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The map label for this gene is gcvT [H]

Identifier: 209549483

GI number: 209549483

Start: 1932751

End: 1933887

Strand: Direct

Name: gcvT [H]

Synonym: Rleg2_1889

Alternate gene names: 209549483

Gene position: 1932751-1933887 (Clockwise)

Preceding gene: 209549480

Following gene: 209549484

Centisome position: 42.59

GC content: 65.17

Gene sequence:

>1137_bases
TTGGACGATACTGCTGCCCTGAAGAAAACCCCGCTGCATGCCCTGCATCTCCAGCTCGGCGCCCGCATGGTGCCGTTCGC
GGGTTACGATATGCCGGTGCAATATCCGGCAGGCGTGATGAAGGAACACATTCATACCCGCACCGAGGCCGGCCTCTTCG
ATGTCTCCCATATGGGCCAGGTCATCGTGAAGGCGAAGTCGGGCAGCTACGAGGATGCGGCGCTGGCGCTCGAAAGCCTC
GTGCCGGTCGATATCCTGGGCCTCGCCGAAGGCCGTCAGCGCTATGGCTTCTTCACCGACGACAGCGGCTGCATCCTCGA
CGATCTGATGATCAGCCATCTCGACGATCACCTTTTCGTCGTCGTCAACGCTTCCTGCAAGGAGGCCGATCTCGCTCATC
TACAGACCCATATCGGCGACCGCTGCGACATCACGCTGCTGAACCGCGCCCTGATCGCGCTACAGGGCCCGCGTGCGGTC
GAAGTTCTCGCCGAACTCTGGGCCGACGTCGCGGCGATGAAATTCATGGACGTGCGCCACTGCCGGCTGCACGATGTTTC
CTGTCTCGTCTCGCGCTCCGGCTACAGCGGCGAGGACGGCTTCGAAATCTCGATCCCGGCAGACAAGGCCGTCGATGTCA
CCATGCGGCTGCTCGAGCATCCCGACGTCCAGGCGATCGGCCTCGGTGCCCGCGACTCGCTGCGCCTCGAAGCCGGCCTC
TGCCTCTACGGCAACGATATCGACACGACCACGTCGCCCGTCGAAGCGGCGCTCGAATGGGCGATGCAGAAGGCGCGGCG
CTCGGGTGGCGCCCGCGCCGGCGGTTTTCCGGGCTCCGGCCGCATCCTCTCCGAACTCGAAAATGGCGCCGCCCGCCGCC
GCGTCGGCCTGAAGCCTGAGGGAAAGGCGCCGGTGCGTGGCCATGCCAAGCTCTATGCCGATGCCGAGGGCAAGGCCGAA
ATCGGCGAAGTCACCTCAGGCGGCTTCGGCCCCAGCGTCGAAGGCCCCGTCGCCATGGGCTACGTGCCGGTCTCGCATGC
TGCGGCCGGCACCCTCGTCTACGCCGAAGTGCGCGGCAAATATTTGCCGATCACCGTCAGCGCCCTGCCCTTCGTCACAC
CGACCTACAAACGCTAA

Upstream 100 bases:

>100_bases
GGCAAAGGGACAGAGGGGGCTCAGGAGAGAAGTGCGCAGCCGCGCCTTCAGATTTGAGCCCGCGCCTTCGCAAAAAAGGC
GCAAACCCCGGAGGCGTCTT

Downstream 100 bases:

>100_bases
ACCTTTTCCAGAGAGGACGAACAATGCTGAAATTTACCGAAGAACACGAATGGCTGCAGATCGAAGGCAGCGTTGCGACC
GTTGGTATCACCAATTATGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MDDTAALKKTPLHALHLQLGARMVPFAGYDMPVQYPAGVMKEHIHTRTEAGLFDVSHMGQVIVKAKSGSYEDAALALESL
VPVDILGLAEGRQRYGFFTDDSGCILDDLMISHLDDHLFVVVNASCKEADLAHLQTHIGDRCDITLLNRALIALQGPRAV
EVLAELWADVAAMKFMDVRHCRLHDVSCLVSRSGYSGEDGFEISIPADKAVDVTMRLLEHPDVQAIGLGARDSLRLEAGL
CLYGNDIDTTTSPVEAALEWAMQKARRSGGARAGGFPGSGRILSELENGAARRRVGLKPEGKAPVRGHAKLYADAEGKAE
IGEVTSGGFGPSVEGPVAMGYVPVSHAAAGTLVYAEVRGKYLPITVSALPFVTPTYKR

Sequences:

>Translated_378_residues
MDDTAALKKTPLHALHLQLGARMVPFAGYDMPVQYPAGVMKEHIHTRTEAGLFDVSHMGQVIVKAKSGSYEDAALALESL
VPVDILGLAEGRQRYGFFTDDSGCILDDLMISHLDDHLFVVVNASCKEADLAHLQTHIGDRCDITLLNRALIALQGPRAV
EVLAELWADVAAMKFMDVRHCRLHDVSCLVSRSGYSGEDGFEISIPADKAVDVTMRLLEHPDVQAIGLGARDSLRLEAGL
CLYGNDIDTTTSPVEAALEWAMQKARRSGGARAGGFPGSGRILSELENGAARRRVGLKPEGKAPVRGHAKLYADAEGKAE
IGEVTSGGFGPSVEGPVAMGYVPVSHAAAGTLVYAEVRGKYLPITVSALPFVTPTYKR
>Mature_378_residues
MDDTAALKKTPLHALHLQLGARMVPFAGYDMPVQYPAGVMKEHIHTRTEAGLFDVSHMGQVIVKAKSGSYEDAALALESL
VPVDILGLAEGRQRYGFFTDDSGCILDDLMISHLDDHLFVVVNASCKEADLAHLQTHIGDRCDITLLNRALIALQGPRAV
EVLAELWADVAAMKFMDVRHCRLHDVSCLVSRSGYSGEDGFEISIPADKAVDVTMRLLEHPDVQAIGLGARDSLRLEAGL
CLYGNDIDTTTSPVEAALEWAMQKARRSGGARAGGFPGSGRILSELENGAARRRVGLKPEGKAPVRGHAKLYADAEGKAE
IGEVTSGGFGPSVEGPVAMGYVPVSHAAAGTLVYAEVRGKYLPITVSALPFVTPTYKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=379, Percent_Identity=44.5910290237467, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI257796258, Length=360, Percent_Identity=44.4444444444444, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI257796254, Length=372, Percent_Identity=40.5913978494624, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI257796256, Length=314, Percent_Identity=44.9044585987261, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI24797151, Length=298, Percent_Identity=24.496644295302, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789272, Length=379, Percent_Identity=34.0369393139842, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17560118, Length=387, Percent_Identity=41.8604651162791, Blast_Score=244, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6320222, Length=394, Percent_Identity=38.8324873096447, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI20129441, Length=384, Percent_Identity=40.3645833333333, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40497; Mature: 40497

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDTAALKKTPLHALHLQLGARMVPFAGYDMPVQYPAGVMKEHIHTRTEAGLFDVSHMGQ
CCCCHHHHHCCHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEHHHCCE
VIVKAKSGSYEDAALALESLVPVDILGLAEGRQRYGFFTDDSGCILDDLMISHLDDHLFV
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCHHHCCEEECCCCCHHHHHHHHHCCCEEEE
VVNASCKEADLAHLQTHIGDRCDITLLNRALIALQGPRAVEVLAELWADVAAMKFMDVRH
EEECCCCHHHHHHHHHHCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
CRLHDVSCLVSRSGYSGEDGFEISIPADKAVDVTMRLLEHPDVQAIGLGARDSLRLEAGL
HHHHCHHHEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCCEEEEEEE
CLYGNDIDTTTSPVEAALEWAMQKARRSGGARAGGFPGSGRILSELENGAARRRVGLKPE
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCC
GKAPVRGHAKLYADAEGKAEIGEVTSGGFGPSVEGPVAMGYVPVSHAAAGTLVYAEVRGK
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCC
YLPITVSALPFVTPTYKR
EEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MDDTAALKKTPLHALHLQLGARMVPFAGYDMPVQYPAGVMKEHIHTRTEAGLFDVSHMGQ
CCCCHHHHHCCHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEHHHCCE
VIVKAKSGSYEDAALALESLVPVDILGLAEGRQRYGFFTDDSGCILDDLMISHLDDHLFV
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCHHHCCEEECCCCCHHHHHHHHHCCCEEEE
VVNASCKEADLAHLQTHIGDRCDITLLNRALIALQGPRAVEVLAELWADVAAMKFMDVRH
EEECCCCHHHHHHHHHHCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
CRLHDVSCLVSRSGYSGEDGFEISIPADKAVDVTMRLLEHPDVQAIGLGARDSLRLEAGL
HHHHCHHHEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCCEEEEEEE
CLYGNDIDTTTSPVEAALEWAMQKARRSGGARAGGFPGSGRILSELENGAARRRVGLKPE
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCC
GKAPVRGHAKLYADAEGKAEIGEVTSGGFGPSVEGPVAMGYVPVSHAAAGTLVYAEVRGK
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCC
YLPITVSALPFVTPTYKR
EEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA