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The map label for this gene is betA [H]

Identifier: 209548380

GI number: 209548380

Start: 793929

End: 795578

Strand: Reverse

Name: betA [H]

Synonym: Rleg2_0776

Alternate gene names: 209548380

Gene position: 795578-793929 (Counterclockwise)

Preceding gene: 209548381

Following gene: 209548377

Centisome position: 17.53

GC content: 64.12

Gene sequence:

>1650_bases
ATGCAAGCAGATTTCGTCATCATCGGCTCAGGCTCGGCCGGCTCGGCGCTTGCCTATCGCCTCTCCGAAGACGGCAAGAA
CAGCGTCCTCGTCATCGAGGCGGGCGGCAGCGATTTCGGGCCGTTTATCCAGATGCCGGCGGCCCTTGCCTGGCCGATGA
GCATGAAGCGCTACAATTGGGGCTATTTGTCCGAGCCGGAGCCGAACCTCAACAACCGGCGCATCACCGCGCCGCGCGGC
AAGGTGATCGGCGGGTCCTCCTCGATCAACGGCATGGTCTATGTGCGCGGCCATGCCGAGGATTTCAACCGCTGGGAGGA
GCTCGGCGCCGGCGGCTGGGCCTATGCCGATGTCCTCCCCTATTTCAAGCGGATGGAGCATTCGCATGGTGGCGAGGAGG
GTTGGCGCGGCACCGACGGGCCGCTGCATGTCCAGCGCGGCGGTTTCACCAATCCGCTGTTTCGGGCCTTTGTCGAGGCC
GGCAAACAGGCGGGCTTCGAGACGACCGAGGATTATAACGGCAGCAAGCAGGAAGGCTTCGGGCTGATGGAGCAGACCAT
CTTTTCCGGCCGCCGCTGGTCTGCCGCCAACGCCTATCTGAAACCGGCGCTGAAGCGGAAAAATGTCGAGATCATCTACG
GCTTTGCGCAAAGGATCGTGATCGAAGACGGCCGGGCGACCGGCGTCGAGATCGAGCGCGGCGGCAAAATAGAGGTGGTC
AAGGCCAACCGCGAGGTGATCGTCTCGGCCTCCTCGTTCAATTCGCCGAAGCTGTTGATGTTGTCGGGCATCGGCCCGGG
CGAGCATCTCAAGGAAATGGGCATCGAGGTGAAGGCCGACCGGCCGGGGGTCGGCGCCAACCTGCAGGACCATATGGAAT
TCTACTTTCAGCAGGTGAGCACCAAGCCGGTGTCGCTCTATTCCTGGCTGCCGTGGTTCTGGCAGGGAGTGGCGGGCGCG
CAATGGCTGCTGTCCAAGGGCGGGCTCGGCGCCTCCAACCAGTTCGAGGCCTGCGCCTTCCTGCGCTCGGCGCCCGGGCT
GAAGCAGCCCGACATCCAATACCATTTCCTGCCGGTGGCAATCAGCTATGACGGCAAGGCGGCAGCCAAAAGCCACGGTT
TCCAGGTGCATGTCGGCTACAACCTGTCGAAATCGCGCGGCAGCGTGACGCTGCGCTCGCCCGACCCGAAGGCCGACCCG
GTGCTGCGCTTCAACTATATGAGCCATGCCGAGGACTGGGAGAAATTCCGCCACTGCGTGCGGCTGACCCGCGAGCTCTT
CGGGCAAGCGGCCTTCGACGACTACCGCGGGGCAGAGATCCAGCCCGGAGAAAGTGTGCAAAGCGACGAAGAGATCGACG
CCTTCCTGCGCGAGCATCTGGAAAGCGCCTATCACCCCTGCGGCACCTGCAAGATGGGCGCCAAGGACGATCCAATGGCG
GTGGTCGATCCCCAGACCCGGGTGATCGGGGTCGAGGCCTTGCGCGTCGCCGACAGCTCGATCTTCCCGCACGTCACCTA
CGGCAACCTCAACGGCCCGTCGATCATGACCGGCGAAAAGGCCGCCGACCACATCCTCGGCAAACAGCCGCTGGCGCGCT
CGAACCAGGAACCCTGGGTCAATCCGCGGGCCGCCGTCAGCGATCGGTGA

Upstream 100 bases:

>100_bases
CCTTCTCCCCGCCTGCGGGGAGAAGGTGGCGGCAGCCGGATGAGGGGCAGGCCCGGCGAACAAGCAGCCCGACGAAGGGC
AAATCGAGAAAGACAATACC

Downstream 100 bases:

>100_bases
TGTTAAATGCATGTCGCCCGGAAGTGTGCAGCGGTTCCGGGATAACGACATGCATCAAAACAAAGAGCTAAAGCGCGTCG
CATGAATCAAGTTTGATGCG

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MQADFVIIGSGSAGSALAYRLSEDGKNSVLVIEAGGSDFGPFIQMPAALAWPMSMKRYNWGYLSEPEPNLNNRRITAPRG
KVIGGSSSINGMVYVRGHAEDFNRWEELGAGGWAYADVLPYFKRMEHSHGGEEGWRGTDGPLHVQRGGFTNPLFRAFVEA
GKQAGFETTEDYNGSKQEGFGLMEQTIFSGRRWSAANAYLKPALKRKNVEIIYGFAQRIVIEDGRATGVEIERGGKIEVV
KANREVIVSASSFNSPKLLMLSGIGPGEHLKEMGIEVKADRPGVGANLQDHMEFYFQQVSTKPVSLYSWLPWFWQGVAGA
QWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVAISYDGKAAAKSHGFQVHVGYNLSKSRGSVTLRSPDPKADP
VLRFNYMSHAEDWEKFRHCVRLTRELFGQAAFDDYRGAEIQPGESVQSDEEIDAFLREHLESAYHPCGTCKMGAKDDPMA
VVDPQTRVIGVEALRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKQPLARSNQEPWVNPRAAVSDR

Sequences:

>Translated_549_residues
MQADFVIIGSGSAGSALAYRLSEDGKNSVLVIEAGGSDFGPFIQMPAALAWPMSMKRYNWGYLSEPEPNLNNRRITAPRG
KVIGGSSSINGMVYVRGHAEDFNRWEELGAGGWAYADVLPYFKRMEHSHGGEEGWRGTDGPLHVQRGGFTNPLFRAFVEA
GKQAGFETTEDYNGSKQEGFGLMEQTIFSGRRWSAANAYLKPALKRKNVEIIYGFAQRIVIEDGRATGVEIERGGKIEVV
KANREVIVSASSFNSPKLLMLSGIGPGEHLKEMGIEVKADRPGVGANLQDHMEFYFQQVSTKPVSLYSWLPWFWQGVAGA
QWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVAISYDGKAAAKSHGFQVHVGYNLSKSRGSVTLRSPDPKADP
VLRFNYMSHAEDWEKFRHCVRLTRELFGQAAFDDYRGAEIQPGESVQSDEEIDAFLREHLESAYHPCGTCKMGAKDDPMA
VVDPQTRVIGVEALRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKQPLARSNQEPWVNPRAAVSDR
>Mature_549_residues
MQADFVIIGSGSAGSALAYRLSEDGKNSVLVIEAGGSDFGPFIQMPAALAWPMSMKRYNWGYLSEPEPNLNNRRITAPRG
KVIGGSSSINGMVYVRGHAEDFNRWEELGAGGWAYADVLPYFKRMEHSHGGEEGWRGTDGPLHVQRGGFTNPLFRAFVEA
GKQAGFETTEDYNGSKQEGFGLMEQTIFSGRRWSAANAYLKPALKRKNVEIIYGFAQRIVIEDGRATGVEIERGGKIEVV
KANREVIVSASSFNSPKLLMLSGIGPGEHLKEMGIEVKADRPGVGANLQDHMEFYFQQVSTKPVSLYSWLPWFWQGVAGA
QWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVAISYDGKAAAKSHGFQVHVGYNLSKSRGSVTLRSPDPKADP
VLRFNYMSHAEDWEKFRHCVRLTRELFGQAAFDDYRGAEIQPGESVQSDEEIDAFLREHLESAYHPCGTCKMGAKDDPMA
VVDPQTRVIGVEALRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKQPLARSNQEPWVNPRAAVSDR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=553, Percent_Identity=49.1862567811935, Blast_Score=524, Evalue=1e-148,
Organism=Escherichia coli, GI1786503, Length=543, Percent_Identity=50.6445672191529, Blast_Score=527, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17532301, Length=547, Percent_Identity=45.3382084095064, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642042, Length=563, Percent_Identity=37.4777975133215, Blast_Score=318, Evalue=9e-87,
Organism=Drosophila melanogaster, GI45551458, Length=569, Percent_Identity=37.4340949033392, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI45549471, Length=569, Percent_Identity=37.4340949033392, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24642048, Length=591, Percent_Identity=33.502538071066, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24642055, Length=569, Percent_Identity=35.5008787346221, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24642039, Length=575, Percent_Identity=34.0869565217391, Blast_Score=275, Evalue=6e-74,
Organism=Drosophila melanogaster, GI17137792, Length=552, Percent_Identity=33.1521739130435, Blast_Score=271, Evalue=8e-73,
Organism=Drosophila melanogaster, GI24650267, Length=569, Percent_Identity=34.622144112478, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI18859995, Length=566, Percent_Identity=34.452296819788, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24642035, Length=578, Percent_Identity=34.4290657439446, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24642059, Length=562, Percent_Identity=33.9857651245552, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24642037, Length=574, Percent_Identity=33.9721254355401, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24642051, Length=562, Percent_Identity=31.1387900355872, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI18859993, Length=575, Percent_Identity=33.0434782608696, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI24645930, Length=581, Percent_Identity=28.0550774526678, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24642057, Length=590, Percent_Identity=27.4576271186441, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 60412; Mature: 60412

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQADFVIIGSGSAGSALAYRLSEDGKNSVLVIEAGGSDFGPFIQMPAALAWPMSMKRYNW
CCCCEEEEECCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHCCHHHHCCHHHHCCCC
GYLSEPEPNLNNRRITAPRGKVIGGSSSINGMVYVRGHAEDFNRWEELGAGGWAYADVLP
CCCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHH
YFKRMEHSHGGEEGWRGTDGPLHVQRGGFTNPLFRAFVEAGKQAGFETTEDYNGSKQEGF
HHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCC
GLMEQTIFSGRRWSAANAYLKPALKRKNVEIIYGFAQRIVIEDGRATGVEIERGGKIEVV
HHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEEEEEEEEEECCCCCCEEEECCCEEEEE
KANREVIVSASSFNSPKLLMLSGIGPGEHLKEMGIEVKADRPGVGANLQDHMEFYFQQVS
ECCCEEEEEECCCCCCCEEEEECCCCHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHC
TKPVSLYSWLPWFWQGVAGAQWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVA
CCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEE
ISYDGKAAAKSHGFQVHVGYNLSKSRGSVTLRSPDPKADPVLRFNYMSHAEDWEKFRHCV
EECCCCHHHCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHH
RLTRELFGQAAFDDYRGAEIQPGESVQSDEEIDAFLREHLESAYHPCGTCKMGAKDDPMA
HHHHHHHCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
VVDPQTRVIGVEALRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKQPLARSNQEPWV
EECCCCEEEEEEHEEECCCCCCCEEEECCCCCCCEECCCHHHHHHHCCCCCCCCCCCCCC
NPRAAVSDR
CCCCCCCCC
>Mature Secondary Structure
MQADFVIIGSGSAGSALAYRLSEDGKNSVLVIEAGGSDFGPFIQMPAALAWPMSMKRYNW
CCCCEEEEECCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHCCHHHHCCHHHHCCCC
GYLSEPEPNLNNRRITAPRGKVIGGSSSINGMVYVRGHAEDFNRWEELGAGGWAYADVLP
CCCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHH
YFKRMEHSHGGEEGWRGTDGPLHVQRGGFTNPLFRAFVEAGKQAGFETTEDYNGSKQEGF
HHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCC
GLMEQTIFSGRRWSAANAYLKPALKRKNVEIIYGFAQRIVIEDGRATGVEIERGGKIEVV
HHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEEEEEEEEEECCCCCCEEEECCCEEEEE
KANREVIVSASSFNSPKLLMLSGIGPGEHLKEMGIEVKADRPGVGANLQDHMEFYFQQVS
ECCCEEEEEECCCCCCCEEEEECCCCHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHC
TKPVSLYSWLPWFWQGVAGAQWLLSKGGLGASNQFEACAFLRSAPGLKQPDIQYHFLPVA
CCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEE
ISYDGKAAAKSHGFQVHVGYNLSKSRGSVTLRSPDPKADPVLRFNYMSHAEDWEKFRHCV
EECCCCHHHCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHH
RLTRELFGQAAFDDYRGAEIQPGESVQSDEEIDAFLREHLESAYHPCGTCKMGAKDDPMA
HHHHHHHCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
VVDPQTRVIGVEALRVADSSIFPHVTYGNLNGPSIMTGEKAADHILGKQPLARSNQEPWV
EECCCCEEEEEEHEEECCCCCCCEEEECCCCCCCEECCCHHHHHHHCCCCCCCCCCCCCC
NPRAAVSDR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA