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The map label for this gene is hom [H]

Identifier: 209549144

GI number: 209549144

Start: 1569994

End: 1571319

Strand: Direct

Name: hom [H]

Synonym: Rleg2_1545

Alternate gene names: 209549144

Gene position: 1569994-1571319 (Clockwise)

Preceding gene: 209549143

Following gene: 209549145

Centisome position: 34.6

GC content: 61.92

Gene sequence:

>1326_bases
ATGGCAGATGCCCTCAAAATCGGCATTGCGGGCTTGGGCACCGTTGGCGCCTCGCTAGTCCGCATCATTCAGCAGAAGAG
CAACGAGCTTGCCGTCACCTGCGGGCGTCCGATCACCATCACGGCGGTCTCCGCGCGTGACAAAACGAGAGACCGCGGTA
TCGATCTTTCCGCTGTCACCTGGTTCGATCGGCCGGAAGATCTTGCCGAAAAGGGCGATATCGACGTCTTCGTCGAGCTG
ATGGGCGGCGCCGAAGGAGCTGCCAACACCTCCGTACGCGCCGCACTTAAGCGTGGTCTCCACGTGGTGACAGCCAACAA
GGCGCTGCTTGCCTATCACGGCGTCGAGCTTGCGACGATTGCCGAGGAGAAGGGCGCGCTTCTAAACTTCGAGGCCGCGG
TGGCCGGCGGCATCCCGGTCATCAAGGCGCTGCGCGAATCGCTGACCGGCAATGCCGTCTCGCGCATCTATGGCATCATG
AACGGCACCTGCAATTACATCCTGACCAAGATGGAAAAGGAGGGGCTTTCCTTCGCCGAGTGCCTGAAGGAAGCCCAGCG
GCTGGGTTATGCCGAGGCCGATCCGGCCTTCGACATCGAGGGCAACGACACCGCCCATAAGCTTTCCATCCTGACGACGC
TCGCCTTCGGCAATCGCATCGCGGCCGACGATATCTATCTCGAAGGCATCACCAACATCTCGATCGAGGATATCCACGCC
GCCGCCGAGCTCGGTTATCGTATCAAGCTCCTGGGCGTTGCCCAGCGCACCGACACCGGCATCGAGCAGCGCGTGCATCC
GACCATGGTGCCGGTCGATTCGGTCATTGCCCAGGTCGACGGCGTTACCAATGCGGTGGCGATCGAATCCGACGTGCTCG
GCGAACTGCTGATGGTCGGTCCCGGCGCCGGCGGCAATTCGACGGCCTCGTCCGTACTGGGCGATATCGCCGATATCGCC
AAAAGCCAGCCGGGCGCACAACGCGTGCCGGTGCTCGGCCATCCCGCAAAAGCGCTGGAACCCTACCGCAAGGCGCAGAT
GCAGAGCCACGAGGGCGGCTACTTTATCCGCCTGACCGTGCTCGACCGCACGGGCGTCTTTGCCAGCGTTGCAACCCGCA
TGGCGGAAAACAACATCTCGTTGGAATCGATCGTCCAGCGCTCCAAGCAACATCTGGCGCCGTCGCACCACCAGACGATC
ATTCTCGTCACCCATGCGACGATGGAAGAGTCGGTGCGCAAGGCGGTCGCCTCGATCAAGTCGGAAGGCTATCTCTTCGG
CGAACCGCAGGTGATTCGTATCGAGCGGCCGAAAGAAGACGCTTAA

Upstream 100 bases:

>100_bases
ACGATGCACAACGTCATTTCGCTGAACGCGCACCGTTAATCCAACTCCTAAGGCAGCCGCGTCCTGCGGCTGCCGCCACA
CAGACATTCAGGATCGATCC

Downstream 100 bases:

>100_bases
GCTTTTACAGCCGGCGAATATCAGCCGCCCTGTCTTGTTGAACTGGCAGTTCAACAAGACAGGGCGTTTTTTGTTGATCG
TCCGGGCTCCCCTTACGGAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MADALKIGIAGLGTVGASLVRIIQQKSNELAVTCGRPITITAVSARDKTRDRGIDLSAVTWFDRPEDLAEKGDIDVFVEL
MGGAEGAANTSVRAALKRGLHVVTANKALLAYHGVELATIAEEKGALLNFEAAVAGGIPVIKALRESLTGNAVSRIYGIM
NGTCNYILTKMEKEGLSFAECLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNRIAADDIYLEGITNISIEDIHA
AAELGYRIKLLGVAQRTDTGIEQRVHPTMVPVDSVIAQVDGVTNAVAIESDVLGELLMVGPGAGGNSTASSVLGDIADIA
KSQPGAQRVPVLGHPAKALEPYRKAQMQSHEGGYFIRLTVLDRTGVFASVATRMAENNISLESIVQRSKQHLAPSHHQTI
ILVTHATMEESVRKAVASIKSEGYLFGEPQVIRIERPKEDA

Sequences:

>Translated_441_residues
MADALKIGIAGLGTVGASLVRIIQQKSNELAVTCGRPITITAVSARDKTRDRGIDLSAVTWFDRPEDLAEKGDIDVFVEL
MGGAEGAANTSVRAALKRGLHVVTANKALLAYHGVELATIAEEKGALLNFEAAVAGGIPVIKALRESLTGNAVSRIYGIM
NGTCNYILTKMEKEGLSFAECLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNRIAADDIYLEGITNISIEDIHA
AAELGYRIKLLGVAQRTDTGIEQRVHPTMVPVDSVIAQVDGVTNAVAIESDVLGELLMVGPGAGGNSTASSVLGDIADIA
KSQPGAQRVPVLGHPAKALEPYRKAQMQSHEGGYFIRLTVLDRTGVFASVATRMAENNISLESIVQRSKQHLAPSHHQTI
ILVTHATMEESVRKAVASIKSEGYLFGEPQVIRIERPKEDA
>Mature_440_residues
ADALKIGIAGLGTVGASLVRIIQQKSNELAVTCGRPITITAVSARDKTRDRGIDLSAVTWFDRPEDLAEKGDIDVFVELM
GGAEGAANTSVRAALKRGLHVVTANKALLAYHGVELATIAEEKGALLNFEAAVAGGIPVIKALRESLTGNAVSRIYGIMN
GTCNYILTKMEKEGLSFAECLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNRIAADDIYLEGITNISIEDIHAA
AELGYRIKLLGVAQRTDTGIEQRVHPTMVPVDSVIAQVDGVTNAVAIESDVLGELLMVGPGAGGNSTASSVLGDIADIAK
SQPGAQRVPVLGHPAKALEPYRKAQMQSHEGGYFIRLTVLDRTGVFASVATRMAENNISLESIVQRSKQHLAPSHHQTII
LVTHATMEESVRKAVASIKSEGYLFGEPQVIRIERPKEDA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=247, Percent_Identity=31.1740890688259, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790376, Length=359, Percent_Identity=23.9554317548747, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=122, Percent_Identity=31.9672131147541, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46920; Mature: 46789

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADALKIGIAGLGTVGASLVRIIQQKSNELAVTCGRPITITAVSARDKTRDRGIDLSAVT
CCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHCCCCEEEEE
WFDRPEDLAEKGDIDVFVELMGGAEGAANTSVRAALKRGLHVVTANKALLAYHGVELATI
ECCCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEECCEEEEECCCEEEEE
AEEKGALLNFEAAVAGGIPVIKALRESLTGNAVSRIYGIMNGTCNYILTKMEKEGLSFAE
HHCCCCEEEEHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH
CLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNRIAADDIYLEGITNISIEDIHA
HHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCEEECCCEEEECCCCCCHHHHHH
AAELGYRIKLLGVAQRTDTGIEQRVHPTMVPVDSVIAQVDGVTNAVAIESDVLGELLMVG
HHHCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHHHHCCCCCEEEECHHHHCCEEEEC
PGAGGNSTASSVLGDIADIAKSQPGAQRVPVLGHPAKALEPYRKAQMQSHEGGYFIRLTV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
LDRTGVFASVATRMAENNISLESIVQRSKQHLAPSHHQTIILVTHATMEESVRKAVASIK
EECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHH
SEGYLFGEPQVIRIERPKEDA
CCCEEECCCEEEEEECCCCCC
>Mature Secondary Structure 
ADALKIGIAGLGTVGASLVRIIQQKSNELAVTCGRPITITAVSARDKTRDRGIDLSAVT
CCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHCCCCEEEEE
WFDRPEDLAEKGDIDVFVELMGGAEGAANTSVRAALKRGLHVVTANKALLAYHGVELATI
ECCCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEECCEEEEECCCEEEEE
AEEKGALLNFEAAVAGGIPVIKALRESLTGNAVSRIYGIMNGTCNYILTKMEKEGLSFAE
HHCCCCEEEEHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH
CLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNRIAADDIYLEGITNISIEDIHA
HHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCEEECCCEEEECCCCCCHHHHHH
AAELGYRIKLLGVAQRTDTGIEQRVHPTMVPVDSVIAQVDGVTNAVAIESDVLGELLMVG
HHHCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHHHHCCCCCEEEECHHHHCCEEEEC
PGAGGNSTASSVLGDIADIAKSQPGAQRVPVLGHPAKALEPYRKAQMQSHEGGYFIRLTV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
LDRTGVFASVATRMAENNISLESIVQRSKQHLAPSHHQTIILVTHATMEESVRKAVASIK
EECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHH
SEGYLFGEPQVIRIERPKEDA
CCCEEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]