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The map label for this gene is sthA [H]

Identifier: 209549110

GI number: 209549110

Start: 1541979

End: 1543388

Strand: Reverse

Name: sthA [H]

Synonym: Rleg2_1509

Alternate gene names: 209549110

Gene position: 1543388-1541979 (Counterclockwise)

Preceding gene: 209549111

Following gene: 209549109

Centisome position: 34.01

GC content: 62.48

Gene sequence:

>1410_bases
ATGATGCTTCAGTACGATCTTGTTGTGGTGGGCAGCGGTCCCGCGGGGCGCCGCGGCGCGATCCAGGCTGCGAAACTCGG
CAAGAAAGTGCTTGTCATCGAGCAGGGCAAACGCGTCGGCGGCGTCTCCGTGCATACCGGCACCATTCCTTCCAAAACGC
TGCGCGAGACCGCGCTCAATCTCTCCGGCTGGCGCGAACGCGGCTTCTACGGCCGGTCTTACCGCGTCAAGGAAGAGATC
AGCGCGGATGACCTGCGCCGCCGCCTGCTGATCACGCTCAACCACGAGGTCGAGGTGCTGGAACACCAGTTCGCCCGCAA
CCGCGTGCAGCATATTCGCGGCAAGGCGAGCTTCATCAATCCGTCGACGCTGCAGGTGATCAAGGATGACGGCGAGATCA
CCCAGGTCACCGGCGCCAGCGTGCTGCTTGCCGTCGGCACGAAACCGTTCCGCCCCGATTACATACCCTTCGACGGCAAG
ACCGTTCTCGACAGCGACGAGTTGCTCGATATCCAGGAGCTGCCGCGCTCGATGGTCGTTATCGGCGCCGGCGTCATCGG
CATCGAATATGCGACAATCTTCAGCGCGCTCGACACGGCCGTGACCGTGATCGATCCGAAGGCGACGATGCTCGACTTCA
TCGACAAGGAAATCGTCGAGGATTTCACCTACCAGCTGCGCGACCGCAACATGAAGCTGCTGCTTGGCCAGAAGGCCGAC
AAGGTGGAGACGCTCGAGGGCGGCAAGGTCGAACTGACGCTCGACAGCGGCCGCCGCCTGACGACCGACATGGTGCTGTT
TGCCGCCGGCCGCATGGGCGCGACCGATGCGCTGAACCTTCCGGCCATCGGCCTCGAAGCCGACAGCCGCGGCCGCCTCA
AGGTCAATCCGGAAACATTCCAGACGTCGGTTGCCAATGTCTATGCCGCCGGCGACGTCGTCGGCTTTCCGAGCCTTGCC
TCGACCTCGATGGAACAGGGCCGCATCGCCGCCCGCGTCGCGATCGGCGCGGTTGCCAAGGAGCCGCCGAAATATTTCCC
CTACGGCATCTATGCCGTGCCGGAGATTTCCACCTGCGGCCTGACCGAAGAGGAGATGAAGGAGCGCGGCATTCCCTATG
AATGCGGCATCGCCCGTTTCCGCGAAACCTCGCGCGGTCATATCATGGGCCTCGACACCGGGCTTTTGAAGCTGATCTTC
TCGCTGAAGACACGCCGCCTGCTCGGCGTGCATATCGTCGGCGAAGGCGCCACCGAGCTGGTGCATATCGGCCAGGCGGT
GCTCAATCTCAAAGGCACGGTCGAATATTTCGTCGAAAATACCTTCAACTATCCGACGCTTGCCGAAGCCTACAAGATCG
CCGGCCTCGACGCCTGGAACCGGATGGGCGACATCAAGTCGGAACTTTAG

Upstream 100 bases:

>100_bases
TGAAACGGCACTTGTAAAACAATCTGTAACATTGACCGGCTACCGATAGACGGGCGACATCTTTGCGTCGCAAATGATTC
CATTTCCAATCCGGGGCCAG

Downstream 100 bases:

>100_bases
AACGCATCCCGGACGACAGAGCTGTCGACTCGATCCGGCCGTCCAAAAACGGAGCCGAACGACATTGCGCATCATTTCGC
TCAACGCCTGGGGCGGCAGG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MMLQYDLVVVGSGPAGRRGAIQAAKLGKKVLVIEQGKRVGGVSVHTGTIPSKTLRETALNLSGWRERGFYGRSYRVKEEI
SADDLRRRLLITLNHEVEVLEHQFARNRVQHIRGKASFINPSTLQVIKDDGEITQVTGASVLLAVGTKPFRPDYIPFDGK
TVLDSDELLDIQELPRSMVVIGAGVIGIEYATIFSALDTAVTVIDPKATMLDFIDKEIVEDFTYQLRDRNMKLLLGQKAD
KVETLEGGKVELTLDSGRRLTTDMVLFAAGRMGATDALNLPAIGLEADSRGRLKVNPETFQTSVANVYAAGDVVGFPSLA
STSMEQGRIAARVAIGAVAKEPPKYFPYGIYAVPEISTCGLTEEEMKERGIPYECGIARFRETSRGHIMGLDTGLLKLIF
SLKTRRLLGVHIVGEGATELVHIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGDIKSEL

Sequences:

>Translated_469_residues
MMLQYDLVVVGSGPAGRRGAIQAAKLGKKVLVIEQGKRVGGVSVHTGTIPSKTLRETALNLSGWRERGFYGRSYRVKEEI
SADDLRRRLLITLNHEVEVLEHQFARNRVQHIRGKASFINPSTLQVIKDDGEITQVTGASVLLAVGTKPFRPDYIPFDGK
TVLDSDELLDIQELPRSMVVIGAGVIGIEYATIFSALDTAVTVIDPKATMLDFIDKEIVEDFTYQLRDRNMKLLLGQKAD
KVETLEGGKVELTLDSGRRLTTDMVLFAAGRMGATDALNLPAIGLEADSRGRLKVNPETFQTSVANVYAAGDVVGFPSLA
STSMEQGRIAARVAIGAVAKEPPKYFPYGIYAVPEISTCGLTEEEMKERGIPYECGIARFRETSRGHIMGLDTGLLKLIF
SLKTRRLLGVHIVGEGATELVHIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGDIKSEL
>Mature_469_residues
MMLQYDLVVVGSGPAGRRGAIQAAKLGKKVLVIEQGKRVGGVSVHTGTIPSKTLRETALNLSGWRERGFYGRSYRVKEEI
SADDLRRRLLITLNHEVEVLEHQFARNRVQHIRGKASFINPSTLQVIKDDGEITQVTGASVLLAVGTKPFRPDYIPFDGK
TVLDSDELLDIQELPRSMVVIGAGVIGIEYATIFSALDTAVTVIDPKATMLDFIDKEIVEDFTYQLRDRNMKLLLGQKAD
KVETLEGGKVELTLDSGRRLTTDMVLFAAGRMGATDALNLPAIGLEADSRGRLKVNPETFQTSVANVYAAGDVVGFPSLA
STSMEQGRIAARVAIGAVAKEPPKYFPYGIYAVPEISTCGLTEEEMKERGIPYECGIARFRETSRGHIMGLDTGLLKLIF
SLKTRRLLGVHIVGEGATELVHIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGDIKSEL

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=31.317494600432, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=27.1948608137045, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI291045266, Length=494, Percent_Identity=26.7206477732794, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI22035672, Length=390, Percent_Identity=27.1794871794872, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI33519430, Length=483, Percent_Identity=24.4306418219462, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI33519428, Length=483, Percent_Identity=24.4306418219462, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI33519426, Length=483, Percent_Identity=24.4306418219462, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI148277065, Length=483, Percent_Identity=24.4306418219462, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI148277071, Length=483, Percent_Identity=24.4306418219462, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI291045268, Length=359, Percent_Identity=27.0194986072423, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI87082354, Length=469, Percent_Identity=39.4456289978678, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=29.9126637554585, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=27.1334792122538, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1789915, Length=443, Percent_Identity=26.410835214447, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=30.0653594771242, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=23.3820459290188, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71983429, Length=358, Percent_Identity=27.0949720670391, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71983419, Length=358, Percent_Identity=26.8156424581006, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982272, Length=491, Percent_Identity=25.4582484725051, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=27.1186440677966, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=24.6808510638298, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=24.8936170212766, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=30.5555555555556, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24640553, Length=487, Percent_Identity=27.5154004106776, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24640549, Length=487, Percent_Identity=27.5154004106776, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24640551, Length=487, Percent_Identity=27.5154004106776, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 51361; Mature: 51361

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLQYDLVVVGSGPAGRRGAIQAAKLGKKVLVIEQGKRVGGVSVHTGTIPSKTLRETALN
CEEEEEEEEEECCCCCCCCCHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHCC
LSGWRERGFYGRSYRVKEEISADDLRRRLLITLNHEVEVLEHQFARNRVQHIRGKASFIN
CCCHHHCCCCCCCEEEHHHCCHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
PSTLQVIKDDGEITQVTGASVLLAVGTKPFRPDYIPFDGKTVLDSDELLDIQELPRSMVV
CCEEEEEECCCCEEEECCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHCCCEEEE
IGAGVIGIEYATIFSALDTAVTVIDPKATMLDFIDKEIVEDFTYQLRDRNMKLLLGQKAD
EECCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
KVETLEGGKVELTLDSGRRLTTDMVLFAAGRMGATDALNLPAIGLEADSRGRLKVNPETF
CEEECCCCEEEEEECCCCEEEHHEEEEECCCCCCCCCCCCCEEEECCCCCCCEEECHHHH
QTSVANVYAAGDVVGFPSLASTSMEQGRIAARVAIGAVAKEPPKYFPYGIYAVPEISTCG
HHHHHHEEECCCCCCCCCHHHCCHHCCCEEEHHHHHHHHCCCCCCCCCCEEECCCCCCCC
LTEEEMKERGIPYECGIARFRETSRGHIMGLDTGLLKLIFSLKTRRLLGVHIVGEGATEL
CCHHHHHHCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCEEEEEEEECCCHHHH
VHIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGDIKSEL
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCHHHHHHCCHHHCC
>Mature Secondary Structure
MMLQYDLVVVGSGPAGRRGAIQAAKLGKKVLVIEQGKRVGGVSVHTGTIPSKTLRETALN
CEEEEEEEEEECCCCCCCCCHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHCC
LSGWRERGFYGRSYRVKEEISADDLRRRLLITLNHEVEVLEHQFARNRVQHIRGKASFIN
CCCHHHCCCCCCCEEEHHHCCHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
PSTLQVIKDDGEITQVTGASVLLAVGTKPFRPDYIPFDGKTVLDSDELLDIQELPRSMVV
CCEEEEEECCCCEEEECCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHCCCEEEE
IGAGVIGIEYATIFSALDTAVTVIDPKATMLDFIDKEIVEDFTYQLRDRNMKLLLGQKAD
EECCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
KVETLEGGKVELTLDSGRRLTTDMVLFAAGRMGATDALNLPAIGLEADSRGRLKVNPETF
CEEECCCCEEEEEECCCCEEEHHEEEEECCCCCCCCCCCCCEEEECCCCCCCEEECHHHH
QTSVANVYAAGDVVGFPSLASTSMEQGRIAARVAIGAVAKEPPKYFPYGIYAVPEISTCG
HHHHHHEEECCCCCCCCCHHHCCHHCCCEEEHHHHHHHHCCCCCCCCCCEEECCCCCCCC
LTEEEMKERGIPYECGIARFRETSRGHIMGLDTGLLKLIFSLKTRRLLGVHIVGEGATEL
CCHHHHHHCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCEEEEEEEECCCHHHH
VHIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGDIKSEL
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]