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The map label for this gene is sul [H]

Identifier: 209549565

GI number: 209549565

Start: 2018327

End: 2019196

Strand: Reverse

Name: sul [H]

Synonym: Rleg2_1971

Alternate gene names: 209549565

Gene position: 2019196-2018327 (Counterclockwise)

Preceding gene: 209549567

Following gene: 209549564

Centisome position: 44.5

GC content: 64.83

Gene sequence:

>870_bases
GTGACAGGGTTCGAAGGCAGTTTATGGCGTGTGGGCCATGGCCGGGAGATCGAACTCGGCGGTCGTTCTGTCATCATGGC
GATCATCAACGTGACACCGGACTCCTTTTCCGACGGCGGACGCTTCGAAACCGTCGATGCTGCTGTCGAACACGCGCTTC
GGGCGGTTAACGAGGGAGCCGGGATTGTCGACATCGGCGGCGAATCCACCCGGCCGAACGCCGCTGCGGTCAGCCCCTCC
GAGGAGCAGGCGCGCGTGCTGCCGGTGATCGAGGCGCTGCGCGGGCGCACCCAGGCGCTGATCTCGATCGATACCTATCG
CGTCGAAACGGCGCGGCTGGCGGTCAGTGCCGGCGCCCATATCGTCAATGATGTGTTCGGGCTGCAGAAGGAGCCCGATA
TCGCCGACATCGCCGCGGCGACCGGCGCCGGGCTCTGCATCATGCATACCGGCCGCGACAGGGCGAAGCTTCCCGACGTG
ATTGCCGACCAGGTGCATTTTCTCAAGCGGTCGCTTGAGATCGCTCGGGCCGCCGGCGTCAACAGCGACCGCATCGTGCT
CGATCCGGGCTTCGGCTTCGCCAAGGAGACGGCGGAGGAGAACCTCGAACTGATGGCGCGGTTTTCCGAACTTTCCCGCT
TCGGCCTGCCGCTGCTTGCCGGGACGTCGCGCAAGCGCTTCCTCGGCGCGGTGACGGGGCGTGAGGCTGCCGACAGGGAT
GTAGCTACGGCCGTCACCAGTGCCCTGCTCAGGCTTCAAGGGGCAGCGGTTTTCCGGGTGCACAATGTCGCAATCAACAG
GGATGCGCTTGATATCGCCGATGCTATGCTGAATGCGCGCCAGGAATTCGAGAGGAAGCGGCCGACATGA

Upstream 100 bases:

>100_bases
CTGAACGCAACCCGTGTTGAAATCGACCGGAGCTTGGGGCATAGCCACCGCAAGCGCAATATCGGATGGCGCTTTTTTCG
CGATCGATGGGATAAGTCTG

Downstream 100 bases:

>100_bases
CCACCTACACGATCACGCTGCAGAACTGCGCCTTCTTTGCGCGCCACGGCGTTCATGACGAGGAGGAATTCCTCGGCCAG
CGCTTCTTCGTCGATGCCGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTGFEGSLWRVGHGREIELGGRSVIMAIINVTPDSFSDGGRFETVDAAVEHALRAVNEGAGIVDIGGESTRPNAAAVSPS
EEQARVLPVIEALRGRTQALISIDTYRVETARLAVSAGAHIVNDVFGLQKEPDIADIAAATGAGLCIMHTGRDRAKLPDV
IADQVHFLKRSLEIARAAGVNSDRIVLDPGFGFAKETAEENLELMARFSELSRFGLPLLAGTSRKRFLGAVTGREAADRD
VATAVTSALLRLQGAAVFRVHNVAINRDALDIADAMLNARQEFERKRPT

Sequences:

>Translated_289_residues
MTGFEGSLWRVGHGREIELGGRSVIMAIINVTPDSFSDGGRFETVDAAVEHALRAVNEGAGIVDIGGESTRPNAAAVSPS
EEQARVLPVIEALRGRTQALISIDTYRVETARLAVSAGAHIVNDVFGLQKEPDIADIAAATGAGLCIMHTGRDRAKLPDV
IADQVHFLKRSLEIARAAGVNSDRIVLDPGFGFAKETAEENLELMARFSELSRFGLPLLAGTSRKRFLGAVTGREAADRD
VATAVTSALLRLQGAAVFRVHNVAINRDALDIADAMLNARQEFERKRPT
>Mature_288_residues
TGFEGSLWRVGHGREIELGGRSVIMAIINVTPDSFSDGGRFETVDAAVEHALRAVNEGAGIVDIGGESTRPNAAAVSPSE
EQARVLPVIEALRGRTQALISIDTYRVETARLAVSAGAHIVNDVFGLQKEPDIADIAAATGAGLCIMHTGRDRAKLPDVI
ADQVHFLKRSLEIARAAGVNSDRIVLDPGFGFAKETAEENLELMARFSELSRFGLPLLAGTSRKRFLGAVTGREAADRDV
ATAVTSALLRLQGAAVFRVHNVAINRDALDIADAMLNARQEFERKRPT

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=263, Percent_Identity=40.3041825095057, Blast_Score=197, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324073, Length=317, Percent_Identity=29.9684542586751, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30918; Mature: 30787

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFEGSLWRVGHGREIELGGRSVIMAIINVTPDSFSDGGRFETVDAAVEHALRAVNEGA
CCCCCCCEEECCCCCEEEECCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCCC
GIVDIGGESTRPNAAAVSPSEEQARVLPVIEALRGRTQALISIDTYRVETARLAVSAGAH
CEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHEEEHHHHHHHHCCHH
IVNDVFGLQKEPDIADIAAATGAGLCIMHTGRDRAKLPDVIADQVHFLKRSLEIARAAGV
HHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHHCCC
NSDRIVLDPGFGFAKETAEENLELMARFSELSRFGLPLLAGTSRKRFLGAVTGREAADRD
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHCCCCHHHHH
VATAVTSALLRLQGAAVFRVHNVAINRDALDIADAMLNARQEFERKRPT
HHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGFEGSLWRVGHGREIELGGRSVIMAIINVTPDSFSDGGRFETVDAAVEHALRAVNEGA
CCCCCCEEECCCCCEEEECCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCCC
GIVDIGGESTRPNAAAVSPSEEQARVLPVIEALRGRTQALISIDTYRVETARLAVSAGAH
CEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHEEEHHHHHHHHCCHH
IVNDVFGLQKEPDIADIAAATGAGLCIMHTGRDRAKLPDVIADQVHFLKRSLEIARAAGV
HHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHHCCC
NSDRIVLDPGFGFAKETAEENLELMARFSELSRFGLPLLAGTSRKRFLGAVTGREAADRD
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHCCCCHHHHH
VATAVTSALLRLQGAAVFRVHNVAINRDALDIADAMLNARQEFERKRPT
HHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]