Click here to switch to the map view.

The map label for this gene is trpC [H]

Identifier: 209549416

GI number: 209549416

Start: 1869117

End: 1869929

Strand: Direct

Name: trpC [H]

Synonym: Rleg2_1822

Alternate gene names: 209549416

Gene position: 1869117-1869929 (Clockwise)

Preceding gene: 209549415

Following gene: 209549417

Centisome position: 41.19

GC content: 63.35

Gene sequence:

>813_bases
ATGAGCGATATTCTGAAGAAGATCGAACTTTACAAGCGCGAGGAAATCGCCGCCGCCAAGGCTGCGGTGTCGCTTGCCGA
CCTGAAGGCGATGCAGGCCGGCCAGTCCGCTCCGCGTGGTTTCTACAAGGCGCTCGTTGCCCAGCGTGACGCCGGCAATT
TCGGCCTGATCGCCGAGATCAAGAAGGCGAGCCCGTCCAAGGGCCTCATTCGCCCGGATTTCGATCCGCCGGCGCTGGCA
AAGGCTTACGAAGCCGGTGGCGCCGCCTGCCTTTCCGTGCTGACCGACACGCCGAGCTTTCAGGGTGCCCCGGAATTCCT
GACGACGGCACGGGACGCCTGTGCCCTGCCCGCTTTGCGCAAGGATTTCATGTTCGAGACCTATCAGGTCCATGAGGCGC
GCGCCTGGGGCGCCGACTGCATTCTGCTGATCATGGCGTCGCTGACCGATGACGAGGCCGAGCGGCTGCAGGACGAGGCC
TTCTCGCTCGGCATGGATGTGCTGGTCGAGGTTCACGATGCCGAGGAGATGGAGCGGGCGCTGAAGCTTTCCTCGCCGCT
CATCGGTATCAACAACCGCAATCTGCGGACCTTCGAGGTCAGCCTGACGGTCAGCGAGACGCTTGCCTCCATGGTTCCCG
CCGACCGACTCCTCATCGGCGAAAGCGGCATCTTCACCCATGCCGATTGCAAGCGTCTGCAGGCCGTCGATATCAGCACC
TTCCTTGTCGGCGAAAGCCTGATGCGAAAAGACGACGTAACGGCCGCCACCCGCGCGCTGCTCTTCGGCGAAGCCGCCAT
CGCGGCCGAATGA

Upstream 100 bases:

>100_bases
TGGCATGACGCTTGCCGCGCAGTCGCTCGATAGCGGTGCCACCGCGCTTGCCCTCGACAAACTCATCGCCGTTTCCAACG
ATATCGACTAGGATTGCCCG

Downstream 100 bases:

>100_bases
TATGAGCGGCGGAAAGCCCGGCCTCACGCATATCGATGCCTCCGGCGAGGCGCATATGGTCGATGTCTCCGACAAGGCCG
AGACGGTGCGCATCGCCACG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MSDILKKIELYKREEIAAAKAAVSLADLKAMQAGQSAPRGFYKALVAQRDAGNFGLIAEIKKASPSKGLIRPDFDPPALA
KAYEAGGAACLSVLTDTPSFQGAPEFLTTARDACALPALRKDFMFETYQVHEARAWGADCILLIMASLTDDEAERLQDEA
FSLGMDVLVEVHDAEEMERALKLSSPLIGINNRNLRTFEVSLTVSETLASMVPADRLLIGESGIFTHADCKRLQAVDIST
FLVGESLMRKDDVTAATRALLFGEAAIAAE

Sequences:

>Translated_270_residues
MSDILKKIELYKREEIAAAKAAVSLADLKAMQAGQSAPRGFYKALVAQRDAGNFGLIAEIKKASPSKGLIRPDFDPPALA
KAYEAGGAACLSVLTDTPSFQGAPEFLTTARDACALPALRKDFMFETYQVHEARAWGADCILLIMASLTDDEAERLQDEA
FSLGMDVLVEVHDAEEMERALKLSSPLIGINNRNLRTFEVSLTVSETLASMVPADRLLIGESGIFTHADCKRLQAVDIST
FLVGESLMRKDDVTAATRALLFGEAAIAAE
>Mature_269_residues
SDILKKIELYKREEIAAAKAAVSLADLKAMQAGQSAPRGFYKALVAQRDAGNFGLIAEIKKASPSKGLIRPDFDPPALAK
AYEAGGAACLSVLTDTPSFQGAPEFLTTARDACALPALRKDFMFETYQVHEARAWGADCILLIMASLTDDEAERLQDEAF
SLGMDVLVEVHDAEEMERALKLSSPLIGINNRNLRTFEVSLTVSETLASMVPADRLLIGESGIFTHADCKRLQAVDISTF
LVGESLMRKDDVTAATRALLFGEAAIAAE

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=267, Percent_Identity=40.4494382022472, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=206, Percent_Identity=38.8349514563107, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29129; Mature: 28997

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILKKIELYKREEIAAAKAAVSLADLKAMQAGQSAPRGFYKALVAQRDAGNFGLIAEI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEH
KKASPSKGLIRPDFDPPALAKAYEAGGAACLSVLTDTPSFQGAPEFLTTARDACALPALR
HHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KDFMFETYQVHEARAWGADCILLIMASLTDDEAERLQDEAFSLGMDVLVEVHDAEEMERA
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEECCHHHHHHH
LKLSSPLIGINNRNLRTFEVSLTVSETLASMVPADRLLIGESGIFTHADCKRLQAVDIST
HHHCCCEEECCCCCEEEEEEEEEHHHHHHHHCCCCCEEECCCCCEECHHHHHHHHCCHHH
FLVGESLMRKDDVTAATRALLFGEAAIAAE
HHHHHHHHHHCCHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
SDILKKIELYKREEIAAAKAAVSLADLKAMQAGQSAPRGFYKALVAQRDAGNFGLIAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEH
KKASPSKGLIRPDFDPPALAKAYEAGGAACLSVLTDTPSFQGAPEFLTTARDACALPALR
HHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KDFMFETYQVHEARAWGADCILLIMASLTDDEAERLQDEAFSLGMDVLVEVHDAEEMERA
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEECCHHHHHHH
LKLSSPLIGINNRNLRTFEVSLTVSETLASMVPADRLLIGESGIFTHADCKRLQAVDIST
HHHCCCEEECCCCCEEEEEEEEEHHHHHHHHCCCCCEEECCCCCEECHHHHHHHHCCHHH
FLVGESLMRKDDVTAATRALLFGEAAIAAE
HHHHHHHHHHCCHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA