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The map label for this gene is rmlA [H]

Identifier: 209548784

GI number: 209548784

Start: 1192209

End: 1193078

Strand: Reverse

Name: rmlA [H]

Synonym: Rleg2_1181

Alternate gene names: 209548784

Gene position: 1193078-1192209 (Counterclockwise)

Preceding gene: 209548785

Following gene: 209548778

Centisome position: 26.29

GC content: 60.69

Gene sequence:

>870_bases
ATGAAGGGCATTATTCTCGCCGGCGGCACGGGCACACGTCTGCATCCGATCACCCAGGCGGTCTCGAAACAGTTGATGCC
GGTCTACGACAAGCCGATGATCTATTATCCGCTGACGACGCTCATGCTCGCCGGCATCAGGGAGTTGCTGATCATCACCA
CGCCTCACGACGTCGAAGCCTTCAAGCGCCTTCTCGGCGACGGATCGCAATGGGGAATTTCGCTGACCTATGCGGTACAG
CCGAGCCCGGACGGCCTTGCCCAGGCCTTCATCATCGGCGCCGACTTCGTGCACGGCGACAGCTCCGCCCTCGTCCTCGG
CGACAACATCTTCTACGGGCACGGACTGCCGGAAATCATGAAATCCGGCACGAGCCGGCGGGAAGGCGCAACGGTGTTCG
CCTATCACGTCACCGATCCGGAACGCTATGGCGTTGTCGGCTTTGACAAAAAGATGAATGCGCTGTCGATCGAGGAGAAA
CCGAAGCAGCCAAAATCGAACTGGGCGGTGACCGGCCTCTATTTCTACGACCAGCAGGTGGTCGATATCGCCGCCAACCT
GAAGCCGTCACCGCGCGGCGAATTGGAAATCACCGATGTCAACCGCACCTATCTTGAGCGCGGCCAGCTTTTCGTGGAGC
TGATGGGCCGGGGTTATGCCTGGCTCGACACCGGCACACCAGACAGCCTGCACGATGCCGCAGGTTTCGTCAGCACGCTG
GAGAAACGCCAGGGCTTCAAGATCGCCTGCCCCGAAGAAGTCGCCTGGCGCATGGGTTACATCTCGCAGGACGACCTCGC
CAAGCTCGCGGAGAAGCTCGGCAAGAGCGCCTATGGCCAGTACCTGACGAAGCTCTCCCCGGATTGGTGA

Upstream 100 bases:

>100_bases
AAGCTCGCCAGAACATATGGACTCCGGCTCCCGGAGTGGAAGCAGTCCATGACGATTGTCATGCAAGACCTTTTGAACAA
GGGTCTTTAAGGAGATGGGC

Downstream 100 bases:

>100_bases
GCGACTTGTGACCTTGGAAACCGCTACAGGTTTTCGATTCAGGCGCTCGGGAATTCCGCCAGCCGGGCGGCGTAACGCGC
CATGGTGTCGACTTCGAAAT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKGIILAGGTGTRLHPITQAVSKQLMPVYDKPMIYYPLTTLMLAGIRELLIITTPHDVEAFKRLLGDGSQWGISLTYAVQ
PSPDGLAQAFIIGADFVHGDSSALVLGDNIFYGHGLPEIMKSGTSRREGATVFAYHVTDPERYGVVGFDKKMNALSIEEK
PKQPKSNWAVTGLYFYDQQVVDIAANLKPSPRGELEITDVNRTYLERGQLFVELMGRGYAWLDTGTPDSLHDAAGFVSTL
EKRQGFKIACPEEVAWRMGYISQDDLAKLAEKLGKSAYGQYLTKLSPDW

Sequences:

>Translated_289_residues
MKGIILAGGTGTRLHPITQAVSKQLMPVYDKPMIYYPLTTLMLAGIRELLIITTPHDVEAFKRLLGDGSQWGISLTYAVQ
PSPDGLAQAFIIGADFVHGDSSALVLGDNIFYGHGLPEIMKSGTSRREGATVFAYHVTDPERYGVVGFDKKMNALSIEEK
PKQPKSNWAVTGLYFYDQQVVDIAANLKPSPRGELEITDVNRTYLERGQLFVELMGRGYAWLDTGTPDSLHDAAGFVSTL
EKRQGFKIACPEEVAWRMGYISQDDLAKLAEKLGKSAYGQYLTKLSPDW
>Mature_289_residues
MKGIILAGGTGTRLHPITQAVSKQLMPVYDKPMIYYPLTTLMLAGIRELLIITTPHDVEAFKRLLGDGSQWGISLTYAVQ
PSPDGLAQAFIIGADFVHGDSSALVLGDNIFYGHGLPEIMKSGTSRREGATVFAYHVTDPERYGVVGFDKKMNALSIEEK
PKQPKSNWAVTGLYFYDQQVVDIAANLKPSPRGELEITDVNRTYLERGQLFVELMGRGYAWLDTGTPDSLHDAAGFVSTL
EKRQGFKIACPEEVAWRMGYISQDDLAKLAEKLGKSAYGQYLTKLSPDW

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=257, Percent_Identity=23.3463035019455, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI11761621, Length=257, Percent_Identity=23.3463035019455, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=67.9442508710801, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=67.3684210526316, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1787488, Length=242, Percent_Identity=26.4462809917355, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=236, Percent_Identity=25, Blast_Score=81, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=258, Percent_Identity=28.2945736434109, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355443, Length=274, Percent_Identity=24.8175182481752, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644084, Length=274, Percent_Identity=24.8175182481752, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 31911; Mature: 31911

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGTGTRLHPITQAVSKQLMPVYDKPMIYYPLTTLMLAGIRELLIITTPHDVEA
CCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHEEEEEECCCCHHH
FKRLLGDGSQWGISLTYAVQPSPDGLAQAFIIGADFVHGDSSALVLGDNIFYGHGLPEIM
HHHHHCCCCCCCEEEEEEECCCCCHHHEEEEEECEEEECCCCEEEEECCEEECCCHHHHH
KSGTSRREGATVFAYHVTDPERYGVVGFDKKMNALSIEEKPKQPKSNWAVTGLYFYDQQV
HCCCCCCCCCEEEEEECCCCHHCCEEEECCCCCEEECCCCCCCCCCCEEEEEEEEECHHH
VDIAANLKPSPRGELEITDVNRTYLERGQLFVELMGRGYAWLDTGTPDSLHDAAGFVSTL
HHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
EKRQGFKIACPEEVAWRMGYISQDDLAKLAEKLGKSAYGQYLTKLSPDW
HHHCCCEEECHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKGIILAGGTGTRLHPITQAVSKQLMPVYDKPMIYYPLTTLMLAGIRELLIITTPHDVEA
CCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHEEEEEECCCCHHH
FKRLLGDGSQWGISLTYAVQPSPDGLAQAFIIGADFVHGDSSALVLGDNIFYGHGLPEIM
HHHHHCCCCCCCEEEEEEECCCCCHHHEEEEEECEEEECCCCEEEEECCEEECCCHHHHH
KSGTSRREGATVFAYHVTDPERYGVVGFDKKMNALSIEEKPKQPKSNWAVTGLYFYDQQV
HCCCCCCCCCEEEEEECCCCHHCCEEEECCCCCEEECCCCCCCCCCCEEEEEEEEECHHH
VDIAANLKPSPRGELEITDVNRTYLERGQLFVELMGRGYAWLDTGTPDSLHDAAGFVSTL
HHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
EKRQGFKIACPEEVAWRMGYISQDDLAKLAEKLGKSAYGQYLTKLSPDW
HHHCCCEEECHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]