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The map label for this gene is cvrA [H]

Identifier: 209550816

GI number: 209550816

Start: 3328618

End: 3330492

Strand: Direct

Name: cvrA [H]

Synonym: Rleg2_3240

Alternate gene names: 209550816

Gene position: 3328618-3330492 (Clockwise)

Preceding gene: 209550815

Following gene: 209550817

Centisome position: 73.35

GC content: 63.41

Gene sequence:

>1875_bases
ATGGAAGCGTTCTATATCGTGGTGCTGGTCTCGACGGCGCTCGTGCTTCTTGCCGCTTTTTCAAGCCTGCTCGCCTTCCG
GTTCGGCGCGCCCCTCCTGCTGCTTTTCCTGATGATCGGCCTTGCCGCCGGTGTCGACGGCCTCGGCATCGAGTTCAGCA
ACAATTACCTCGCCTATATTCTCGGCTCCATTGCGCTCGCCGTCATCCTGTTCGATTCCGGTTTCGGCACGCCGATGCAT
GCCTTCCGGCTCGCGGCCGTGCCCTCGCTGGCGCTTGCATCGGTCGGTGTGCTGATTACCGCCTCGCTCTTTGCCTTCGC
CGCCATGTGGCTCTTGAACTTCACCTGGCTGGAAGGTCTGCTGCTCGGCTCGATCGTCGCCTCGACGGACGCCGCCGCTG
TCTTCTTCCTGCTGCGCATCGGCGGCATCAACATCCGCGACAAGGTGCGCTCGACGCTGGAGGTCGAATCCGGCACCAAC
GACCCGATGGCGATCTTCCTGACCATCGCCCTCGTCGAGGTGCTGGCGAGCGGCGAGCGCTACGCCGGCATCAATATCGG
CATGCTCGCCATGTTCGTCCAGCAGATGGGCCTCGGCGTCATTCTCGGCCTGCTCGGCGGCATGATGATCGTGCTGATCG
TCAGCAAGCTCGACACCGATCGCGGCCTGACGCCGATCTTCGTGCTGGCGCTCGCTCTTCTCGTCTTCTCCTTCACCGGC
GCAGTCGGCGGCAGCGGCTTCCTCGCCGTCTATGTCGCCGGCATTTACGCGGGAAACCGCAAGATGCAGGCGATCGGCAC
CATCAAGCGCTTCCAGGACGGCATGACCTGGCTGGCGCAGATCATCATGTTCCTGGTGCTCGGCCTCCTCGCCACGCCGT
CGCAATTCCCGGCGATCATCGTGCCGGCCATTCTGCTTGCCCTCTTCCTGATCTTCGTCGCCCGGCCCTTAGCGATCTGG
CTGTCGCTGCTCCCTTTCGATTACACGCAGCAAGAGATCGGCTTCGTTGCCTGGGTCGGCCTGCGCGGCGCCGTCTCCAT
TCTGCTCGCCATTATGCCGATCCTCGGTGGCCTGGAAAACGGCCAGATCTATTTCAACACGGCCTTCATCATCGTGCTGG
TCTCGCTGCTCGTCCAAGGCTGGACGATCAAACCCGTCGCCAAGAAGCTCGGCCTGATCATTCCGCCCCGCATCGGCGCG
GTCGACAAGGTCGAGGTCGACCTGCCGGGTGCTGCCAACCACGAACTGCTCTCCTACCGCGTCATCAAGGATAGCCCGGT
GCTGCGCGGCGAGCGCATTCCGCGCTGGGCGACCCCCTCCCTCGTCATCCGCGACGGCAAATCGATGCGTTATCAATATG
CCGGGCGACTGCGCGAGAACGATCTCGTCTATCTCTTCATCGTGCCGAGCTACTCCCGTCTGCTCGACCGGCTCTTCGCC
AGCCGTGCGCCTGTCGATGAAGACGATGCCGAATTCTTCGGCGCCTTCGCGCTCTCGCCTGCCCGCCCCGCCGCCGATCT
CGATGCCGCCTACGGTCCCGGCCTGCTCAACGAATCTGAAAAAGGCCTGACCATCGCCGAATTGATGCGGCAGCGCCTCG
GCGGCAAGGCCGATTATGCCGACCGCGTCCGTCTCGGTTCGATCATCCTGATCGTCCGCGACCTCGACGAGCACGACCAC
GTCACCTCCGTCGGCATGTCGCTCGAAGCCGTCGAACCGGCGATCACGCTGCCGATCTTCATCAATCTCAAGGACATTAT
CGAGCGGATCCGCGACCGGCTGAAGGGGCGCCGGAGACGGGAAGCAGTAGGCTCCGAAGCCGCTCCGAAAACAGCGGCCG
GACGCGACGAAGGCACACACGAAAACGGTCGCTGA

Upstream 100 bases:

>100_bases
TGCCGTTTACTGATGGACCGCCGCGCGTGAGGAGGGGTTGGATGAGGGCGGATCGGCCGGGTGGCCGTATTCGTGAAGCA
GTCGATGGAAAGGGGTGGGC

Downstream 100 bases:

>100_bases
ACGCCTTGCGTCTCGAATGATCCTTGCTATGGTCGGCGCAATTTCCGCCAACCAAGACTGGATCTCCCCATGCCTTCCTT
CAAGACCCTCGACGATCTTT

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MEAFYIVVLVSTALVLLAAFSSLLAFRFGAPLLLLFLMIGLAAGVDGLGIEFSNNYLAYILGSIALAVILFDSGFGTPMH
AFRLAAVPSLALASVGVLITASLFAFAAMWLLNFTWLEGLLLGSIVASTDAAAVFFLLRIGGINIRDKVRSTLEVESGTN
DPMAIFLTIALVEVLASGERYAGINIGMLAMFVQQMGLGVILGLLGGMMIVLIVSKLDTDRGLTPIFVLALALLVFSFTG
AVGGSGFLAVYVAGIYAGNRKMQAIGTIKRFQDGMTWLAQIIMFLVLGLLATPSQFPAIIVPAILLALFLIFVARPLAIW
LSLLPFDYTQQEIGFVAWVGLRGAVSILLAIMPILGGLENGQIYFNTAFIIVLVSLLVQGWTIKPVAKKLGLIIPPRIGA
VDKVEVDLPGAANHELLSYRVIKDSPVLRGERIPRWATPSLVIRDGKSMRYQYAGRLRENDLVYLFIVPSYSRLLDRLFA
SRAPVDEDDAEFFGAFALSPARPAADLDAAYGPGLLNESEKGLTIAELMRQRLGGKADYADRVRLGSIILIVRDLDEHDH
VTSVGMSLEAVEPAITLPIFINLKDIIERIRDRLKGRRRREAVGSEAAPKTAAGRDEGTHENGR

Sequences:

>Translated_624_residues
MEAFYIVVLVSTALVLLAAFSSLLAFRFGAPLLLLFLMIGLAAGVDGLGIEFSNNYLAYILGSIALAVILFDSGFGTPMH
AFRLAAVPSLALASVGVLITASLFAFAAMWLLNFTWLEGLLLGSIVASTDAAAVFFLLRIGGINIRDKVRSTLEVESGTN
DPMAIFLTIALVEVLASGERYAGINIGMLAMFVQQMGLGVILGLLGGMMIVLIVSKLDTDRGLTPIFVLALALLVFSFTG
AVGGSGFLAVYVAGIYAGNRKMQAIGTIKRFQDGMTWLAQIIMFLVLGLLATPSQFPAIIVPAILLALFLIFVARPLAIW
LSLLPFDYTQQEIGFVAWVGLRGAVSILLAIMPILGGLENGQIYFNTAFIIVLVSLLVQGWTIKPVAKKLGLIIPPRIGA
VDKVEVDLPGAANHELLSYRVIKDSPVLRGERIPRWATPSLVIRDGKSMRYQYAGRLRENDLVYLFIVPSYSRLLDRLFA
SRAPVDEDDAEFFGAFALSPARPAADLDAAYGPGLLNESEKGLTIAELMRQRLGGKADYADRVRLGSIILIVRDLDEHDH
VTSVGMSLEAVEPAITLPIFINLKDIIERIRDRLKGRRRREAVGSEAAPKTAAGRDEGTHENGR
>Mature_624_residues
MEAFYIVVLVSTALVLLAAFSSLLAFRFGAPLLLLFLMIGLAAGVDGLGIEFSNNYLAYILGSIALAVILFDSGFGTPMH
AFRLAAVPSLALASVGVLITASLFAFAAMWLLNFTWLEGLLLGSIVASTDAAAVFFLLRIGGINIRDKVRSTLEVESGTN
DPMAIFLTIALVEVLASGERYAGINIGMLAMFVQQMGLGVILGLLGGMMIVLIVSKLDTDRGLTPIFVLALALLVFSFTG
AVGGSGFLAVYVAGIYAGNRKMQAIGTIKRFQDGMTWLAQIIMFLVLGLLATPSQFPAIIVPAILLALFLIFVARPLAIW
LSLLPFDYTQQEIGFVAWVGLRGAVSILLAIMPILGGLENGQIYFNTAFIIVLVSLLVQGWTIKPVAKKLGLIIPPRIGA
VDKVEVDLPGAANHELLSYRVIKDSPVLRGERIPRWATPSLVIRDGKSMRYQYAGRLRENDLVYLFIVPSYSRLLDRLFA
SRAPVDEDDAEFFGAFALSPARPAADLDAAYGPGLLNESEKGLTIAELMRQRLGGKADYADRVRLGSIILIVRDLDEHDH
VTSVGMSLEAVEPAITLPIFINLKDIIERIRDRLKGRRRREAVGSEAAPKTAAGRDEGTHENGR

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=552, Percent_Identity=40.7608695652174, Blast_Score=332, Evalue=4e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 67437; Mature: 67437

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAFYIVVLVSTALVLLAAFSSLLAFRFGAPLLLLFLMIGLAAGVDGLGIEFSNNYLAYI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEECCCHHHHH
LGSIALAVILFDSGFGTPMHAFRLAAVPSLALASVGVLITASLFAFAAMWLLNFTWLEGL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGSIVASTDAAAVFFLLRIGGINIRDKVRSTLEVESGTNDPMAIFLTIALVEVLASGER
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCC
YAGINIGMLAMFVQQMGLGVILGLLGGMMIVLIVSKLDTDRGLTPIFVLALALLVFSFTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
AVGGSGFLAVYVAGIYAGNRKMQAIGTIKRFQDGMTWLAQIIMFLVLGLLATPSQFPAII
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VPAILLALFLIFVARPLAIWLSLLPFDYTQQEIGFVAWVGLRGAVSILLAIMPILGGLEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHEEHHHHHHHHHHHHHHHHHCCCCC
GQIYFNTAFIIVLVSLLVQGWTIKPVAKKLGLIIPPRIGAVDKVEVDLPGAANHELLSYR
CEEEEHHHHHHHHHHHHHCCCCCCHHHHHCCEECCCCCCCCCEEEEECCCCCCCCCEEEE
VIKDSPVLRGERIPRWATPSLVIRDGKSMRYQYAGRLRENDLVYLFIVPSYSRLLDRLFA
EECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHH
SRAPVDEDDAEFFGAFALSPARPAADLDAAYGPGLLNESEKGLTIAELMRQRLGGKADYA
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCH
DRVRLGSIILIVRDLDEHDHVTSVGMSLEAVEPAITLPIFINLKDIIERIRDRLKGRRRR
HHHHHCEEEEEEECCCCCCHHHHHCCCHHHCCCEEEEEEEECHHHHHHHHHHHHHHHHHH
EAVGSEAAPKTAAGRDEGTHENGR
HHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEAFYIVVLVSTALVLLAAFSSLLAFRFGAPLLLLFLMIGLAAGVDGLGIEFSNNYLAYI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEECCCHHHHH
LGSIALAVILFDSGFGTPMHAFRLAAVPSLALASVGVLITASLFAFAAMWLLNFTWLEGL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGSIVASTDAAAVFFLLRIGGINIRDKVRSTLEVESGTNDPMAIFLTIALVEVLASGER
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCC
YAGINIGMLAMFVQQMGLGVILGLLGGMMIVLIVSKLDTDRGLTPIFVLALALLVFSFTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
AVGGSGFLAVYVAGIYAGNRKMQAIGTIKRFQDGMTWLAQIIMFLVLGLLATPSQFPAII
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VPAILLALFLIFVARPLAIWLSLLPFDYTQQEIGFVAWVGLRGAVSILLAIMPILGGLEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHEEHHHHHHHHHHHHHHHHHCCCCC
GQIYFNTAFIIVLVSLLVQGWTIKPVAKKLGLIIPPRIGAVDKVEVDLPGAANHELLSYR
CEEEEHHHHHHHHHHHHHCCCCCCHHHHHCCEECCCCCCCCCEEEEECCCCCCCCCEEEE
VIKDSPVLRGERIPRWATPSLVIRDGKSMRYQYAGRLRENDLVYLFIVPSYSRLLDRLFA
EECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHH
SRAPVDEDDAEFFGAFALSPARPAADLDAAYGPGLLNESEKGLTIAELMRQRLGGKADYA
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCH
DRVRLGSIILIVRDLDEHDHVTSVGMSLEAVEPAITLPIFINLKDIIERIRDRLKGRRRR
HHHHHCEEEEEEECCCCCCHHHHHCCCHHHCCCEEEEEEEECHHHHHHHHHHHHHHHHHH
EAVGSEAAPKTAAGRDEGTHENGR
HHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA