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The map label for this gene is guaD [H]

Identifier: 209548305

GI number: 209548305

Start: 724975

End: 725448

Strand: Reverse

Name: guaD [H]

Synonym: Rleg2_0700

Alternate gene names: 209548305

Gene position: 725448-724975 (Counterclockwise)

Preceding gene: 209548308

Following gene: 209548304

Centisome position: 15.99

GC content: 61.18

Gene sequence:

>474_bases
ATGGAAAACCACGAGCCGTTTTTACGCGAGGCGATTGCGCTCTCGAAATCCGCGATGGACCAAGGCGACGAACCATTCGG
CTCGGTGCTGGTGAAGGATGGCGAGGTCATCCTGCGCGCCGAAAACAGCGTCTTCACCGGCCACGATATGACGAACCACG
CCGAAATGAACCTGATTAAATCTGCAGCGAAGCACTACGACACCGGTTTTCTCGCCGACTGCACGCTCTATACCAGCACG
GAGCCGTGCGCGATGTGCTCCGGGGCGATTTACTGGTCAGGCATCGGGCGCATGGTGTTTGCGTGCTCCGAAGCCCGGCT
TGGCGAGATCGCCGGGATCGGGCTGAACGTGCCGAGCCGGGCGGTCTTGCAAACCGGCGCGCGCACCGTCACTGTGGTTG
GCCCGACGAACCTCGAAGACGAAGCCGCGGAAGTGCATCAGGCATTCTGGCCGAAGCATCTCGGCAAGGCTTAG

Upstream 100 bases:

>100_bases
TTGCCGCGATCCGGATCGCCGATCCTCAATCGGATTTGCAGCCCTTGGAAATCCCTCCGATTCAAGACAAACTCTTGCTC
TAGCTTTTGGGGGGACTGTG

Downstream 100 bases:

>100_bases
CCTCAGGCGGGAGCTTGGCGAAAGCGCGCCTCCGTCATTCCAGGCCTCGAGCCTGGGATCCATGCCCACTGCGGTCGTGC
GCGTCAGCCCCCCTCTGCCC

Product: zinc-binding CMP/dCMP deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MENHEPFLREAIALSKSAMDQGDEPFGSVLVKDGEVILRAENSVFTGHDMTNHAEMNLIKSAAKHYDTGFLADCTLYTST
EPCAMCSGAIYWSGIGRMVFACSEARLGEIAGIGLNVPSRAVLQTGARTVTVVGPTNLEDEAAEVHQAFWPKHLGKA

Sequences:

>Translated_157_residues
MENHEPFLREAIALSKSAMDQGDEPFGSVLVKDGEVILRAENSVFTGHDMTNHAEMNLIKSAAKHYDTGFLADCTLYTST
EPCAMCSGAIYWSGIGRMVFACSEARLGEIAGIGLNVPSRAVLQTGARTVTVVGPTNLEDEAAEVHQAFWPKHLGKA
>Mature_157_residues
MENHEPFLREAIALSKSAMDQGDEPFGSVLVKDGEVILRAENSVFTGHDMTNHAEMNLIKSAAKHYDTGFLADCTLYTST
EPCAMCSGAIYWSGIGRMVFACSEARLGEIAGIGLNVPSRAVLQTGARTVTVVGPTNLEDEAAEVHQAFWPKHLGKA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=106, Percent_Identity=39.622641509434, Blast_Score=82, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17541138, Length=111, Percent_Identity=39.6396396396396, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17554608, Length=106, Percent_Identity=39.622641509434, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17555996, Length=110, Percent_Identity=35.4545454545455, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 16899; Mature: 16899

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENHEPFLREAIALSKSAMDQGDEPFGSVLVKDGEVILRAENSVFTGHDMTNHAEMNLIK
CCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEECCCEEECCCCCCHHHHHHHH
SAAKHYDTGFLADCTLYTSTEPCAMCSGAIYWSGIGRMVFACSEARLGEIAGIGLNVPSR
HHHHHCCCCCEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCH
AVLQTGARTVTVVGPTNLEDEAAEVHQAFWPKHLGKA
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENHEPFLREAIALSKSAMDQGDEPFGSVLVKDGEVILRAENSVFTGHDMTNHAEMNLIK
CCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEECCCEEECCCCCCHHHHHHHH
SAAKHYDTGFLADCTLYTSTEPCAMCSGAIYWSGIGRMVFACSEARLGEIAGIGLNVPSR
HHHHHCCCCCEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCH
AVLQTGARTVTVVGPTNLEDEAAEVHQAFWPKHLGKA
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]