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The map label for this gene is ppi [H]

Identifier: 209549345

GI number: 209549345

Start: 1790752

End: 1791324

Strand: Direct

Name: ppi [H]

Synonym: Rleg2_1749

Alternate gene names: 209549345

Gene position: 1790752-1791324 (Clockwise)

Preceding gene: 209549344

Following gene: 209549346

Centisome position: 39.46

GC content: 58.64

Gene sequence:

>573_bases
ATGAAACTCTTTTATCTCGCATTTGCCGGCGTGTTGTATCTCGCCTCCTTCGCGGGGGATGCCTTCGCCCAGTCAGCCGA
TCATTATCTCACCATCCAGTTGAAGAACGGCCCCGTCGTCATCCAACTGATGCCTGAGGTTGCGCCGAAGCATGTCGCCC
AGATCGAGGCGCTGGCCAAGAAGGGCGAATACGACAACGTCGCATTCCACCGCGTCATCGACGGCTTCATGGCCCAGACC
GGCGACGTCAAATACGGCAATATGGAAAAGGGTTTCGATGCGAGCCTCGCCGGCACCGGCTCCTCCGACATGCCGGATAT
TCCGGCCGAGTTCTCCAAGACCCCGTTCGTGCGCGGCACGGTCGGCATGGCCCGCTCGCAGGATCCGAATTCCGCCAATT
CGCAGTTCTTCATCATGTTCGCCGATGGCTCCTTCCTCAACGGCCAGTACACCGTTGTCGGCAAGGTCGTTTCCGGCATG
GAGAATGTCGACAAGATCAAGCGCGGCGAAGGCCAGAACGGCGAAGTCAAAAGTCCCGACCGGATGATCAAGGTCACCCT
GGGCAAGAAGTAA

Upstream 100 bases:

>100_bases
GCCCAGACTGACGAGTACAAGTCTAACAAGTACAAAGTCTGATAAGAACCAAGTCCAGCAAGCGCAAAGACCAGGCGGAA
CCCGCCGCAACGGAGCCCAC

Downstream 100 bases:

>100_bases
GTTACGAGAGAAACAAGAGGAGAAGACAATGGCCGAGATCAAGGATCCCGAAAACACGATCATTCTGGAAACCACCAAGG
GCAAGGTTGTCATTCAGCTT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKLFYLAFAGVLYLASFAGDAFAQSADHYLTIQLKNGPVVIQLMPEVAPKHVAQIEALAKKGEYDNVAFHRVIDGFMAQT
GDVKYGNMEKGFDASLAGTGSSDMPDIPAEFSKTPFVRGTVGMARSQDPNSANSQFFIMFADGSFLNGQYTVVGKVVSGM
ENVDKIKRGEGQNGEVKSPDRMIKVTLGKK

Sequences:

>Translated_190_residues
MKLFYLAFAGVLYLASFAGDAFAQSADHYLTIQLKNGPVVIQLMPEVAPKHVAQIEALAKKGEYDNVAFHRVIDGFMAQT
GDVKYGNMEKGFDASLAGTGSSDMPDIPAEFSKTPFVRGTVGMARSQDPNSANSQFFIMFADGSFLNGQYTVVGKVVSGM
ENVDKIKRGEGQNGEVKSPDRMIKVTLGKK
>Mature_190_residues
MKLFYLAFAGVLYLASFAGDAFAQSADHYLTIQLKNGPVVIQLMPEVAPKHVAQIEALAKKGEYDNVAFHRVIDGFMAQT
GDVKYGNMEKGFDASLAGTGSSDMPDIPAEFSKTPFVRGTVGMARSQDPNSANSQFFIMFADGSFLNGQYTVVGKVVSGM
ENVDKIKRGEGQNGEVKSPDRMIKVTLGKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=139, Percent_Identity=35.9712230215827, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1786736, Length=146, Percent_Identity=35.6164383561644, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1789763, Length=167, Percent_Identity=34.1317365269461, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=138, Percent_Identity=32.6086956521739, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980594, Length=138, Percent_Identity=32.6086956521739, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=144, Percent_Identity=32.6388888888889, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=145, Percent_Identity=31.7241379310345, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17552780, Length=134, Percent_Identity=35.8208955223881, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=33.7423312883436, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=28.9156626506024, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136360, Length=167, Percent_Identity=28.7425149700599, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20543; Mature: 20543

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFYLAFAGVLYLASFAGDAFAQSADHYLTIQLKNGPVVIQLMPEVAPKHVAQIEALAK
CEEHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHH
KGEYDNVAFHRVIDGFMAQTGDVKYGNMEKGFDASLAGTGSSDMPDIPAEFSKTPFVRGT
CCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCEECCCCCCCCCCCCCHHCCCCEEEEC
VGMARSQDPNSANSQFFIMFADGSFLNGQYTVVGKVVSGMENVDKIKRGEGQNGEVKSPD
CCCCCCCCCCCCCCEEEEEEECCCEECCEEEEHHHHHHCHHHHHHHHCCCCCCCCCCCCC
RMIKVTLGKK
EEEEEEECCC
>Mature Secondary Structure
MKLFYLAFAGVLYLASFAGDAFAQSADHYLTIQLKNGPVVIQLMPEVAPKHVAQIEALAK
CEEHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHH
KGEYDNVAFHRVIDGFMAQTGDVKYGNMEKGFDASLAGTGSSDMPDIPAEFSKTPFVRGT
CCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCEECCCCCCCCCCCCCHHCCCCEEEEC
VGMARSQDPNSANSQFFIMFADGSFLNGQYTVVGKVVSGMENVDKIKRGEGQNGEVKSPD
CCCCCCCCCCCCCCEEEEEEECCCEECCEEEEHHHHHHCHHHHHHHHCCCCCCCCCCCCC
RMIKVTLGKK
EEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA