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The map label for this gene is nhaK [H]

Identifier: 209549840

GI number: 209549840

Start: 2308569

End: 2310149

Strand: Reverse

Name: nhaK [H]

Synonym: Rleg2_2253

Alternate gene names: 209549840

Gene position: 2310149-2308569 (Counterclockwise)

Preceding gene: 209549843

Following gene: 209549838

Centisome position: 50.91

GC content: 64.45

Gene sequence:

>1581_bases
ATGGAACCAACCCAGTTATTCGAGCTTGTTATCGCGATGTTTCTGGCGATCATCGCGCTGCACTATGCCGCCCACAGGCT
CGGACTGCCGCCGTCCGTCGCGCTGCTGACCGGTGGCGCTTTGCTGGCGTTTGTGCCGGGACTGCCGGCGATTTCAGTCG
ATCCCGGGCTGGTGCTGGTCATCTTCCTGCCGCCGCTGTTGATGGATGGCGCCTGGTCCATCGCGCTGTCGCGGCTGCGG
CGCCACATGATCGGGATCGCCTCGCTTGCCGTCGGCGCTGTCTTCTTCACCTGCGCCGTGGTGGCCGTTGTCGTCCATCT
CATCTTTCCGTCACTTCCCTGGGCCGCCTGCGCGGCACTGGGCGCGATCGTTGCGCCGCCGGACGCGGTCTCGGCGCGCG
CCGTGCTCGAGCACGTCAGGCTGCCACGACGGCTGCAGATTCTGCTGGAAGGCGAGAGCCTGCTCAACGATGCGAGCGGC
CTGGTTCTTTTCCGTTTTGCCGTTGCCGCCGCCGCAACGGGCGCCTTCAGCGCGGGGGAGGCGGTTGGCGACTTCTTCGT
GCTGGCGCTCGGCGGCGCCATTGTCGGCATCGTCATCGCAGCCGCATGGGTCAAACTCATCCGGCATCTCGGCGACGACT
ATCTGATCATAGCGGCCACCGTGCTGCTCGGCTGGATTTCCTATCTGCTTGGCGAACTGCTGCATGTTTCCGGCGTCATC
GCCACCGTGACCACGGGCCTGGTCGCTTCCTGGCACCAGCACACGGTATTTTCAGCGGCGACGCGCATGCGAGGCACGTC
GTTCTGGACTGTGATGATCTTCCTGATGGAAGCTGCGGTCTTCACATTGATCGGGCTGTCGCTCCGCGATGTCGTCGAAC
GCGGCGGCGGCTTTAGCACTGTGATCGCGACAATGGGACTGCCGATGCTGGCAGTCCTCGTGACACTCGTCGCCGCGCGG
TTTGTCTGGGTCTTTGCCTCCGACCTCGTCATCAAATCATGTGCAGCGTTGGGGTTCACACGTACCCGGCCGCTCGGCGC
CGGCGGGGCAACCGTTCTGAGCTGGGCAGGCGTGCGCGGCGTGGTCACGCTCGCCTTGGCGCTGAGCCTGCCCGAAGGGT
TCCCGGGCCGCGACTTCATCCTCGCCACGTCCTTTACCGTCATTCTCGGAACCGTGCTCGTACAGGGCACAACATTGGGG
CGGGTGATTGCCTGGGCGCGGCTGGCGCCTGAGACGGAAAGAGCGCGCCTGACAATGAGCCAGGCGGAAGCCGCCATGGC
ACAGGTGCAGCTCGGGATCGTGCAAAACCTGGCCTATGACGCCGAGGGAAAGCTCATCCATCCGCAATTGCTGGAGCGCT
ATCAGCGCAGGGCGACGGCAATCGTCGACTATGCCGAGAGAACCGAGCATTACGTGCCGCTGCTCCACGCTCATTTCGAC
GTGGTTCTCGAAGCGGTCGCGACAGGGCGCCGGGAACTCATTCGCCTCCACCGCGCCGGCGACATCGATGACGAGACGTT
GGACGAGCTGGAACGCGATCTCGATCTCGAGGAACTGAGCGCAATCTCGGCCAAGGCCTGA

Upstream 100 bases:

>100_bases
CGCAGCCTTTACAGCGCGTCGTGTCTTTTCAGATGCGCAAGGCCGCTGTAACTCTTTGCGGCAGGCATCCGACATTCGTT
GCTGAGCCAGGGCAGGGCAC

Downstream 100 bases:

>100_bases
CGTTCACTCACGCCGCGGCGCTCGCGACGCGTGCCTATCCGGCCTGGCATCCCGCTCTAAATGGCAATCTGTTCGCCGAG
CTCGACGACGCGGTTTGACG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MEPTQLFELVIAMFLAIIALHYAAHRLGLPPSVALLTGGALLAFVPGLPAISVDPGLVLVIFLPPLLMDGAWSIALSRLR
RHMIGIASLAVGAVFFTCAVVAVVVHLIFPSLPWAACAALGAIVAPPDAVSARAVLEHVRLPRRLQILLEGESLLNDASG
LVLFRFAVAAAATGAFSAGEAVGDFFVLALGGAIVGIVIAAAWVKLIRHLGDDYLIIAATVLLGWISYLLGELLHVSGVI
ATVTTGLVASWHQHTVFSAATRMRGTSFWTVMIFLMEAAVFTLIGLSLRDVVERGGGFSTVIATMGLPMLAVLVTLVAAR
FVWVFASDLVIKSCAALGFTRTRPLGAGGATVLSWAGVRGVVTLALALSLPEGFPGRDFILATSFTVILGTVLVQGTTLG
RVIAWARLAPETERARLTMSQAEAAMAQVQLGIVQNLAYDAEGKLIHPQLLERYQRRATAIVDYAERTEHYVPLLHAHFD
VVLEAVATGRRELIRLHRAGDIDDETLDELERDLDLEELSAISAKA

Sequences:

>Translated_526_residues
MEPTQLFELVIAMFLAIIALHYAAHRLGLPPSVALLTGGALLAFVPGLPAISVDPGLVLVIFLPPLLMDGAWSIALSRLR
RHMIGIASLAVGAVFFTCAVVAVVVHLIFPSLPWAACAALGAIVAPPDAVSARAVLEHVRLPRRLQILLEGESLLNDASG
LVLFRFAVAAAATGAFSAGEAVGDFFVLALGGAIVGIVIAAAWVKLIRHLGDDYLIIAATVLLGWISYLLGELLHVSGVI
ATVTTGLVASWHQHTVFSAATRMRGTSFWTVMIFLMEAAVFTLIGLSLRDVVERGGGFSTVIATMGLPMLAVLVTLVAAR
FVWVFASDLVIKSCAALGFTRTRPLGAGGATVLSWAGVRGVVTLALALSLPEGFPGRDFILATSFTVILGTVLVQGTTLG
RVIAWARLAPETERARLTMSQAEAAMAQVQLGIVQNLAYDAEGKLIHPQLLERYQRRATAIVDYAERTEHYVPLLHAHFD
VVLEAVATGRRELIRLHRAGDIDDETLDELERDLDLEELSAISAKA
>Mature_526_residues
MEPTQLFELVIAMFLAIIALHYAAHRLGLPPSVALLTGGALLAFVPGLPAISVDPGLVLVIFLPPLLMDGAWSIALSRLR
RHMIGIASLAVGAVFFTCAVVAVVVHLIFPSLPWAACAALGAIVAPPDAVSARAVLEHVRLPRRLQILLEGESLLNDASG
LVLFRFAVAAAATGAFSAGEAVGDFFVLALGGAIVGIVIAAAWVKLIRHLGDDYLIIAATVLLGWISYLLGELLHVSGVI
ATVTTGLVASWHQHTVFSAATRMRGTSFWTVMIFLMEAAVFTLIGLSLRDVVERGGGFSTVIATMGLPMLAVLVTLVAAR
FVWVFASDLVIKSCAALGFTRTRPLGAGGATVLSWAGVRGVVTLALALSLPEGFPGRDFILATSFTVILGTVLVQGTTLG
RVIAWARLAPETERARLTMSQAEAAMAQVQLGIVQNLAYDAEGKLIHPQLLERYQRRATAIVDYAERTEHYVPLLHAHFD
VVLEAVATGRRELIRLHRAGDIDDETLDELERDLDLEELSAISAKA

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=479, Percent_Identity=23.1732776617954, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI5454070, Length=459, Percent_Identity=22.2222222222222, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI294997330, Length=429, Percent_Identity=22.8438228438228, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI110227626, Length=429, Percent_Identity=22.8438228438228, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI14211919, Length=377, Percent_Identity=22.8116710875332, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI27734935, Length=381, Percent_Identity=21.259842519685, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4759144, Length=386, Percent_Identity=27.4611398963731, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI194239733, Length=387, Percent_Identity=24.5478036175711, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI15529998, Length=433, Percent_Identity=22.1709006928406, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI41872703, Length=413, Percent_Identity=23.0024213075061, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI27777632, Length=417, Percent_Identity=23.5011990407674, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790501, Length=512, Percent_Identity=31.0546875, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71999817, Length=453, Percent_Identity=22.7373068432671, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71999819, Length=453, Percent_Identity=22.7373068432671, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25147678, Length=490, Percent_Identity=23.6734693877551, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71999821, Length=433, Percent_Identity=22.6327944572748, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980847, Length=403, Percent_Identity=20.8436724565757, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71987559, Length=421, Percent_Identity=23.5154394299287, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71987545, Length=421, Percent_Identity=23.5154394299287, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71987535, Length=456, Percent_Identity=22.3684210526316, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71987537, Length=456, Percent_Identity=22.3684210526316, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25150332, Length=396, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=326, Percent_Identity=21.1656441717791, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71992107, Length=326, Percent_Identity=21.1656441717791, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71990932, Length=405, Percent_Identity=20.4938271604938, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71993590, Length=410, Percent_Identity=22.4390243902439, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71993582, Length=410, Percent_Identity=22.4390243902439, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71990924, Length=405, Percent_Identity=20.4938271604938, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=340, Percent_Identity=21.1764705882353, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221473215, Length=403, Percent_Identity=22.8287841191067, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI221473212, Length=423, Percent_Identity=22.9314420803783, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221473222, Length=389, Percent_Identity=23.3933161953728, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281364513, Length=389, Percent_Identity=23.3933161953728, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221510734, Length=440, Percent_Identity=22.9545454545455, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221510738, Length=480, Percent_Identity=23.125, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510736, Length=440, Percent_Identity=22.9545454545455, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221510732, Length=440, Percent_Identity=22.9545454545455, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585580, Length=440, Percent_Identity=22.9545454545455, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585578, Length=440, Percent_Identity=22.9545454545455, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221510740, Length=440, Percent_Identity=22.9545454545455, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281360447, Length=381, Percent_Identity=22.5721784776903, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 55966; Mature: 55966

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPTQLFELVIAMFLAIIALHYAAHRLGLPPSVALLTGGALLAFVPGLPAISVDPGLVLV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHCCCCCEECCCCCEEH
IFLPPLLMDGAWSIALSRLRRHMIGIASLAVGAVFFTCAVVAVVVHLIFPSLPWAACAAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GAIVAPPDAVSARAVLEHVRLPRRLQILLEGESLLNDASGLVLFRFAVAAAATGAFSAGE
CCCCCCCCHHHHHHHHHHHCCCHHHHHEECCHHHHCCCCHHHHHHHHHHHHHHCCCCCHH
AVGDFFVLALGGAIVGIVIAAAWVKLIRHLGDDYLIIAATVLLGWISYLLGELLHVSGVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATVTTGLVASWHQHTVFSAATRMRGTSFWTVMIFLMEAAVFTLIGLSLRDVVERGGGFST
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VIATMGLPMLAVLVTLVAARFVWVFASDLVIKSCAALGFTRTRPLGAGGATVLSWAGVRG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
VVTLALALSLPEGFPGRDFILATSFTVILGTVLVQGTTLGRVIAWARLAPETERARLTMS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHH
QAEAAMAQVQLGIVQNLAYDAEGKLIHPQLLERYQRRATAIVDYAERTEHYVPLLHAHFD
HHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVLEAVATGRRELIRLHRAGDIDDETLDELERDLDLEELSAISAKA
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MEPTQLFELVIAMFLAIIALHYAAHRLGLPPSVALLTGGALLAFVPGLPAISVDPGLVLV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHCCCCCEECCCCCEEH
IFLPPLLMDGAWSIALSRLRRHMIGIASLAVGAVFFTCAVVAVVVHLIFPSLPWAACAAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GAIVAPPDAVSARAVLEHVRLPRRLQILLEGESLLNDASGLVLFRFAVAAAATGAFSAGE
CCCCCCCCHHHHHHHHHHHCCCHHHHHEECCHHHHCCCCHHHHHHHHHHHHHHCCCCCHH
AVGDFFVLALGGAIVGIVIAAAWVKLIRHLGDDYLIIAATVLLGWISYLLGELLHVSGVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATVTTGLVASWHQHTVFSAATRMRGTSFWTVMIFLMEAAVFTLIGLSLRDVVERGGGFST
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VIATMGLPMLAVLVTLVAARFVWVFASDLVIKSCAALGFTRTRPLGAGGATVLSWAGVRG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
VVTLALALSLPEGFPGRDFILATSFTVILGTVLVQGTTLGRVIAWARLAPETERARLTMS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHH
QAEAAMAQVQLGIVQNLAYDAEGKLIHPQLLERYQRRATAIVDYAERTEHYVPLLHAHFD
HHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVLEAVATGRRELIRLHRAGDIDDETLDELERDLDLEELSAISAKA
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA