BacMap

Definition	Rhizobium leguminosarum bv. trifolii WSM2304 chromosome, complete genome.
Accession	NC_011369
Length	4,537,948

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The map label for this gene is hbdH1 [H]

Identifier: 209548544

GI number: 209548544

Start: 963611

End: 964399

Strand: Reverse

Name: hbdH1 [H]

Synonym: Rleg2_0941

Alternate gene names: 209548544

Gene position: 964399-963611 (Counterclockwise)

Preceding gene: 209548547

Following gene: 209548542

Centisome position: 21.25

GC content: 65.02

Gene sequence:

>789_bases
ATGGATCTCGGCATCGAAGGCAAACGGGCGCTCATCCTCGCCTCCTCGCGCGGGCTTGGCCTCGGCATCGCCGTAGCGCT
GGCGCGCGAAGGCACCAACGTGCTGCTTTGCGGACGCAGCGGCGACCAGCTGGAAGCCAATTGCAAGGCGATCAACAGCG
AAGGCAAAGGTCGTGCCGACTGGATCTGGGCCGACCTCGGGGATGAACGCTTCGTCGAAACAGTGACAAGCGCGGTGAAG
GAGAAGTTCGCCGGGCTCGATATCCTCGTCAACAATACCGGCGGGCCAACGCCCGGCACGACCGAGGATATGACGGGTGA
AAAGCTCGAGACCTATTTCCTCTCGATGGTCGCCCGCGTCATCACGCTGACCAATGCGCTGCTGCCCGGCATGAAGGCAC
AGGGCTGGGGTCGCATCCTGACGGTCGCCTCCTCAGGCGTGATCGAGCCGATCGCCAATCTGGCGCTGTCGAATACGCTG
CGCCCGGCACTTGCCGGCTGGAGCAAGACACTTGCCTCCGAAGTGGCGGGCTTCGGCGTTACCACCAATCTGCTGTTGCC
GGGCAGCATCCTGACGGGCCGCCTCGACGATCTCGACGGCGCGGCGGCAAAGCGGACGGGCAAGAGCCTCGAAGAGATCC
GCACCGATAAGGAAGCGCGCATTCCGGTCGGCCGCTACGGCCGAGTGGAGGAATTTGCCGCAGCGGCTGCCTTCCTGTGC
AGCCAGCCGGCAAGTTACATCACCGGCTCGCTGATCCGCTGCGACGGCGGCGCGGCCCGATCCGTCTAG

Upstream 100 bases:

>100_bases
CGTCAACGTCAATTGGCAAACGCCGCCGAACCGATCACGCTCCCTTTCCTTTTCCGCCGCGTGCGCCTTATACATCGATC
GAAGAGTTTGGAGGACAATC

Downstream 100 bases:

>100_bases
AACAGGATGATTTTAGGCCCAGTTGGCCTAAAATCTGAATCCTGTTCTCAATTAAAGAGTTAGAGCATGATGTTGTCCGA
AAACCGCGCGCTTTTCGGCA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: BDH; 3-hydroxybutyrate dehydrogenase; 3-HBDH [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MDLGIEGKRALILASSRGLGLGIAVALAREGTNVLLCGRSGDQLEANCKAINSEGKGRADWIWADLGDERFVETVTSAVK
EKFAGLDILVNNTGGPTPGTTEDMTGEKLETYFLSMVARVITLTNALLPGMKAQGWGRILTVASSGVIEPIANLALSNTL
RPALAGWSKTLASEVAGFGVTTNLLLPGSILTGRLDDLDGAAAKRTGKSLEEIRTDKEARIPVGRYGRVEEFAAAAAFLC
SQPASYITGSLIRCDGGAARSV

Sequences:

>Translated_262_residues
MDLGIEGKRALILASSRGLGLGIAVALAREGTNVLLCGRSGDQLEANCKAINSEGKGRADWIWADLGDERFVETVTSAVK
EKFAGLDILVNNTGGPTPGTTEDMTGEKLETYFLSMVARVITLTNALLPGMKAQGWGRILTVASSGVIEPIANLALSNTL
RPALAGWSKTLASEVAGFGVTTNLLLPGSILTGRLDDLDGAAAKRTGKSLEEIRTDKEARIPVGRYGRVEEFAAAAAFLC
SQPASYITGSLIRCDGGAARSV
>Mature_262_residues
MDLGIEGKRALILASSRGLGLGIAVALAREGTNVLLCGRSGDQLEANCKAINSEGKGRADWIWADLGDERFVETVTSAVK
EKFAGLDILVNNTGGPTPGTTEDMTGEKLETYFLSMVARVITLTNALLPGMKAQGWGRILTVASSGVIEPIANLALSNTL
RPALAGWSKTLASEVAGFGVTTNLLLPGSILTGRLDDLDGAAAKRTGKSLEEIRTDKEARIPVGRYGRVEEFAAAAAFLC
SQPASYITGSLIRCDGGAARSV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=32.03125, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4503301, Length=261, Percent_Identity=30.6513409961686, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=28.8537549407115, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI226371731, Length=190, Percent_Identity=28.9473684210526, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=27.4900398406374, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI66933014, Length=174, Percent_Identity=29.8850574712644, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI126723750, Length=259, Percent_Identity=26.2548262548263, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=25.2873563218391, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI59889578, Length=235, Percent_Identity=29.3617021276596, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=32.295719844358, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=32.156862745098, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=26.8, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787905, Length=261, Percent_Identity=26.0536398467433, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=26.953125, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082160, Length=263, Percent_Identity=26.9961977186312, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI2367175, Length=261, Percent_Identity=30.6513409961686, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=27.4131274131274, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=24.21875, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=28.996282527881, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=30.0380228136882, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=30.8270676691729, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=30.5970149253731, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17565030, Length=257, Percent_Identity=29.9610894941634, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=28.3524904214559, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=31.3207547169811, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=30.4511278195489, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=259, Percent_Identity=29.3436293436293, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=27.4509803921569, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=29.8804780876494, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=30, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=32.4324324324324, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=28.3524904214559, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=28.5171102661597, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=28.1954887218045, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=27.3408239700375, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=29.811320754717, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=25.8555133079848, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=237, Percent_Identity=28.2700421940928, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=26.2948207171315, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=261, Percent_Identity=24.904214559387, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=25.2873563218391, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=31.640625, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=30.8, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=28.2352941176471, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=28.8, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24584744, Length=190, Percent_Identity=30, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574402, Length=190, Percent_Identity=30, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355319, Length=261, Percent_Identity=29.1187739463602, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161076933, Length=190, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584748, Length=190, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639444, Length=269, Percent_Identity=24.5353159851301, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011294
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.30 [H]

Molecular weight: Translated: 27382; Mature: 27382

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGIEGKRALILASSRGLGLGIAVALAREGTNVLLCGRSGDQLEANCKAINSEGKGRAD
CCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCCHHHEECCCCCCCEE
WIWADLGDERFVETVTSAVKEKFAGLDILVNNTGGPTPGTTEDMTGEKLETYFLSMVARV
EEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ITLTNALLPGMKAQGWGRILTVASSGVIEPIANLALSNTLRPALAGWSKTLASEVAGFGV
HHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TTNLLLPGSILTGRLDDLDGAAAKRTGKSLEEIRTDKEARIPVGRYGRVEEFAAAAAFLC
EEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHH
SQPASYITGSLIRCDGGAARSV
CCCHHHHCCCEEEECCCCCCCC
>Mature Secondary Structure
MDLGIEGKRALILASSRGLGLGIAVALAREGTNVLLCGRSGDQLEANCKAINSEGKGRAD
CCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCCHHHEECCCCCCCEE
WIWADLGDERFVETVTSAVKEKFAGLDILVNNTGGPTPGTTEDMTGEKLETYFLSMVARV
EEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ITLTNALLPGMKAQGWGRILTVASSGVIEPIANLALSNTLRPALAGWSKTLASEVAGFGV
HHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TTNLLLPGSILTGRLDDLDGAAAKRTGKSLEEIRTDKEARIPVGRYGRVEEFAAAAAFLC
EEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHH
SQPASYITGSLIRCDGGAARSV
CCCHHHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA