Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 209549563

GI number: 209549563

Start: 2017454

End: 2017957

Strand: Reverse

Name: folK [H]

Synonym: Rleg2_1969

Alternate gene names: 209549563

Gene position: 2017957-2017454 (Counterclockwise)

Preceding gene: 209549564

Following gene: 209549558

Centisome position: 44.47

GC content: 65.48

Gene sequence:

>504_bases
ATGCGATCGGCCACACTCGGCCTCGGCGGCAATATCGGCGATCCCGTCAAAGCGATGGCCGCCGCGCTGCAGCGGCTGGA
CGGACGAGATGACTGCCGGATTACGGCGGTCTCGCGGCTCTATCGCACGCCGCCCTGGGGCAAGACCGACCAATCCTTCT
TCTTCAATGCCTGCGCCGCCGTCGAAACCCGGCTGGAGCCCGAGGCTTTGCTCGATGTCTGCCTGTCGATCGAGCGGGAG
ATGAAACGCGAGCGTATCGAGCGCTGGGGTCCGCGCACACTCGATATCGACGTGCTGACCTATGGCGACGTTATCCAGGA
GGCGCCGCGGCTGGAACTGCCGCATCCGCGCATGACCGATCGCGGTTTCGTGCTGATGCCGCTTGCCGATATCGCGCCGG
GCCTGCTCGTCAGGGGCAGGGCGGTCAGCGACTGGCTTGAAGATGCCGAGGTGGCGGGCATCGAGGTTGCCGATAACAGC
CGCGACTGGTGGCTGCAAAGCTGA

Upstream 100 bases:

>100_bases
GTCCGGCGGGCAAAGATCACGGTGCGCAAGCCGAATGCGCCGGTGCCCGGCGTGCTCGATTTCGTGCAGGTGAGCGTTGA
ACACTTTGCCTGAGACCGCA

Downstream 100 bases:

>100_bases
GGCGGAGATCCTGAAACGGAAAACGGCGGGAAACCCGCCGCTTCAGGAAAATCCGCTACACGCTTGATCTACTGGATGGA
GCCGACGGCCATCTCGTCGA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MRSATLGLGGNIGDPVKAMAAALQRLDGRDDCRITAVSRLYRTPPWGKTDQSFFFNACAAVETRLEPEALLDVCLSIERE
MKRERIERWGPRTLDIDVLTYGDVIQEAPRLELPHPRMTDRGFVLMPLADIAPGLLVRGRAVSDWLEDAEVAGIEVADNS
RDWWLQS

Sequences:

>Translated_167_residues
MRSATLGLGGNIGDPVKAMAAALQRLDGRDDCRITAVSRLYRTPPWGKTDQSFFFNACAAVETRLEPEALLDVCLSIERE
MKRERIERWGPRTLDIDVLTYGDVIQEAPRLELPHPRMTDRGFVLMPLADIAPGLLVRGRAVSDWLEDAEVAGIEVADNS
RDWWLQS
>Mature_167_residues
MRSATLGLGGNIGDPVKAMAAALQRLDGRDDCRITAVSRLYRTPPWGKTDQSFFFNACAAVETRLEPEALLDVCLSIERE
MKRERIERWGPRTLDIDVLTYGDVIQEAPRLELPHPRMTDRGFVLMPLADIAPGLLVRGRAVSDWLEDAEVAGIEVADNS
RDWWLQS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=137, Percent_Identity=43.7956204379562, Blast_Score=116, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=38.2352941176471, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18722; Mature: 18722

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSATLGLGGNIGDPVKAMAAALQRLDGRDDCRITAVSRLYRTPPWGKTDQSFFFNACAA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VETRLEPEALLDVCLSIEREMKRERIERWGPRTLDIDVLTYGDVIQEAPRLELPHPRMTD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHCCCCCCCCCCCCC
RGFVLMPLADIAPGLLVRGRAVSDWLEDAEVAGIEVADNSRDWWLQS
CCEEEEEHHHHCCCCEECCCHHHHHHHHHHHCCEEEECCCCCCCCCC
>Mature Secondary Structure
MRSATLGLGGNIGDPVKAMAAALQRLDGRDDCRITAVSRLYRTPPWGKTDQSFFFNACAA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VETRLEPEALLDVCLSIEREMKRERIERWGPRTLDIDVLTYGDVIQEAPRLELPHPRMTD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHCCCCCCCCCCCCC
RGFVLMPLADIAPGLLVRGRAVSDWLEDAEVAGIEVADNSRDWWLQS
CCEEEEEHHHHCCCCEECCCHHHHHHHHHHHCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]