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The map label for this gene is dxs [C]

Identifier: 209549625

GI number: 209549625

Start: 2094215

End: 2095171

Strand: Reverse

Name: dxs [C]

Synonym: Rleg2_2032

Alternate gene names: 209549625

Gene position: 2095171-2094215 (Counterclockwise)

Preceding gene: 209549626

Following gene: 209549624

Centisome position: 46.17

GC content: 60.92

Gene sequence:

>957_bases
ATGAACGCGTCAGTAAACCCACCCAAGCTCTATGATTGCCGCGACGCATTCGCCTCTACGCTTGAACGGTTGGCAGCCGA
AAACGACACGATCGTTGCCGTTTGCAACGACTCCGTCGGCTCCTCCAAGCTCGGCGGCTTCAAGGCGAAGTTCGGAGAGC
GCCTCGTCAATGTCGGCATAGCCGAGCAGAACATGGTTGGCGTTGCAGCAGGCCTTGCCAACGGCGGACGCCTTCCATTC
GTATGCGCCGCTGCTCCGTTTCTGACGGGCCGGTCGCTGGAGCAGATCAAGGCCGATATTTCCTACTCGAATGCCAACGT
CAAGCTGGTGGGCATTTCTTCCGGAATGGCATATGGCGAACTCGGTCCGACGCATCACTCGATCGAAGACTTCGCCTGGA
CGCGGGTGCTGCCCAACCTTCCGGTCATTGCACCATGTGACCGCATCGAAACCGCCGCTGCCGTTGCGTGGGCCGCGACC
TATAACGGGCCTTGTTTCCTGCGTCTGTCTCGCGTTGGCGTGCCCGACCTGCTTCCGGAGGGGCACAGGTTCGAACTCGG
GAAGGCAAATCTCCTTCGCCAGGGTTCCGACGTCACCCTTATTGCCAACGGCACTTTGACTCATCGGATTCTGAAGGCTG
CCAAAATCCTCGCGGACCGCGGCATCAATGCCAGGGTTCTGAACCTTGCGACGGTTCGTCCAATCGACGCGGAGGCTATC
ATCGCCGCGGCTAGGGAAACCGGAGCGATCGTCACAGCCGAAGAGCATTCGATCTTTGGCGGGCTCGGTTCCGCGGTCGC
CGAAGTGGTGGTCGACAACGCTCCAGTCCCGATGAAGCGTCTAGGCGTTCCCGGCATCTATGCCCCCACAGGTTCGGCAG
AGTTCCTGCTCGACGAGTTCGGGATGGCGCCGGCCGCCATCGCCGACGCAGCGCAGTCGCTGATCAGGCGCAAGTAA

Upstream 100 bases:

>100_bases
CGGAATATCGTTCATGCAAGACCGGGTCGACTGGCACCACAAGGTGCCGAACAAGGAACAGTACGAAATTGCATTGGCAG
AATTGTCGGAGGCACTCTAA

Downstream 100 bases:

>100_bases
TTGAGGTCACGTGACCGGCGGGGACGCCTTTTTTCGTCCCGGTCGTCACCTGATCCGGGGAGGATAGAATGCGGGCAATT
CTGGCAATCGACCAGGGCAC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MNASVNPPKLYDCRDAFASTLERLAAENDTIVAVCNDSVGSSKLGGFKAKFGERLVNVGIAEQNMVGVAAGLANGGRLPF
VCAAAPFLTGRSLEQIKADISYSNANVKLVGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDRIETAAAVAWAAT
YNGPCFLRLSRVGVPDLLPEGHRFELGKANLLRQGSDVTLIANGTLTHRILKAAKILADRGINARVLNLATVRPIDAEAI
IAAARETGAIVTAEEHSIFGGLGSAVAEVVVDNAPVPMKRLGVPGIYAPTGSAEFLLDEFGMAPAAIADAAQSLIRRK

Sequences:

>Translated_318_residues
MNASVNPPKLYDCRDAFASTLERLAAENDTIVAVCNDSVGSSKLGGFKAKFGERLVNVGIAEQNMVGVAAGLANGGRLPF
VCAAAPFLTGRSLEQIKADISYSNANVKLVGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDRIETAAAVAWAAT
YNGPCFLRLSRVGVPDLLPEGHRFELGKANLLRQGSDVTLIANGTLTHRILKAAKILADRGINARVLNLATVRPIDAEAI
IAAARETGAIVTAEEHSIFGGLGSAVAEVVVDNAPVPMKRLGVPGIYAPTGSAEFLLDEFGMAPAAIADAAQSLIRRK
>Mature_318_residues
MNASVNPPKLYDCRDAFASTLERLAAENDTIVAVCNDSVGSSKLGGFKAKFGERLVNVGIAEQNMVGVAAGLANGGRLPF
VCAAAPFLTGRSLEQIKADISYSNANVKLVGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDRIETAAAVAWAAT
YNGPCFLRLSRVGVPDLLPEGHRFELGKANLLRQGSDVTLIANGTLTHRILKAAKILADRGINARVLNLATVRPIDAEAI
IAAARETGAIVTAEEHSIFGGLGSAVAEVVVDNAPVPMKRLGVPGIYAPTGSAEFLLDEFGMAPAAIADAAQSLIRRK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=308, Percent_Identity=35.7142857142857, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4507521, Length=308, Percent_Identity=35.7142857142857, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI133778974, Length=297, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI225637463, Length=306, Percent_Identity=32.6797385620915, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI225637459, Length=306, Percent_Identity=32.6797385620915, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI225637461, Length=306, Percent_Identity=32.6797385620915, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI291084858, Length=254, Percent_Identity=26.7716535433071, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI156564403, Length=266, Percent_Identity=27.0676691729323, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4557353, Length=265, Percent_Identity=24.5283018867925, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI34101272, Length=265, Percent_Identity=24.5283018867925, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786622, Length=296, Percent_Identity=32.0945945945946, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788808, Length=196, Percent_Identity=32.6530612244898, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI48994911, Length=277, Percent_Identity=27.7978339350181, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539652, Length=307, Percent_Identity=30.6188925081433, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17538422, Length=310, Percent_Identity=26.4516129032258, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=26.605504587156, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645119, Length=307, Percent_Identity=33.2247557003257, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45551847, Length=307, Percent_Identity=33.2247557003257, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45550715, Length=307, Percent_Identity=33.2247557003257, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24666278, Length=308, Percent_Identity=31.4935064935065, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI160714832, Length=263, Percent_Identity=27.7566539923954, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI160714828, Length=268, Percent_Identity=27.9850746268657, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358145, Length=329, Percent_Identity=29.1793313069909, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24650940, Length=329, Percent_Identity=29.1793313069909, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33309; Mature: 33309

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASVNPPKLYDCRDAFASTLERLAAENDTIVAVCNDSVGSSKLGGFKAKFGERLVNVGI
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
AEQNMVGVAAGLANGGRLPFVCAAAPFLTGRSLEQIKADISYSNANVKLVGISSGMAYGE
CCCCHHEEEECCCCCCCCCEEEECCCHHCCCCHHHHHHHCEECCCEEEEEEECCCCCCCC
LGPTHHSIEDFAWTRVLPNLPVIAPCDRIETAAAVAWAATYNGPCFLRLSRVGVPDLLPE
CCCCCCCHHHHHHHHHCCCCCEECCCHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCC
GHRFELGKANLLRQGSDVTLIANGTLTHRILKAAKILADRGINARVLNLATVRPIDAEAI
CCEEECCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHH
IAAARETGAIVTAEEHSIFGGLGSAVAEVVVDNAPVPMKRLGVPGIYAPTGSAEFLLDEF
HHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCEEECCCCCHHHHHHHH
GMAPAAIADAAQSLIRRK
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNASVNPPKLYDCRDAFASTLERLAAENDTIVAVCNDSVGSSKLGGFKAKFGERLVNVGI
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
AEQNMVGVAAGLANGGRLPFVCAAAPFLTGRSLEQIKADISYSNANVKLVGISSGMAYGE
CCCCHHEEEECCCCCCCCCEEEECCCHHCCCCHHHHHHHCEECCCEEEEEEECCCCCCCC
LGPTHHSIEDFAWTRVLPNLPVIAPCDRIETAAAVAWAATYNGPCFLRLSRVGVPDLLPE
CCCCCCCHHHHHHHHHCCCCCEECCCHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCC
GHRFELGKANLLRQGSDVTLIANGTLTHRILKAAKILADRGINARVLNLATVRPIDAEAI
CCEEECCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHH
IAAARETGAIVTAEEHSIFGGLGSAVAEVVVDNAPVPMKRLGVPGIYAPTGSAEFLLDEF
HHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCEEECCCCCHHHHHHHH
GMAPAAIADAAQSLIRRK
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]