstream 100 bases:

>100_bases
CGGCAAGAACGATCGGTATCATCGGCGGCGGCCAGCTCGGCCGCATGCTGGCCATTGCCGCTGCCAGGCTGAATTTTCGC
ACGGTCATTCTCGAGCCGCA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MMTDRPSVAIIMGSQSDWETMKNAADTLEALEIAYDARIISAHRTPDRLVNFAKGARAEGFKVIIAGAGGAAHLPGMAAS
MTPLPVFGVPVQSKTMSGQDSLLSIVQMPAGIPVGTLAIGKAGAVNAALLAAAVLALSDEEVADRLDEWRERQSAAVAEY
PMDDL

Sequences:

>Translated_165_residues
MMTDRPSVAIIMGSQSDWETMKNAADTLEALEIAYDARIISAHRTPDRLVNFAKGARAEGFKVIIAGAGGAAHLPGMAAS
MTPLPVFGVPVQSKTMSGQDSLLSIVQMPAGIPVGTLAIGKAGAVNAALLAAAVLALSDEEVADRLDEWRERQSAAVAEY
PMDDL
>Mature_165_residues
MMTDRPSVAIIMGSQSDWETMKNAADTLEALEIAYDARIISAHRTPDRLVNFAKGARAEGFKVIIAGAGGAAHLPGMAAS
MTPLPVFGVPVQSKTMSGQDSLLSIVQMPAGIPVGTLAIGKAGAVNAALLAAAVLALSDEEVADRLDEWRERQSAAVAEY
PMDDL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=62.3376623376623, Blast_Score=163, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6324702, Length=153, Percent_Identity=49.0196078431373, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17234; Mature: 17234

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTDRPSVAIIMGSQSDWETMKNAADTLEALEIAYDARIISAHRTPDRLVNFAKGARAEG
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCCC
FKVIIAGAGGAAHLPGMAASMTPLPVFGVPVQSKTMSGQDSLLSIVQMPAGIPVGTLAIG
EEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCEECC
KAGAVNAALLAAAVLALSDEEVADRLDEWRERQSAAVAEYPMDDL
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMTDRPSVAIIMGSQSDWETMKNAADTLEALEIAYDARIISAHRTPDRLVNFAKGARAEG
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCCC
FKVIIAGAGGAAHLPGMAASMTPLPVFGVPVQSKTMSGQDSLLSIVQMPAGIPVGTLAIG
EEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCEECC
KAGAVNAALLAAAVLALSDEEVADRLDEWRERQSAAVAEYPMDDL
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]