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The map label for this gene is pdhA [H]

Identifier: 209549202

GI number: 209549202

Start: 1630116

End: 1631162

Strand: Direct

Name: pdhA [H]

Synonym: Rleg2_1603

Alternate gene names: 209549202

Gene position: 1630116-1631162 (Clockwise)

Preceding gene: 209549201

Following gene: 209549203

Centisome position: 35.92

GC content: 62.08

Gene sequence:

>1047_bases
ATGGCGCCGCGAAAGACCGCGACCGTTTCCAGCCGCAAAACTGCAGCGAAACCGGCAGCCAAGGCATCGAATGGAGGCCC
GGTAGCCGACTTCGATCGCGATGAGGAGCTCAAGGCCTATCGCGAGATGCTGCTGATCCGCCGCTTCGAGGAGAAGGCCG
GCCAGCTTTACGGCATGGGCTTCATCGGCGGCTTTTGCCACCTTTACATCGGTCAGGAAGCTGTCGTCGTCGGCATGCAG
ATGGCGCAGAAGGAAGGCGACCAGGTCATCACCGCCTATCGCGATCACGGCCACATGCTGGCAACCGGCATGGAAGCGCG
CGGCGTCATGGCGGAGTTGACCGGCCGCCGCAGCGGCTATTCCCACGGGAAGGGCGGCTCGATGCACATGTTCTCGAAAG
AGAAGCATTTCTACGGCGGCCACGGCATCGTCGGCGCCCAGGTTTCGCTCGGAACCGGTCTTGCCTTTGCAAACCATTAC
CGCGGCAACGGCAATGTCTCGATTGCCTATTTCGGCGATGGCGCCGCCAACCAGGGCCAGGTCTACGAGAGCTTCAACAT
GGCGGCTCTCTGGAAGCTGCCGATCGTCTATATCGTCGAAAACAACCGTTACGCCATGGGCACCTCGACGGCACGCGCCA
CCGCGCAGTCGAACTACTCGCTGCGCGGCTCCGGCTTCGGCATTCCCGGCATCCAGGTCGACGGCATGGACGTTCGCGCC
GTCAAGGCGGCCGCTGACGAGGCGCTCGAACATTGCCGCTCCGGCAAGGGTCCGATCATCCTCGAAATGCTGACCTATCG
TTATCGCGGTCACTCCATGTCGGATCCGGCGAAATATCGCTCGAAGGAAGAAGTGCAGAAGATGCGCTCCGAGCAGGACC
CGATCGAGCAGGTCAAGGCGCGCCTCATCGAAAAGGGTTGGGCCTCGGAAGACGATCTGAAGGCGATCGACAAGGATATC
CGCGACATCGTCGCCGACAGCGCCGACTTCGCCCAGGCCGATCCGGAGCCGGATGCATCCGCGCTCTACACCGACATTCT
GCTCTAA

Upstream 100 bases:

>100_bases
AGCACCGAATACGAGCCATGCAATTATGGCATTGCTGTGGTCTTATTTCTTCCCTAAGGTACGCGCCACCGAGAAACGAC
AAACCCATAGGGAGGGTTGA

Downstream 100 bases:

>100_bases
TCGGGGAGGGAACCCATGCCTATCGATATCCTCATGCCCGCCCTCTCTCCGACCATGGAAGAAGGCACGCTGTCCAAATG
GCTGAAGCAGGAAGGTGACA

Product: pyruvate dehydrogenase (acetyl-transferring) E1 component, subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MAPRKTATVSSRKTAAKPAAKASNGGPVADFDRDEELKAYREMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQ
MAQKEGDQVITAYRDHGHMLATGMEARGVMAELTGRRSGYSHGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANHY
RGNGNVSIAYFGDGAANQGQVYESFNMAALWKLPIVYIVENNRYAMGTSTARATAQSNYSLRGSGFGIPGIQVDGMDVRA
VKAAADEALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEQDPIEQVKARLIEKGWASEDDLKAIDKDI
RDIVADSADFAQADPEPDASALYTDILL

Sequences:

>Translated_348_residues
MAPRKTATVSSRKTAAKPAAKASNGGPVADFDRDEELKAYREMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQ
MAQKEGDQVITAYRDHGHMLATGMEARGVMAELTGRRSGYSHGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANHY
RGNGNVSIAYFGDGAANQGQVYESFNMAALWKLPIVYIVENNRYAMGTSTARATAQSNYSLRGSGFGIPGIQVDGMDVRA
VKAAADEALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEQDPIEQVKARLIEKGWASEDDLKAIDKDI
RDIVADSADFAQADPEPDASALYTDILL
>Mature_347_residues
APRKTATVSSRKTAAKPAAKASNGGPVADFDRDEELKAYREMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQM
AQKEGDQVITAYRDHGHMLATGMEARGVMAELTGRRSGYSHGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANHYR
GNGNVSIAYFGDGAANQGQVYESFNMAALWKLPIVYIVENNRYAMGTSTARATAQSNYSLRGSGFGIPGIQVDGMDVRAV
KAAADEALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEQDPIEQVKARLIEKGWASEDDLKAIDKDIR
DIVADSADFAQADPEPDASALYTDILL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=320, Percent_Identity=53.4375, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI291084742, Length=324, Percent_Identity=52.1604938271605, Blast_Score=325, Evalue=3e-89,
Organism=Homo sapiens, GI4505685, Length=324, Percent_Identity=52.1604938271605, Blast_Score=325, Evalue=3e-89,
Organism=Homo sapiens, GI291084744, Length=331, Percent_Identity=51.0574018126888, Blast_Score=318, Evalue=3e-87,
Organism=Homo sapiens, GI291084757, Length=324, Percent_Identity=47.2222222222222, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI11386135, Length=315, Percent_Identity=31.4285714285714, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI258645172, Length=315, Percent_Identity=31.4285714285714, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI32564172, Length=345, Percent_Identity=50.4347826086956, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17536047, Length=317, Percent_Identity=52.6813880126183, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI86563357, Length=352, Percent_Identity=30.1136363636364, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI86563355, Length=352, Percent_Identity=30.1136363636364, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321026, Length=315, Percent_Identity=50.1587301587302, Blast_Score=318, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24639744, Length=324, Percent_Identity=49.6913580246914, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI28571106, Length=324, Percent_Identity=49.6913580246914, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24639740, Length=324, Percent_Identity=49.6913580246914, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=50.8196721311475, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24639748, Length=324, Percent_Identity=50, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI21355903, Length=327, Percent_Identity=28.7461773700306, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37940; Mature: 37809

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRKTATVSSRKTAAKPAAKASNGGPVADFDRDEELKAYREMLLIRRFEEKAGQLYGMG
CCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEH
FIGGFCHLYIGQEAVVVGMQMAQKEGDQVITAYRDHGHMLATGMEARGVMAELTGRRSGY
HHHHHHHEEECCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCHHHHHHCCCCCC
SHGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANHYRGNGNVSIAYFGDGAANQGQ
CCCCCCCEEEEECCCCEECCCCEEEEEEECCCCCHHHHEECCCCCEEEEEECCCCCCCCC
VYESFNMAALWKLPIVYIVENNRYAMGTSTARATAQSNYSLRGSGFGIPGIQVDGMDVRA
HHHCCCCEEEEECCEEEEEECCEEEECCCHHHHHHCCCCEECCCCCCCCCEEECCCCHHH
VKAAADEALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEQDPIEQVKA
HHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHH
RLIEKGWASEDDLKAIDKDIRDIVADSADFAQADPEPDASALYTDILL
HHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
APRKTATVSSRKTAAKPAAKASNGGPVADFDRDEELKAYREMLLIRRFEEKAGQLYGMG
CCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEH
FIGGFCHLYIGQEAVVVGMQMAQKEGDQVITAYRDHGHMLATGMEARGVMAELTGRRSGY
HHHHHHHEEECCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCHHHHHHCCCCCC
SHGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANHYRGNGNVSIAYFGDGAANQGQ
CCCCCCCEEEEECCCCEECCCCEEEEEEECCCCCHHHHEECCCCCEEEEEECCCCCCCCC
VYESFNMAALWKLPIVYIVENNRYAMGTSTARATAQSNYSLRGSGFGIPGIQVDGMDVRA
HHHCCCCEEEEECCEEEEEECCEEEECCCHHHHHHCCCCEECCCCCCCCCEEECCCCHHH
VKAAADEALEHCRSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEQDPIEQVKA
HHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHH
RLIEKGWASEDDLKAIDKDIRDIVADSADFAQADPEPDASALYTDILL
HHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]