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The map label for this gene is pleC [H]

Identifier: 209549672

GI number: 209549672

Start: 2138853

End: 2140388

Strand: Direct

Name: pleC [H]

Synonym: Rleg2_2079

Alternate gene names: 209549672

Gene position: 2138853-2140388 (Clockwise)

Preceding gene: 209549666

Following gene: 209549675

Centisome position: 47.13

GC content: 61.78

Gene sequence:

>1536_bases
ATGAGTACCGGCGTCAGCACATCGACCGACAAGATTATCGTCGACAGGTCGCGCAGCCACCGCAACAAGGCCGTTTCCAA
GGCCGTGCGGCAAACGCGCGAACGTCTTCAGTCCGGCCATGCGTCCAATTCTTCCTTCGATCGTGACGTGCTCAAGATGT
ATGTGGCGTCGATGCTGCAGGGCGCAACGATCATGCCGCTCTTCATCGTCCTCATCACCGCGCTTGGCGTCTATATCACT
GAAAATACGCAGTTGCTCTTCTGGGCGCTGCTGACGCTCACCTGTCAAACCGGCAATATCCTGCTTGCCCGGCGCGCCCG
CCGGCAGGAAATCACCCCGGAGAGCGCCCGCAAATGGCGCCGCCTGCTGCTGCTCGGCCAGTTCCTGCTCGGCTGCTGCT
GGGCGGTCTTCGCGCTGCAGGGCTGCGACACCTGCGAACCGTCGAGCTTCATCCTTTATAAGGGTGCGACGCTGCTGATC
GCGCTCTCCGTCACGGCGATGTCGAATTTCATGCTGACGCCCGCCGTGCTCGTCGCCTTCGCGCCGGCGATCCTGGCACT
TGCCGCCAAGAGCGGCCTGTCGCGCGATCTCCTCGAAATCAGCCTGACGGGGCTCTTCACCAGCACCCTCGTCTTCTTCA
ACTATATCAGCGACCGGCTGTTCAAGTCGAACCTCAGGATCCTTTCCTACCAGTCGGAGAAGGACGACCTGATCGCCGAG
CTGGAAGTGGCGAAATCGATGTCGGACGAGGCGCGTCGCCGCGCCGAAGAGGCAAACCTCGCCAAGTCCCGCTTCCTTGC
CTCCATGTCGCACGAGCTCAGGACCCCGCTCAACGCCATTCTCGGCTTCTCCGAGGTGATGTCGGCCGAAGTCATGGGGC
CGCTCGCCAATCCGACCTACAAGGAATATGCCGGCGATATCCACCGCTCCGGCCAGCATCTGCTCGATCTCATCAACGAG
ATCCTCGACCTCTCCCGCATCGAGGCCGGCAAATACGAGCTCAGCGAGGAGGCGATCTCACTTCTCGATATCACCGAAGA
TTGCATCGGCATGGTCCAGCTGCGTGCGCGCGCCAAGAACATCGCCATTTCGGATCAATTCGAACGTCAGTTGCCGGCCA
TCTGGGCGGATGAAAAGTCGATGCGCCAGGTGGTCCTCAACCTTCTCTCCAATGCGGTCAAGTTCACGCCGCAGGGCGGC
GAAATTCACGTCAAGGTCGGCTGGACCGCCGGCGGCGGACAGTACATCTCCATCAAGGACAACGGCCCCGGCATTCCGGA
AGAGGAAATTCCCGTGGTCCTGTCGGCCTTCGGCCAGGGTTCGATCGCCATCAAGAGCGCCGAACAGGGCACCGGCCTCG
GCCTGCCGATCGTCCAGGCGATCCTTGCCAAGCATGACGGACAATTCCTACTGAAATCGAAGCTGCGCGAGGGCACCGAG
GTCATCGCCATCCTGCCCGCCAAACGCGTGCTGCAGAGCCTGCCGGCCGTGGAAGAGGCCCAGGCCGTCGCGCGCAAGCG
CAAGAGTTTTGCCTGA

Upstream 100 bases:

>100_bases
GCCTCCTTAAAAAACAAATCCTTGGCAAAGATGGCAAACATCTTCTTAAGAATTGCCGGTTAAGCTCTTATCCACCCTGG
GATGAAGTTTCAACGTGCAC

Downstream 100 bases:

>100_bases
TTCAGCCAAAAAACAGGCGTTTACCGAGGACAAAGCCAAGATAGAGGCAGCAGGCGGCGATCATGCAGCTCACCGCGAAT
GAGCCGAGATCCTTGGCATG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSTGVSTSTDKIIVDRSRSHRNKAVSKAVRQTRERLQSGHASNSSFDRDVLKMYVASMLQGATIMPLFIVLITALGVYIT
ENTQLLFWALLTLTCQTGNILLARRARRQEITPESARKWRRLLLLGQFLLGCCWAVFALQGCDTCEPSSFILYKGATLLI
ALSVTAMSNFMLTPAVLVAFAPAILALAAKSGLSRDLLEISLTGLFTSTLVFFNYISDRLFKSNLRILSYQSEKDDLIAE
LEVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSAEVMGPLANPTYKEYAGDIHRSGQHLLDLINE
ILDLSRIEAGKYELSEEAISLLDITEDCIGMVQLRARAKNIAISDQFERQLPAIWADEKSMRQVVLNLLSNAVKFTPQGG
EIHVKVGWTAGGGQYISIKDNGPGIPEEEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFLLKSKLREGTE
VIAILPAKRVLQSLPAVEEAQAVARKRKSFA

Sequences:

>Translated_511_residues
MSTGVSTSTDKIIVDRSRSHRNKAVSKAVRQTRERLQSGHASNSSFDRDVLKMYVASMLQGATIMPLFIVLITALGVYIT
ENTQLLFWALLTLTCQTGNILLARRARRQEITPESARKWRRLLLLGQFLLGCCWAVFALQGCDTCEPSSFILYKGATLLI
ALSVTAMSNFMLTPAVLVAFAPAILALAAKSGLSRDLLEISLTGLFTSTLVFFNYISDRLFKSNLRILSYQSEKDDLIAE
LEVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSAEVMGPLANPTYKEYAGDIHRSGQHLLDLINE
ILDLSRIEAGKYELSEEAISLLDITEDCIGMVQLRARAKNIAISDQFERQLPAIWADEKSMRQVVLNLLSNAVKFTPQGG
EIHVKVGWTAGGGQYISIKDNGPGIPEEEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFLLKSKLREGTE
VIAILPAKRVLQSLPAVEEAQAVARKRKSFA
>Mature_510_residues
STGVSTSTDKIIVDRSRSHRNKAVSKAVRQTRERLQSGHASNSSFDRDVLKMYVASMLQGATIMPLFIVLITALGVYITE
NTQLLFWALLTLTCQTGNILLARRARRQEITPESARKWRRLLLLGQFLLGCCWAVFALQGCDTCEPSSFILYKGATLLIA
LSVTAMSNFMLTPAVLVAFAPAILALAAKSGLSRDLLEISLTGLFTSTLVFFNYISDRLFKSNLRILSYQSEKDDLIAEL
EVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSAEVMGPLANPTYKEYAGDIHRSGQHLLDLINEI
LDLSRIEAGKYELSEEAISLLDITEDCIGMVQLRARAKNIAISDQFERQLPAIWADEKSMRQVVLNLLSNAVKFTPQGGE
IHVKVGWTAGGGQYISIKDNGPGIPEEEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFLLKSKLREGTEV
IAILPAKRVLQSLPAVEEAQAVARKRKSFA

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=31.8897637795276, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1788713, Length=273, Percent_Identity=34.0659340659341, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87081816, Length=249, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=30.1310043668122, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=29.8039215686275, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786600, Length=268, Percent_Identity=27.6119402985075, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786912, Length=257, Percent_Identity=28.7937743190661, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI87082128, Length=210, Percent_Identity=31.4285714285714, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=27.5423728813559, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790436, Length=381, Percent_Identity=24.9343832020997, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790300, Length=250, Percent_Identity=23.6, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=24.1666666666667, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=205, Percent_Identity=27.3170731707317, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=222, Percent_Identity=28.8288288288288, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=24.0506329113924, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56070; Mature: 55939

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGVSTSTDKIIVDRSRSHRNKAVSKAVRQTRERLQSGHASNSSFDRDVLKMYVASMLQ
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
GATIMPLFIVLITALGVYITENTQLLFWALLTLTCQTGNILLARRARRQEITPESARKWR
CCHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
RLLLLGQFLLGCCWAVFALQGCDTCEPSSFILYKGATLLIALSVTAMSNFMLTPAVLVAF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
APAILALAAKSGLSRDLLEISLTGLFTSTLVFFNYISDRLFKSNLRILSYQSEKDDLIAE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHH
LEVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSAEVMGPLANPTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
KEYAGDIHRSGQHLLDLINEILDLSRIEAGKYELSEEAISLLDITEDCIGMVQLRARAKN
HHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IAISDQFERQLPAIWADEKSMRQVVLNLLSNAVKFTPQGGEIHVKVGWTAGGGQYISIKD
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCEEEEEEC
NGPGIPEEEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFLLKSKLREGTE
CCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCE
VIAILPAKRVLQSLPAVEEAQAVARKRKSFA
EEEECCHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STGVSTSTDKIIVDRSRSHRNKAVSKAVRQTRERLQSGHASNSSFDRDVLKMYVASMLQ
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
GATIMPLFIVLITALGVYITENTQLLFWALLTLTCQTGNILLARRARRQEITPESARKWR
CCHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
RLLLLGQFLLGCCWAVFALQGCDTCEPSSFILYKGATLLIALSVTAMSNFMLTPAVLVAF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
APAILALAAKSGLSRDLLEISLTGLFTSTLVFFNYISDRLFKSNLRILSYQSEKDDLIAE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHH
LEVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSAEVMGPLANPTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
KEYAGDIHRSGQHLLDLINEILDLSRIEAGKYELSEEAISLLDITEDCIGMVQLRARAKN
HHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IAISDQFERQLPAIWADEKSMRQVVLNLLSNAVKFTPQGGEIHVKVGWTAGGGQYISIKD
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCEEEEEEC
NGPGIPEEEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFLLKSKLREGTE
CCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCE
VIAILPAKRVLQSLPAVEEAQAVARKRKSFA
EEEECCHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]