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The map label for this gene is cobC [H]

Identifier: 209549715

GI number: 209549715

Start: 2179988

End: 2181031

Strand: Reverse

Name: cobC [H]

Synonym: Rleg2_2122

Alternate gene names: 209549715

Gene position: 2181031-2179988 (Counterclockwise)

Preceding gene: 209549716

Following gene: 209549714

Centisome position: 48.06

GC content: 65.13

Gene sequence:

>1044_bases
GTGAGCGCGCCGATCGCCCATGGCGGCGGTATCACCGCTGCAGCCGCTGCTTTCGGCGGCAGGCCGGAAGACTGGCTCGA
CCTTTCCACAGGAATCAACCCCTGTCCCGTCGCCCTGCCTGACATCCCGGCAAGGGCCTGGCACCGTCTGCCGGACAGGC
ATCTCGTCGACGAGGCAAGATTTGCGGCCCGCGATCATTATGGCAGCGGAGCGATCCTGCCGCTGCCGGTGCCCGGGACG
CAATCGGTGATCCAGCTTCTGCCGCGCCTGCTTCGACAGGGAGGTCGGGTCGCCGCGACGGACGACAGGGTCGCCGTGAC
GGACAATAGAATTGCCGTGGTGTCGCCGACGTATGGCGAATATGCGCGCGCCTTCGCCTCGGCCGGTTTTGCCGTCGATG
CGGTCGACGATATTGCTGCGATCGGCGGTGAACACAGGCTTGCCGTCGTCGTCAATCCGAACAATCCGGACGGCAGGGTC
TGGTCGACCGAAACGCTGATTGCCCTGCATGAGAGAATGAAGGCGGCAGGCGGGATTCTCGTCGTCGACGAGGCCTTCGG
TGATACCGAGCCGGCGCGGAGCCTCGCAGCCCGTGCCCAAGAATTTCCAAATCTGATCATCTTCCGGTCCTTCGGCAAGT
TCTTCGGGCTTGCCGGCCTGCGGCTCGGTTTTGCGATCGCGCGCCAGGATATTCTGGCGGGTTTCGAGGACGGGCTCGGC
CCTTGGGCGGTCTCAGGCCCGGCGCTGTCGCTGGCCGCCTCGCTGCTGCGCTCCGACGTCTCCGCGATCCGTCACTCCCT
CGATACACGCAGCGCCGCGCTGCAGGCGACGCTGACCTCGGCCGGGTTGCGGATCAGGGGAGGAACGGCATTGTTCACCC
TTGCCGCCGATAGCAGGGCGAGCGACATTTACACGCATCTTTGCCGGCATCATATTCTCGTCCGCAAGTTCGATTATGCG
CCGGATTGGCTGCGGTTCGGCTTGACGCCCGATCCGGCGGCGGACAGGCGGCTTGGCGAAGCCCTTCAGGGATTTGAGCG
ATGA

Upstream 100 bases:

>100_bases
CACAGGACGCATTGGGAACCGATCTTGGTGCTGTCGGGCTGAGACGGGGGCAGGTGGCCGGTTCCTATATGCATCTGATC
GACCTTGCGAGAGCGGCCGC

Downstream 100 bases:

>100_bases
CGATCGACGAAAACCTTCTTGTGTTGCTTCTGGCGCTGCTGCTCGACCGGATCGCCGGGGATCCGCAATGGCTGTGGTCA
CGCGTGCCGCATCCCGTCGT

Product: L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSAPIAHGGGITAAAAAFGGRPEDWLDLSTGINPCPVALPDIPARAWHRLPDRHLVDEARFAARDHYGSGAILPLPVPGT
QSVIQLLPRLLRQGGRVAATDDRVAVTDNRIAVVSPTYGEYARAFASAGFAVDAVDDIAAIGGEHRLAVVVNPNNPDGRV
WSTETLIALHERMKAAGGILVVDEAFGDTEPARSLAARAQEFPNLIIFRSFGKFFGLAGLRLGFAIARQDILAGFEDGLG
PWAVSGPALSLAASLLRSDVSAIRHSLDTRSAALQATLTSAGLRIRGGTALFTLAADSRASDIYTHLCRHHILVRKFDYA
PDWLRFGLTPDPAADRRLGEALQGFER

Sequences:

>Translated_347_residues
MSAPIAHGGGITAAAAAFGGRPEDWLDLSTGINPCPVALPDIPARAWHRLPDRHLVDEARFAARDHYGSGAILPLPVPGT
QSVIQLLPRLLRQGGRVAATDDRVAVTDNRIAVVSPTYGEYARAFASAGFAVDAVDDIAAIGGEHRLAVVVNPNNPDGRV
WSTETLIALHERMKAAGGILVVDEAFGDTEPARSLAARAQEFPNLIIFRSFGKFFGLAGLRLGFAIARQDILAGFEDGLG
PWAVSGPALSLAASLLRSDVSAIRHSLDTRSAALQATLTSAGLRIRGGTALFTLAADSRASDIYTHLCRHHILVRKFDYA
PDWLRFGLTPDPAADRRLGEALQGFER
>Mature_346_residues
SAPIAHGGGITAAAAAFGGRPEDWLDLSTGINPCPVALPDIPARAWHRLPDRHLVDEARFAARDHYGSGAILPLPVPGTQ
SVIQLLPRLLRQGGRVAATDDRVAVTDNRIAVVSPTYGEYARAFASAGFAVDAVDDIAAIGGEHRLAVVVNPNNPDGRVW
STETLIALHERMKAAGGILVVDEAFGDTEPARSLAARAQEFPNLIIFRSFGKFFGLAGLRLGFAIARQDILAGFEDGLGP
WAVSGPALSLAASLLRSDVSAIRHSLDTRSAALQATLTSAGLRIRGGTALFTLAADSRASDIYTHLCRHHILVRKFDYAP
DWLRFGLTPDPAADRRLGEALQGFER

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=156, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36958; Mature: 36827

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPIAHGGGITAAAAAFGGRPEDWLDLSTGINPCPVALPDIPARAWHRLPDRHLVDEAR
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHH
FAARDHYGSGAILPLPVPGTQSVIQLLPRLLRQGGRVAATDDRVAVTDNRIAVVSPTYGE
HHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEECCCEEEEECCEEEEECCCHHH
YARAFASAGFAVDAVDDIAAIGGEHRLAVVVNPNNPDGRVWSTETLIALHERMKAAGGIL
HHHHHHHCCCEEHHHHHHHHCCCCCEEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCEE
VVDEAFGDTEPARSLAARAQEFPNLIIFRSFGKFFGLAGLRLGFAIARQDILAGFEDGLG
EEECCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PWAVSGPALSLAASLLRSDVSAIRHSLDTRSAALQATLTSAGLRIRGGTALFTLAADSRA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEEEECCCCH
SDIYTHLCRHHILVRKFDYAPDWLRFGLTPDPAADRRLGEALQGFER
HHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAPIAHGGGITAAAAAFGGRPEDWLDLSTGINPCPVALPDIPARAWHRLPDRHLVDEAR
CCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHH
FAARDHYGSGAILPLPVPGTQSVIQLLPRLLRQGGRVAATDDRVAVTDNRIAVVSPTYGE
HHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEECCCEEEEECCEEEEECCCHHH
YARAFASAGFAVDAVDDIAAIGGEHRLAVVVNPNNPDGRVWSTETLIALHERMKAAGGIL
HHHHHHHCCCEEHHHHHHHHCCCCCEEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCEE
VVDEAFGDTEPARSLAARAQEFPNLIIFRSFGKFFGLAGLRLGFAIARQDILAGFEDGLG
EEECCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PWAVSGPALSLAASLLRSDVSAIRHSLDTRSAALQATLTSAGLRIRGGTALFTLAADSRA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEEEECCCCH
SDIYTHLCRHHILVRKFDYAPDWLRFGLTPDPAADRRLGEALQGFER
HHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]