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The map label for this gene is apt

Identifier: 209550354

GI number: 209550354

Start: 2818870

End: 2819415

Strand: Reverse

Name: apt

Synonym: Rleg2_2775

Alternate gene names: 209550354

Gene position: 2819415-2818870 (Counterclockwise)

Preceding gene: 209550355

Following gene: 209550351

Centisome position: 62.13

GC content: 62.45

Gene sequence:

>546_bases
ATGGACAAGAATACGACTTCGGAACTCGCAGCCAGCATCCGCTCCATTCCAGACTATCCTAAGCCCGGCATCATCTTCCG
CGACATCACCACGTTGCTCGGCAACCCCCGGGCGTTCCGCCGGGCGGTCGATGAACTCGTGCAGCCCTATGCGGGCACGA
AAATCGACAAGATTGCCGGCATGGAGGCACGCGGCTTCATTCTCGGCGGTGCGGTGGCGCATCAGCTTTCCTCCGGCTTC
GTGCCAATCCGGAAGAAGGGCAAGCTGCCGCATGAGACCGTGCGCATCGCCTACAGCCTGGAATACGGCGTCGACGAGAT
GGAGATGCATCGCGATGCGGTGCAGCCCGGCGAGAAGGTGATCCTTGTCGATGACCTGATCGCCACCGGCGGTACGGCCG
TGGGTGCCACCAAGCTGCTGCGCCAGATCGGCGCTGAGGTGGTCGGAGCCTGCTTTGTCATCGATCTTCCGGATCTCGGC
GGCCGCAAGAAGCTGGAAGAGCTCGGCGTCGTCGTGCACACGCTGGTCGAATTCTCCGGGCACTAA

Upstream 100 bases:

>100_bases
CTGTTCCAAACTAATGGTTAGAGCATGATGTCGTCCGAAAGCCGCTCGCACTTTTCGGCATCATGCTCTGGTTTCATGCG
CTCGCAGATACGGACTTTCC

Downstream 100 bases:

>100_bases
GCCCATATCCGATGCCGGCGGCCTCAGTCGAATTCGAGCACGCCGCTCTCGAAGCGCATGACGGCTTCGCCGTTCTGATT
GACGCCCTCGCAGAGAATGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MDKNTTSELAASIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAGMEARGFILGGAVAHQLSSGF
VPIRKKGKLPHETVRIAYSLEYGVDEMEMHRDAVQPGEKVILVDDLIATGGTAVGATKLLRQIGAEVVGACFVIDLPDLG
GRKKLEELGVVVHTLVEFSGH

Sequences:

>Translated_181_residues
MDKNTTSELAASIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAGMEARGFILGGAVAHQLSSGF
VPIRKKGKLPHETVRIAYSLEYGVDEMEMHRDAVQPGEKVILVDDLIATGGTAVGATKLLRQIGAEVVGACFVIDLPDLG
GRKKLEELGVVVHTLVEFSGH
>Mature_181_residues
MDKNTTSELAASIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAGMEARGFILGGAVAHQLSSGF
VPIRKKGKLPHETVRIAYSLEYGVDEMEMHRDAVQPGEKVILVDDLIATGGTAVGATKLLRQIGAEVVGACFVIDLPDLG
GRKKLEELGVVVHTLVEFSGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=156, Percent_Identity=47.4358974358974, Blast_Score=150, Evalue=4e-37,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=49.5867768595041, Blast_Score=127, Evalue=4e-30,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=53.757225433526, Blast_Score=198, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17509087, Length=175, Percent_Identity=42.2857142857143, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=166, Percent_Identity=40.3614457831325, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=169, Percent_Identity=37.8698224852071, Blast_Score=102, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=41.7647058823529, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_RHILW (B5ZY62)

Other databases:

- EMBL:   CP001191
- RefSeq:   YP_002282271.1
- ProteinModelPortal:   B5ZY62
- SMR:   B5ZY62
- GeneID:   6981519
- GenomeReviews:   CP001191_GR
- KEGG:   rlt:Rleg2_2775
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19518; Mature: 19518

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNTTSELAASIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAG
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCC
MEARGFILGGAVAHQLSSGFVPIRKKGKLPHETVRIAYSLEYGVDEMEMHRDAVQPGEKV
CCCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHEEEEEECCCCCHHHHHHHHHCCCCCEE
ILVDDLIATGGTAVGATKLLRQIGAEVVGACFVIDLPDLGGRKKLEELGVVVHTLVEFSG
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCC
H
C
>Mature Secondary Structure
MDKNTTSELAASIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAG
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCC
MEARGFILGGAVAHQLSSGFVPIRKKGKLPHETVRIAYSLEYGVDEMEMHRDAVQPGEKV
CCCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHEEEEEECCCCCHHHHHHHHHCCCCCEE
ILVDDLIATGGTAVGATKLLRQIGAEVVGACFVIDLPDLGGRKKLEELGVVVHTLVEFSG
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA