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The map label for this gene is yphC [C]

Identifier: 209548434

GI number: 209548434

Start: 849340

End: 850383

Strand: Reverse

Name: yphC [C]

Synonym: Rleg2_0831

Alternate gene names: 209548434

Gene position: 850383-849340 (Counterclockwise)

Preceding gene: 209548436

Following gene: 209548432

Centisome position: 18.74

GC content: 66.0

Gene sequence:

>1044_bases
ATGAAAGCCATGTATTACGAAGCCTTCGAGCAGGCGCCCGAGATCCGCACCCTGCCCGATCCGACGCCTTCCGAGGACGG
CGTCGTCATATCGGTCGGCGCCAGCGGGCTCTGCCGCAGCGACTGGCACGGCTGGATGGGGCATGACCCCGATATCCGCC
TGCCGCATGTGCCGGGGCACGAGCTTGCCGGAAAGATCGTCGCCACCGGCCGCGGTGTGATGCGTTTCAAGGTGGGCGAC
CGGGTGACTGTGCCGTTCGTTTCCGGCTGTGGCCATTGCGGAGAGTGCCATTCCGGCAACCAGCAGGTCTGCCCGAACCA
GTTCCAGCCGGGCTTCACCCATTGGGGATCCTTCGCCGAATATGTGGCGATCGATTATGCCGACACCAATCTGGTGCATC
TGCCCGAGACGATCGACGATGCGACGGCGGCAAGCCTCGGCTGCCGCTTCGCCACCTCGTTCCGCGCCGTCGCCGACCAG
GCACGCACCGGGCCCGGCGAATGGATCGCCGTGCATGGCTGCGGCGGCGTCGGCCTGTCGGCGATCATGATCGCCACGGC
ACTCGGCGCCAATGCGATCGGCATCGACATATCCGAGGAGAAGCTCGCCTTCGCCAGAGAGTGCGGGGCAGTGGCAACGG
TCAATGCCTCCGGCGTCGCGGATGTGGCGGAGGCGGTGCGCGAGATCACTAAAGGCGGCGCGCATGTCTCGATCGACGCG
CTCGGCCATCCCGCCACCTGCTTCAACTCGATCAAGAATCTGCGCCGGCGCGGCCGGCATGTGCAGGTGGGGCTGATGCT
CGGCGAACATGCCACGCCGCAAATCCCGATGGCGCAGGTGATCGGCCACGAATTGGAGATCTACGGCAGCCACGGCATGC
AGGCCTGGCGCTATGACGCCATGCTGTCGATGCTGGCGGCCGGCAAGATCGCCCCGCAGAAGCTGATCGGACGTCGAGTC
ACCTTGGAGGAGGCCGTGCCGACGCTGATGGCGCTCGACAAGGCGGAGGCCACGGGGATCAGCGTGATTACGCGGTTTTC
GTGA

Upstream 100 bases:

>100_bases
GGGTGCATCAGCAAAAATGATGGAATGGACCGTTGGAACGGGGGCCTGCCGCATGCGATCATAGGGTCAAATCGCGAGAC
GGCAGCAAGGGAAGACGCCG

Downstream 100 bases:

>100_bases
GGGAGTTTTGCTGTCTCGCCTGTGACAAGCGTGAGAGGGAACCAAGGCGCTGCCACGATTCCGCTTCTCCCCCGCGGGCA
GAAGATGCCGGCAGGCAGAT

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKAMYYEAFEQAPEIRTLPDPTPSEDGVVISVGASGLCRSDWHGWMGHDPDIRLPHVPGHELAGKIVATGRGVMRFKVGD
RVTVPFVSGCGHCGECHSGNQQVCPNQFQPGFTHWGSFAEYVAIDYADTNLVHLPETIDDATAASLGCRFATSFRAVADQ
ARTGPGEWIAVHGCGGVGLSAIMIATALGANAIGIDISEEKLAFARECGAVATVNASGVADVAEAVREITKGGAHVSIDA
LGHPATCFNSIKNLRRRGRHVQVGLMLGEHATPQIPMAQVIGHELEIYGSHGMQAWRYDAMLSMLAAGKIAPQKLIGRRV
TLEEAVPTLMALDKAEATGISVITRFS

Sequences:

>Translated_347_residues
MKAMYYEAFEQAPEIRTLPDPTPSEDGVVISVGASGLCRSDWHGWMGHDPDIRLPHVPGHELAGKIVATGRGVMRFKVGD
RVTVPFVSGCGHCGECHSGNQQVCPNQFQPGFTHWGSFAEYVAIDYADTNLVHLPETIDDATAASLGCRFATSFRAVADQ
ARTGPGEWIAVHGCGGVGLSAIMIATALGANAIGIDISEEKLAFARECGAVATVNASGVADVAEAVREITKGGAHVSIDA
LGHPATCFNSIKNLRRRGRHVQVGLMLGEHATPQIPMAQVIGHELEIYGSHGMQAWRYDAMLSMLAAGKIAPQKLIGRRV
TLEEAVPTLMALDKAEATGISVITRFS
>Mature_347_residues
MKAMYYEAFEQAPEIRTLPDPTPSEDGVVISVGASGLCRSDWHGWMGHDPDIRLPHVPGHELAGKIVATGRGVMRFKVGD
RVTVPFVSGCGHCGECHSGNQQVCPNQFQPGFTHWGSFAEYVAIDYADTNLVHLPETIDDATAASLGCRFATSFRAVADQ
ARTGPGEWIAVHGCGGVGLSAIMIATALGANAIGIDISEEKLAFARECGAVATVNASGVADVAEAVREITKGGAHVSIDA
LGHPATCFNSIKNLRRRGRHVQVGLMLGEHATPQIPMAQVIGHELEIYGSHGMQAWRYDAMLSMLAAGKIAPQKLIGRRV
TLEEAVPTLMALDKAEATGISVITRFS

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=265, Percent_Identity=29.811320754717, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4501933, Length=275, Percent_Identity=29.8181818181818, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156523966, Length=244, Percent_Identity=30.327868852459, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4501939, Length=244, Percent_Identity=30.327868852459, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI34577061, Length=252, Percent_Identity=29.7619047619048, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI71565152, Length=272, Percent_Identity=29.7794117647059, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4501929, Length=273, Percent_Identity=29.3040293040293, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI262073058, Length=279, Percent_Identity=27.5985663082437, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI71743840, Length=279, Percent_Identity=27.5985663082437, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI194239674, Length=324, Percent_Identity=28.0864197530864, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI13236495, Length=324, Percent_Identity=28.0864197530864, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI194239676, Length=211, Percent_Identity=31.7535545023697, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI87082125, Length=340, Percent_Identity=30, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787863, Length=331, Percent_Identity=29.3051359516616, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081918, Length=283, Percent_Identity=34.2756183745583, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786825, Length=397, Percent_Identity=26.7002518891688, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788073, Length=307, Percent_Identity=28.0130293159609, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=26.4880952380952, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI226510992, Length=300, Percent_Identity=30, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=25.8720930232558, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790718, Length=333, Percent_Identity=28.5285285285285, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786552, Length=293, Percent_Identity=27.3037542662116, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788407, Length=322, Percent_Identity=27.0186335403727, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786518, Length=263, Percent_Identity=28.1368821292776, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082401, Length=133, Percent_Identity=33.8345864661654, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=267, Percent_Identity=29.5880149812734, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=267, Percent_Identity=29.5880149812734, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17562584, Length=352, Percent_Identity=27.8409090909091, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=232, Percent_Identity=30.6034482758621, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=221, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=207, Percent_Identity=30.9178743961353, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=332, Percent_Identity=29.2168674698795, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=340, Percent_Identity=26.1764705882353, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=319, Percent_Identity=32.6018808777429, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319621, Length=252, Percent_Identity=34.1269841269841, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=307, Percent_Identity=31.5960912052117, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323961, Length=321, Percent_Identity=32.0872274143302, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319955, Length=331, Percent_Identity=29.9093655589124, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=331, Percent_Identity=29.9093655589124, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=312, Percent_Identity=27.2435897435897, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323980, Length=205, Percent_Identity=32.1951219512195, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=333, Percent_Identity=27.3273273273273, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=202, Percent_Identity=30.1980198019802, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737895, Length=348, Percent_Identity=26.7241379310345, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17137530, Length=315, Percent_Identity=27.3015873015873, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737897, Length=323, Percent_Identity=26.625386996904, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36862; Mature: 36862

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMYYEAFEQAPEIRTLPDPTPSEDGVVISVGASGLCRSDWHGWMGHDPDIRLPHVPGH
CCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCCCH
ELAGKIVATGRGVMRFKVGDRVTVPFVSGCGHCGECHSGNQQVCPNQFQPGFTHWGSFAE
HHCCEEEECCCCEEEEECCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHE
YVAIDYADTNLVHLPETIDDATAASLGCRFATSFRAVADQARTGPGEWIAVHGCGGVGLS
EEEEEECCCCEEECCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHH
AIMIATALGANAIGIDISEEKLAFARECGAVATVNASGVADVAEAVREITKGGAHVSIDA
HHHHHHHHCCCEEEECCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
LGHPATCFNSIKNLRRRGRHVQVGLMLGEHATPQIPMAQVIGHELEIYGSHGMQAWRYDA
CCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCCEEEEEECCCCHHHHHHH
MLSMLAAGKIAPQKLIGRRVTLEEAVPTLMALDKAEATGISVITRFS
HHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAMYYEAFEQAPEIRTLPDPTPSEDGVVISVGASGLCRSDWHGWMGHDPDIRLPHVPGH
CCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCCCH
ELAGKIVATGRGVMRFKVGDRVTVPFVSGCGHCGECHSGNQQVCPNQFQPGFTHWGSFAE
HHCCEEEECCCCEEEEECCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHE
YVAIDYADTNLVHLPETIDDATAASLGCRFATSFRAVADQARTGPGEWIAVHGCGGVGLS
EEEEEECCCCEEECCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHH
AIMIATALGANAIGIDISEEKLAFARECGAVATVNASGVADVAEAVREITKGGAHVSIDA
HHHHHHHHCCCEEEECCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
LGHPATCFNSIKNLRRRGRHVQVGLMLGEHATPQIPMAQVIGHELEIYGSHGMQAWRYDA
CCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCCEEEEEECCCCHHHHHHH
MLSMLAAGKIAPQKLIGRRVTLEEAVPTLMALDKAEATGISVITRFS
HHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]