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The map label for this gene is fhs [H]

Identifier: 209550394

GI number: 209550394

Start: 2862395

End: 2864074

Strand: Reverse

Name: fhs [H]

Synonym: Rleg2_2815

Alternate gene names: 209550394

Gene position: 2864074-2862395 (Counterclockwise)

Preceding gene: 209550396

Following gene: 209550392

Centisome position: 63.11

GC content: 62.98

Gene sequence:

>1680_bases
ATGCCATCAATCAAATCCGATATCGAAATCGCGCGCGCTGCGGCCAAGAAGCCGATCTTCGAAATCGGCGCGAAGCTCGG
CATTCCGGTCGAGCAGCTCGTTCCCTACGGTCACGACAAGGCAAAGGTCAGCGCCGAATTCATCGCCGGGCAAGCGGGCA
AGAAGGACGGCAAGCTGATCCTTGTCACGGCGATCAATCCGACGCCGGCGGGCGAGGGCAAGACGACGACGACCGTGGGC
CTCGGTGACGGGCTGAACCGGATCGGCAAAAAAGCTATCGTCTGCATCCGCGAGGCTTCGCTCGGCCCCTGCTTCGGCGT
CAAGGGCGGCGCAGCCGGTGGCGGTTTTGCGCAGGTCGTGCCGATGGAAGACATCAACCTGCATTTCACCGGCGATTTCC
ATGCGATCACCTCGGCGCACAATCTGCTGGCGGCGATGATCGACAATCACATTTACTGGGGCAACGAAGAGAATATCGAT
ATCCGCCGCATCACCTGGCGGCGGGTGATGGATATGAACGACCGGGCGCTCAGAAGCATGGTCTCCTCGCTCGGCGGCGT
TGCCAACGGCTTCCCGCGCCAGGGCGGGTTCGACATCACCGTTGCCTCCGAAGTGATGGCGATCCTCTGCCTCGCCACCG
ACCTCACGGATCTGGAGCGGCGGCTCGGCGACATCATCATCGGCTATCGCTTCGACAGGACGCCGGTGCATGCGCGCGAC
CTGAAAGCCGACGGCGCCATGGCGGTGCTGCTGAAGGATGCGATGCAGCCGAACCTCGTGCAGACGCTCGAGAACAATCC
GGCCTTTGTGCATGGCGGGCCGTTCGCCAACATCGCCCATGGCTGCAATTCGGTGACGGCGACGAAGACGGCGCTGAAGC
TGGGCGACTATGTGGTGACGGAAGCGGGCTTCGGGGCCGATCTCGGCGCCGAGAAATTTTTCGACATCAAGTGCCGTAAG
GCCGGGTTGAAGCCGGATGCGGCGGTTATCGTCGCGACCGTCAGGGCGCTGAAGATGAATGGCGGGGTGAAGAAGGACGA
CCTCGGTACCGAGGATGTCGCGGCGCTGAAGAAGGGCTGCGCCAATCTTGGCCGCCACGTCGCCAATGTCCGCCGGTTCG
GTGTGCCGGTGGTCGTGGCGATCAACCATTTCATCTCCGATACCGACGCCGAAATCGCGGCGGTGAAGGAATTTGTTTCG
AGGCTCGGCGCCGAGGCGATCCTTTGCCGCCACTGGGCGCTGGGTTCGGCCGGCATCGAGGAGCTGGCGCACAAGGTGGT
GGAGCTCGCCGAATCCGGTCAGGCGAAATTCCAGCCGCTCTATGGCGACGATATTTCGCTGTTCGAGAAGATCGAGATCG
TCGCCTCGAAGATCTACCATGCCGGCGAGGTGACGGCCGACAAGGCGGTGCGCGACCAGTTGCAGACATGGGAGGAGCAG
GGCTACGGCAAGCTGCCGGTCTGCATGGCCAAGACGCAATATTCCTTCTCCACCGATCCCAGCCTGCGCGGCGCGCCGGA
AGGCCACATCGTTACCGTGCGGGAGGTGCGGCTTTCGGCGGGGGCCGGCTTCGTCGTCGCCATCACCGGCGAGATCATGA
CCATGCCCGGGCTGCCGAAGTCACCGTCGGCGGAGCGGATTTTCCTGAATGAGCAGGGTTATATCGAGGGGCTGTTCTGA

Upstream 100 bases:

>100_bases
CAAGGCGCAGCGCTATTCACACCTCGCCGATATTTCGCTATCCCGATGAAGAGGGAACAACGCCTCCGCGCCCCGCGGCA
GGCCGGGACGGGGAACATCC

Downstream 100 bases:

>100_bases
TTGGTGCACGTGACATCTTTCTCACTAGATCTGCGAGACCTGCCCCTCATCCGCCTGCCGGCACCTTCTCCCCGTAAACG
GGGCGAAGGGGGTGTGCCGC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MPSIKSDIEIARAAAKKPIFEIGAKLGIPVEQLVPYGHDKAKVSAEFIAGQAGKKDGKLILVTAINPTPAGEGKTTTTVG
LGDGLNRIGKKAIVCIREASLGPCFGVKGGAAGGGFAQVVPMEDINLHFTGDFHAITSAHNLLAAMIDNHIYWGNEENID
IRRITWRRVMDMNDRALRSMVSSLGGVANGFPRQGGFDITVASEVMAILCLATDLTDLERRLGDIIIGYRFDRTPVHARD
LKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVTATKTALKLGDYVVTEAGFGADLGAEKFFDIKCRK
AGLKPDAAVIVATVRALKMNGGVKKDDLGTEDVAALKKGCANLGRHVANVRRFGVPVVVAINHFISDTDAEIAAVKEFVS
RLGAEAILCRHWALGSAGIEELAHKVVELAESGQAKFQPLYGDDISLFEKIEIVASKIYHAGEVTADKAVRDQLQTWEEQ
GYGKLPVCMAKTQYSFSTDPSLRGAPEGHIVTVREVRLSAGAGFVVAITGEIMTMPGLPKSPSAERIFLNEQGYIEGLF

Sequences:

>Translated_559_residues
MPSIKSDIEIARAAAKKPIFEIGAKLGIPVEQLVPYGHDKAKVSAEFIAGQAGKKDGKLILVTAINPTPAGEGKTTTTVG
LGDGLNRIGKKAIVCIREASLGPCFGVKGGAAGGGFAQVVPMEDINLHFTGDFHAITSAHNLLAAMIDNHIYWGNEENID
IRRITWRRVMDMNDRALRSMVSSLGGVANGFPRQGGFDITVASEVMAILCLATDLTDLERRLGDIIIGYRFDRTPVHARD
LKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVTATKTALKLGDYVVTEAGFGADLGAEKFFDIKCRK
AGLKPDAAVIVATVRALKMNGGVKKDDLGTEDVAALKKGCANLGRHVANVRRFGVPVVVAINHFISDTDAEIAAVKEFVS
RLGAEAILCRHWALGSAGIEELAHKVVELAESGQAKFQPLYGDDISLFEKIEIVASKIYHAGEVTADKAVRDQLQTWEEQ
GYGKLPVCMAKTQYSFSTDPSLRGAPEGHIVTVREVRLSAGAGFVVAITGEIMTMPGLPKSPSAERIFLNEQGYIEGLF
>Mature_558_residues
PSIKSDIEIARAAAKKPIFEIGAKLGIPVEQLVPYGHDKAKVSAEFIAGQAGKKDGKLILVTAINPTPAGEGKTTTTVGL
GDGLNRIGKKAIVCIREASLGPCFGVKGGAAGGGFAQVVPMEDINLHFTGDFHAITSAHNLLAAMIDNHIYWGNEENIDI
RRITWRRVMDMNDRALRSMVSSLGGVANGFPRQGGFDITVASEVMAILCLATDLTDLERRLGDIIIGYRFDRTPVHARDL
KADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVTATKTALKLGDYVVTEAGFGADLGAEKFFDIKCRKA
GLKPDAAVIVATVRALKMNGGVKKDDLGTEDVAALKKGCANLGRHVANVRRFGVPVVVAINHFISDTDAEIAAVKEFVSR
LGAEAILCRHWALGSAGIEELAHKVVELAESGQAKFQPLYGDDISLFEKIEIVASKIYHAGEVTADKAVRDQLQTWEEQG
YGKLPVCMAKTQYSFSTDPSLRGAPEGHIVTVREVRLSAGAGFVVAITGEIMTMPGLPKSPSAERIFLNEQGYIEGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=41.8679549114332, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI36796743, Length=624, Percent_Identity=42.6282051282051, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=33.7209302325581, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=624, Percent_Identity=43.2692307692308, Blast_Score=453, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17568739, Length=624, Percent_Identity=43.2692307692308, Blast_Score=453, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=41.5481832543444, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.85303514377, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=41.2238325281804, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=41.2238325281804, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=41.2238325281804, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=41.2238325281804, Blast_Score=438, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59710; Mature: 59579

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIKSDIEIARAAAKKPIFEIGAKLGIPVEQLVPYGHDKAKVSAEFIAGQAGKKDGKLI
CCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEE
LVTAINPTPAGEGKTTTTVGLGDGLNRIGKKAIVCIREASLGPCFGVKGGAAGGGFAQVV
EEEEECCCCCCCCCCEEEEECCCCHHHHCHHEEEEEECCCCCCCCCCCCCCCCCCCEEEE
PMEDINLHFTGDFHAITSAHNLLAAMIDNHIYWGNEENIDIRRITWRRVMDMNDRALRSM
EECCCEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEHHHHHHCCCHHHHHHH
VSSLGGVANGFPRQGGFDITVASEVMAILCLATDLTDLERRLGDIIIGYRFDRTPVHARD
HHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHCCEEEEEEECCCCCCHHH
LKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVTATKTALKLGDYVVT
CCCCCHHHHHHHHHCCCHHHHHHCCCCCEEECCCCHHHHHCCCCCHHHHHHHHHCCEEEE
EAGFGADLGAEKFFDIKCRKAGLKPDAAVIVATVRALKMNGGVKKDDLGTEDVAALKKGC
CCCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ANLGRHVANVRRFGVPVVVAINHFISDTDAEIAAVKEFVSRLGAEAILCRHWALGSAGIE
HHHHHHHHHHHHHCCCEEEEEHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHH
ELAHKVVELAESGQAKFQPLYGDDISLFEKIEIVASKIYHAGEVTADKAVRDQLQTWEEQ
HHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GYGKLPVCMAKTQYSFSTDPSLRGAPEGHIVTVREVRLSAGAGFVVAITGEIMTMPGLPK
CCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEEECCEEECCCCCC
SPSAERIFLNEQGYIEGLF
CCCCCEEEECCCCCEECCC
>Mature Secondary Structure 
PSIKSDIEIARAAAKKPIFEIGAKLGIPVEQLVPYGHDKAKVSAEFIAGQAGKKDGKLI
CCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEE
LVTAINPTPAGEGKTTTTVGLGDGLNRIGKKAIVCIREASLGPCFGVKGGAAGGGFAQVV
EEEEECCCCCCCCCCEEEEECCCCHHHHCHHEEEEEECCCCCCCCCCCCCCCCCCCEEEE
PMEDINLHFTGDFHAITSAHNLLAAMIDNHIYWGNEENIDIRRITWRRVMDMNDRALRSM
EECCCEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEHHHHHHCCCHHHHHHH
VSSLGGVANGFPRQGGFDITVASEVMAILCLATDLTDLERRLGDIIIGYRFDRTPVHARD
HHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHCCEEEEEEECCCCCCHHH
LKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVTATKTALKLGDYVVT
CCCCCHHHHHHHHHCCCHHHHHHCCCCCEEECCCCHHHHHCCCCCHHHHHHHHHCCEEEE
EAGFGADLGAEKFFDIKCRKAGLKPDAAVIVATVRALKMNGGVKKDDLGTEDVAALKKGC
CCCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ANLGRHVANVRRFGVPVVVAINHFISDTDAEIAAVKEFVSRLGAEAILCRHWALGSAGIE
HHHHHHHHHHHHHCCCEEEEEHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHH
ELAHKVVELAESGQAKFQPLYGDDISLFEKIEIVASKIYHAGEVTADKAVRDQLQTWEEQ
HHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GYGKLPVCMAKTQYSFSTDPSLRGAPEGHIVTVREVRLSAGAGFVVAITGEIMTMPGLPK
CCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEEECCEEECCCCCC
SPSAERIFLNEQGYIEGLF
CCCCCEEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA