Click here to switch to the map view.

The map label for this gene is ppi [H]

Identifier: 209549346

GI number: 209549346

Start: 1791353

End: 1791862

Strand: Direct

Name: ppi [H]

Synonym: Rleg2_1750

Alternate gene names: 209549346

Gene position: 1791353-1791862 (Clockwise)

Preceding gene: 209549345

Following gene: 209549347

Centisome position: 39.47

GC content: 60.2

Gene sequence:

>510_bases
ATGGCCGAGATCAAGGATCCCGAAAACACGATCATTCTGGAAACCACCAAGGGCAAGGTTGTCATTCAGCTTTTGCCGCA
GGTCGCCCCGGAGCATGTCGCCCGCATCAAGGAACTCGCCCGCGAAAAGGCCTATGACGGCGTCGTCTTCCACCGCGTCA
TCCAGGATTTCATGGCGCAGACGGGCGATGTCGAATTCGGCAAGAAGGGTTCGGAAACCTTCAATCCTGGCCGTGCCGGC
ATGGGCGGCTCCTCCAAGCCGGATCTGAAGGCTGAATTCTCCGCCACCACGCATACGCGCGGCACCTGCTCGATGGCCCG
TTCGCAGAACCCGAACTCGGCCAATTCGCAGTTCTTCATCTGCTTCACCGACGCGCCCTGGCTGAACAAGCAGTATTCCG
TCTGGGGCCAGGTCATCGAAGGCATGGACAACGTCGACAAGATCAAGCGCGGCGAGCCGGTTTCCGATCCGGACTCGATC
GTCTCGATGCGGGTTGCCGCCGACGTCTGA

Upstream 100 bases:

>100_bases
CGCGGCGAAGGCCAGAACGGCGAAGTCAAAAGTCCCGACCGGATGATCAAGGTCACCCTGGGCAAGAAGTAAGTTACGAG
AGAAACAAGAGGAGAAGACA

Downstream 100 bases:

>100_bases
TTGTGATTTCTGCTGAAACCCGCTCTTGCGCGTCAACCGCGTGGGGGCGGGTTTCGCTTTGCCTGAAAGTGCCGTTATGC
GCGTAGACCTTTTCGATTTC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MAEIKDPENTIILETTKGKVVIQLLPQVAPEHVARIKELAREKAYDGVVFHRVIQDFMAQTGDVEFGKKGSETFNPGRAG
MGGSSKPDLKAEFSATTHTRGTCSMARSQNPNSANSQFFICFTDAPWLNKQYSVWGQVIEGMDNVDKIKRGEPVSDPDSI
VSMRVAADV

Sequences:

>Translated_169_residues
MAEIKDPENTIILETTKGKVVIQLLPQVAPEHVARIKELAREKAYDGVVFHRVIQDFMAQTGDVEFGKKGSETFNPGRAG
MGGSSKPDLKAEFSATTHTRGTCSMARSQNPNSANSQFFICFTDAPWLNKQYSVWGQVIEGMDNVDKIKRGEPVSDPDSI
VSMRVAADV
>Mature_168_residues
AEIKDPENTIILETTKGKVVIQLLPQVAPEHVARIKELAREKAYDGVVFHRVIQDFMAQTGDVEFGKKGSETFNPGRAGM
GGSSKPDLKAEFSATTHTRGTCSMARSQNPNSANSQFFICFTDAPWLNKQYSVWGQVIEGMDNVDKIKRGEPVSDPDSIV
SMRVAADV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=145, Percent_Identity=31.7241379310345, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI24308049, Length=144, Percent_Identity=35.4166666666667, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706339, Length=152, Percent_Identity=32.8947368421053, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4505991, Length=135, Percent_Identity=36.2962962962963, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547215, Length=149, Percent_Identity=32.8859060402685, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI22547212, Length=149, Percent_Identity=32.8859060402685, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI7657473, Length=149, Percent_Identity=32.8859060402685, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI5031987, Length=135, Percent_Identity=36.2962962962963, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1786736, Length=147, Percent_Identity=38.0952380952381, Blast_Score=90, Evalue=7e-20,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=36.6197183098592, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=36.1111111111111, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=155, Percent_Identity=32.9032258064516, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=159, Percent_Identity=32.0754716981132, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506307, Length=143, Percent_Identity=34.965034965035, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=33.5664335664336, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=151, Percent_Identity=33.112582781457, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=138, Percent_Identity=35.5072463768116, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=154, Percent_Identity=29.8701298701299, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=142, Percent_Identity=30.9859154929577, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=152, Percent_Identity=33.5526315789474, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321848, Length=142, Percent_Identity=33.8028169014084, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=138, Percent_Identity=34.0579710144928, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322492, Length=192, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17986117, Length=189, Percent_Identity=32.2751322751323, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647301, Length=136, Percent_Identity=35.2941176470588, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45549139, Length=137, Percent_Identity=36.4963503649635, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664125, Length=151, Percent_Identity=33.7748344370861, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21357783, Length=151, Percent_Identity=33.7748344370861, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24652460, Length=145, Percent_Identity=33.1034482758621, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922912, Length=150, Percent_Identity=36, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18561; Mature: 18430

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKDPENTIILETTKGKVVIQLLPQVAPEHVARIKELAREKAYDGVVFHRVIQDFMAQ
CCCCCCCCCEEEEEECCCCEEEHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TGDVEFGKKGSETFNPGRAGMGGSSKPDLKAEFSATTHTRGTCSMARSQNPNSANSQFFI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHCCCCCCCCCEEEE
CFTDAPWLNKQYSVWGQVIEGMDNVDKIKRGEPVSDPDSIVSMRVAADV
EECCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AEIKDPENTIILETTKGKVVIQLLPQVAPEHVARIKELAREKAYDGVVFHRVIQDFMAQ
CCCCCCCCEEEEEECCCCEEEHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TGDVEFGKKGSETFNPGRAGMGGSSKPDLKAEFSATTHTRGTCSMARSQNPNSANSQFFI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHCCCCCCCCCEEEE
CFTDAPWLNKQYSVWGQVIEGMDNVDKIKRGEPVSDPDSIVSMRVAADV
EECCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA