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The map label for this gene is mdtA [H]

Identifier: 209548542

GI number: 209548542

Start: 961011

End: 962318

Strand: Reverse

Name: mdtA [H]

Synonym: Rleg2_0939

Alternate gene names: 209548542

Gene position: 962318-961011 (Counterclockwise)

Preceding gene: 209548544

Following gene: 209548541

Centisome position: 21.21

GC content: 63.99

Gene sequence:

>1308_bases
ATGAAGAAATTTTGGATCACTGTCAGCGTTATCGCAGTTGCCGCCGTCGGCGTCTGGCAATTCGGGAATCTGATCCCCTA
TGCCTCCCGCATTCCCACCCTCTCGCAGTTCATCAAGCAGCCGGTTGGCGGCAATGGCGGGCAGCCGGCACAGGGCGATC
AGGCGCAGGCCGATCAAGCGCAGAACGGTGGGCAACGTCAGGGCGGCGGGCGCAGACGCGGCGGCGGCGGCCCGACGATC
GTGAAGACCGTTGCAGCCGTGAAAACGGCGCTGCCGACGGATGTGACGGCGTCCGGCTGGGCCGATGCCGACGACAACAC
CACCATTGCAGCGCAGGAACAGGGCCTGATCGTCAGCATCAATGGCCAGGATGGAGCGACCGTCAAAGCCGGCGACCTGA
TCGCCAAGCTCGACGACCGGACGGCCAAGGCCGCCGTCGACAAGGACAATGCGATGATCGTCCGGGACACGGCGACGCTT
TCGGAATCCGAAACCGCGCTGGTGCGCGCGCAGGACCTCTTCGACCAGAAAGCCGGCACTCAGCAGAGCCTCGATCAGGC
GAGAGCCGCCCGCGATACCGCTGCCGCGACCGTCGATGCCGATAAGGCGACGCTCGCCTCGGATCAGATCATCCTCGAAA
ACACCGATATCCGCGCGCCCTTCGACGGCCGGCTCGGCGATATCGCCATCAGCAAGGGGGCTTTCCTCAATGCCGGCTCG
GCGATCGTCACCATCGCCAAATACGATCCGATCTATGTGAAATTCCACCTGCAGGAACGCTATCTCAGGGAATTGAAGAG
CGCGCTCGCAGCCGGCCCGGTCGAGGTCAGCACGGTTCCGGCTTCTACCAAGGGGCAGGTCCGCAAGGGCGAAATCAGCT
TCTACGACAACACCGTCGACACGGCCTCGGGCACGATCCTCGCCAAGGCGAAATTCGAGAATGCCTCCGGCGCGCTCTGG
CCCGGCCAGTCGGTCAACATCGTCGTGCATTTCAACAATGACGAACAGCAGGTGGTGGTGCCGACCGTGGCCGTCAGCCC
CGGTCCGGACGGGTTCTTCGCCTTTGTCGCCAAGGACGGCAAATCGCATCTGACGCCGGTCACCGTTGCCCGCGCCAATG
GCGGCTTCACCGCCATCGCATCGGGTCTTTCGGAAGGCGACCATGTCGTCGTCGAGGGCCAGGGCCAGCTTAGCGACCAG
CAGGCGATCAACGAGCAGTTCGACGAAAAGGCGCTTGATGTCGCCTCCGCCGACGCGGCTCGGCAGCCCCAGCAATCCGA
GACGATCGCGGTGGGAGCTCAGCAATGA

Upstream 100 bases:

>100_bases
AGTGATTGCGACCCGGGAATTATGTCTTTTTTGCGCCGCAATATAAGCGGCTCAATCGGGGCATAAAAATCGCCCCCCAT
TCAACACCCCGGTCTCGCCC

Downstream 100 bases:

>100_bases
TCCCGAATTTCTGTATCCAGCGCCCCGTCGCGACGACGCTGCTTGCCATCGGCGTCATTCTGGCCGGTCTTGCCGGTTAC
CGGCTCGTGCCCGTCGCGGC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKKFWITVSVIAVAAVGVWQFGNLIPYASRIPTLSQFIKQPVGGNGGQPAQGDQAQADQAQNGGQRQGGGRRRGGGGPTI
VKTVAAVKTALPTDVTASGWADADDNTTIAAQEQGLIVSINGQDGATVKAGDLIAKLDDRTAKAAVDKDNAMIVRDTATL
SESETALVRAQDLFDQKAGTQQSLDQARAARDTAAATVDADKATLASDQIILENTDIRAPFDGRLGDIAISKGAFLNAGS
AIVTIAKYDPIYVKFHLQERYLRELKSALAAGPVEVSTVPASTKGQVRKGEISFYDNTVDTASGTILAKAKFENASGALW
PGQSVNIVVHFNNDEQQVVVPTVAVSPGPDGFFAFVAKDGKSHLTPVTVARANGGFTAIASGLSEGDHVVVEGQGQLSDQ
QAINEQFDEKALDVASADAARQPQQSETIAVGAQQ

Sequences:

>Translated_435_residues
MKKFWITVSVIAVAAVGVWQFGNLIPYASRIPTLSQFIKQPVGGNGGQPAQGDQAQADQAQNGGQRQGGGRRRGGGGPTI
VKTVAAVKTALPTDVTASGWADADDNTTIAAQEQGLIVSINGQDGATVKAGDLIAKLDDRTAKAAVDKDNAMIVRDTATL
SESETALVRAQDLFDQKAGTQQSLDQARAARDTAAATVDADKATLASDQIILENTDIRAPFDGRLGDIAISKGAFLNAGS
AIVTIAKYDPIYVKFHLQERYLRELKSALAAGPVEVSTVPASTKGQVRKGEISFYDNTVDTASGTILAKAKFENASGALW
PGQSVNIVVHFNNDEQQVVVPTVAVSPGPDGFFAFVAKDGKSHLTPVTVARANGGFTAIASGLSEGDHVVVEGQGQLSDQ
QAINEQFDEKALDVASADAARQPQQSETIAVGAQQ
>Mature_435_residues
MKKFWITVSVIAVAAVGVWQFGNLIPYASRIPTLSQFIKQPVGGNGGQPAQGDQAQADQAQNGGQRQGGGRRRGGGGPTI
VKTVAAVKTALPTDVTASGWADADDNTTIAAQEQGLIVSINGQDGATVKAGDLIAKLDDRTAKAAVDKDNAMIVRDTATL
SESETALVRAQDLFDQKAGTQQSLDQARAARDTAAATVDADKATLASDQIILENTDIRAPFDGRLGDIAISKGAFLNAGS
AIVTIAKYDPIYVKFHLQERYLRELKSALAAGPVEVSTVPASTKGQVRKGEISFYDNTVDTASGTILAKAKFENASGALW
PGQSVNIVVHFNNDEQQVVVPTVAVSPGPDGFFAFVAKDGKSHLTPVTVARANGGFTAIASGLSEGDHVVVEGQGQLSDQ
QAINEQFDEKALDVASADAARQPQQSETIAVGAQQ

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=354, Percent_Identity=32.2033898305085, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1789665, Length=326, Percent_Identity=29.7546012269939, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786668, Length=341, Percent_Identity=28.1524926686217, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1789929, Length=298, Percent_Identity=26.8456375838926, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081951, Length=202, Percent_Identity=25.7425742574257, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45381; Mature: 45381

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFWITVSVIAVAAVGVWQFGNLIPYASRIPTLSQFIKQPVGGNGGQPAQGDQAQADQA
CCEEEEEHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHH
QNGGQRQGGGRRRGGGGPTIVKTVAAVKTALPTDVTASGWADADDNTTIAAQEQGLIVSI
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEE
NGQDGATVKAGDLIAKLDDRTAKAAVDKDNAMIVRDTATLSESETALVRAQDLFDQKAGT
ECCCCCEEECCCEEEECCCCHHHHEECCCCEEEEEECCCCCCCCHHEEHHHHHHHHCCCC
QQSLDQARAARDTAAATVDADKATLASDQIILENTDIRAPFDGRLGDIAISKGAFLNAGS
HHHHHHHHHHHHHHHEEECCCCCEECCCEEEEECCCCCCCCCCCCCCEEEECCCEEECCC
AIVTIAKYDPIYVKFHLQERYLRELKSALAAGPVEVSTVPASTKGQVRKGEISFYDNTVD
EEEEEEECCCEEEEEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECEEEEECCCCC
TASGTILAKAKFENASGALWPGQSVNIVVHFNNDEQQVVVPTVAVSPGPDGFFAFVAKDG
CCCCEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCEEEEEEECC
KSHLTPVTVARANGGFTAIASGLSEGDHVVVEGQGQLSDQQAINEQFDEKALDVASADAA
CCCCCEEEEEECCCCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHH
RQPQQSETIAVGAQQ
CCCCCCCEEEEECCC
>Mature Secondary Structure
MKKFWITVSVIAVAAVGVWQFGNLIPYASRIPTLSQFIKQPVGGNGGQPAQGDQAQADQA
CCEEEEEHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHH
QNGGQRQGGGRRRGGGGPTIVKTVAAVKTALPTDVTASGWADADDNTTIAAQEQGLIVSI
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEE
NGQDGATVKAGDLIAKLDDRTAKAAVDKDNAMIVRDTATLSESETALVRAQDLFDQKAGT
ECCCCCEEECCCEEEECCCCHHHHEECCCCEEEEEECCCCCCCCHHEEHHHHHHHHCCCC
QQSLDQARAARDTAAATVDADKATLASDQIILENTDIRAPFDGRLGDIAISKGAFLNAGS
HHHHHHHHHHHHHHHEEECCCCCEECCCEEEEECCCCCCCCCCCCCCEEEECCCEEECCC
AIVTIAKYDPIYVKFHLQERYLRELKSALAAGPVEVSTVPASTKGQVRKGEISFYDNTVD
EEEEEEECCCEEEEEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECEEEEECCCCC
TASGTILAKAKFENASGALWPGQSVNIVVHFNNDEQQVVVPTVAVSPGPDGFFAFVAKDG
CCCCEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCEEEEEEECC
KSHLTPVTVARANGGFTAIASGLSEGDHVVVEGQGQLSDQQAINEQFDEKALDVASADAA
CCCCCEEEEEECCCCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHH
RQPQQSETIAVGAQQ
CCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA